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Models with distal outcomes have been commonly used to evaluate the effect of categorical latent variables on an observed dependent variable, which can be binary, counting, or continuous. Several a...

Emerging evidence suggests that vicarious racial experiences of discrimination may negatively influence child health. Few studies have focus on childhood asthma symptoms and potential moderators of such relationship. We used two population-based cross-sectional studies from the Social Change Allergy and Asthma in Latin America project in Salvador, Brazil. A total of 1003 children and mothers interviewed in 2006 were included, of whom 873 were reached again in 2013. Vicarious racial discrimination was assessed in mothers by applying the Experiences of Discrimination scale. Data on wheeze and environmental exposures were collected with standardized questionnaires. Levels of allergen-specific IgE were measured to identify atopy. Generalized estimating equations were used to estimate the association between maternal discrimination and wheezing and asthma phenotypes. Interaction terms were evaluated to identify whether mothers’ mental health and family social support modified such associations. Children whose mothers reported racial discrimination had greater odds of have asthma symptoms (OR 1.75; 95% CI 1.15–2.67) and non-atopic asthma (OR 1.92; 95% CI 1.09–3.40). When we considered effect modification by social support, we found a higher ORs when the level of social support was lower (OR 2.43; 95% IC 1.19–4.97) than when the level of social support was higher (OR 1.12; CI 0.64–1.96). Maternal discrimination was associated with asthma symptoms and with non-atopic phenotype among their children. Enjoying wider social support network appears to buffer the effect on asthmatic symptoms. Intervention on childhood asthma needs to incorporate strategies that target the family.

Resumo Este estudo avaliou a acurácia de indicadores de obesidade abdominal (OA), definindo uma variável latente como padrão-ouro. Foram estudados 12.232 participantes do ELSA-Brasil de 35 a 74 anos. Avaliou-se três indicadores de OA, estratificados por sexo e raça/cor: circunferência da cintura (CC), razão cintura quadril (RCQ) e índice de conicidade (Índice C). Todos os grupos mostraram elevadas prevalências de OA, maiores entre os homens brancos (~70%) e mulheres pretas (~60%). Observou-se alta acurácia da CC para homens, RCQ e índice C entre homens e mulheres para discriminar OA latente. Identificou-se os seguintes pontos de corte para os indicadores de OA entre os homens brancos, pardos e pretos, respectivamente: CC: 89,9; 90,2 e 91,7cm; RCQ: 0,92; 0,92 e 0,90; índice C: 1,24; 1,24 e 1,24. Para as mulheres brancas, pardas e pretas, respectivamente, os pontos de corte identificados foram: CC: 80,4; 82,7 e 85,4cm; RCQ: 0,82; 0,83 e 0,84; índice C: 1,20; 1,22 e 1,19. A CC entre os homens e a RCQ e índice C entre homens e mulheres apresentaram alto poder para discriminar OA latente, sendo o índice C o melhor indicador. Abstract This study evaluated the accuracy of abdominal obesity (AO) indicators, defining a latent variable as the gold standard. The study included 12,232 participants of the ELSA-Brasil (Brazil’s Longitudinal Study of Adult Health), between 35 and 74 years of age. Three AO indicators were evaluated: waist circumference (WC), waist hip ratio (WHR) and conicity index (C index). Analyses were stratified by sex and race/skin color. All groups had a high prevalence of AO, being greater among white men (~70%) and black women (~60%). A high incidence of WC was observed for men, WHR and C index between men and women for discriminating latent AO. The following cutoff points for AO indicators were identified among white, brown and black men, respectively: WC: 89.9cm; 90.2cm and 91.7cm; WHR: 0.92; 0.92 and 0.90; C index: 1.24; 1.24 and 1.24. The cutoff points identified among white, brown and black women were, respectively: WC: 80.4cm, 82.7cm and 85.4cm; WHR: 0.82; 0.83 and 0.84; C index: 1.20; 1.22 and 1.19 The WC among men and the WHR and C index among men and women presented high power to discriminate latent AO, the C index being the best indicator.

Background: Statistical models for analysis of correlated count data are important for answering epidemiological questions that involve taking individual count measurements repeatedly over time through the use of longitudinal studies. Conventional regression models for this type of data are inadequate, leading to improper conclusions and inference. An important application of longitudinal studies in Public Health is the evaluation and monitoring of patients with infectious diseases, such as HIV/AIDS, to determine their health status, to verify the treatment effects, and to make prognosis concerning the evolution of the disease, including interdependencies of clinical manifestations. The purpose of this article is to characterize different statistical strategies for analysis of longitudinal count data, emphasizing how to choose the most suitable model for the data and how to interpret the results.Methods:We illustrate their applicability by evaluating the effect of associated factors on lymphocyte CD4+T cell count in HIV seropositive patients in Salvador/Bahia - Brazil. We describe Poisson and Negative Binomial models using multilevel (ML) approach and generalized estimations equations (GEE) for analysis of longitudinal count data.Results: It is worth noting that the interpretation of the results from ML and GEE differs and they should not be compared directly.Conclusion: We believe that the statistical methodology for analysis of longitudinal studies with correlated count data can be useful to address several important questions in public health, particularly by helping to monitor patients and checking the effectiveness of treatments.

This study aimed to identify neighborhood profiles perceived by adolescents and young adults and estimate their association with global and leisure-time physical activity. Data from 1,637 individuals aged 15 to 24 years were taken from a cross-sectional study with cluster sampling, conducted in a city in the State of Bahia, Brazil, in 2011. Physical activity was measured using the International Physical Activity Questionnaire (IPAQ), short version, in addition to a question about leisure activities. The perception of characteristics of the physical and social environment of the neighborhood was based on a scale with 14 questions. Neighborhood profiles were defined through latent class analysis (LCA), and the estimation of their effects on physical activity used a model with distal outcomes. The latent profile analysis resulted in three neighborhood patterns, described as "urban, sociable, and favorable to physical activity - class 1" (39.6%); "sociable and safe - class 2" (24.4%), "insecure, low sociability - class 3" (36%). Individuals belonging to "class 1" showed the highest probability to exercise (56.4%), while for classes 2 and 3 these percentages corresponded to 46.3% and 42.8%, respectively. A statistically significant association was identified only in the "urban, sociable and favorable to physical activity" class, whose chance of performing leisure activities was 72% (OR = 1.72; 95%CI: 1.29-2.29). Neighborhoods with attributes that favor the practice of physical activity and the existence of urbanization elements increase the chance of active leisure behavior among adolescents and young adults. The use of LCA and the model with distal outcomes are promising and innovative in neighborhood approaches.Os objetivos do estudo foram identificar perfis de vizinhança percebidos por adolescentes e adultos jovens, e estimar sua associação com a realização de atividade física global e de lazer. Utilizaram-se dados de 1.637 indivíduos entre 15 e 24 anos, de um estudo transversal, com amostragem por conglomerados, de uma cidade do Estado da Bahia, Brasil, em 2011. A atividade física foi mensurada pelo International Physical Activity Questionnaire (IPAQ), versão curta, além de questão sobre atividade no lazer. A percepção de características do ambiente físico e social da vizinhança se baseou em escala com 14 questões. Perfis de vizinhança foram definidos por meio de análise de classes latentes (LCA), e a estimação dos seus efeitos na atividade física usou o modelo com respostas distais. A análise de perfil latente resultou em três padrões de vizinhança, descritos como “urbana, sociável e favorável à atividade física - classe 1” (39,6%); “sociável e segura - classe 2” (24,4%); e “insegura, de baixa sociabilidade - classe 3” (36%). Os indivíduos pertencentes à “classe 1” apresentaram maior probabilidade de se exercitar (56,4%), enquanto, para as classes 2 e 3, estes percentuais corresponderam a 46,3% e 42,8%, respectivamente. Associação estatisticamente significante foi identificada apenas na classe “urbana, sociável e favorável à atividade física”, cuja chance de realizar atividade de lazer foi de 72% (OR = 1,72; IC95%: 1,29-2,29). Bairros com atributos favoráveis à prática de atividade física e a existência de elementos de urbanização aumentam a chance do comportamento ativo no lazer entre os adolescentes e adultos jovens. O uso de LCA e do modelo com repostas distais é promissor e inovador na abordagem sobre vizinhança.Los objetivos del estudio fueron identificar los perfiles de vecindario percibidos por los adolescentes y los adultos jóvenes y estimar su asociación con la realización de actividad física global y de ocio. Se utilizaron datos de 1.637 individuos entre 15 y 24 años, procedentes de un estudio transversal, con muestreo por conglomerados, de una ciudad del estado de Bahia, Brasil, en 2011. La actividad física se midió mediante el International Physical Activity Questionnaire (IPAQ), versión corta, además de una pregunta sobre actividad en el ocio. La percepción de las características del entorno físico y social del vecindario se basó en una escala con 14 preguntas. Los perfiles de la vecindad se definieron a través del análisis de clase latente (ACL), y la estimación de sus efectos sobre la actividad física utilizó el modelo con respuestas distales. El análisis de perfil latente dio como resultado tres patrones de vecindario, descritos como “urbano, sociable y favorable a la actividad física - clase 1” (39,6 %); “sociable y seguro - clase 2” (24,4 %), “inseguro, de baja sociabilidad - clase 3” (36%). Los individuos pertenecientes a la “clase 1” presentaron la mayor probabilidad de hacer ejercicio (56,4 %), mientras que para las clases 2 y 3 estos porcentajes correspondieron a 46,3 % y 42,8 %, respectivamente. Solamente se identificó una asociación estadísticamente significativa en la clase “urbana, sociable y favorable a la actividad física”, cuya probabilidad de realizar actividad de ocio fue de 72 % (OR = 1,72; IC95%: 1,29-2,29). Los barrios con atributos favorables para la actividad física y la existencia de elementos de urbanización aumentan la posibilidad de un comportamiento activo en el ocio entre los adolescentes y los adultos jóvenes. El uso de ACL y el modelo con respuestas distales son enfoques prometedores e innovadores para la vecindad.

To evaluate the performance of tuberculosis control in Brazilian municipalities.This is an ecological study on Brazilian municipalities that notified at least four new cases of tuberculosis, with a minimum of one new case of pulmonary tuberculosis between 2015 and 2018. The municipalities were stratified according to the population in50 thousand, 50-100 thousand, 100-300 thousand, and300 thousand inhabitants, and the k-means method was used to group them within each population range according to the performance of six indicators of the disease.A total of 2,845 Brazilian municipalities were included, comprising 98.5% (208,007/211,174) of new tuberculosis cases in the period. For each population range, three groups (A, B, and C) of municipalities were identified according to the performance of the indicators: A, the most satisfactory; B, the intermediates; and C, the least satisfactory. Municipalities in group A with100 thousand inhabitants presented results above the targets for laboratory confirmation (≥ 72%), abandonment (≤ 5%), and cure (≥ 90%), and comprised 2% of new cases of the disease. Conversely, municipalities of groups B and C presented at least five indicators with results below the targets - HIV testing (100%), contact investigation (90%), directly observed therapy (90%), abandonment (5%), and cure (90%) -, and corresponded to 66.7% of new cases of tuberculosis. In group C of municipalities with300 thousand inhabitants, which included 19 of the 27 capitals and 43.1% of new cases of tuberculosis, the lowest percentages of contact investigation (mean = 56.4%) and directly observed therapy (mean = 15.4%) were verified, in addition to high abandonment (mean = 13.9%) and low coverage of primary health care (mean = 66.0%).Most new cases of tuberculosis occurred in municipalities with unsatisfactory performance for disease control. Expanding the coverage of primary health care in these places can reduce abandonment and increase the contact investigation and directly observed therapy.

Background Reports have shown correlations between the immune response to vector saliva and Leishmaniasis outcome. We followed dogs in an endemic area for two years characterizing resistance or susceptibility to canine visceral leishmaniasis (CVL) according to Leishmania infantum diagnosis and clinical development criteria. Then, we aimed to identify a biosignature based on parasite load, serum biological mediators’ interactions, and vector exposure intensity associated with CVL resistance and susceptibility. Methodology/Principal findings A prospective two-year study was conducted in an area endemic for CVL. Dogs were evaluated at 6-month intervals to determine infection, clinical manifestations, immune profile, and sandfly exposure. CVL resistance or susceptibility was determined upon the conclusion of the study. After two years, 78% of the dogs were infected with L. infantum (53% susceptible and 47% resistant to CVL). Susceptible dogs presented higher splenic parasite load as well as persistence of the parasite during the follow-up, compared to resistant ones. Susceptible dogs also displayed a higher number of correlations among the investigated biological mediators, before and after infection diagnosis. At baseline, anti-saliva antibodies, indicative of exposure to the vector, were detected in 62% of the dogs, reaching 100% in one year. Higher sandfly exposure increased the risk of susceptibility to CVL by 1.6 times (CI: 1.11–2.41). We identified a discriminatory biosignature between the resistant and susceptible dogs assessing splenic parasite load, interaction of biological mediators, PGE2 serum levels and intensity of exposure to sandfly. All these parameters were elevated in susceptible dogs compared to resistant animals. Conclusions/Significance The biosignature identified in our study reinforces the idea that CVL is a complex multifactorial disease that is affected by a set of factors which are correlated and, for a better understanding of CVL, should not be evaluated in an isolated way., Author summary Visceral Leishmaniasis (VL) is a disease that can affect humans and dogs, caused by a parasite called Leishmania transmitted through the bite of sandfly insects. During the bite, together with the parasite, the insects also inoculate their saliva into the host. The host immune response produces molecules to the sandfly saliva, such as antibodies and cytokines that can impact VL resistance or susceptibility. The presence of these molecules also indicates if the insects bit the hosts. We followed dogs of a VL endemic area for two years to study Canine Visceral Leishmaniasis (CVL) and immune response to sandfly saliva. Dogs were evaluated at 6-month intervals to determine Leishmania infection, clinical manifestations, parasite load, immune response, and sandfly exposure. CVL resistance or susceptibility was determined upon the conclusion of the study. Dogs living in the endemic area were intensely bitten, as at the beginning of the study, 62% of the dogs present anti-saliva antibodies, reaching 100% after one year. Our findings revealed a biosignature of CVL susceptibility characterized by elevated parasite load, interaction of cytokines, and higher exposure to the sandfly. This data reinforced that CVL is a complex disease affected by several factors related to each other.

OBJETIVO Avaliar o desempenho no controle da tuberculose dos municípios brasileiros. MÉTODOS Estudo ecológico com municípios brasileiros que notificaram pelo menos quatro casos novos de tuberculose, com no mínimo um caso novo de tuberculose pulmonar entre 2015 e 2018. Os municípios foram estratificados de acordo com a população em < 50 mil, 50–100 mil, 100–300 mil e > 300 mil habitantes e foi utilizado o método k-médias para agrupá-los dentro de cada faixa populacional segundo desempenho de seis indicadores da doença. RESULTADOS Foram incluídos 2.845 municípios brasileiros abrangendo 98,5% (208.007/211.174) dos casos novos de tuberculose do período. Para cada faixa populacional identificou-se três grupos (A, B e C) de municípios segundo desempenho dos indicadores: A os mais satisfatórios, B os intermediários e C os menos satisfatórios. Municípios do grupo A com < 100 mil habitantes apresentaram resultados acima das metas para confirmação laboratorial (≥ 72%), abandono (≤ 5%) e cura (≥ 90%), e abrangeram 2% dos casos novos da doença. Por outro lado, os municípios dos grupos B e C apresentaram pelo menos cinco indicadores com resultados abaixo das metas – testagem HIV (< 100%), exame de contatos (< 90%), tratamento diretamente observado (< 90%), abandono (> 5%) e cura (< 90%) –, e corresponderam a 66,7% dos casos novos de tuberculose. Já no grupo C dos municípios com > 300 mil habitantes, que incluiu 19 das 27 capitais e 43,1% dos casos novos de tuberculose, encontrou-se os menores percentuais de exames de contatos (média = 56,4%) e tratamento diretamente observado (média = 15,4%), elevado abandono (média = 13,9%) e baixa cobertura da atenção básica (média = 66,0%). CONCLUSÕES Grande parte dos casos novos de tuberculose ocorreu em municípios com desempenho insatisfatório para o controle da doença, onde expandir a cobertura da atenção básica pode reduzir o abandono e elevar o exame de contatos e tratamento diretamente observado.

The objective of the present study was to evaluate the association between social position and anthropometric status in women and men Brazilian adult. This was a cross-sectional study that used baseline data collected from 2008 to 2010 for the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil, in Portuguese), in the six major Brazilian state capital cities. A total of 15,105 active and retired civil servants aged from 35 to 74 years. Two latent variables were defined by latent class analysis, social position and anthropometric status. Both constructs and the analyses were separately evaluated by sex. Associations were assessed using multivariate logistic regression analysis with adjustment for age, self-reported skin color/race, and marital status. Around 44% of the women and 26% of the men were classified as overweight or obese. Social position tended to be lower in women (43.2%) and higher among men (40.4%). Heavier women were more likely to be black and brown-skinned, whereas slimmer women were more likely to be white. After adjustment, women’s weight increased as social position decreased (OR = 1.52; 95%CI: 1.36-1.70), whereas in men weight decreased as social position decreased (OR = 0.87; 95%CI: 0.76-0.99). Social position affected the anthropometric status of women and men differently, with body patterns also being affected by ethnicity/skin color, showing the potentiality of taking the intersectional perspective when investigating the possible social determinants of the phenomenon. Resumo: O objetivo do estudo foi avaliar a associação entre posição social e o estado antropométrico em brasileiros adultos de ambos os sexos. O estudo transversal usou dados coletados entre 2008 e 2010 pelo Estudo Longitudinal de Saúde do Adulto (ELSA-Brasil), nas seis maiores capitais brasileiras. Um total de 15.105 funcionários públicos, ativos e aposentados, de ambos os sexos, entre 35 e 74 anos de idade. Duas variáveis latentes foram definidas pela análise de classes latentes: posição social e estado antropométrico. Os construtos e análises foram avaliados separadamente por sexo. As associações foram avaliadas com o uso de análise de regressão logística multivariada, ajustada para idade, cor/raça e estado civil. Em torno de 44% das mulheres e 26% dos homens foram classificados com sobrepeso ou obesidade. A posição social tendia a ser mais baixa nas mulheres (43,2%) e mais alta nos homens (40,4%). Houve uma proporção maior de mulheres com sobrepeso ou obesidade entre as pretas e pardas, e proporção maior de mulheres magras entre as brancas. Nas mulheres, após ajustes, o peso aumentava na medida em que a posição social diminuía (OR = 1,52; IC95%: 1,36-1,70), enquanto nos homens o peso diminuía junto com a diminuição da posição social (OR = 0,87; IC95%: 0,76-0,99). A posição social afetou de maneira diferente o estado antropométrico de mulheres e homens, com perfis corporais afetados também pela raça/cor da pele, indicando o potencial de levar em conta a perspectiva interseccional ao investigar os possíveis determinantes sociais do fenômeno. Resumen: El objetivo de este estudio fue evaluar la asociación entre posición social y estatus antropométrico de adultos brasileños de ambos sexos. Fue un estudio transversal, realizado usando datos de referencia recogidos entre 2008 y 2010, del Estudio Longitudinal Brasileño de Salud en Adultos (ELSA-Brasil), llevado a cabo en seis de las mayores capitales de estado brasileñas. Un total de 15.105 activos y jubilados, mujeres y hombres funcionarios públicos de 35 a 74 años de edad. Se definieron dos variables latentes mediante análisis de clases latentes: posición social y estatus antropométrico. Ambos constructos y análisis fueron evaluados separadamente por sexo. Las asociaciones fueron evaluadas usando una regresión logística multivariada con ajuste por edad, color de piel/raza autoinformado y estatus marital. Alrededor de un 44% de las mujeres y un 26% de los hombres fueron clasificados como con sobrepeso u obesos. La posición social tendió a ser más baja en mujeres (43,2%) y más alta entre hombres (40,4%). Las mujeres con más peso tenían más probabilidad de ser negras y mulatas/mestizas y las mujeres más delgadas tenían más probabilidad de ser blancas. En mujeres, tras el ajuste, se incrementó más el peso cuanto mayor decrecía la posición social (OR = 1,52; IC95%: 1,36-1,70), mientras en hombres el peso decrecía al igual que la posición social (OR = 0,87; IC95%: 0,76-0,99). La posición social afectó diferentemente al estatus antropométrico de mujeres y hombres, con los patrones corporales también estando afectados por etnicidad/color de piel, mostrando su potencialidad tomando en consideración la perspectiva transversal, cuando se está investigando los posibles determinantes sociales del fenómeno.

Background Record linkage is the process of identifying and combining records about the same individual from two or more different datasets. While there are many open source and commercial data linkage tools, the volume and complexity of currently available datasets for linkage pose a huge challenge; hence, designing an efficient linkage tool with reasonable accuracy and scalability is required. Methods We developed CIDACS-RL (Centre for Data and Knowledge Integration for Health – Record Linkage), a novel iterative deterministic record linkage algorithm based on a combination of indexing search and scoring algorithms (provided by Apache Lucene). We described how the algorithm works and compared its performance with four open source linkage tools (AtyImo, Febrl, FRIL and RecLink) in terms of sensitivity and positive predictive value using gold standard dataset. We also evaluated its accuracy and scalability using a case-study and its scalability and execution time using a simulated cohort in serial (single core) and multi-core (eight core) computation settings. Results Overall, CIDACS-RL algorithm had a superior performance: positive predictive value (99.93% versus AtyImo 99.30%, RecLink 99.5%, Febrl 98.86%, and FRIL 96.17%) and sensitivity (99.87% versus AtyImo 98.91%, RecLink 73.75%, Febrl 90.58%, and FRIL 74.66%). In the case study, using a ROC curve to choose the most appropriate cut-off value (0.896), the obtained metrics were: sensitivity = 92.5% (95% CI 92.07–92.99), specificity = 93.5% (95% CI 93.08–93.8) and area under the curve (AUC) = 97% (95% CI 96.97–97.35). The multi-core computation was about four times faster (150 seconds) than the serial setting (550 seconds) when using a dataset of 20 million records. Conclusion CIDACS-RL algorithm is an innovative linkage tool for huge datasets, with higher accuracy, improved scalability, and substantially shorter execution time compared to other existing linkage tools. In addition, CIDACS-RL can be deployed on standard computers without the need for high-speed processors and distributed infrastructures.

IntroductionBrazil’s Bolsa Familia Program (BFP) is the world’s largest conditional cash transfer scheme. We shall use a large cohort of applicants for different social programmes to evaluate the effect of BFP receipt on premature all-cause and cardiovascular mortality.Methods and analysisWe will identify BFP recipients and non-recipients among new applicants from 2004 to 2015 in the 100 Million Brazilian Cohort, a database of 114 million individuals containing sociodemographic and mortality information of applicants to any Brazilian social programme. For individuals applying from 2011, when we have better recorded income data, we shall compare premature (age 30–69) cardiovascular and all-cause mortality among BFP recipients and non-recipients using regression discontinuity design (RDD) with household monthly per capita income as the forcing variable. Effects will be estimated using survival models accounting for individuals follow-up. To test the sensitivity of our findings, we will estimate models with different bandwidths, include potential confounders as covariates in the survival models, and restrict our data to locations with the most reliable data. In addition, we will estimate the effect of BFP on studied outcomes using propensity score risk-set matching, separately for individuals that applied ≤2010 and >2011, allowing comparability with RDD. Analyses will be stratified by geographical region, gender, race/ethnicity and socioeconomic position. We will investigate differential impacts of BFP and the presence of effect modification for a combination of characteristics, including gender and race/ethnicity.Ethics and disseminationThe study was approved by the ethics committees of Oswaldo Cruz Foundation and the University of Glasgow College of Medicine and Veterinary Life Sciences. The deidentified dataset will be provided to researchers, and data analysis will be performed in a safe computational environment without internet access. Study findings will be published in high quality peer-reviewed research articles. The published results will be disseminated in the social media and to policy-makers.

Background Conditional cash transfer programmes (CCTs) make monetary transfers to poor families conditional on health check-ups and/or education attendance. CCTs have been key in reducing poverty and improving child and maternal health in low- and middle-income countries (LMICs) but their impact on cardiovascular mortality have not been studied. We aimed to evaluate the effect of the CCT Bolsa Familia Program (BFP) on premature all-cause and cardiovascular mortality in Brazil. Methods The 100 Million Brazilian Cohort combined information about individuals applying for social programmes, the BFP and mortality data. We analysed ∼8 million individuals aged 30-69 who applied from 2011 to 2015. We calculated inverse probability weights (IPW) for the probability to receive BFP based on baseline observed characteristics (age, education, race, geographical location, household characteristics and year of application). Individuals were followed until they reached 70 years of age, died by any cause, or until 31st Dec 2015. We used Poisson regression (with person-years as the offset) and IPWs to compare BFP recipients to a comparable control population. Females and males were analysed separately. Results By following individuals for up to 4 years, 43,562 deaths by all-causes occurred among 4,197,658 females and 69,209 deaths among 3,672,393 males. Female BFP beneficiaries had approximately 60% lower all-cause mortality (IRR=0.40;95%CI=0.37-0.42) and CVD mortality (IRR=0.42;95%CI=0.37-0.47) than non-beneficiaries. Males who are BFP beneficiaries had ∼50% lower all-cause (IRR=0.53;95%CI=0.52-0.55) and 60% lower cardiovascular mortality (IRR=0.40;95%CI=0.38-0.42) than non-beneficiaries. Conclusions BFP, the world's largest CCT, may substantially decrease premature mortality. CCTs might have important implications for the growing burden of non-communicable diseases, with impacts potentially due to improved nutrition, socioeconomic conditions and improved primary care access. Key messages The Brazilian CCT, a widely recognized programme for poverty alleviation, have showed to be associated with lower overall and cardiovascular premature mortality in both women and men. Other countries, particularly LMICs, may learn from the health benefits of CCTs and should consider its potential large effect on mortality when planning austerity policies.

Asthma patterns in childhood are important predictors of unwanted outcomes in adolescence. We aimed to define asthma phenotypes in childhood and adolescence and evaluate the transitions between these phenotypes and factors potentially associated with the transitions. Baseline (1445 children), first round (1363 children/early adolescents) and second round (1206 adolescents) data from the SCAALA Project in Salvador, Brazil, were used. Phenotypes were defined by latent class analysis at three time points. Transitions between phenotypes were described and the effects of factors associated with transition probabilities estimated using latent transition analysis. The “asymptomatic” and “symptomatic” phenotypes were identified. Approximately 5–6% of asymptomatic children in childhood/later childhood and early adolescence became symptomatic later in time. Maternal common mental disorders were identified as important risk factor for unhealthy states. Asthma manifestations are characterized by frequent movements, especially between childhood and adolescence. Our study, by simultaneously defining disease subtypes, and examining the transitions and their potential predictors, highlights the importance of longitudinal studies to advance the understanding of the effects of social, environmental and biological mechanisms underlying asthma trajectories over time.

The existence of an imperfect reference standard presents complications when evaluating the unbiased performance of novel diagnostic techniques. This is especially true in the absence of a gold standard, as is the case in chronic Chagas disease (CD) diagnosis. To circumvent this constraint, we elected to use latent class analysis (LCA). Previously, our group demonstrated the high performance of four Trypanosoma cruzi–chimeric proteins (Molecular Biology Institute of Paraná [IBMP]-8.1, -8.2, -8.3, and -8.4) for CD diagnosis using several distinct immunoassays. Although commercial tests had previously been established as a reference standard, the diagnostic performance of these chimeric antigens could present bias because these tests fail to produce 100% accurate results. Thus, we used LCA to assess the performance of these IBMP chimeric antigens in chronic CD diagnosis. Using the LCA model as a gold standard, sensitivity and specificity values ranged from 93.5% to 99.4% and 99.6% to 100%, respectively. The accuracy values were 96.2% for IBMP-8.2, approximately 98% for IBMP-8.1 and IBMP-8.3, and nearly 100% for IBMP-8.4. For IBMP-8.1 and IBMP-8.2, higher positive predictive values were associated with increases in hypothetical prevalence. Similarly, higher hypothetical prevalence resulted in lower negative predictive values for IBMP-8.1, IBMP-8.2, and IBMP-8.3. In addition, samples with serodiscordant results from commercial serological tests were analyzed using LCA. Molecular Biology Institute of Paraná -8.1 demonstrated potential for use in confirmatory testing with regard to samples with inconsistent results. Moreover, our findings further confirmed the remarkable performance of the IBMP-8.4 antigen to diagnose chronic CD in both endemic and non-endemic areas.

Exposures to geohelminths during gestation or early childhood may reduce risk of wheezing illness/asthma and atopy during childhood in tropical regions.To investigate the effect of maternal and early childhood geohelminths on development of wheeze/asthma and atopy during the first 5 years of life.A cohort of 2,404 neonates was followed to 5 years of age in a rural district in coastal Ecuador. Data on wheeze were collected by questionnaire and atopy was measured by allergen skin prick test reactivity to 10 allergens at 5 years. Stool samples from mothers and children were examined for geohelminths by microscopy.A total of 2,090 (86.9%) children were evaluated at 5 years. Geohelminths were observed in 45.5% of mothers and in 34.1% of children by 3 years. Wheeze and asthma were reported for 12.6% and 5.7% of children, respectively, whereas 14.0% had skin test reactivity at 5 years. Maternal geohelminths were associated with an increased risk of wheeze (adjusted odds ratio, 1.41; 95% confidence interval, 1.06-1.88), whereas childhood geohelminths over the first 3 years of life were associated with reduced risk of wheeze (adjusted odds ratio, 0.70; 95% confidence interval, 0.52-0.96) and asthma (adjusted odds ratio, 0.60; 95% confidence interval, 0.38-0.94) but not skin prick test reactivity. The effects on wheeze/asthma were greatest with later age of first infection, were observed only in skin test-negative children, but were not associated with parasite burden or specific geohelminths.Although maternal exposures to geohelminths may increase childhood wheeze, childhood geohelminths during the first 3 years may provide protection through a nonallergic mechanism. Registered as an observational study (ISRCTN41239086).

Background: The interruption of exclusive breastfeeding (EBF) is worrying. This study aimed to identify behavior patterns towards EBF among mothers and health professionals. Methods: This is a cross-sectional analysis of a cohort consisting of 1309 women. We used latent class analysis (LCA), considering 15 indicators for defining 4 constructs: maternal emotional state, availability to breastfeed, maternal attitude, and health professional’s attitude towards breastfeeding. Results: Among mothers, 36.5% were classified as being in an unfavorable emotional state; they presented a higher probability of feeling tired, nervous, and sad; 14.7% had less availability to breastfeed and a higher probability of including primiparous and partners not helping to care for the child; 41.5% had negative attitude towards breastfeeding, including mothers more likely to give a pacifier and bottle. Among health professionals, 62.0% were categorized with unfavorable attitude towards breastfeeding, not providing guidance on breastfeeding in the hospital.

Background Asthma prevalence is 339 million globally. ‘Severe asthma’ (SA) comprises subjects with uncontrolled asthma despite proper management. Objectives To compare asthma from diverse ethnicities and environments. Methods A cross-sectional analysis of two adult cohorts, a Brazilian (ProAR) and a European (U-BIOPRED). U-BIOPRED comprised of 311 non-smoking with Severe Asthma (SAn), 110 smokers or ex-smokers with SA (SAs) and 88 mild to moderate asthmatics (MMA) while ProAR included 544 SA and 452 MMA. Although these projects were independent, there were similarities in objectives and methodology, with ProAR adopting operating procedures of U-BIOPRED. Results Among SA subjects, age, weight, proportion of former smokers and FEV1 pre-bronchodilator were similar. The proportion of SA with a positive skin prick tests (SPT) to aeroallergens, the scores of sino-nasal symptoms and quality of life were comparable. In addition, blood eosinophil counts (EOS) and the % of subjects with EOS > 300 cells/μl were not different. The Europeans with SA however, were more severe with a greater proportion of continuous oral corticosteroids (OCS), worse symptoms and more frequent exacerbations. FEV1/FVC pre- and post-bronchodilator were lower among the Europeans. The MMA cohorts were less comparable in control and treatment, but similar in the proportion of allergic rhinitis, gastroesophageal reflux disease and EOS >3%. Conclusions ProAR and U-BIOPRED cohorts, with varying severity, ethnicity and environment have similarities, which provide the basis for global external validation of asthma phenotypes. This should stimulate collaboration between asthma consortia with the aim of understanding SA, which will lead to better management.

Brazil has recently integrated HIV Pre-exposure Prophylaxis (PrEP) into its public health system and offered to key populations such as transgender women (TGW). This study investigates factors associated with PrEP refusal among TGW living in one of the largest and poorest cities of Brazil. We recruited 127 TGW using Respondent Driven Sampling (RDS) in Salvador, Brazil. Latent class analysis (LCA) was used to define acceptability of PrEP. Two latent classes were identified: “high acceptability of PrEP” (91.3%) and “PrEP refusal” (8.7%). PrEP was less acceptable among white TGW and among those age 25 or older, with income above minimum wage (≥ US$252.87), and reporting unprotected receptive anal intercourse with (URAI) causal partners. The findings highlight how nuanced strategies that takes into consideration unique characteristics are needed to effectively address the acceptability of PrEP.

Estudos sobre padrões alimentares dependem da validade dos métodos, como o questionário de frequência alimentar (QFA), para estimar consumo alimentar de longo prazo, que pode ser superestimado e o método precisa ser validado. Questiona-se se estudos de validação aninhados a estudos com desenho amostral complexo (DAC) deveriam ignorar a dependência dos dados. Este estudo objetiva validar o QFA aplicado a adolescentes escolares e estimar os fatores de calibração em um estudo com amostragem complexa. A validade do QFA é testada frente a registros alimentares (RA) aplicados a 85 adolescentes em um estudo com DAC, com estimação dos fatores de calibração (λ) para energia, nutrientes e grupos alimentares (GA). Coeficiente de correlação intraclasse foi calculado; diferenças médias foram comparadas via modelagem, e foram realizadas análises de concordância. As médias entre os métodos diferiram para energia e nutrientes (p

Clustered binary responses are often found in ecological studies. Data analysis may include modeling the marginal probability response. However, when the association is the main scientific focus, modeling the correlation structure between pairs of responses is the key part of the analysis. Second-order generalized estimating equations (GEE) are established in the literature. Some of them are more efficient in computational terms, especially facing large clusters. Alternating logistic regression (ALR) and orthogonalized residual (ORTH) GEE methods are presented and compared in this paper. Simulation results show a slightly superiority of ALR over ORTH. Marginal probabilities and odds ratios are also estimated and compared in a real ecological study involving a three-level hierarchical clustering. ALR and ORTH models are useful for modeling complex association structure with large cluster sizes.

Background Visceral leishmaniasis (VL) is a zoonosis of great importance. Limitations in current VL control measures compromise efficacy, indicating the need to implement new strategies. The aim of this study was to evaluate the effectiveness of the mass use of deltamethrin-impregnated collars in dogs as a public health measure to control and prevent canine visceral leishmaniasis (CVL). Methodology An interventional study was implemented in two endemic areas in the district of Monte Gordo (Bahia-Brazil): an intervention area, in which VL seronegative dogs were collared, and a control area in which only conventional CVL control measures were applied. At baseline, seropositive dogs were removed and seronegative dogs were included. Dogs were then reevaluated every 7–8 months for almost two years. At each time point, dogs in the intervention area that remained seronegative received new collars and newly identified seronegative dogs were included and collared. The local zoonosis control authorities were notified of any dogs that tested seropositive in both areas, which were subsequently marked for euthanasia as mandated by the Brazilian Ministry of Health. Principal findings In the first serological survey, seroprevalence was similar in both areas. At the second evaluation, significant reductions in seroprevalence were seen in both areas, while seroprevalence in the intervention area reduced to 6.0% during the final evaluation versus an increase of 11.0% in the control area. This significant increase and the estimated relative risk (RR = 0.55) indicated protection against CVL in the intervention area. Although CVL incidence did not differ significantly between the areas, an increased tendency was observed in the control area, which could be due to low seroconversion rates throughout the study or a high loss to follow-up. Conclusions/Significance Although our evaluation of the effectiveness of deltamethrin-impregnated collars as a community-wide public health control measure was inconclusive, this measure likely provides protection over time. In endemic areas of Brazil, this strategy represents an operational challenge for local zoonosis control authorities, indicating the need for adjustments, including improved collar design., Author summary Visceral leishmaniasis (VL) is a serious public health problem. Cases of canine VL (CVL) tend to precede cases of human VL and current control measures are ineffective in significantly reducing the number of disease cases. Therefore, in light of the need for new strategies, we evaluated the mass use of dog collars impregnated with deltamethrin as a public health measure to control and prevent CVL in a highly endemic region in Brazil. Although our results were inconclusive, they do point to the possible effectiveness of this measure if it were comprehensively implemented over an extended period of time. We identified the need to adjust the currently employed implementation strategy and call attention to the operational challenges faced by local zoonosis prevention authorities.

In large prospective cohort studies, accumulation of covariate information and follow-up data make up the majority of the cost involved in the study. This might lead to the study being infeasible when there are some expensive variables and/or the event is rare. Prentice (Biometrika 73(1):1–11, 1986) proposed the case-cohort study for time to event data to tackle this problem. There has been extensive research on the analysis of univariate and clustered failure time data, where the clusters are formed among different individuals under case-cohort sampling scheme. However, recurrent event data are quite common in biomedical and public health research. In this paper, we propose case-cohort sampling schemes for recurrent events. We consider a multiplicative rates model for the recurrent events and propose a weighted estimating equations approach for parameter estimation. We show that the estimators are consistent and asymptotically normally distributed. The proposed estimator performed well in finite samples in our simulation studies. For illustration purposes, we examined the association between prior occurrence of measles on acute lower respiratory tract infections (ALRI) among young children in Brazil.

The study sought to analyze the association between adolescents and young adults' access to primary health care services and Family Health Strategy (FHS) services. It is a cross-sectional study based on a household survey of 812 individuals aged between 15 and 24 years in Camaçari, Bahia State, Brazil, through cluster sampling. Demographic, socioeconomic, health and health service variables were used to describe the population according to primary health care area. The association between primary health care coverage area and access to its services, access barriers and participation in educational activities were estimated through prevalence ratios (PR) using multilevel logistic regression models in the R software. Access to primary health care services was reported by 89.5% of individuals, with no statistically significant differences between this type of access and primary health care coverage area. However, among individuals who reside in areas covered by FHS, there was greater access to harm reduction and health promotion actions (PR = 3.0; 95%CI: 1.68-5.34), but also lower probability of being seen by a health worker on the same day the appointment was scheduled (PR = 0.60; 95%CI: 0.48-0.74) and lower availability of public transportation (RP = 0.59; 95%CI: 0.39-0.90). Study results point to a high prevalence of access to primary health care services among adolescents and young adults. Though we did not observe a difference in access between areas with FHS coverage, young people's greater participation in prevention and health promotion activities reinforces this strategy's importance within Brazilian Unified National Health System (SUS).O estudo teve como objetivo analisar a associação entre o acesso aos serviços de atenção primária à saúde dos adolescentes e adultos jovens e a cobertura da Estratégia Saúde da Família (ESF). Trata-se de estudo transversal, a partir de um inquérito domiciliar realizado com 812 indivíduos de 15 a 24 anos de idade, em Camaçari, Bahia, Brasil, por meio de uma amostragem por conglomerados. Variáveis demográficas, socioeconômicas, de saúde e dos serviços de saúde foram utilizadas para descrição da população, segundo a área de cobertura de atenção primária à saúde. A associação entre área de cobertura da atenção primária à saúde e acesso aos serviços desta, as barreiras de acesso e a participação em atividades educativas foram estimadas por meio da razão de prevalência (RP), com uso do modelo de regressão logística multinível no software R. O acesso aos serviços de atenção primária à saúde foi referido por 89,5% dos indivíduos, não havendo diferenças estatisticamente significantes entre esse tipo de acesso e a área de cobertura da ESF. Entretanto, entre indivíduos residentes em áreas cobertas pela ESF, verificou-se maior acesso às ações de prevenção de agravos e promoção da saúde (RP = 3,0; IC95%: 1,68-5,34), mas também menor probabilidade de o atendimento ocorrer no mesmo dia de marcação da consulta (RP = 0,60; IC95%: 0,48-0,74) e menor disponibilidade de transporte coletivo (RP = 0,59; IC95%: 0,39-0,90). Os dados deste estudo apontaram elevada prevalência de acesso aos serviços de atenção primátria à saúde entre os adolescentes e adultos jovens. Ainda que não se tenham observado diferenças do acesso entre as áreas com cobertura da ESF, a maior participação desses indivíduos em atividades de prevenção e promoção da saúde reforçam a importância dessa estratégia no âmbito do Sistema Único de Saúde (SUS).El objetivo de este estudio fue analizar la asociación entre el acceso a los servicios de atención primaria en salud de adolescentes y adultos jóvenes y la cobertura de la Estrategia de Salud Familiar (ESF). Se trata de un estudio transversal, a partir de una encuesta domiciliaria, realizada con 812 individuos de 15 a 24 años de edad, en Camaçari, Bahía, Brasil, mediante una muestra por conglomerados. Se utilizaron variables demográficas, socioeconómicas, de salud y de servicios de salud para la descripción de la población, según el área de cobertura de atención primaria en salud. La asociación entre área de cobertura de la atención primaria en salud y el acceso a los servicios de esta, las barreras de acceso, y la participación en actividades educativas se estimaron mediante la razón de prevalencia (RP), con el uso del modelo de regresión logística multinivel en el software R. Un 89,5% de los individuos informó de acceso a servicios de atención primaria en salud, no existiendo diferencias estadísticamente significativas entre este tipo de acceso y el área de cobertura de la ESF. No sólo entre individuos residentes en áreas cubiertas por la ESF se verificó un mayor acceso a las acciones de prevención de enfermedades y promoción de la salud (RP = 3,0; IC95%: 1,68-5,34), sino también una menor probabilidad de que la atención se produzca el mismo día en el que se fija la consulta (RP = 0,60; IC95%: 0,48-0,74) y una menor disponibilidad de transporte colectivo (RP = 0,59; IC95%: 0,39-0,90). Los datos de este estudio apuntaron una elevada prevalencia de acceso a los servicios de la atención primaria en salud entre los adolescentes y adultos jóvenes. A pesar de que no se hayan observado diferencias de acceso entre las áreas con cobertura de la ESF, la mayor participación de estos individuos en actividades de prevención y promoción de la salud refuerza la importancia de esta estrategia en el ámbito del SUS.

Social, individual, and programmatic vulnerability of men who have sex with men (MSM) in the context of the HIV epidemic and other sexually transmitted infections (STI) is a reality in many countries. The survey Behavior, Attitudes, Practices, and Prevalence of HIV and Syphilis in Men Who Have Sex with Men in 10 Brazilian Cities selected 383 MSM in the city of Salvador, Bahia State, Brazil, using the respondent driven sampling (RDS) technique. Individual vulnerability: early sexual initiation (51%), average of eight sex partners, and unprotected receptive anal sex with casual (32%) and steady partners (45%) and positive rapid tests HIV (6.5%) and syphilis (9%). Social vulnerability: young adults (80%), black race/skin color (91%), mean monthly family income of BRL 1,000.00, and personal history of discrimination (57%). Programmatic factors: no previous HIV test (63%) and no access to lubricant gel (88%). The study showed a profile of vulnerability and the urgent need for interventions and STI prevention in the MSM population in Salvador, in addition to high prevalence rates for HIV and syphilis. La vulnerabilidad social, individual y programática de los hombres que mantienen sexo con hombres (HSH) en un contexto de infección del VIH y enfermedades de transmisión sexual (ETS) es una realidad en muchos países. En la encuesta Comportamiento, Actitudes, Prácticas y Prevalencia de VIH y Sífilis entre Hombres que Practican Sexo con Hombres en 10 Ciudades Brasileñas, 383 hombres conformaron la selección en Salvador, Bahía, Brasil, según respondent driven sampling (RDS). El perfil de la vulnerabilidad personal es: inicio temprano de la actividad sexual (51%), promedio de 8 parejas sexuales, la práctica de relaciones sexuales receptivas sin protección: pareja ocasional (32%), fijos (45%), VIH positivo (6,5%) y sífilis (8,8%). Vulnerabilidad social: adultos jóvenes (80%), negros (91%), con ingresos medios por hogar de R$ 1.000,00 y que sufrieron algún tipo de discriminación (57%). Factores programáticos: ninguna prueba de VIH en la vida (63%) y sin acesso a gel lubrificante (88%). Identificado un perfil de vulnerabilidad, y la urgente uimplementación de la intervención y la prevención de enfermedades de transmisión sexual entre los HSH en la ciudad. Hubo un perfil de vulnerabilidad y una necesidad urgente de acciones de intervención y prevención de enfermedades de transmisión sexual durante la investigación de la población en este municipio, además de una alta prevalencia de VIH y sífilis. A vulnerabilidade social, individual e programática dos homens que fazem sexo com homens (HSH), no contexto da epidemia do HIV e doenças sexualmente transmissíveis (DST) é uma realidade em muitos países. A pesquisa Comportamento, Atitudes, Práticas e Prevalência de HIV e Sífilis entre Homens que Fazem Sexo com Homens em 10 Cidades Brasileiras, selecionou, no Município de Salvador, Bahia, Brasil, 383 HSH via técnica respondent driven sampling (RDS). Vulnerabilidade individual: início precoce da vida sexual (51%), média de oito parceiros sexuais, sexo anal receptivo desprotegido com parceiro casual (32%) e fixo (45%), e teste rápido positivo: HIV (6,5%) e sífilis (9%). Vulnerabilidade social: adultos jovens (80%), negros (91%), renda familiar média de R$ 1.000,00 e sofreram algum tipo de discriminação (57%). Fatores programáticos: sem teste do HIV (63%), sem acesso ao gel lubrificante (88%). Observou-se um perfil de vulnerabilidade e urgente necessidade de ações de intervenção e prevenção às DST no município na população pesquisada, além de altas prevalências do HIV e sífilis.

Background: Abdominal adiposity is a risk factor for cardiovascular disease. Objective: To determine the magnitude of the association between abdominal adiposity, according to five different indicators, and the carotid intima-media thickness (CIMT). Methods: Data from 8,449 participants aged 35 to 74 years from the ELSA-Brazil study were used. The effect of waist circumference (WC), waist-to-hip ratio (WHR), conicity index (C index), lipid accumulation product (LAP) and visceral adiposity index (VAI) on CIMT were evaluated. Data were stratified by gender and analyzed using multivariate linear and logistic regressions. A significance level of 5% was considered. Results: Participants with CIMT > P75 showed a higher frequency of abdominal adiposity (men >72% and women >66%) compared to those with CIMT < P75. Abdominal adiposity was associated with the mean CIMT, mainly through WC in men (0.04; 95%CI: 0.033; 0.058). The abdominal adiposity identified by the WC, WHR, LAP, and VAI indicators in women showed an effect of 0.02 mm on the CIMT (WC: 0.025, 95%CI: 0.016, 0.035; WHR: 0.026, 95%CI: 0.016, 0.035; LAP: 0.024, 95%CI: 0.014; 0.034; VAI: 0.020, 95%CI: 0.010, 0.031). In the multiple logistic regression, the abdominal adiposity diagnosed by WC showed an important effect on the CIMT in both genders (men: OR = 1.47, 95%CI: 1.22-1.77, women: OR = 1.38; 95%CI: 1.17-1.64). Conclusion: Abdominal adiposity, identified through WC, WHR, LAP, and VAI, was associated with CIMT in both genders, mainly for the traditional anthropometric indicator, WC. Resumo Fundamento: A adiposidade abdominal é um fator de risco para doença cardiovascular. Objetivo: Determinar a magnitude da associação entre a adiposidade abdominal, segundo cinco diferentes indicadores, e a espessura médio-intimal de carótidas (EMI-C). Métodos: Usou-se dados de 8.449 participantes de 35 a 74 anos do ELSA-Brasil. Foi avaliado o efeito da circunferência da cintura (CC), razão cintura quadril (RCQ), índice de conicidade (Índice C), produto da acumulação lipídica (LAP) e índice de adiposidade visceral (IAV) sobre EMI-C. Os dados foram estratificados por sexo e analisados por meio de regressões linear e logística multivariadas. Foi adotado nível de significância de 5%. Resultados: Participantes com EMI-C acima do P75 mostraram maior frequência de adiposidade abdominal (homens acima de 72% e mulheres acima de 66%) em comparação aos participantes com EMI-C abaixo do P75. A adiposidade abdominal foi associada com a média da EMI-C, principalmente por meio da CC entre homens (0,04 IC95%: 0,033; 0,058). A adiposidade abdominal identificada pelos indicadores CC, RCQ, LAP e IAV entre as mulheres mostrou efeito de 0,02 mm sobre a EMI-C (CC: 0,025 IC95%: 0,016; 0,035; RCQ: 0,026 IC95%: 0,016; 0,035; LAP: 0,024 IC95%: 0,014; 0,034; IAV: 0,020 IC95%: 0,010; 0,031). Na regressão logística múltipla a adiposidade abdominal diagnosticada pela CC mostrou importante efeito sobre a EMI-C em ambos os sexos (homens: OR = 1,47; IC95%: 1,22-1,77; mulheres: OR = 1,38; IC95%: 1,17-1,64). Conclusão: A adiposidade abdominal, identificada por meio da CC, RCQ, LAP e IAV, foi associada à EMI-C em ambos os sexos, com destaque para o tradicional indicador antropométrico CC.

Introduction Discrimination related to gender identity may directly influence vulnerability to HIV through increased exposure to unprotected receptive anal intercourse (URAI). Little is known about the relationship between gender-based discrimination (GBD) and URAI with stable partners among transgender women. Methods This mixed-methods research began with a cross-sectional survey conducted between 2014 and 2016 with transgender women in Salvador, the capital city in one of the poorest regions in Brazil. Respondent-driven sampling was used to recruit the study population. GBD was defined through Latent Class Analysis. Additionally, 19 semi-structured interviews with participants were transcribed and analyzed through thematic content analysis. Results URAI with stable partners was commonly reported (37.3%). GDB was positively associated with URAI among stable partners (OR = 6.47; IC 95%: 1.67–25.02). The analysis of the interviews illustrated how GBD impacted transgender women in diverse ways. Experiences with GBD perpetrated by the family often initiated a trajectory of economic vulnerability that led many to engage in survival sex work. The constant experience with GBD contributed to participants feeling an immense sense of trust with their stable partners, ultimately diminished their desire to use condoms. Further, the high frequency of GBD contributed to poor mental health overall, though some participants said engagement in transgender advocacy efforts provided a vital source of resilience and support. Conclusion Our mixed-method study capitalizes upon the strengths of diverse data sets to produce a holistic understanding of GBD and URAI with stable partners. Furthermore, by confirming the association between greater GBD and URAI, we have demonstrated how GBD can impact condom negotiation in diverse relationships.

Purpose: To analyze the factors associated with commuting by bicycling and walking in adult participants from ELSA-Brasil (Longitudinal Study of Adult Health). Design: Cross-sectional. Setting: Six teaching/research institutions throughout Brazil. Participants: A total of 15 105 civil servants. Measures: Commuting by bicycling and walking was analyzed using the long-form International Physical Activity Questionnaire. Analysis: A hierarchical model containing possible factors associated with commuting by bicycling and walking was constructed. Crude and adjusted odds ratios were calculated using multinomial logistic regression. Results: Considering the 2 forms of commuting, 66% of the participants were being considered inactive or insufficiently active. In women, being “heavier,” feeling unsafe practicing physical activity, and being a former smoker were factors negatively associated with commuting by bicycling and walking. In men, active commuting was less common among those who were overweight or had abdominal obesity, those with a negative perception of safety, and those reporting that there was nowhere suitable in the neighborhood to practice physical activity. Conclusion: Obesity and negative perceptions in the neighborhood are associated with inactive or insufficiently active commuting. The relevance of this finding for public health is reinforce developing policies aimed at promoting health in Brazil and in other countries with similar characteristics.

This study investigates the association between personal-level and group-level discrimination and common mental disorders (CMDs) among Afro-Brazilian women, aiming to explore the role of skin color on this association. This is a cross-sectional study involving 1130 women who were participating in the Social Change, Asthma and Allergy in Latin America (SCAALA) study, whose children were recruited from 24 geographical micro-regions representative of the population without sanitation. Measures of discrimination were defined by: experiences (personal-level) and concern about discrimination (group-level) using the Experiences of Discrimination Scale. Skin color was registered by self-declaration, being classified as white, brown, and black. The association between “self-reported” discrimination and CMDs was evaluated using Poisson regression analysis. Prevalence of CMDs was high (38.3%), especially in the group exposed to discriminatory experiences and black women. Experiences and concern about discrimination were positive and significantly associated with mental health, before and after adjustment for potential confounders. The effect of discrimination on CMDs was lower among black women, suggesting the development of other strategies to confront racism. This study emphasizes the use of both personal- and group-level discrimination measures, as well as skin color, for the evaluation of mental disorders in public health research. Further studies of health consequences of discrimination will require investigation of protective factors for mental disorders in the population suffering discrimination and racism.

Submitted by Maria Creuza Silva (mariakreuza@yahoo.com.br) on 2018-08-06T12:50:49Z No. of bitstreams: 1 Maria B. Carmo et al. 2017.pdf: 499359 bytes, checksum: 207b7523bd33b6bdce73cedaa3b4faf1 (MD5) Made available in DSpace on 2018-08-06T12:50:49Z (GMT). No. of bitstreams: 1 Maria B. Carmo et al. 2017.pdf: 499359 bytes, checksum: 207b7523bd33b6bdce73cedaa3b4faf1 (MD5) Previous issue date: 2017 Objective: To analyze the prevalence of common mental disorders (CMD) assessed with the Self Reporting Questionnaire (SRQ-20), using the established cutoff point, and comparing it with the results of a joint correspondence factor analysis (CFA) and cluster analysis and of a latent class analysis (LCA). Methods: A cross-sectional study was carried out in an urban sample of 1,095 women aged 19 to 55 years. Joint CFA-cluster analysis and LCA were used. Results: We found a high prevalence of CMD, regardless of classification method (37.6% when using the cutoff point; 44.4% and 52% for LCA and joint CFA-cluster, respectively). The alternative analysis strategies describe the cases more efficiently when compared to the traditional cutoff method, especially regarding more severe symptoms. Both alternative strategies also provide a description of the SRQ-20 dimensions in their particularities, which may be useful for the planning and implementation of specific actions in a given population. Conclusion: The SRQ-20 cutoff point seems to nderestimate the magnitude of CMD among women. The alternative methods of analysis presented herein highlight the different possibilities of using this important instrument of screening for mental health. São Paulo

The integration of disparate large and heterogeneous socioeconomic and clinical databases is considered essential to capture and model longitudinal and social aspects of diseases. However, such integration is challenging: databases are stored in disparate locations, make use of different identifiers, have variable data quality, record information in bespoke purpose-specific formats and have different levels of metadata. Novel computational methods are required to integrate them and enable their statistical analyses for epidemiological research purposes. In this paper, we describe a probabilistic approach for constructing a very large population-based cohort comprised of 114 million individuals using linkages between clinical databases from the National Health System and administrative databases from governmental social programmes. We present our data integration model for creating data marts (epidemiological data) and discuss our evaluation results in controlled and uncontrolled scenarios, which demonstrate that our model and tools achieve high accuracy (minimum of 91%) in different probabilistic data integration scenarios.

Background and aimsA cooperation Brazil-UK was set in mid-2013 aiming at to build a huge cohort comprised by individuals registered in CadastroÚnico (CADU), a socioeconomic database used in social programmes of the Brazilian government. Epidemiologists and statisticians wish to assess the impact of Bolsa Família (PBF), a conditional cash transfer programme, on the incidence of several diseases (tuberculosis, leprosy, HIV etc). The cohort must contain all individuals who received at least one payment from PBF between 2007 and 2012, which results in a 100-million records according to our preliminary analysis. These individuals must be probabilistically linked with databases from the Unified Health System (SUS), such as hospitalization (SIH), notifiable diseases (SINAN), mortality (SIM), live births (SINASC), to produce data marts (domain-specific data) to the proposed studies. Within this cooperation, our first goal was to design and evaluate probabilistic methods to routine link the cohort, PBF, and SUS outcomes. ApproachWe implemented two probabilistic linkage methods: a full probabilistic, based on the Dice similarity (Sorensen index) of Bloom filters; and an hybrid approach, based on rules to deterministic and probabilistic matching. We performed linkages involving CADU (2011 extraction) and SUS outcomes (SIH, SINAN, and SIM) with samples from 3 states (Sergipe, Santa Catarina and Bahia) with an increasing size (from 1,447,512 to 12,036,010). ResultsUsing a Dice between 0.90 and 0.92, our methods retrieved more than 95% of true positive pairs amongst the linked pairs. For Sergipe, we obtained as : , , , respectively for SIH, SINAN, and SIM. For Bahia: , , . Another linkage between CADU (1,447,512 records) and SINAN (624 records), for tuberculosis in Sergipe, returned 397 (full probabilistic) and 311 (hybrid) linked pairs, being 306 and 300 true positives. Another execution considering CADU (1,988,599 records) and SINAN (2,094 records), for tuberculosis in Santa Catarina, returned 791 (full probabilistic) and 500 (hybrid) linked pairs, with 667 and 472 true positives. Linking CADU (1.685,697 records) and SIM, for mortality of children under-4, returned 18 linked pairs, all of them true positives, for a Dice between 0.90 and 0.92 and with 100% of sensitivity, specificity, and positive predictive value. ConclusionDue to the absence of gold standards, we use samples with increasing sizes and manual review when adequate. Our results are quite accurate, although obtained with an unique extraction of CADU. We are starting to run linkages with the entire cohort.

O presente estudo tem como objetivo estimar a prevalência de coinfecção HIV/HBV e HIV/HCV entre os casos de AIDS notificados no Brasil e descrever o perfil epidemiológico dos casos coinfectados. A coinfecção foi identificada pelo relacionamento probabilístico entre todos os pacientes com HIV notificados como casos de AIDS, e os casos de hepatites virais B e C em diferentes bases de dados do Ministério da Saúde, no período de 1999 a 2010. Nesse período, 370.672 casos de AIDS foram notificados, sendo 3.724 coinfectados com HBV e 5.932 com HCV. As mulheres têm menos chance de coinfecção que os homens. A chance de coinfecção aumenta com a idade, sendo três vezes maior entre os coinfectados com HBV com 45 anos ou mais. Este estudo permitiu uma importante avaliação dos perfis de coinfecção por HBV/HIV e HCV/HIV no Brasil pela utilização de dados secundários do Ministério da Saúde. Os achados deste estudo podem ser úteis para planejar ações de vigilância epidemiológica no Brasil. The aim of this study is to estimate the prevalence of HIV/HBV and HIV/HCV coinfections among AIDS cases reported in Brazil, and to describe the epidemiological profile of these cases. Coinfection was identified through probabilistic record linkage of the data of all patients carrying the HIV virus recorded as AIDS patients and of those patients reported as carriers of hepatitis B or C virus in various databases from the Brazilian Ministry of Health from 1999 to 2010. In this period 370,672 AIDS cases were reported, of which 3,724 were HIV/HBV coinfections. Women are less likely to become coinfected than men and the chance of coinfection increases with age. This study allowed an important evaluation of HBV/HIV and HCV/HIV coinfections in Brazil using information obtained via merging secondary databases from the Ministry of Health, without conducting seroprevalence research. The findings of this study might be important for planning activities of the Brazilian epidemiologic surveillance agencies. Estimar la prevalencia de las coinfecciones VIH/VHB y VIH/VHC entre los casos de SIDA notificados en Brasil y describir el perfil epidemiológico de las coinfecciones. Los casos de coinfección se identificaron por el método de conexión probabilística entre los pacientes con VIH notificados como SIDA y los casos de hepatitis B y C en los diversos sistemas de información del Ministerio de la Salud entre 1999 y 2010. Entre 1999 y 2010, 370.672 casos de SIDA fueron notificados, estos 3724 coinfectados con VHB y 5932 con VHC. Las mujeres son menos propensas a ser co-infectadas que los hombres. La oportunidad de coinfección aumenta con la edad. Este estudio proporciona una evaluación importante de los perfiles de la coinfección por VIH/VHB y VHC/VIH en Brasil, a través de la utilización de datos secundarios del Ministerio de Salud. Este estudio sirve para orientar las acciones de vigilancia epidemiológica en Brasil, así como guiar estudios de prevalencia e incidencia que fomenten una mejor comprensión de la coinfección VIH/VHB y VIH/VHC.