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2. Efficacy and Safety of Phentermine/Topiramate in Adults with Overweight or Obesity: A Systematic Review and Meta-Analysis.

Author

Lei, Xiang‐Guo, Ruan, Jia‐Qi, Lai, Chen, Sun, Ziyi, Yang, Xi, Lei, Xiang-Guo, and Ruan, Jia-Qi

Subjects
MEDICAL subject headings, WEIGHT loss, TOPIRAMATE, OBESITY, BODY weight, BLOOD pressure, RESEARCH, CLINICAL trials, COMBINATION drug therapy, META-analysis, RESEARCH methodology, SYSTEMATIC reviews, FRUCTOSE, MEDICAL cooperation, EVALUATION research, AMPHETAMINES, TREATMENT effectiveness, COMPARATIVE studies
Abstract

Objective: The study objective was to examine the association between phentermine/topiramate therapy and weight loss and adverse events in adults with overweight or obesity by meta-analysis and systematic review.Methods: Medical Subject Headings and free-text terms were selected to search for eligible trials in PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), and Embase up to April 18, 2020. The quality of randomized controlled trials was evaluated by the Cochrane risk-of-bias tool. Meta-analysis was performed using random-effect models.Results: Phentermine/topiramate therapy resulted in an average weight loss of 7.73 kg (95% CI: 6.60-8.85) in general compared with placebo. The weight loss was related to the dose of phentermine/topiramate. Compared with placebo, the average weight loss was 3.55 kg (95% CI: 2.22-4.88) for 3.75/23 mg, 7.27 kg (95% CI: 6.40-8.13) for 7.5/46 mg, and 8.25 kg (95% CI: 6.92-9.79) for 15/92 mg. For phentermine/topiramate participants in different weight-loss subgroups, the weight loss of participants with ≥5%, ≥10%, and ≥15% baseline weight loss was 3.18 (95% CI: 2.75-3.67), 5.32 (95% CI: 4.53-6.25), and 5.65 (95% CI: 3.55-9.01), respectively. Compared with placebo, the adverse events associated with the treatment mainly included dysgeusia (odds ratio [OR] = 8.86, 95% CI: 5.65-13.89), paresthesia (OR = 8.51, 95% CI: 6.20-11.67), dry mouth (OR = 6.71, 95% CI: 5.03-8.94), disturbance in attention (OR = 4.48, 95% CI: 2.39-8.41), irritability (OR = 4.10, 95% CI: 2.29-7.33), hypoesthesia (OR = 3.81, 95% CI: 1.32-11.00), constipation (OR = 2.43, 95% CI: 2.02-2.93), and dizziness (OR = 2.26, 95% CI: 1.72-2.98). Phentermine/topiramate also reduced waist circumference, blood pressure, blood sugar levels, and lipid levels.Conclusions: Phentermine/topiramate has considerable benefit in reducing body weight, and the efficacy was closely related to the dosage. However, it increased the risk of nervous system-related adverse events. [ABSTRACT FROM AUTHOR]

Published
2021
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4. Study of neutron activation yields in spallation reaction of 400 MeV/u carbon on a thick lead target

Author

Ma, Fei, primary, Ge, Hong-Lin, additional, Zhang, Xue-Ying, additional, Zhang, Hong-Bin, additional, Ju, Yong-Qin, additional, Chen, Liang, additional, Yang, Lei, additional, Fu, Fen, additional, Zhang, Ya-Ling, additional, Li, Jian-Yang, additional, Liang, Tian-Jiao, additional, Zhou, Bin, additional, Wang, Song-Lin, additional, Li, Jin-Yang, additional, Xu, Jun-Kui, additional, Lei, Xiang-Guo, additional, Qin, Zhi, additional, and Gu, Long, additional

Published
2014
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5. Measured and Simulated Performance of a Four-Segmented Clover Detector

Author

Zhang, Ning-Tao, primary, Lei, Xiang-Guo, additional, Zhang, Yu-Hu, additional, Zhou, Xiao-Hong, additional, Liu, Min-Liang, additional, Guo, Ying-Xiang, additional, Fang, Yong-De, additional, Li, Shi-Cheng, additional, Zhou, Hou-Bing, additional, Ding, Bing, additional, Wang, Hai-Xia, additional, Wu, Xiao-Guang, additional, He, Chuang-Ye, additional, and Zheng, Yun, additional

Published
2012
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6. Half-Lives of Low-Lying Isomeric States in 169 Ta

Author

Zhang, Yu-hu, primary, Zhao, Qing-zhong, additional, Zhu, Shao-fei, additional, Xu, Hu-shan, additional, Zhou, Xiao-hong, additional, Guo, Ying-xiang, additional, Lei, Xiang-guo, additional, Lu, Jun, additional, Gou, Quan-bu, additional, Liu, Zhong, additional, Jin, Han-juan, additional, Luo, Yi-xiao, additional, Sun, Xiang-fu, additional, and Zhu, Yong-tai, additional

Published
1998
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7. Evidence for Octupole Correlations in 117 Xe

Author

Liu, Zhong, primary, Sun, Xiang-fu, additional, Zhou, Xiao-hong, additional, Lei, Xiang-guo, additional, Guo, Ying-xiang, additional, Jin, Han-juan, additional, Zhang, Yu-hu, additional, Chen, Xin-feng, additional, Luo, Yi-xiao, additional, Wen, Shu-xian, additional, Yang, Chun-xiang, additional, Yuan, Guan-jun, additional, Li, Guang-sheng, additional, Liu, Xiang-an, additional, and Chen, Yong-shou, additional

Published
1996
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8. A High-Spin Isomer in 198 Bi

Author

Zhou, Xiao-hong, primary, Sun, Xiang-fu, additional, Guo, Ying-xiang, additional, Lei, Xiang-guo, additional, Chen, Xin-feng, additional, Liu, Zhong, additional, Zhang, Yu-hu, additional, Jin, Han-juan, additional, Luo, Yi-xiao, additional, Wen, Shu-xian, additional, Yuan, Guan-jun, additional, Li, Guang-sheng, additional, and Yang, Chun-xiang, additional

Published
1996
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9. Signature Inversion of Yrast Band in Odd-Odd 162 Lu Nucleus

Author

Zhang, Yu-hu, primary, Zhou, Xiao-hong, additional, Zhao, Qing-zhong, additional, Sun, Xiang-fu, additional, Lei, Xiang-guo, additional, Guo, Ying-xiang, additional, Liu, Zhong, additional, Chen, Xing-feng, additional, Zhu, Yong-tai, additional, Wen, Shu-xian, additional, Yuan, Guan-jun, additional, and Liu, Xiang-an, additional

Published
1996
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10. Identification of Oblate Band in Odd–Odd 184Au.

Author

Zhang Yu-Hu, Wang Hua-Lei, De Angelis, G., Marginean, N., Gadea, A., Napoli, D. R., Axiotis, M., Rusu, C., Martinez, T., Zhou Xiao-Hong, Guo Wen-Tao, Liu Min-Liang, Lei Xiang-Guo, Guo Ying-Xiang, and Xu Fu-Rong

Published
2004

11. Decay of the 67-μs Isomer in 142Pm.

Author

Liu Min-Liang, Zhang Yu-Hu, Zhou Xiao-Hong, Guo Ying-Xiang, Lei Xiang-Guo, Liu Zhong, He Jian-Jun, Wen Shu-Xian, Wu Xiao-Guang, and Yuan Guan-Jun

Published
2004

12. Excited States in 207Rn.

Author

Luo Wan-Ju, Guo Ying-Xiang, Zhou Xiao-Hong, Zhang Yu-Hu, Lei Xiang-Guo, Liu Zhong, Zheng Yong, Liu Min-Liang, He Jian-Jun, and Zhu Li-Hua and Wen Shu-Xian

Published
2003

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