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5 results on '"Leonard, Issa"'

1. Host Nuclear Genome Copy Number Variations Identify High-Risk Anal Precancers in People Living with HIV

Author

Mutetwa, Tinaye, primary, Liu, Yuxin, additional, Silvera, Richard, additional, Evans, Michelle, additional, Yurich, Michael, additional, Tripodi, Joseph, additional, Leonard, Issa, additional, Houldsworth, Jane, additional, Gümüş, Zeynep, additional, Bowcock, Anne M., additional, Sigel, Keith, additional, Gaisa, Michael, additional, and Polak, Paz, additional

Published
2024
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2. Urachal Carcinoma Shares Genomic Alterations with Colorectal Carcinoma and May Respond to Epidermal Growth Factor Inhibition

Author

Collazo-Lorduy, Ana, primary, Castillo-Martin, Mireia, additional, Wang, Li, additional, Patel, Vaibhav, additional, Iyer, Gopa, additional, Jordan, Emmet, additional, Al-Ahmadie, Hikmat, additional, Leonard, Issa, additional, Oh, William K., additional, Zhu, Jun, additional, McBride, Russell B., additional, Cordon-Cardo, Carlos, additional, Solit, David B., additional, Sfakianos, John P., additional, and Galsky, Matthew D., additional

Published
2016
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3. Development of t(8;21) and RUNX1-RUNX1T1 in the Philadelphia-positive clone of a patient with chronic myelogenous leukemia: additional evidence for multiple steps involved in disease progression

Author

Ronald Hoffman, Leonard Issa, John Mascarenhas, Vesna Najfeld, Joseph Tripodi, Manpreet Sidhu, and Nathaniel Wisch

Subjects
Adult, Male, Cancer Research, medicine.medical_specialty, Adolescent, Oncogene Proteins, Fusion, Chromosomes, Human, Pair 21, Clone (cell biology), Trisomy, Hematocrit, Biology, Trisomy 8, Translocation, Genetic, Pathogenesis, Chromosome 15, Young Adult, RUNX1 Translocation Partner 1 Protein, hemic and lymphatic diseases, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Proto-Oncogene Proteins, Genetics, medicine, Humans, Philadelphia Chromosome, Molecular Biology, In Situ Hybridization, Fluorescence, Aged, medicine.diagnostic_test, Cytogenetics, Middle Aged, medicine.disease, medicine.anatomical_structure, Immunology, Core Binding Factor Alpha 2 Subunit, Disease Progression, Female, Bone marrow, Blast Crisis, Chronic myelogenous leukemia, Chromosomes, Human, Pair 8, Transcription Factors
Abstract

A 65-year-old patient with a high hemoglobin and hematocrit was treated for 14 months with therapeutic phlebotomy when cytogenetics of bone marrow revealed 100% cells with the Ph chromosome and 45% of the Ph+ cells contained trisomy 8. Treatment with tyrosine kinase inhibitors did not reduce the BCR-ABL1 fusion positive clone. Instead, the Ph positive cells acquired further the t(8;21)/ RUNX1-RUNX1T1 , del(4q) and trisomy 15 chromosomal abnormalities which were resistant to further treatment. Literature review revealed eight other patients who either had t(9;22) and t(8;21) simultaneously or developed t(8;21) in the Ph positive clone. We conclude that there are rare patients with CML who either present in blast crisis with coexistence of t(9;22) and t(8;21) with or without +8, or progress to blast crisis with acquiring RUNX1-RUNX1T1 in the BCR-ABL1 clone which may or may not be therapy related and represent a later event in a multistep pathogenesis.

Published
2010

5. Host Nuclear Genome Copy Number Variations Identify High-Risk Anal Precancers in People Living With HIV.

Author

Mutetwa T, Liu Y, Silvera R, Evans M, Yurich M, Tripodi J, Leonard I, Houldsworth J, Gümüş Z, Bowcock AM, Sigel K, Gaisa M, and Polak P

Subjects
Humans, Male, Female, Middle Aged, Adult, Papillomavirus Infections complications, Papillomavirus Infections virology, Papillomavirus Infections genetics, Squamous Intraepithelial Lesions genetics, Squamous Intraepithelial Lesions virology, Anus Neoplasms genetics, Anus Neoplasms virology, HIV Infections complications, DNA Copy Number Variations genetics, Precancerous Conditions genetics, Precancerous Conditions virology, Precancerous Conditions pathology
Abstract

Background: People living with HIV (PLWH) have substantially increased incidence of anal precancer and cancer. There are very little data regarding genomic disturbances in anal precancers among PLWH. In this study, specific chromosomal variants were identified in anal squamous intraepithelial lesions., Methods: Overall, 63 anal biopsy specimens (27 low-grade intraepithelial lesions [LSIL] and 36 high-grade intraepithelial lesions [HSIL]) were collected from PLWH obtained as part of anal cancer screening in our NYC-based health system. Data on patient demographics, anal cytological, and high-risk human papillomavirus (HR-HPV) diagnoses were collected. Specimens were tested for a panel of chromosomal alterations associated with HPV-induced oncogenesis using fluorescence in situ hybridization, and analyses compared the associations of these alterations with clinical characteristics., Results: Gains of 3q26, 5p15, 20q13, and cen7 were detected in 42%, 31%, 31%, and 19% of HSIL compared with 7%, 0%, 4%, and 0% of LSIL, respectively. If at least 1 abnormality was observed, 89% had a 3q26 gain. In lesions with 5p15 gains, 20q13 gains co-occurred in 91% of cases, while cen7 gain only co-occurred with the other 3 alterations. The sensitivity and specificity of any alteration to predict HSIL were 47% (95% CI: 30%-65%) and 93% (95% CI: 76%-99%), respectively., Conclusions: Genomic alterations seen in HPV-associated cancers may help distinguish anal LSIL from HSIL. 3q26 amplification may be an early component of anal carcinogenesis, preceding 5p16, 20q13, and/or chr7., Impact: Insights into potential genomic biomarkers for discriminating high-risk anal precancers are shared., Competing Interests: The authors have no funding or conflicts of interest to disclose., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)

Published
2024
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