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2. CKD GENERAL AND CLINICAL EPIDEMIOLOGY 2

Author

Davids, M. R., Marais, N., Jacobs, J., Cohen, E., Krause, I., Goldberg, E., Garty, M., Dursun, B., Sahan, Y., Tanriverdi, H., Rota, S., Uslu, S., Senol, H., Minutolo, R., Gabbai, F. B., Agarwal, R., Chiodini, P., Borrelli, S., Stanzione, G., Nappi, F., Bellizzi, V., Conte, G., Nicola, L. D., J. V., De, Johnson, S., Fremeaux Bacchi, V., Ardissino, G., Ariceta, G., Beauchamp, J., Cohen, D., Greenbaum, L. A., Ogawa, M., Schaefer, F., Licht, C., Scalzotto, E., Nalesso, F., Zaglia, T., Corradi, V., Neri, M., Martino, F., Zanella, M., Brendolan, A., Mongillo, M., Ronco, C., Chinnappa, S., Mooney, A., A. M., El, Y. K., Tu, Tan, L. B., Jung, J. Y., Kim, A. J., Ro, H., Lee, C., Chang, J. H., Lee, H. H., Chung, W., Clarke, A. L., Young, H. M., Hull, K. L., Hudson, N., Burton, J. O., Smith, A. C., Marx, S., Petrilla, A., Filipovic, I., Lee, W. C., Meijers, B., Poesen, R., Storr, M., Claes, K., Kuypers, D., Evenepoel, P., Aukland, M., Betriu, A., Martinez Alonso, M., Arcidiacono, M. V., Cannata Andia, J., Pascual, J., Valdivielso, J. M., Fernandez Giraldez, E., Kingswood, J. C., Zonnenberg, B., Sauter, M., Zakar, G., Biro, B., Besenczi, B., Varga, A., Pekacs, P., Pizzini, P., Pisano, A., Leonardis, D., Panuccio, V., Cutrupi, S., Tripepi, G., Mallamaci, F., Zoccali, C., Arnold, J., Baharani, J., Rayner, H., B. H., So, Blackwell, S., Jardine, A. G., Macgregor, M. S., Cunha, C., Barreto, P., Pereira, S., Ventura, A., Mota, M., Seabra, J., Sakaguchi, T., Kobayashi, S., Yano, T., Yoshimoto, W., Bancu, I., Bastons, J. B., Escayola, M. C., Vallespin, E. V., Poblet, M. B., Luque, D. M., Fabregas, M. P., Chen, J., Chen, S., Chang, J., Hwang, S., Chen, H., Ahbap, E., Kara, E., Basturk, T., Sahutoglu, T., Koc, Y., Sakaci, T., Sevinc, M., Akgol, C., Ozagari, A. A., Unsal, A., Minami, S., Hesaka, A., Yamaguchi, S., Iwahashi, E., Sakai, S., Fujimoto, T., Sasaki, K., Fujita, Y., Yokoyama, K., Marks, A., Fluck, N., Prescott, G., Robertson, L., Smith, W. C., Black, C., Ohsawa, M., Fujioka, T., Omori, S., Isurugi, T., Tanno, K., Onoda, T., Omama, S., Ishibashi, Y., Makita, S., Okayama, A., Garland, J. S., Simpson, C. S., Metangi, M. F., Parfrey, B., Johri, A. M., Sloan, L., Mcauley, J., Cunningham, R., Mullan, R., Quinn, M., Harron, C., Chiu, H., Murphy Burke, D., Werb, R., Jung, B., Chan Yan, C., Duncan, J., Forzley, B., Lowry, R., Hargrove, G., Carson, R., Levin, A., Karim, M., Reznik, E. V., G. I. V., Rollino, C., Troiano, M., Bagatella, M., Liuzzo, C., Quarello, F., Roccatello, D., Blaslov, K., Bulum, T., Prkacin, I., Duvnjak, L., Heleniak, Z., Cieplinska, M., Szychlinski, T., Pryczkowska, M., Bartosinska, E., Wiatr, H., Kotlowska, H., Tylicki, L., Rutkowski, B., Song, Y. R., Kim, S. G., Kim, H. J., Noh, J. W., Tong, A., Jesudason, S., Craig, J. C., Winkelmayer, W. C., Hung, P. H., Huang, Y. T., Hsiao, C. Y., Sung, P. S., Guo, H. R., Tsai, K. J., Wu, C., Su, S., Kao, S., Lu, K., Lin, Y., Lin, W., Lee, H., Cheng, M., Wang, W., Yang, L., Wang, M., Lela, I. V., Sekoranja, M., Poljicanin, T., Karanovic, S., Abramovic, M., Matijevic, V., Stipancic, Z., Leko, N., Cvitkovic, A., Dika, Z., Kos, J., Laganovic, M., Grollman, A. P., Jelakovic, B., Dryl Rydzynska, T., Prystacki, T., Malyszko, J., Trifiro', Gianluca, Sultana, J., Giorgianni, F., Ingrasciotta, Y., Muscianisi, M., Tari, D. U., Perrotta, M., Buemi, Michele, Canale, V., Arcoraci, Vincenzo, Santoro, Domenico, Rizzo, M., Iheanacho, I., Van, F. E., Goldsmith, D., Grandtnerova, B., Beratsova, Z., Cervenˇova, M., Cˇervenˇ, J., Markech, M., Stefanikova, A., Engelen, W., Elseviers, M., Gheuens, E., Colson, C., Muyshondt, I., and Daelemans, R.

Subjects
Transplantation, medicine.medical_specialty, business.industry, urologic and male genital diseases, medicine.disease, Gastroenterology, female genital diseases and pregnancy complications, Nephrology, Internal medicine, mental disorders, Medicine, Stage (cooking), Metabolic syndrome, business, Kidney disease
Published
2014
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3. FIXED DOSE COMBINATION THERAPY IS ASSOCIATED WITH BETTER BLOOD PRESSURE CONTROL AND LOWER ALBUMINURIA IN REAL-LIFE COHORT DURING 7 YEARS OF FOLLOW UP. ENAH – CROATIAN RURAL STUDY

Author

Jelakovic, A., primary, Abramovic, M., additional, Dika, Z., additional, Domislovic, V., additional, Djapic, K., additional, Fucek, M., additional, Gelineo, L., additional, Josipovic, J., additional, Karanovic, S., additional, Kos, J., additional, Leko, N., additional, Matijevic, V., additional, Premuzic, V., additional, Brinar, I. Vukovic, additional, and Jelakovic, B., additional

Published
2018
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4. HYPERTENSION AND CARDIOVASCULAR RISK FACTORS IN CROATIA. DATA FROM THE 2017. WORLD HYPERTENSION DAY

Author

Milicic, B., primary, Dapic, K., additional, Domislovic, V., additional, Brozovic, M., additional, Drenjancevic, I., additional, Dobrincic, Z., additional, Gulin, M., additional, Cavrak, V. Herceg, additional, Josipovic, J., additional, Jelakovic, A., additional, Kolar, L., additional, Leko, N., additional, Pavlovic, D., additional, Prkacin, I., additional, Radic, J., additional, Stevanovic, R., additional, Stupin, A., additional, Brinar, I. Vukovic, additional, Vrkic, T. Zeljkovic, additional, and Jelakovic, B., additional

Published
2018
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5. OLDER SUBJECTS WOULD MORE LIKELY USE SMARTPHONE APPLICATIONS FOR HYPERTENSION THAN MIDDLE-AGED PATIENTS. DATA FROM THE 2017 WORLD HYPERTENSION DAY IN CROATIA

Author

Dapic, K., primary, Domislovic, V., additional, Milicic, B., additional, Drenjacevic, I., additional, Gulin, M., additional, Grba, E., additional, Cavrak, V. Herceg, additional, Jelakovic, A., additional, Josipovic, J., additional, Kralj, V., additional, Leko, N., additional, Lugovic, N., additional, Mrsic, M., additional, Pavlovic, D., additional, Prkacin, I., additional, Radic, J., additional, Ravic, M., additional, Brinar, I. Vukovic, additional, Zeljkovic Vrkic, T., additional, and Jelakovic, B., additional

Published
2018
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6. [OP.2B.03] GLOMERULAR HYPERFILTRATION AS A RISK FACTOR FOR RENAL IMPAIRMENT AND HYPERTENSION IN APPARENTLY HEALTHY SUBJECTS

Author

Vrdoljak, A., primary, Ivkovic, V., additional, Karanovic, S., additional, Dika, Z., additional, Domislovic, V., additional, Dapic, K., additional, Gallineo, L., additional, Ivandic, E., additional, Josipovic, J., additional, Vukovic, I., additional, Kos, J., additional, Laganovic, M., additional, Vrkic, T. Zeljkovic, additional, Prlic, M. Fistrek, additional, Pecin, I., additional, Fucek, M., additional, Sertic, J., additional, Leko, N., additional, and Jelakovic, B., additional

Published
2016
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7. [OP.5C.04] HEART RATE IS ASSOCIATED WITH GLOMERULAR HYPERFILTRATION IN APPARENTLY HEALTHY SUBJECTS

Author

Vrdoljak, A., primary, Ivkovic, V., additional, Karanovic, S., additional, Dika, Z., additional, Domislovic, V., additional, Dapic, K., additional, Gallineo, L., additional, Ivandic, E., additional, Josipovic, J., additional, Vukovic, I., additional, Kos, J., additional, Laganovic, M., additional, Vrkic, T. Zeljkovic, additional, Prlic, M. Fistrek, additional, Pecin, I., additional, Fucek, M., additional, Sertic, J., additional, Leko, N., additional, and Jelakovic, B., additional

Published
2016
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8. [OP.5B.09] ARISTOLOCHIC ACID NEPHROPATHY. A CASE OF SLOWER VASCULAR AGING?

Author

Premuzc, V., primary, Ivkovic, V., additional, Leko, N., additional, Stipancic, Z., additional, Teskera, T., additional, Vinkovic, M., additional, Barisic, M., additional, Karanovic, S., additional, Vrdoljak, A., additional, Vukovic, I., additional, Dika, Z., additional, Laganovic, M., additional, and Jelakovic, B., additional

Published
2016
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9. PP.05.06

Author

Ivkovic, V., primary, Kos, J., additional, Karanovic, S., additional, Lela, I. Vukovic, additional, Premuzic, V., additional, Dika, Z., additional, Laganovic, M., additional, Pecin, I., additional, Fucek, M., additional, Simicevic, L., additional, Sertic, J., additional, Vrdoljak, A., additional, Leko, N., additional, and Jelakovic, B., additional

Published
2015
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10. 4D.11

Author

Premuzic, V., primary, Leko, N., additional, Stipancic, Z., additional, Ivkovic, V., additional, Teskera, T., additional, Vinkovic, M., additional, Barisic, M., additional, Karanovic, S., additional, Lela, I. Vukovic, additional, Dika, Z., additional, Laganovic, M., additional, and Jelakovic, B., additional

Published
2015
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11. Effect of computer-assisted European Best Practice Guideline implementation on adherence and target attainment: ORAMA results

Author

Covic, A, Locatelli, F, Macdougall, Ic, Wiecek, A, Shikov, P, Nikolov, D, Deliyska, B, Paskalev, D, Simeonov, P, Belavic, Z, Jerko, B, Leko, N, Bogadi, I, Winkler, Re, Buhl, M, Wilbrandt, E, Edinger, M, Mall, M, Dammerboer, C, Urzowski, H, Flender, D, Kunowski, G, Müller, A, Anschütz, H, Prager, G, Lüth, Jb, Gaspare De Santo, N, Lodeserto, C, Bonomini, M, Meneghel, G, Ragaiolo, M, Cancarini, Giovanni, Rotolo, U, Zepa, L, Saumane Baza, G, Rivots, G, Rozentals, R, Rydzewski, A, Antczak Jedrzejczak, D, Ratajewski, W, Frankiewicz, D, Mazur, O, Grazyna, B, Kosicki, A, Sydor, A, Muszytowski, M, Mircescu, G, Mugosa Ratkovic, M, Pljesa, S, Nesic, V, Dimkovic, N, Curic, S, Lazarevic, M, and Kovacevic, Z.

Subjects
hemodialysis, erhythropoietin, anemia
Published
2009

13. Renal anemia: comparing current Eastern and Western European management practice (ORAMA)

Author

Wiecek, A, Covic, A, Locatelli, F, Macdougall, Ic, ORAMA STUDY GROUP, COLLABORATORS SHIKOV, P, Nikolov, D, Deliyska, B, Paskalev, D, Simeonov, P, Belavic, Z, Jerko, B, Leko, N, Bogadi, I, Winkler, Re, Buhl, M, Wilbrandt, E, Edinger, M, Mall, M, Dammerboer, C, Urzowski, H, Flender, D, Kunowski, G, Müller, A, Anschütz, H, Prager, G, Johann, Borwin, DE SANTO NG, Lodeserto, C, Bonomini, M, Meneghel, G, Ragaiolo, M, Cancarini, Giovanni, Rotolo, U, Zepa, L, SAUMANE BAZA, G, Ritovs, G, Rozentals, R, Rydzewski, A, ANTCZAK JEDRZEJCZAK, D, Ratajewski, W, Frankiewicz, D, Mazur, O, Grazyna, B, Andrezej, K, Antoni, S, Marek, M, Mircescu, G, Ratkovic, Mm, Pljesa, S, Nesic, V, Dimkovic, N, Curic, S, Lazarevic, M, and Kovacevic, Z.

Subjects
malattia renale cronica, anemia, chronic kidney disease
Published
2008

14. Influence of blood pressure and hypertension on proximal tubular damage should be considered in endemic (Balkan) nephropathy

Author

Jelaković, B., Miletić-Medved, M., Leko, N., Čvoriščec, D., Pećin, I., Kos, J., Kovač-Peić, A., Sonicki, Z., Grollman, A.P., and Dika, Ž.

Subjects
urogenital system, Hypertension, Endemic Nephropathy, Tubular Damage, urologic and male genital diseases
Abstract

Proximal tubular damage is an early sign of renal impairment in endemic (Balkan) nephropathy, and low molecular proteinuria is hallmark of it.

Published
2008

15. Endemic nephropathy and hypertension : myth or reality

Author

Leko, N, Teskera , T, Baričić , M, Vinković, M, Bitunjac , M, Miletić-Medved, M, Cvitković, A, and Bistrović, D

Subjects
endemic nephropathy
Abstract

Endemic nephropathy patients before ERSD have hypertension more frequent than before, in statistically significant number of patients.

Published
2008

17. Varied clinical course of endemic nephropathy in three members from the same household

Author

Jelaković, B., Kovač-Peić, A., Medverec, Z., Jakovina, K., Vukelić, M., Leko, N., Miletić-Medved, M., Miller, F., Slade, N., Brdar, B., Grollman, A.P., and Kes, Petar

Subjects
Endemic Nephropathy, Urothelial Cancer, Nephritis
Abstract

Endemic (Balkan) nephropathy is chronic tubulointerstitial nephritis characterized by insidious onset and progression to the end stage renal disease.

Published
2008

18. Endemic nephropathy and hypertension

Author

Leko, N, Kos , J, Barišić , M, Teskera , T, Vinković, M, Miletić-Medved, M, Pećin, J, Dika, Ž, Kovač-Peić , A, Čvoriščec, D, Cvitković, A, Bistrović, D, and Jelaković, B

Subjects
endemic nephropathy, hypertension, urologic and male genital diseases
Abstract

prevalence of hypertension in the same in endemic nephropathy as in non CKD patients. Blood preasurre influence influence microalbuminuria and alpha 1microglobulinuria in rural population. proximal tubule damage caused with hypertension and hihg blood preasurre shoud be considered in evaluation of renal impairment in early phase of endemic nephropathy.

Published
2008

19. ORAMA: a study to investigate EBPG impact on renal anaemia - design and baseline data

Author

Locatelli, F, Covic, A, Macdougall, Ic, Wiecek, A, ORAMA STUDY GROUP, COLLABORATORS COVIC, A, Shikov, P, Nikolov, D, Deliyska, B, Paskalev, D, Simeonov, P, Belavic, Z, Jerko, B, Leko, N, Winkler, Re, Buhi, M, Wilbrandt, E, Edinger, M, Mall, M, Dammerboer, C, Urzowski, H, Flender, D, Kunowski, G, Müller, A, Anschütz, H, Prager, G, DE SANTO NG, Lodeserto, C, Bonomini, M, Meneghel, G, Ragaiolo, M, Cancarini, Giovanni, Rotolo, U, Zepa, L, SAUMANE BAZA, G, Ritovs, G, Rosentals, R, Rydzewski, A, ANTCZAK JEDRZEJCZAK, D, Ratajewski, W, Frankiewicz, D, Mazur, O, Bogdanowicz, G, Kosicki, A, Sydor, A, Muszytowski, M, Mircescu, G, Ratkovic, Mm, Pljesa, S, Nesic, V, Dimkovic, N, Curic, S, Lazarevic, M, and Kovacevic, Z.

Subjects
anemia, dialysis, erhythropoietin
Published
2008

22. Prevalencija, liječenje i kontrola hipertenzije u Hrvatskim endemskim žarištima

Author

Dika, Živka, Pećin, Ivan, Miletić Medved, Marica, Kovač Peić, Ana Marija, Kos, Jelena, Barešić, Marko, Leko, N, Zeljković, Vrkić, Tajana, Jelaković, Bojan, Kuzmanić, Duško, Laganović, Mario, and Jelaković, Bojan

Subjects
Prevalencija, liječenje i kontrola, hipertenzija, Hrvatska, endemska žarišta
Abstract

Rad govori o prevalenciji, liječenju i kontroli hipertenzije u Hrvatskim žarištima endemske nefropatije

Published
2006

23. Endemic (Balkan) nephropathy remains a significant medical problem in the Bosnian endemic region

Author

Stipančić, Ž., Leko, N., Teskera, T., Jelaković, B., Maver, Hubert, and Rudan, Pavao

Subjects
education, parasitic diseases, social sciences, Endemic Nephropathy, Hemodialysis, Cancer, health care economics and organizations, humanities
Abstract

It is a slow, progressive bilateral tubulointerstitial disease with an endemic occurence in rural regions of Bosnia and Herzegovina, Croatia, Serbia, Bulgaria and Romania.

Published
2006

28. Angiotensin-converting enzyme gene polymorphism in endemic nephropathy patients

Author

Jelaković, Bojan, Sertić, Jadranka, Čvorišćec, Dubravka, Leko, N., Stavljenić-Rukavina, Ana, Kuzmanić, Duško, Boršo, Gordana, Laganović, Mario, Baričić, I., Čeović, Stjepan, Timio, Mario, Wizemann, Volker, and Venanzi, Sandro

Abstract

Endemic nephropathy is a chronic tubulointerstitial nephritis of unknown etiopathogenesis occurring in great river valleys of the Danubian river basin.

Published
1999

29. Angiotensin-converting enzyme gene polymorphism in endemic nephropathy

Author

Jelaković, Bojan, Čvorišćec, Dubravka, Sertić, Jadranka, Leko, N., Kuzmanić, Duško, Boršo, Gordana, Laganović, Mario, Barišić, I., and Čeović, Stjepan

Abstract

The aim of the study was to investigate the polymorphism of the ACE gene in patients with EN included in the chronic hemodialysis program.

Published
1999

30. ANGIOTENSIN-CONVETING ENZYME (ACE) GENE POLYMORPHISM IN ENDEMIC NEPHROPATHY (EN) PATIENTS

Author

Jelaković, Bojan, Čvorišćec, Dubravka, Sertić, Jadranka, Leko, N., Kuzmanić, Duško, Boršo, Gordana, Laganović, Mario, Barišić, I., Čeović, Stjepan, Timio, Mario, Wizmann, Volker, and Venanzi, Sandro

Subjects
ace gene polymorphism, endemic nephropathy
Abstract

The aim of the study was to investigate the polymorphism of the ACE gene in patients with EN included in the chronic hemodilaysis (CH) program. According to our knowledge this is the first study that analyses ACE gene polymorphisim and serum ACE activity in patients with chronic tubulointerstitial nephritis i.e. EN. The study was performed in 73 patients on CH, in 28 the diagnosis of EN was established. A 287 bp insertion/deletion (I/D) polymorphism in intron 16 of the ACE gene was examined by PCR and gel electrophoresis, whereas serum ACE activity were determined by sphectrophotometric method utilising the synthetic tripeptide substrate FAPGG. Results showed that the DD genotype was more often in patients with EN (42.8% vs. 26.6% in other patients, p > 0.05).The frequency of D allele in EN was 0.64 (p < 0.05 vs. the control group). Patients with DD genotype were the youngest at the time when diagnosis of EN was made ( 46.8ą6.2 vs. 48.2ą.2.1 ID and 47.7ą1.7 II; p > 0.05) and duration of the disease till CH was in those patients the shortest (p > 0.05). The values of serum ACE in the entire group of patients did not differ depending on ACE gene polymorphism (p > 0.05). On analysing the serum ACE activity in EN patients we, however, observed that this values were higher in patients with DD genotype than in those with II (39 vs. 28; p < 0.05). In other patients on CH there were no differences in serum ACE regarding ACE genotype. Based on our results we concluded that the frequency of D allele was increased in EN patients on CH, which together with increased serum ACE activity in these patients indicated the need for further studies of the ACE gene polymorphism. Regardless this polymorphism is a mediator, a genetic modifier or a marker of kidney disease progression in EN this could be valuable in better understanding of EN etiopathogenesis as well as it could be helpful in more sophisticated prevention.

Published
1999

31. Polimorfizam ACE gena u bolesnika s endemskom nefropatijom

Author

Jelaković, Bojan, Sertić, Jadranka, Leko, N., Ferenčak, Goran, Kuzmanić, Duško, Laganović, Mario, Boršo, Gordana, Čvorišćec, Dubravka, and Baričić, M.

Subjects
ACE gen, endemska nefropatija
Abstract

Polimorfizam ACE gena analizirali smo u 73 bolesnika na programu kronične hemodijalize (HD) Opće bolnice "Dr. Josip Benčević" Sl. Brod. EN je bila uzrok terminalnog bubrežnog zatajenje u 28 bolesnika...

Published
1998

32. Angiotensin-converting enzyme gene polymorphism in endemic nephropathy patients

Author

Čvorišćec, Dubravka, Jelaković, Bojan, Boršo, Gordana, Leko, N., Ferenčak, Goran, Gršković, Branka, Kuzmanić, Duško, Sertić, Jadranka, and Stavljenić Rukavina, Ana

Abstract

In this study we investigated angiotensin-converting enzyme gene and association with circulating ACE activity in 73 patients included in the chronic hemodialysis program.

Published
1998

33. Consensus statement on screening, diagnosis, classification and treatment of endemic (Balkan) nephropathy

Author

Jelakovi , B., primary, Nikoli , J., additional, Radovanovi , Z., additional, Nortier, J., additional, Cosyns, J.-P., additional, Grollman, A. P., additional, Ba i -Juki , N., additional, Belicza, M., additional, Bukvi , D., additional,  avaljuga, S., additional,  vori  ec, D., additional, Cvitkovi , A., additional, Dika,  ivka, additional, Dimitrov, P., additional,  ukanovi , L., additional, Edwards, K., additional, Ferluga, D., additional, Fu tar-Preradovi , L., additional, Gluhovschi, G., additional, Imamovi , G., additional, Jakovina, T., additional, Kes, P., additional, Leko, N., additional, Medverec, Z., additional, Mesi , E., additional, Mileti -Medved, M., additional, Miller, F., additional, Pavlovi , N., additional, Pasini, J., additional, Ple tina, S., additional, Polenakovi , M., additional, Stefanovi , V., additional, Tomi , K., additional, Trna evi , S., additional, Vukovi  Lela, I., additional, and  tern-Padovan, R., additional

Published
2013
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34. AKI - human studies

Author

Kutlay, S., primary, Kurultak, I., additional, Nergizoglu, G., additional, Erturk, S., additional, Karatan, O., additional, Azevedo, P., additional, Pinto, C. T., additional, Pereira, C. M., additional, Marinho, A., additional, Vanmassenhove, J., additional, Hoste, E., additional, Glorieux, G., additional, Dhondt, A., additional, Vanholder, R., additional, Van Biesen, W., additional, Rei, S., additional, Aleksandrova, I., additional, Kiselev, V., additional, Ilynskiy, M., additional, Berdnikov, G., additional, Marchenkova, L., additional, Daher, E. F., additional, Vieira, A. P. F., additional, Souza, J. B., additional, Falcao, F. S., additional, Costa, C. R., additional, Fernandes, A. A. C. S., additional, Mota, R. M. S., additional, Lima, R. S. A., additional, Silva Junior, G. B., additional, Ulusal Okyay, G., additional, Erten, Y., additional, Er, R., additional, Aybar, M., additional, Inal, S., additional, Tekbudak, M., additional, Aygencel, G., additional, Onec, K., additional, Bali, M., additional, Sindel, S., additional, Soto, K., additional, Fidalgo, P., additional, Papoila, A. L., additional, Lentini, P., additional, Zanoli, L., additional, Granata, A., additional, Contestabile, A., additional, Basso, A., additional, Berlingo, G., additional, de Cal, M., additional, Pellanda, V., additional, Dell'Aquila, R., additional, Fortrie, G., additional, Stads, S., additional, van Bommel, J., additional, Zietse, R., additional, Betjes, M. G., additional, Berrada, A., additional, Arias, C., additional, Riera, M., additional, Orfila, M. A., additional, Rodriguez, E., additional, Barrios, C., additional, Peruzzi, L., additional, Chiale, F., additional, Camilla, R., additional, Martano, C., additional, Cresi, F., additional, Bertino, E., additional, Coppo, R., additional, Klimenko, A., additional, Villevalde, S., additional, Efremovtseva, M., additional, Kobalava, Z., additional, Pipili, C., additional, Ioannidou, S., additional, Kokkoris, S., additional, Poulaki, S., additional, Tripodaki, E.-S., additional, Parisi, M., additional, Papastylianou, A., additional, Nanas, S., additional, Wang, Y.-n., additional, Cheng, H., additional, Chen, Y.-p., additional, Wen, Z., additional, Li, X., additional, Shen, P., additional, Zou, Y., additional, Lu, Y., additional, Ma, X., additional, Chen, Y., additional, Ren, H., additional, Chen, X., additional, Chen, N., additional, Yue, T., additional, Elmamoun, S., additional, Wodeyar, H., additional, Goldsmith, C., additional, Abraham, A., additional, Wootton, A., additional, Ahmed, S., additional, Hill, C., additional, Curtis, S., additional, Miller, A., additional, Hine, T., additional, Stevens, K. 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N., additional, Kul, A., additional, Ye, N., additional, Zhang, Y., additional, Baines, R., additional, Westacott, R., additional, Trew, J., additional, Kirtley, J., additional, Selby, N., additional, Carr, S., additional, Xu, G., additional, Steffgen, J., additional, Blaschke, S., additional, Brun-Schulte-Wissing, N., additional, Pagel, P., additional, Huber, F., additional, Mapes, J., additional, Jaehnige, A., additional, Pestel, S., additional, Deray, G., additional, Rouviere, O., additional, Bacigalupo, L., additional, Maes, B., additional, Hannedouche, T., additional, Vrtovsnik, F., additional, Rigothier, C., additional, Billiouw, J.-M., additional, Campioni, P., additional, Marti-Bonmati, L., additional, Gao, Y.-m., additional, Li, D., additional, Woo, S., additional, Lee, J., additional, Noh, H., additional, Kwon, S. H., additional, Han, D. C., additional, Hetherington, L., additional, Valluri, A., additional, McQuarrie, E., additional, Fleming, S., additional, Geddes, C., additional, Bell, S., additional, MacKinnon, B., additional, Patton, A., additional, Sneddon, J., additional, Donnan, P., additional, Vadiveloo, T., additional, Marwick, C., additional, Bennie, M., additional, Davey, P., additional, Yasuda, H., additional, Tsuji, N., additional, Tsuji, T., additional, Iwakura, T., additional, Ohashi, N., additional, Kato, A., additional, Fujigaki, Y., additional, Sasaki, S., additional, Kawarazaki, H., additional, Shibagaki, Y., additional, Kimura, K., additional, Lingaraju, U., additional, Rajanna, S., additional, Radhakrishnan, H., additional, Parekh, A., additional, Sreedhar, C. G., additional, Sarvi, R., additional, Rainone, F., additional, Merlino, L., additional, Ritchie, J. P., additional, Kalra, P. A., additional, Jacinto, C. N., additional, Abreu, K. L. S., additional, Neves, M., additional, Baptista, J. 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F., additional, Liborio, A. B., additional, Thereza, B. M. F., additional, Mendes, C. C. P., additional, and Sousa, A. R. O., additional

Published
2013
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36. METABOLIC CHARACTERISTICS AND HEART RATE OF NEWLY DIAGNOSED NON-TREATED HYPERTENSIVE, PREHYPERTENSIVE AND NORMOTENSIVE SUBJECTS

Author

Karanovic, S., primary, Juric, D., additional, Juras, J., additional, Capkun, V., additional, Dika, Z., additional, Vukovic Lela, I., additional, Fistrek, M., additional, Kos, J., additional, Laganovic, M., additional, Cvitkovic, A., additional, Premuzic, V., additional, Pecin, I., additional, Bitunjac, M., additional, Leko, N., additional, and Jelakovic, B., additional

Published
2011
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37. HEART SCORE IN RURAL PREHYPERTENSIVES

Author

Karanovic, S., primary, Juric, D., additional, Vukovic lela, I., additional, Fistrek, M., additional, Premuzic, V., additional, Cvitkovic, A., additional, Dika, Z., additional, Kos, J., additional, Capkun, V., additional, Laganovic, M., additional, Fodor, L J., additional, Bitunjac, M., additional, Leko, N., additional, Pecin, I., additional, and Jelakovic, B., additional

Published
2011
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38. Ispitivanje fizikalno-kemijskih i senzornih svojstava 'Vlašićke' kobasice tijekom čuvanja.

Author

Operta, S., Leko, N., Tahmaz, J., and Alkić, M.

Abstract

Copyright of MESO is the property of Zadruzna Stampa D.D. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2015

39. LEPTIN AND HEART RATE IN SUBJECTS WITH LOW CARDIOVASCULAR RISK

Author

Ivkovic, V., Kos, J., Karanovic, S., Lela, I. Vukovic, Premuzic, V., Dika, Z., Laganovic, M., Pecin, I., Fucek, M., Livija Simicevic, Sertic, J., Vrdoljak, A., Leko, N., Jelakovic, B., and Zanchetti, Alberto

Subjects
Leptin, cardiovascular risk
Abstract

Objective: Several studies showed that leptin may be associated with faster heart rate (HR) and it was questioned whether this could be associated with increased cardiovascular risk. Our goal was to examine the possible association of leptin and HR in subjects with low cardiovascular risk. Design and method: Participants (N = 208 ; 135 females ; 137 normotensives, 34 prehypertensives and 37 untreated hypertensives) were selected from a random sample of 2487 subjects enrolled in an observational study. Subjects with diabetes, chronic kidney disease, pregnancy, terminal illness and treated hypertensives were excluded. BP was measured using Omron M6 device following ESH/ESC guidelines. Leptin concentration was determined by ELISA. Results: In the whole group leptin concentration was higher (12.10 (6.12-17.50) vs. 4.01 (1.70- 8.17), p < 0.001) in women than in men. There were no significant differences in leptin concentrations between normotensives (NT), prehypertensives (PHT) and untreated hypertensives (uHT). However, uHT (11.20 (6.00- 16.90)) had significantly higher leptin concentration than NT (8.60 (3.60-14.65) ; p < 0.05) and non-significantly higher than PHT (8.04 (3.60-12.60 ; p > 0.05)). There were no differences between NT and PHT (p > 0.05). HR was similar in all three BP groups (p = 0.82). Leptin was positively correlated with BMI, albuminuria, CRP and insulin concentrations (p < 0.05). HR was positively correlated with eGFR and insulin and negatively with HDL. There were no significant correlations of leptin and HR in any of three BP groups. In multivariate analysis leptin was not a significant predictor of HR (Beta = -0.01, p = 0.90), systolic (Beta = -0.06, p = 0.27) or diastolic BP (Beta = 0.03, p = 0.58). BMI and female sex were positively associated with leptin concentration in multivariate analysis (p < 0.05). Conclusions: In our group of subjects with low cardiovascular risk leptin was not associated with HR. Hypertensive patients had higher leptin concentrations than NT and non- significantly higher than PHT subjects, latter two having similar leptin concentrations.

42. Education and cooking methods in the management of calcium and PTH serum levels in patients on hemodialysis: a randomized controlled study.

Author

Vrdoljak I, Pozaić A, Bituh M, Leko N, Vrdoljak Margeta T, Pavlović D, and Panjkota Krbavčić I

Subjects
Humans, Female, Male, Middle Aged, Aged, Cooking methods, Treatment Outcome, Adult, Chronic Kidney Disease-Mineral and Bone Disorder blood, Chronic Kidney Disease-Mineral and Bone Disorder etiology, Chronic Kidney Disease-Mineral and Bone Disorder therapy, Renal Dialysis, Parathyroid Hormone blood, Calcium blood, Patient Education as Topic, Vitamin D blood, Vitamin D analogs & derivatives
Abstract

Background: Chronic kidney disease associated mineral bone disorder (CKD-MBD) is one of the major causes of excess morbidity and mortality in hemodialysis patients. The purpose of this study was to investigate whether education about dietary intakes and specific food processing methods affect serum calcium and PTH concentrations in hemodialysis patients., Methods: Forty-seven hemodialysis patients were randomly divided into a control and an intervention group. All participants were on individualized phosphate binder therapy. Both groups received education on dietary intake by a trained dietitian. The intervention group received additional education on specific preparation methods of different foodstuffs and consumed two hospital meals prepared according to these methods during hemodialysis. Serum calcium and PTH levels, and vitamin D analog therapy dosage were periodically monitored during the 1-year study period., Results: At the baseline of the study, there were no differences between control and intervention groups in serum calcium (p = 0.078), serum PTH (p = 0.670), and vitamin D analog therapy dosage (p = 0.184). At the end of the study, serum calcium was better regulated in the intervention group, resulting in a significant difference between the study groups (p = 0.013). This was also confirmed by serum PTH levels in the intervention group, which remained stable until the end of the study (p = 0.110)., Discussion: Additional education on specific food processing techniques may result in improved management of serum calcium and PTH levels, which could ultimately provide better control of secondary hyperparathyroidism in hemodialysis patients., (© 2024. The Author(s) under exclusive licence to Italian Society of Nephrology.)

Published
2024
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43. CHRONIC KIDNEY DISEASE IN RURAL POPULATION.

Author

Domislović M, Domislović V, Stevanović R, Fuček M, Dika Ž, Karanović S, Kos J, Jelaković A, Premužić V, Leko N, Josipović J, Brzić I, Željković Vrkić T, Capak K, and Jelaković B

Subjects
Humans, Male, Female, Adult, Middle Aged, Aged, Albuminuria epidemiology, Albuminuria etiology, Albuminuria urine, Rural Population, Prevalence, Risk Factors, Creatinine urine, Renal Insufficiency, Chronic diagnosis, Renal Insufficiency, Chronic epidemiology, Hypertension complications, Diabetes Mellitus
Abstract

The aims of the study were to provide data on chronic kidney disease (CKD) prevalence in rural population and to analyze the association with cardiovascular risk factors and aging. A random sample of 2193 farmers (1333 female (F) and 860 male (M), mean age 50.61±17.12) were enrolled. Questionnaire and clinical examination were conducted. Participants provided a spot urine and fasting blood sample. Estimated glomerular filtration rate (eGFR) was estimated using Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. Subjects were classified according to the KDIGO guidelines. The overall prevalence of CKD (eGFR <60 mL/min/1.73 m 2 ) was 8.83% (F vs . M 9.9% vs . 6.3%; p<0.001). Albuminuria (albumin-to-creatinine ratio >30 mg/g) was found in 8.45% (F vs . M p>0.05). Sharp increase in CKD prevalence was found to begin after the sixth decade (29.44% in subjects older than 65 years; F vs . M 30.9% vs . 26.8%; p<0.01). The strongest predictor factors for CKD were age >65 years (OR 22.12), hypertension (OR 6.53), albuminuria (OR 5.71), fasting blood glucose >7 mmol/L (OR 5.49), diabetes (OR 3.07), abdominal obesity (OR 2.05) and non-smoking (OR 0.41). In multivariate analysis, age (OR 1.13), female gender (OR 0.60) and diabetes (OR 1.75) were the independent predictor factors for CKD. In conclusion, CKD prevalence is high in rural population, being higher in women than in men. In both genders, eGFR significantly decreased with aging. Aging is a significant independent predictor of CKD.

Published
2022
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44. Arterial Stiffness in Balkan Endemic Nephropathy, an Environmental Form of Aristolochic Acid Nephropathy.

Author

Premužić V, Ivković V, Leko N, Stipančić Ž, Karanović S, Jelaković A, Vuković Brinar I, Dika Ž, and Jelaković B

Abstract

Balkan endemic nephropathy (BEN), an environmental form of aristolochic acid nephropathy is characterized with later onset and milder forms of hypertension (HT). Thus, we hypothesized that arterial stiffness progresses slower in BEN patients resulting in lower CV mortality. A total of 186 hemodialysed (HD) patients (90 BEN, 96 non-BEN; 67.3 + 13.0 years) were enrolled and followed-up for 25 months. Brachial blood pressure (BP) and pulse wave velocity (PWV) were determined before mid-week dialysis. BEN patients were older (72.1 ± 37.1 vs. 62.8 ± 15.1; p < 0.001), had shorter duration of HT prior commencement of HD than non-BEN patients (36 vs. 84 months; p < 0.001). There were no differences in BP, but BEN patients were treated with less antihypertensive drugs ( p < 0.01). BEN patients had lower PWV values at baseline and at the end of follow-up period despite being chronologically older ( p < 0.001). Baseline PWV > 10 m/s was associated with higher risk for CV mortality (aHR 1.8 [1.4, 2.4]). In multivariate analyses BEN was predictor of lower PWV. During the follow-up period significantly less CV deaths were observed in BEN vs. on-BEN patients (12 vs. 31; p = 0.001). CV mortality adjusted for other risk factors was significantly lower in BEN group (aHR 0.2 [0.1, 0.5]). Overall BEN patients had longer mean survival time on HD (22.3 vs. 18.2 months; p < 0.001). Observed slower vascular aging (i.e., lower PWV) in BEN patients compared to other ESRD patients is related to the later onset of HT and milder stages of HT during predialytic clinical course and better control of BP and phosphate during HD.

Published
2018
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45. When linearity prevails over hierarchy in syntax.

Author

Willer Gold J, Arsenijević B, Batinić M, Becker M, Čordalija N, Kresić M, Leko N, Marušič FL, Milićev T, Milićević N, Mitić I, Peti-Stantić A, Stanković B, Šuligoj T, Tušek J, and Nevins A

Subjects
Adolescent, Adult, Female, Humans, Linguistics, Male, Psycholinguistics, Young Adult, Language
Abstract

Hierarchical structure has been cherished as a grammatical universal. We use experimental methods to show where linear order is also a relevant syntactic relation. An identical methodology and design were used across six research sites on South Slavic languages. Experimental results show that in certain configurations, grammatical production can in fact favor linear order over hierarchical structure. However, these findings are limited to coordinate structures and distinct from the kind of production errors found with comparable configurations such as "attraction" errors. The results demonstrate that agreement morphology may be computed in a series of steps, one of which is partly independent from syntactic hierarchy., Competing Interests: The authors declare no conflict of interest., (Copyright © 2018 the Author(s). Published by PNAS.)

Published
2018
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46. The impact of education and cooking methods on serum phosphate levels in patients on hemodialysis: 1-year study.

Author

Vrdoljak I, Panjkota Krbavčić I, Bituh M, Leko N, Pavlović D, and Vrdoljak Margeta T

Subjects
Aged, Cooking, Female, Humans, Male, Kidney Failure, Chronic therapy, Phosphorus blood, Renal Dialysis methods
Abstract

Introduction: Control of serum phosphate is important for patients on hemodialysis. The aim of the study was to determine if education based on phosphorus-reducing techniques in food preparation and thermal processing, and accordingly prepared and applied diets, will lead to better outcomes than a standard education program to improve phosphate control in patients on hemodialysis., Methods: Forty-seven patients on hemodialysis were divided between an intervention and a control group. All subjects received training about nutrition for hemodialysis patients by trained dietitian. In addition, subjects in the intervention group received additional training in phosphorus-reducing techniques in food preparation and received two hospital meals prepared using suggested cooking methods to reduce the phosphate content of food during dialysis treatment. Serum phosphate, serum albumin, and anthropometric parameters were measured, while nPCR was calculated, at the baseline and during the 1-year study., Findings: No differences in serum phosphate levels were observed between intervention (1.68 mmol/L [1.48-2.03]) and control group (1.88 mmol/L [1.57-2.2]) at baseline (P = 0.130). Although not statistically significant between groups the mean reduction was more apparent in the intervention group (-0.3 mmol/L (-0.4 to 0.1) vs. -0.2 (-0.5 to 0.1)), and lead to significantly reduction of phosphate binder therapy. During the study, the nPCR and anthropometric status of the patients did not change significantly., Discussion: Providing additional education to hemodialysis patients on the specific cooking methods and accordingly prepared meals may decrease serum phosphate levels without significantly affecting nutritional status which may be useful in helping to prevent and treat hyperphosphatemia., (© 2016 International Society for Hemodialysis.)

Published
2017
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47. Chronic dietary exposure to aristolochic acid and kidney function in native farmers from a Croatian endemic area and Bosnian immigrants.

Author

Jelaković B, Vuković Lela I, Karanović S, Dika Ž, Kos J, Dickman K, Šekoranja M, Poljičanin T, Mišić M, Premužić V, Abramović M, Matijević V, Miletić Medved M, Cvitković A, Edwards K, Fuček M, Leko N, Teskera T, Laganović M, Čvorišćec D, and Grollman AP

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Agricultural Workers' Diseases diagnosis, Agricultural Workers' Diseases ethnology, Agricultural Workers' Diseases physiopathology, Agricultural Workers' Diseases prevention & control, Alpha-Globulins urine, Balkan Nephropathy diagnosis, Balkan Nephropathy ethnology, Balkan Nephropathy physiopathology, Balkan Nephropathy prevention & control, Biomarkers blood, Biomarkers urine, Bosnia and Herzegovina ethnology, Creatinine blood, Creatinine urine, Croatia epidemiology, Cross-Sectional Studies, Female, Glomerular Filtration Rate drug effects, Humans, Kidney Tubules, Proximal pathology, Kidney Tubules, Proximal physiopathology, Logistic Models, Male, Middle Aged, Multivariate Analysis, Occupational Exposure prevention & control, Odds Ratio, Prevalence, Residence Characteristics, Risk Factors, Time Factors, Young Adult, Agricultural Workers' Diseases chemically induced, Agriculture, Aristolochic Acids adverse effects, Balkan Nephropathy chemically induced, Diet adverse effects, Emigrants and Immigrants, Food Contamination, Kidney Tubules, Proximal drug effects, Occupational Exposure adverse effects
Abstract

Background and Objectives: Improvements in agricultural practices in Croatia have reduced exposure to consumption of aristolochic acid-contaminated flour and development of endemic (Balkan) nephropathy. Therefore, it was hypothesized that Bosnian immigrants who settled in an endemic area in Croatia 15-30 years ago would be at lower risk of developing endemic nephropathy because of reduced exposure to aristolochic acid. To test this hypothesis, past and present exposure to aristolochic acid, proximal tubule damage as a hallmark of endemic nephropathy, and prevalence of CKD in Bosnian immigrants were analyzed., Design, Setting, Participants, & Measurements: In this cross-sectional observational study from 2005 to 2010, 2161 farmers were divided into groups: indigenous inhabitants from endemic nephropathy and nonendemic nephropathy villages and Bosnian immigrants; α-1 microglobulin-to-creatinine ratio >31.5 mg/g and eGFR<60 ml/min per 1.73 m(2) were considered to be abnormal., Results: CKD and proximal tubule damage prevalence was significantly lower in Bosnian immigrants than inhabitants of endemic nephropathy villages (6.9% versus 16.6%; P<0.001; 1.3% versus 7.3%; P=0.003, respectively); 20 years ago, Bosnian immigrants observed fewer Aristolochia clematitis in cultivated fields (41.9% versus 67.8%) and fewer seeds among wheat seeds (6.1% versus 35.6%) and ate more purchased than homemade bread compared with Croatian farmers from endemic nephropathy villages (38.5% versus 14.8%, P<0.001). Both Croatian farmers and Bosnian immigrants observe significantly fewer Aristolochia plants growing in their fields compared with 15-30 years ago. Prior aristolochic acid exposure was associated with proximal tubule damage (odds ratio, 1.64; 95% confidence interval, 1.04 to 2.58; P=0.02), whereas present exposure was not (odds ratio, 1.31; 95% confidence interval, 0.75 to 2.30; P=0.33). Furthermore, immigrant status was an independent negative predictor of proximal tubule damage (odds ratio, 0.40; 95% confidence interval, 0.19 to 0.86; P=0.02)., Conclusions: Bosnian immigrants and autochthonous Croats residing in endemic areas are exposed significantly less to ingestion of aristolochic acid than in the past. The prevalence of endemic nephropathy and its associated urothelial cancers is predicted to decrease over time., (Copyright © 2015 by the American Society of Nephrology.)

Published
2015
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48. Consensus statement on screening, diagnosis, classification and treatment of endemic (Balkan) nephropathy.

Author

Jelaković B, Nikolić J, Radovanović Z, Nortier J, Cosyns JP, Grollman AP, Bašić-Jukić N, Belicza M, Bukvić D, Čavaljuga S, Čvorišćec D, Cvitković A, Dika Ž, Dimitrov P, Đukanović L, Edwards K, Ferluga D, Fuštar-Preradović L, Gluhovschi G, Imamović G, Jakovina T, Kes P, Leko N, Medverec Z, Mesić E, Miletić-Medved M, Miller F, Pavlović N, Pasini J, Pleština S, Polenaković M, Stefanović V, Tomić K, Trnačević S, Vuković Lela I, and Štern-Padovan R

Subjects
Humans, Balkan Nephropathy classification, Balkan Nephropathy diagnosis, Balkan Nephropathy therapy, Consensus, Disease Management, Mass Screening methods
Abstract

Currently used diagnostic criteria in different endemic (Balkan) nephropathy (EN) centers involve different combinations of parameters, various cut-off values and many of them are not in agreement with proposed international guidelines. Leaders of EN centers began to address these problems at scientific meetings, and this paper is the outgrowth of those discussions. The main aim is to provide recommendations for clinical work on current knowledge and expertise. This document is developed for use by general physicians, nephrologists, urologist, public health experts and epidemiologist, and it is hoped that it will be adopted by responsible institutions in countries harboring EN. National medical providers should cover costs of screening and diagnostic procedures and treatment of EN patients with or without upper urothelial cancers., (© The Author 2013. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.)

Published
2014
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49. The assessment of arterial stiffness in endemic (Balkan) nephropathy patients undergoing haemodialysis.

Author

Premužić V, Teskera T, Leko N, Vuković-Lela I, Ivković V, Laganović M, and Jelaković B

Subjects
Aged, Balkan Nephropathy complications, Balkan Nephropathy therapy, Cardiovascular Diseases etiology, Cardiovascular Diseases physiopathology, Croatia epidemiology, Female, Humans, Male, Middle Aged, Morbidity trends, Risk Factors, Balkan Nephropathy physiopathology, Cardiovascular Diseases epidemiology, Glomerular Filtration Rate physiology, Renal Dialysis, Vascular Stiffness
Abstract

Cardiovascular (CV) complications are the most important cause of morbidity and mortality in patients with advanced chronic kidney disease (CKD). Arterial stiffness (AS) has been recognized as a strong and independent predictor for CV events in CKD. Our aim was to assess indices of AS in a group of Endemic (Balkan) Nephropathy (EN) patients undergoing haemodialysis (HD). Hypertenison was not considered an importnat feauture in earlier stages of the disease, and therefore we presumed that those patients would have lower AS. Interestingly, we found AS to be even higher in this group of EN patients. This result should be confirmed in a larger cohort of EN patients.

Published
2014

50. Angiotensin-converting enzyme gene polymorphism and N-Acetyl-β-D-glucosaminidase excretion in endemic nephropathy.

Author

Pećin I, Cvorišćec D, Miletić-Medved M, Dika Z, Cvitković A, Vitale K, Leko N, Novaković D, Sertić J, Kos J, and Jelaković B

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Alleles, Balkan Nephropathy enzymology, Blood Pressure, Creatinine blood, Croatia, Female, Gene Frequency, Genotype, Humans, Male, Middle Aged, Proteinuria, Young Adult, Acetylglucosaminidase urine, Balkan Nephropathy genetics, Peptidyl-Dipeptidase A genetics, Polymorphism, Genetic
Abstract

Background: Tubular proteinuria and enzymuria are hallmarks of endemic nephropathy (EN). The role of I/D angiotensin convertase (ACE) gene polymorphism has not yet been elucidated in this peculiar chronic tubulointerstitial nephritis, and our aim was to investigate the role of this polymorphism in EN focusing on the urinary N-acetyl-β-D-glucosaminidase (NAG) excretion, a biomarker of proximal tubular damage., Methods: ACE genotype and allele frequencies were determined in 229 farmers (147 women and 82 men) from an endemic Croatian village. The farmers were stratified according to the WHO criteria into the following subgroups: those 'at risk' for EN (n = 37), 'suspected of having EN' (n = 57), and 'others' (n = 135)., Results: There were 74 (32.3%) subjects homozygous for the D allele, 99 (43.2%) heterozygous (ID genotype) and 56 (24.4%) homozygous for the I allele. No differences in allele frequency were found between the established WHO subgroups (p > 0.05). In the whole group, DD subjects had significantly higher values of diastolic blood pressure (p = 0.003) and urinary NAG than subjects with ID and II genotype (5.5 ± 1.2 vs. 4.0 ± 3.0 vs. 3.8 ± 4.2, respectively; p = 0.023). The highest values of serum creatinine (p = 0.02), proteinuria (p = 0.03) and urinary NAG (6.0 ± 3.7 vs. 3.7 ± 2.1 vs. 3.0 ± 1.6, respectively; p = 0.008) were observed in those suspected of having EN group with the DD genotype., Conclusion: ACE gene polymorphism is not a risk factor for EN. However, it might influence the clinical course of EN, and increased excretion of NAG might be a prognostic marker of this chronic tubulointerstitial nephritis., (2011 S. Karger AG, Basel.)

Published
2011
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