Search

Your search keyword '"Lenting, Krissie"' showing total 16 results
Start Over Author "Lenting, Krissie"
16 results on '"Lenting, Krissie"'

3. Data from Radioprotection of IDH1-Mutated Cancer Cells by the IDH1-Mutant Inhibitor AGI-5198

Author

Molenaar, Remco J., primary, Botman, Dennis, primary, Smits, Myrthe A., primary, Hira, Vashendriya V., primary, van Lith, Sanne A., primary, Stap, Jan, primary, Henneman, Peter, primary, Khurshed, Mohammed, primary, Lenting, Krissie, primary, Mul, Adri N., primary, Dimitrakopoulou, Dionysia, primary, van Drunen, Cornelis M., primary, Hoebe, Ron A., primary, Radivoyevitch, Tomas, primary, Wilmink, Johanna W., primary, Maciejewski, Jaroslaw P., primary, Vandertop, W. Peter, primary, Leenders, William P., primary, Bleeker, Fonnet E., primary, and van Noorden, Cornelis J., primary

Published
2023
Full Text
View/download PDF

4. Supplementary Table S1 from Radioprotection of IDH1-Mutated Cancer Cells by the IDH1-Mutant Inhibitor AGI-5198

Author

Molenaar, Remco J., primary, Botman, Dennis, primary, Smits, Myrthe A., primary, Hira, Vashendriya V., primary, van Lith, Sanne A., primary, Stap, Jan, primary, Henneman, Peter, primary, Khurshed, Mohammed, primary, Lenting, Krissie, primary, Mul, Adri N., primary, Dimitrakopoulou, Dionysia, primary, van Drunen, Cornelis M., primary, Hoebe, Ron A., primary, Radivoyevitch, Tomas, primary, Wilmink, Johanna W., primary, Maciejewski, Jaroslaw P., primary, Vandertop, W. Peter, primary, Leenders, William P., primary, Bleeker, Fonnet E., primary, and van Noorden, Cornelis J., primary

Published
2023
Full Text
View/download PDF

8. Isocitrate dehydrogenase 1–mutated human gliomas depend on lactate and glutamate to alleviate metabolic stress

Author

Lenting, Krissie, primary, Khurshed, Mohammed, additional, Peeters, Tom H., additional, Heuvel, Corina N. A. M., additional, Lith, Sanne A. M., additional, Bitter, Tessa, additional, Hendriks, Wiljan, additional, Span, Paul N., additional, Molenaar, Remco J., additional, Botman, Dennis, additional, Verrijp, Kiek, additional, Heerschap, Arend, additional, Laan, Mark, additional, Kusters, Benno, additional, Ewijk, Anne, additional, Huynen, Martijn A., additional, Noorden, Cornelis J. F., additional, and Leenders, William P. J., additional

Published
2018
Full Text
View/download PDF

12. Glioma: experimental models and reality

Author

Pathologie patiënten zorg, Lenting, Krissie, Verhaak, Roel, ter Laan, Mark, Wesseling, Pieter, Leenders, William, Pathologie patiënten zorg, Lenting, Krissie, Verhaak, Roel, ter Laan, Mark, Wesseling, Pieter, and Leenders, William

Published
2017

13. Identification of a novel inactivating mutation in Isocitrate Dehydrogenase 1 (IDH1-R314C) in a high grade astrocytoma

Author

Van Lith, Sanne A M, Navis, Anna C., Lenting, Krissie, Verrijp, Kiek, Schepens, Jan T G, Hendriks, Wiljan J A J, Schubert, Nil A., Venselaar, Hanka, Wevers, Ron A., Van Rooij, Arno, Wesseling, Pieter, Molenaar, Remco J., Van Noorden, Cornelis J F, Pusch, Stefan, Tops, Bastiaan, Leenders, William P J, Van Lith, Sanne A M, Navis, Anna C., Lenting, Krissie, Verrijp, Kiek, Schepens, Jan T G, Hendriks, Wiljan J A J, Schubert, Nil A., Venselaar, Hanka, Wevers, Ron A., Van Rooij, Arno, Wesseling, Pieter, Molenaar, Remco J., Van Noorden, Cornelis J F, Pusch, Stefan, Tops, Bastiaan, and Leenders, William P J

Published
2016

14. Identification of a novel inactivating mutation in Isocitrate Dehydrogenase 1 (IDH1-R314C) in a high grade astrocytoma

Author

van Lith, Sanne A. M., primary, Navis, Anna C., additional, Lenting, Krissie, additional, Verrijp, Kiek, additional, Schepens, Jan T. G., additional, Hendriks, Wiljan J. A. J., additional, Schubert, Nil A., additional, Venselaar, Hanka, additional, Wevers, Ron A., additional, van Rooij, Arno, additional, Wesseling, Pieter, additional, Molenaar, Remco J., additional, van Noorden, Cornelis J. F., additional, Pusch, Stefan, additional, Tops, Bastiaan, additional, and Leenders, William P. J., additional

Published
2016
Full Text
View/download PDF

15. Isocitrate dehydrogenase 1-mutated human gliomas depend on lactate and glutamate to alleviate metabolic stress.

Author

Lenting, Krissie, Khurshed, Mohammed, Peeters, Tom H., van den Heuvel, Corina N. A. M., van Lith, Sanne A. M., de Bitter, Tessa, Hendriks, Wiljan, Span, Paul N., Molenaar, Remco J., Botman, Dennis, Verrijp, Kiek, Heerschap, Arend, ter Laan, Mark, Kusters, Benno, van Ewijk, Anne, Huynen, Martijn A., van Noorden, Cornelis J. F., and Leenders, William P. J.

Abstract

Diffuse gliomas often carry point mutations in isocitrate dehydrogenase (IDH1mut), resulting in metabolic stress. Although IDHmut gliomas are difficult to culture in vitro, they thrive in the brain via diffuse infiltration, suggesting brain-specific tumor-stroma interactions that can compensate for IDH-1 deficits. To elucidate the metabolic adjustments in clinical IDHmut gliomas that contribute to their malignancy, we applied a recently developed method of targeted quantitative RNA next-generation sequencing to 66 clinical gliomas and relevant orthotopic glioma xenografts, with and without the endogenous IDH-1R132H mutation. Datasets were analyzed in R using Manhattan plots to calculate distance between expression profiles, Ward's method to perform unsupervised agglomerative clustering, and the Mann Whitney U test and Fisher's exact tests for supervised group analyses. The significance of transcriptome data was investigated by protein analysis, in situ enzymatic activity mapping, and in vivo magnetic resonance spectroscopy of orthotopic IDH1mut- and IDHwt-glioma xenografts. Gene set enrichment analyses of clinical IDH1mut gliomas strongly suggest a role for catabolism of lactate and the neurotransmitter glutamate, whereas, in IDHwt gliomas, processing of glucose and glutamine are the predominant metabolic pathways. Further evidence of the differential metabolic activity in these cancers comes from in situ enzymatic mapping studies and preclinical in vivo magnetic resonance spectroscopy imaging. Our data support an evolutionary model in which IDHmut glioma cells exist in symbiosis with supportive neuronal cells and astrocytes as suppliers of glutamate and lactate, possibly explaining the diffuse nature of these cancers. The dependency on glutamate and lactate opens the way for novel approaches in the treatment of IDHmut gliomas. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

16. Radioprotection of IDH1-Mutated Cancer Cells by the IDH1-Mutant Inhibitor AGI-5198

Author

Molenaar, Remco J., primary, Botman, Dennis, additional, Smits, Myrthe A., additional, Hira, Vashendriya V., additional, van Lith, Sanne A., additional, Stap, Jan, additional, Henneman, Peter, additional, Khurshed, Mohammed, additional, Lenting, Krissie, additional, Mul, Adri N., additional, Dimitrakopoulou, Dionysia, additional, van Drunen, Cornelis M., additional, Hoebe, Ron A., additional, Radivoyevitch, Tomas, additional, Wilmink, Johanna W., additional, Maciejewski, Jaroslaw P., additional, Vandertop, W. Peter, additional, Leenders, William P., additional, Bleeker, Fonnet E., additional, and van Noorden, Cornelis J., additional

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results