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1. Radiolabeling of the antibody IgG M75 for epitope of human carbonic anhydrase IX by

Author

Adam, Čepa, Jan, Ráliš, Lenka, Marešová, Markéta, Kleinová, Daniel, Seifert, Irena, Sieglová, Vlastimil, Král, Miloslav, Polášek, Monika, Paurová, Milan, Lázníček, and Ondřej, Lebeda

Subjects
Male, Immunoconjugates, Antibodies, Monoclonal, Mice, Nude, Mice, Copper Radioisotopes, Radioimmunodetection, Antigens, Neoplasm, Immunoglobulin G, Positron-Emission Tomography, Animals, Humans, Tissue Distribution, Radiopharmaceuticals, Carbonic Anhydrase IX, Colorectal Neoplasms, HT29 Cells
Abstract

Human carbonic anhydrase IX is a membrane enzyme that is significantly expressed in some types of cancer cells, while copper radioisotopes offer wide range of diagnostic, therapeutic and theranostic properties. The work was focused on a new approach to the labelling of antibody IgG M75 for epitope human carbonic anhydrase IX with copper radioisotopes

Published
2018

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