11,443 results on '"Leonetti, A"'
Search Results
2. Stochastically Structured Illumination Microscopy scan less super resolution imaging
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Fusco, Denzel, Xypakis, Emmanouil, Gigante, Ylenia, Mautone, Lorenza, Di Angelantonio, Silvia, Ponsi, Giorgia, Ruocco, Giancarlo, and Leonetti, Marco
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Physics - Optics ,92C55, 78A70 - Abstract
In Super-resolution, a varying-illumination image stack is required. This enriched the dataset typically necessitates precise mechanical control and micron scale optical alignment and repeatability. Here, we introduce a novel methodology for super-resolution microscopy called Stochastically Structured Illumination Microscopy (S2IM), which bypasses the need for illumination control instead exploiting the random, uncontrolled movement of the target object. We tested our methodology within the clinically relevant ophthalmoscopic setting, harnessing the inherent saccadic motion of the eye to induce stochastic displacement of the illumination pattern on the retina. We opted to avoid human subjects by utilizing a phantom eye model, featuring a retina composed of human induced pluripotent stem cells (iPSC) retinal neurons, and replicating the ocular saccadic movements by custom actuators. Our findings demonstrate that S$^2$IM unlocks scan-less super-resolution with a resolution enhancement of 1.91, with promising prospects also beyond ophthalmoscopy applications such as active matter or atmospheric/astronomical observation.
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- 2024
3. Margination of artificially stiffened red blood cells
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Chachanidze, Revaz D., Aouane, Othmane, Harting, Jens, Wagner, Christian, and Leonetti, Marc
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Condensed Matter - Soft Condensed Matter ,Physics - Biological Physics - Abstract
Margination, a fundamental process in which leukocytes migrate from the flowing blood to the vessel wall, is well-documented in physiology. However, it is still an open question on how the differences in cell size and stiffness of white and red cells contribute to this phenomenon. To investigate the specific influence of cell stiffness, we conduct experimental and numerical studies on the segregation of a binary mixture of artificially stiffened red blood cells within a suspension of healthy cells. The resulting distribution of stiffened cells within the channel is found to depend on the channel geometry, as demonstrated with slit, rectangular, and cylindrical cross-sections. Notably, an unexpected central peak in the distribution of stiffened RBCs, accompanied by fourfold peaks at the corners, emerges in agreement with simulations. Our results unveil a non-monotonic variation in segregation/margination concerning hematocrit and flow rate, challenging the prevailing belief that higher flow rates lead to enhanced margination., Comment: Accepted for publication in Phys. Rev. Fluids
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- 2024
4. Topological complexity of ideal limit points
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Balcerzak, Marek, Glab, Szymon, and Leonetti, Paolo
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Mathematics - General Topology ,Mathematics - Classical Analysis and ODEs ,Mathematics - Functional Analysis - Abstract
Given an ideal $\mathcal{I}$ on the nonnegative integers $\omega$ and a Polish space $X$, let $\mathscr{L}(\mathcal{I})$ be the family of subsets $S\subseteq X$ such that $S$ is the set of $\mathcal{I}$-limit points of some sequence taking values in $X$. First, we show that $\mathscr{L}(\mathcal{I})$ may attain arbitrarily large Borel complexity. Second, we prove that if $\mathcal{I}$ is a $G_{\delta\sigma}$-ideal then all elements of $\mathscr{L}(\mathcal{I})$ are closed. Third, we show that if $\mathcal{I}$ is a simply coanalytic ideal and $X$ is first countable, then every element of $\mathscr{L}(\mathcal{I})$ is simply analytic. Lastly, we studied certain structural properties and the topological complexity of minimal ideals $\mathcal{I}$ for which $\mathscr{L}(\mathcal{I})$ contains a given set.
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- 2024
5. Learning Social Cost Functions for Human-Aware Path Planning
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Eirale, Andrea, Leonetti, Matteo, and Chiaberge, Marcello
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Computer Science - Robotics ,Computer Science - Artificial Intelligence ,Computer Science - Human-Computer Interaction ,Computer Science - Machine Learning - Abstract
Achieving social acceptance is one of the main goals of Social Robotic Navigation. Despite this topic has received increasing interest in recent years, most of the research has focused on driving the robotic agent along obstacle-free trajectories, planning around estimates of future human motion to respect personal distances and optimize navigation. However, social interactions in everyday life are also dictated by norms that do not strictly depend on movement, such as when standing at the end of a queue rather than cutting it. In this paper, we propose a novel method to recognize common social scenarios and modify a traditional planner's cost function to adapt to them. This solution enables the robot to carry out different social navigation behaviors that would not arise otherwise, maintaining the robustness of traditional navigation. Our approach allows the robot to learn different social norms with a single learned model, rather than having different modules for each task. As a proof of concept, we consider the tasks of queuing and respect interaction spaces of groups of people talking to one another, but the method can be extended to other human activities that do not involve motion.
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- 2024
6. The CUbesat Solar Polarimeter (CUSP) mission overview
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Fabiani, Sergio, Del Monte, Ettore, Baffo, Ilaria, Bonomo, Sergio, Brienza, Daniele, Campana, Riccardo, Centrone, Mauro, Contini, Gessica, Costa, Enrico, Cucinella, Giovanni, Curatolo, Andrea, De Angelis, Nicolas, De Cesare, Giovanni, Del Re, Andrea, Di Cosimo, Sergio, Di Filippo, Simone, Di Marco, Alessandro, Di Persio, Giuseppe, Donnarumma, Immacolata, Fanelli, Pierluigi, Leonetti, Paolo, Locarini, Alfredo, Loffredo, Pasqualino, Lombardi, Giovanni, Minervini, Gabriele, Modenini, Dario, Muleri, Fabio, Natalucci, Silvia, Negri, Andrea, Perelli, Massimo, Rossi, Monia, Rubini, Alda, Scalise, Emanuele, Soffitta, Paolo, Terracciano, Andrea, Tortora, Paolo, Zaccagnino, Emauele, and Zambardi, Alessandro
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Solar and Stellar Astrophysics ,Physics - Space Physics - Abstract
The CUbesat Solar Polarimeter (CUSP) project is a future CubeSat mission orbiting the Earth aimed to measure the linear polarization of solar flares in the hard X-ray band, by means of a Compton scattering polarimeter. CUSP will allow us to study the magnetic reconnection and particle acceleration in the flaring magnetic structures of our star. The project is in the framework of the Italian Space Agency Alcor Program, which aims to develop new CubeSat missions. CUSP is approved for a Phase B study that will last for 12 months, starting in mid-2024. We report on the current status of the CUSP mission project as the outcome of the Phase A., Comment: Proceeding of SPIE Conference "Astronomical Telescopes+ Instrumentation", Yokohama (Japan), 16-21 June 2024. arXiv admin note: substantial text overlap with arXiv:2208.06211
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- 2024
7. Characterization of avalanche photodiodes (APDs) for the CUbesat Solar Polarimeter (CUSP) mission
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Cologgi, F., Alimenti, A., Fabiani, S., Torokthii, K., Silva, E., Del Monte, E., Baffo, I., Bonomo, S., Brienza, D., Campana, R., Centrone, M., Contini, G., Costa, E., Curatolo, A., Cucinella, G., DevAngelis, N., De Cesare, G., Del Re, A., Di Cosimo, S., Di Filippo, S., Di Marco, A., Di Persio, G., Donnarumma, I., Fanelli, P., Leonetti, P., Locarini, A., Loffredo, P., Lombardi, G., Minervini, G., Modenini, D., Muleri, F., Natalucci, S., Nigri, A., Perelli, M., Rossi, M., Rubini, A., Scalise, E., Soffitta, P., Terracciano, C., Tortora, P., Zaccagnino, E., and Zambardi, A.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Solar and Stellar Astrophysics ,Physics - Space Physics - Abstract
The CUbesat Solar Polarimeter (CUSP) project is a CubeSat mission orbiting the Earth aimed to measure the linear polarization of solar flares in the hard X-ray band by means of a Compton scattering polarimeter. CUSP will allow the study of the magnetic reconnection and particle acceleration in the flaring magnetic structures of our star. CUSP is a project in the framework of the Alcor Program of the Italian Space Agency aimed at developing new CubeSat missions. It is approved for a Phase B study. In this work, we report on the characterization of the Avalanche Photodiodes (APDs) that will be used as readout sensors of the absorption stage of the Compton polarimeter. We assessed the APDs gain and energy resolution as a function of temperature by irradiating the sensor with a \textsuperscript{55}Fe radioactive source. Moreover, the APDs were also characterized as being coupled to a GAGG scintillator., Comment: Proceeding of SPIE Conference "Astronomical Telescopes+ Instrumentation", Yokohama (Japan), 16-21 June 2024
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- 2024
8. The multi$-$physics analysis and design of CUSP, a two CubeSat constellation for Space Weather and Solar flares X-ray polarimetry
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Lombardi, Giovanni, Fabiani, Sergio, Del Monte, Ettore, Costa, Enrico, Soffitta, Paolo, Muleri, Fabio, Baffo, Ilaria, Biancolini, Marco E., Bonomo, Sergio, Brienza, Daniele, Campana, Riccardo, Centrone, Mauro, Contini, Gessica, Cucinella, Giovanni, Curatolo, Andrea, De Angelis, Nicolas, De Cesare, Giovanni, Del Re, Andrea, Di Cosimo, Sergio, Di Filippo, Simone, Di Marco, Alessandro, Di Meo, Emanuele, Di Persio, Giuseppe, Donnarumma, Immacolata, Fanelli, Pierluigi, Leonetti, Paolo, Locarini, Alfredo, Loffredo, Pasqualino, Lopez, Andrea, Minervini, Gabriele, Modenini, Dario, Natalucci, Silvia, Negri, Andrea, Perelli, Massimo, Rossi, Monia, Rubini, Alda, Scalise, Emanuele, Terracciano, Andrea, Tortora, Paolo, Zaccagnino, Emanuele, and Zambardi, Alessandro
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Solar and Stellar Astrophysics ,Physics - Space Physics - Abstract
The CUbesat Solar Polarimeter (CUSP) project aims to develop a constellation of two CubeSats orbiting the Earth to measure the linear polarization of solar flares in the hard X-ray band by means of a Compton scattering polarimeter on board of each satellite. CUSP will allow to study the magnetic reconnection and particle acceleration in the flaring magnetic structures. CUSP is a project approved for a Phase B study by the Italian Space Agency in the framework of the Alcor program aimed to develop CubeSat technologies and missions. In this paper we describe the a method for a multi-physical simulation analysis while analyzing some possible design optimization of the payload design solutions adopted. In particular, we report the mechanical design for each structural component, the results of static and dynamic finite element analysis, the preliminary thermo-mechanical analysis for two specific thermal cases (hot and cold orbit) and a topological optimization of the interface between the platform and the payload., Comment: Proceeding of SPIE Conference "Astronomical Telescopes+ Instrumentation", Yokohama (Japan), 16-21 June 2024
- Published
- 2024
9. The evaluation of the CUSP scientific performance by a GEANT4 Monte Carlo simulation
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De Cesare, Giovanni, Fabiani, Sergio, Campana, Riccardo, Lombardi, Giovanni, Del Monte, Ettore, Costa, Enrico, Baffo, Ilaria, Bonomo, Sergio, Brienza, Daniele, Centrone, Mauro, Contini, Gessica, Cucinella, Giovanni, Curatolo, Andrea, De Angelis, Nicolas, Del Re, Andrea, Di Cosimo, Sergio, Di Filippo, Simone, Di Marco, Alessandro, Di Persio, Giuseppe, Donnarumma, Immacolata, Fanelli, Pierluigi, Leonetti, Paolo, Locarini, Alfredo, Loffredo, Pasqualino, Minervini, Gabriele, Modenini, Dario, Muleri, Fabio, Natalucci, Silvia, Negri, Andrea, Perelli, Massimo, Rossi, Monia, Rubini, Alda, Scalise, Emanuele, Soffitta, Paolo, Terracciano, Andrea, Tortora, Paolo, Zaccagnino, Emauele, and Zambardi, Alessandro
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Solar and Stellar Astrophysics ,Physics - Space Physics - Abstract
The CUbesat Solar Polarimeter (CUSP) project is a CubeSat mission orbiting the Earth aimed to measure the linear polarization of solar flares in the hard X-ray band by means of a Compton scattering polarimeter. CUSP will allow to study the magnetic reconnection and particle acceleration in the flaring magnetic structures of our star. CUSP is a project in the framework of the Alcor Program of the Italian Space Agency aimed to develop new CubeSat missions. It is approved for a Phase B study. In this work, we report on the accurate simulation of the detector's response to evaluate the scientific performance. A GEANT4 Monte Carlo simulation is used to assess the physical interactions of the source photons with the detector and the passive materials. Using this approach, we implemented a detailed CUSP Mass Model. In this work, we report on the evaluation of the detector's effective area as a function of the beam energy., Comment: Proceeding of SPIE Conference "Astronomical Telescopes+ Instrumentation", Yokohama (Japan), 16-21 June 2024
- Published
- 2024
10. mTOR activation induces endolysosomal remodeling and nonclassical secretion of IL-32 via exosomes in inflammatory reactive astrocytes.
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Leng, Kun, Rooney, Brendan, McCarthy, Frank, Xia, Wenlong, Rose, Indigo, Bax, Sophie, Chin, Marcus, Fathi, Saeed, Herrington, Kari, Leonetti, Manuel, Kao, Aimee, Fancy, Stephen, Elias, Joshua, and Kampmann, Martin
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Astrocytes ,Endolysosomal system ,Extracellular vesicles ,IL-32 ,Inflammatory reactive astrocytes ,Neuroinflammation ,mTOR ,Astrocytes ,Humans ,Exosomes ,TOR Serine-Threonine Kinases ,Lysosomes ,Interleukins ,Endosomes ,Induced Pluripotent Stem Cells ,Cells ,Cultured ,Neuroinflammatory Diseases ,Inflammation - Abstract
Astrocytes respond and contribute to neuroinflammation by adopting inflammatory reactive states. Although recent efforts have characterized the gene expression signatures associated with these reactive states, the cell biology underlying inflammatory reactive astrocyte phenotypes remains under-explored. Here, we used CRISPR-based screening in human iPSC-derived astrocytes to identify mTOR activation a driver of cytokine-induced endolysosomal system remodeling, manifesting as alkalinization of endolysosomal compartments, decreased autophagic flux, and increased exocytosis of certain endolysosomal cargos. Through endolysosomal proteomics, we identified and focused on one such cargo-IL-32, a disease-associated pro-inflammatory cytokine not present in rodents, whose secretion mechanism is not well understood. We found that IL-32 was partially secreted in extracellular vesicles likely to be exosomes. Furthermore, we found that IL-32 was involved in the polarization of inflammatory reactive astrocyte states and was upregulated in astrocytes in multiple sclerosis lesions. We believe that our results advance our understanding of cell biological pathways underlying inflammatory reactive astrocyte phenotypes and identify potential therapeutic targets.
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- 2024
11. Segmentation tool for images of cracks
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Kompanets, Andrii, Duits, Remco, Leonetti, Davide, Berg, Nicky van den, H., H., and Snijder
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Safety-critical infrastructures, such as bridges, are periodically inspected to check for existing damage, such as fatigue cracks and corrosion, and to guarantee the safe use of the infrastructure. Visual inspection is the most frequent type of general inspection, despite the fact that its detection capability is rather limited, especially for fatigue cracks. Machine learning algorithms can be used for augmenting the capability of classical visual inspection of bridge structures, however, the implementation of such an algorithm requires a massive annotated training dataset, which is time-consuming to produce. This paper proposes a semi-automatic crack segmentation tool that eases the manual segmentation of cracks on images needed to create a training dataset for a machine learning algorithm. Also, it can be used to measure the geometry of the crack. This tool makes use of an image processing algorithm, which was initially developed for the analysis of vascular systems on retinal images. The algorithm relies on a multi-orientation wavelet transform, which is applied to the image to construct the so-called "orientation scores", i.e. a modified version of the image. Afterwards, the filtered orientation scores are used to formulate an optimal path problem that identifies the crack. The globally optimal path between manually selected crack endpoints is computed, using a state-of-the-art geometric tracking method. The pixel-wise segmentation is done afterwards using the obtained crack path. The proposed method outperforms fully automatic methods and shows potential to be an adequate alternative to the manual data annotation.
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- 2024
12. Deep Learning for Segmentation of Cracks in High-Resolution Images of Steel Bridges
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Kompanets, Andrii, Pai, Gautam, Duits, Remco, Leonetti, Davide, and Snijder, Bert
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Computer Science - Computer Vision and Pattern Recognition ,Electrical Engineering and Systems Science - Image and Video Processing - Abstract
Automating the current bridge visual inspection practices using drones and image processing techniques is a prominent way to make these inspections more effective, robust, and less expensive. In this paper, we investigate the development of a novel deep-learning method for the detection of fatigue cracks in high-resolution images of steel bridges. First, we present a novel and challenging dataset comprising of images of cracks in steel bridges. Secondly, we integrate the ConvNext neural network with a previous state-of-the-art encoder-decoder network for crack segmentation. We study and report, the effects of the use of background patches on the network performance when applied to high-resolution images of cracks in steel bridges. Finally, we introduce a loss function that allows the use of more background patches for the training process, which yields a significant reduction in false positive rates.
- Published
- 2024
13. Short-term gut microbiota’s shift after laparoscopic Roux-en-Y vs one anastomosis gastric bypass: results of a multicenter randomized control trial
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De Maio, Flavio, Boru, Cristian Eugeniu, Velotti, Nunzio, Capoccia, Danila, Santarelli, Giulia, Verrastro, Ornella, Bianco, Delia Mercedes, Capaldo, Brunella, Sanguinetti, Maurizio, Musella, Mario, Raffaelli, Marco, Leonetti, Frida, Delogu, Giovani, and Silecchia, Gianfranco
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- 2024
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14. Vulnerability to Sea-Level Rise Varies Among Estuaries and Habitat Types: Lessons Learned from a Network of Surface Elevation Tables in Puget Sound
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Davis, Melanie J., Poppe, Katrina L., Rybczyk, John M., Grossman, Eric E., Woo, Isa, Chamberlin, Joshua W., Totman, Michelle, Zackey, W. Todd, Leonetti, Frank, Shull, Suzanne, and De La Cruz, Susan E. W.
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- 2024
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15. Remission of type 2 diabetes: position statement of the Italian society of diabetes (SID)
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Capoccia, Danila, Leonetti, Frida, Natali, Andrea, Tricò, Domenico, Perrini, Sebastio, Sbraccia, Paolo, and Guglielmi, Valeria
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- 2024
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16. A New Surgical Option For Patients with Unresolved Bell’s Palsy
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Leonetti, John P., Shukairy, M. Kareem, North, Monique, Foecking, Eileen, and Burkman, Lisa
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- 2024
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17. The virome of bubaline (Bubalus bubalis) tonsils reveals an unreported bubaline polyomavirus
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Timm, Francine C. B., Campos, Fabrício Souza, Janssen, Luis, dos Santos, Raíssa Nunes, Paredes-Galarza, Bruna, Stone, Nicole Vieira, Oliveira, Martha Trindade, Gasparetto, Raíssa, Müller, Nicolas Felipe Drum, Melgarejo, Alanis da Silva, Corrêa, Miguel Leonetti, Lozano, Lina Marcela Violet, Salvato, Richard Steiner, Godinho, Fernanda Marques de Souza, Barcellos, Regina Bones, Teixeira, Maria Audiléia da Silva, Riet-Correa, Gabriela, Cerqueira, Valíria Duarte, Bezerra Júnior, Pedro Soares, Franco, Ana Cláudia, and Roehe, Paulo Michel
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- 2024
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18. A hierarchic isogeometric hyperelastic solid-shell
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Leonetti, Leonardo and Verhelst, Hugo M.
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- 2024
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19. Core equality of real sequences
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Leonetti, Paolo
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Mathematics - Functional Analysis ,Mathematics - Classical Analysis and ODEs - Abstract
Given an ideal $\mathcal{I}$ on $\omega$ and a bounded real sequence $\textbf{x}$, we denote by $\text{core}_{\textbf{x}}(\mathcal{I})$ the smallest interval $[a,b]$ such that $\{n \in \omega: x_n \notin [a-\varepsilon,b+\varepsilon]\} \in \mathcal{I}$ for all $\varepsilon>0$ (which corresponds to the interval $[\,\liminf \textbf{x}, \limsup \textbf{x}\,]$ if $\mathcal{I}$ is the ideal $\text{Fin}$ of finite subsets of $\omega$). First, we characterize all the infinite real matrices $A$ such that $$ \text{core}_{A\textbf{x}}(\mathcal{J})=\text{core}_{\textbf{x}}(\mathcal{I}) $$ for all bounded sequences $\textbf{x}$, provided that $\mathcal{J}$ is a countably generated ideal on $\omega$ and $A$ maps bounded sequences into bounded sequences. Such characterization fails if both $\mathcal{I}$ and $\mathcal{J}$ are the ideal of asymptotic density zero sets. Next, we show that such equality is possible for distinct ideals $\mathcal{I}, \mathcal{J}$, answering an open question in [J.~Math.~Anal.~Appl.~\textbf{321} (2006), 515--523]. Lastly, we prove that, if $\mathcal{J}=\text{Fin}$, the above equality holds for some matrix $A$ if and only if $\mathcal{I}=\text{Fin}$ or $\mathcal{I}=\text{Fin}\oplus \mathcal{P}(\omega)$.
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- 2024
20. Strong universality, recurrence, and analytic P-ideals in dynamical systems
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Leonetti, Paolo
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Mathematics - Functional Analysis ,Mathematics - Dynamical Systems - Abstract
Given a dynamical system $(X,T)$ and a family $\mathsf{I}\subseteq \mathcal{P}(\omega)$ of "small" sets of nonnegative integers, a point $x \in X$ is said to be $\mathsf{I}$-strong universal if for each $y \in X$ there exists a subsequence $(T^nx: n \in A)$ of its orbit which is convergent to $y$ and, in addition, the set of indexes $A$ is "not small," that is, $A\notin \mathsf{I}$. An analoguous definition is given for $\mathsf{I}$-strong recurrence. In this work, we provide several structural properties and relationships between $\mathsf{I}$-strong universality, $\mathsf{I}$-strong recurrence, and the corresponding ordinary notions of $\mathsf{I}$-universality and $\mathsf{I}$-recurrence. As applications, we provide sufficient conditions which ensure the equivalence between the above notions and the property that each nonempty open set contains some cluster point of some orbit. In addition, we show that if $T$ is a homomorphism on a Fr\'{e}chet space $X$ and there exists a dense set of vectors with null orbit, then for each $y \in X$ the set of all vectors $x \in X$ such that $\lim_{n \in A}T^nx=y$ for some $A\subseteq \omega$ with nonzero upper asymptotic density is either empty or comeager. In the special case of linear dynamical systems on Banach spaces with a dense set of uniformly recurrent vectors, we obtain that $T$ is upper frequently hypercyclic if and only if there exists a hypercyclic vector $x \in X$ for which $\lim_{n \in A}T^nx=0$ for some $A\subseteq \omega$ with nonzero upper asymptotic density., Comment: 31pp, comments are welcome
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- 2024
21. Infrapatellar branch of the saphenous nerve lesion following tibial nailing: it is possible to avoid it?
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Fenga, D., Sanzarello, I., Rizzo, P., Traina, F., Coppini, F., Leonetti, D., and Faldini, C.
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- 2024
- Full Text
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22. Effectiveness of oral semaglutide on glucose control and body weight up to 18 months: a multicenter retrospective real-world study
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Bonora, B. M., Russo, G., Leonetti, F., Strazzabosco, M., Nollino, L., Aimaretti, G., Giaccari, A., Broglio, F., Consoli, A., Avogaro, A., and Fadini, G. P.
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- 2024
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23. Women's subsistence strategies predict fertility across cultures, but context matters
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Page, Abigail E, Ringen, Erik J, Koster, Jeremy, Borgerhoff Mulder, Monique, Kramer, Karen, Shenk, Mary K, Stieglitz, Jonathan, Starkweather, Kathrine, Ziker, John P, Boyette, Adam H, Colleran, Heidi, Moya, Cristina, Du, Juan, Mattison, Siobhán M, Greaves, Russell, Sum, Chun-Yi, Liu, Ruizhe, Lew-Levy, Sheina, Kiabiya Ntamboudila, Francy, Prall, Sean, Towner, Mary C, Blumenfield, Tami, Migliano, Andrea B, Major-Smith, Daniel, Dyble, Mark, Salali, Gul Deniz, Chaudhary, Nikhil, Derkx, Inez E, Ross, Cody T, Scelza, Brooke A, Gurven, Michael D, Winterhalder, Bruce P, Cortez, Carmen, Pacheco-Cobos, Luis, Schacht, Ryan, Macfarlan, Shane J, Leonetti, Donna, French, Jennifer C, Alam, Nurul, Zohora, Fatema tuz, Kaplan, Hillard S, Hooper, Paul L, and Sear, Rebecca
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fertility ,demography ,hunter-gatherers ,subsistence ,women - Published
- 2024
24. Stochastically structured illumination microscopy scan less super resolution imaging
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Denzel Fusco, Emmanouil Xypakis, Ylenia Gigante, Lorenza Mautone, Silvia Di Angelantonio, Giorgia Ponsi, Giancarlo Ruocco, and Marco Leonetti
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Medical technology ,R855-855.5 ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Abstract In super-resolution, a varying illumination image stack is required. This enriched dataset typically necessitates precise mechanical control and micron-scale optical alignment and repeatability. Here, we introduce a novel methodology for super-resolution microscopy called stochastically structured illumination microscopy (S2IM), which bypasses the need for illumination control exploiting instead the random, uncontrolled movement of the target object. We tested our methodology within the clinically relevant ophthalmoscopic setting, harnessing the inherent saccadic motion of the eye to induce stochastic displacement of the illumination pattern on the retina. We opted to avoid human subjects by utilizing a phantom eye model featuring a retina composed of human induced pluripotent stem cells (iPSC) retinal neurons and replicating the ocular saccadic movements by custom actuators. Our findings demonstrate that S2IM unlocks scan-less super-resolution with a resolution enhancement of 1.91, with promising prospects also beyond ophthalmoscopy applications such as active matter or atmospheric/astronomical observation.
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- 2024
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25. Quasi-arithmetic means ad libitum
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Leonetti, Paolo
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Mathematics - Classical Analysis and ODEs - Abstract
Let $\alpha_1, \ldots, \alpha_m$ be two or more positive reals with sum $1$, let $C\subseteq \mathbb{R}^k$ be an open convex set, and $f: C\to \mathbb{R}^k$ be a continuous injection with convex image. For each nonempty set $S\subseteq C$, let $\mathscr{M}(S)$ be the family of quasi-arithmetic means of all $m$-tuples of vectors in $C$ with respect to $f$ and the weights $\alpha_1,\ldots,\alpha_m$, that is, the family $$ \mathscr{M}(S)= \left\{ f^{-1}\left(\alpha_1f(x_1)+\cdots+\alpha_mf(x_m)\right): x_1,\ldots,x_m \in S \right\}. $$ We provide a simple necessary and sufficient condition on $S$ for which the infinite iteration $\bigcup_{n}\mathscr{M}^n(S)$ is relatively dense in the convex hull of $S$.
- Published
- 2023
26. Capacities and Choquet Averages of Ultrafilters
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Cerreia-Vioglio, Simone, Leonetti, Paolo, Maccheroni, Fabio, and Marinacci, Massimo
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Mathematics - Functional Analysis ,Mathematics - Classical Analysis and ODEs ,Mathematics - General Topology - Abstract
We show that a normalized capacity $\nu: \mathcal{P}(\mathbf{N})\to \mathbf{R}$ is invariant with respect to an ideal $\mathcal{I}$ on $\mathbf{N}$ if and only if it can be represented as a Choquet average of $\{0,1\}$-valued finitely additive probability measures corresponding to the ultrafilters containing the dual filter of $\mathcal{I}$. This is obtained as a consequence of an abstract analogue in the context of Archimedean Riesz spaces., Comment: 15 pages, to appear in Proc. Amer. Math. Soc
- Published
- 2023
27. Patch-wise Quadrature of Trimmed Surfaces in Isogeometric Analysis
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Loibl, Michael, Leonetti, Leonardo, Reali, Alessandro, and Kiendl, Josef
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Computer Science - Computational Engineering, Finance, and Science ,Mathematics - Numerical Analysis - Abstract
This work presents an efficient quadrature rule for shell analysis fully integrated in CAD by means of Isogeometric Analysis (IGA). General CAD-models may consist of trimmed parts such as holes, intersections, cut-offs etc. Therefore, IGA should be able to deal with these models in order to fulfil its promise of closing the gap between design and analysis. Trimming operations violate the tensor-product structure of the used Non-Uniform Rational B-spline (NURBS) basis functions and of typical quadrature rules. Existing efficient patch-wise quadrature rules consider actual knot vectors and are determined in 1D. They are extended to further dimensions by means of a tensor-product. Therefore, they are not directly applicable to trimmed structures. The herein proposed method extends patch-wise quadrature rules to trimmed surfaces. Thereby, the number of quadrature points can be signifficantly reduced. Geometrically linear and non-linear benchmarks of plane, plate and shell structures are investigated. The results are compared to a standard trimming procedure and a good performance is observed.
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- 2023
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28. Determining cancer cells division strategy
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Miotto, Mattia, Scalise, Simone, Leonetti, Marco, Ruocco, Giancarlo, Peruzzi, Giovanna, and Gosti, Giorgio
- Subjects
Quantitative Biology - Cell Behavior ,Physics - Biological Physics - Abstract
Heterogeneity in the size distribution of cancer cell populations has been recently linked to drug resistance and invasiveness. However, despite many progresses have been made in understanding how such heterogeneous size distributions arise in fast-proliferating cell types -like bacteria and yeast-, comprehensive investigations on cancer cell populations are still lacking mainly due to the difficulties of monitoring the proliferation of the time scales typical of mammalian cells. From a reductionist cell dynamics point of view, the strategies allowing size homeostasis are roughly grouped into three classes, \emph{i.e.} timer, sizer, or adder. These strategies are empirically distinguishable given the phenomenological measurable relationship between the cell size at birth and at division, which requires following the proliferation at the single-cell level. Here, we show how it is possible to infer the growth regime and division strategy of leukemia cell populations using live cell fluorescence labeling and flow cytometry in combination with a quantitative analytical model where both cell growth and division rates depend on powers of the cell size. Using our novel approach, we found that the dynamics of the size distribution of leukemia Jurkat T-cells is quantitatively reproduced by (i) a sizer-like division strategy, with (ii) division times following an Erlang distribution given by the sum of at least three independent exponentially-distributed times and (iii) fluctuations up to 15\% of the inherited fraction of size at division with respect to the mother cell size. Finally, we note that our experimental and theoretical apparatus can be easily extended to other cell types and environmental conditions, allowing for a comprehensive characterization of the growth and division model different cells can adopt., Comment: 16 pages, 5 figures
- Published
- 2023
29. Photonic Stochastic Emergent Storage: Exploiting Scattering-intrinsic Patterns for Programmable Deep Classification
- Author
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Leonetti, Marco, Gosti, Giorgio, and Ruocco, Giancarlo
- Subjects
Condensed Matter - Disordered Systems and Neural Networks ,Physics - Optics ,78A55 - Abstract
Disorder is a pervasive characteristic of natural systems, offering a wealth of non-repeating patterns. In this study, we present a novel storage method that harnesses naturally-occurring random structures to store an arbitrary pattern in a memory device. This method, the stochastic emergent storage (SES), builds upon the concept of emergent archetypes, where a training set of imperfect examples (prototypes) is employed to instantiate an archetype in an Hopfield-like network through emergent processes. We demostrate this non-Hebbian paradigm in the photonic domain by utilizing random transmission matrices, which govern light scattering in a white-paint turbid medium, as prototypes. Through the implementation of programmable hardware, we successfully realize and experimentally validate the capability to store an arbitrary archetype and perform classification at the speed of light. Leveraging the vast number of modes excited by mesoscopic diffusion, our approach enables the simultaneous storage of thousands of memories without requiring any additional fabrication efforts. Similar to a content addressable memory, all stored memories can be collectively assessed against a given pattern to identify the matching element. Furthermore, by organizing memories spatially into distinct classes, they become features within a higher-level categorical (deeper) optical classification layer.
- Published
- 2023
30. Opposite sides of the same coin: Syndrome evidence, child abuse and the wrongful conviction of Peter Hugh McGregor Ellis
- Author
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Leonetti, Carrie
- Published
- 2024
31. Systematic functional interrogation of SARS-CoV-2 host factors using Perturb-seq.
- Author
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Sunshine, Sara, Puschnik, Andreas, Replogle, Joseph, Laurie, Matthew, Liu, Jamin, Zha, Beth, Nuñez, James, Byrum, Janie, McMorrow, Aidan, Frieman, Matthew, Winkler, Juliane, Qiu, Xiaojie, Rosenberg, Oren, Leonetti, Manuel, Weissman, Jonathan, DeRisi, Joseph, Hein, Marco, and Ye, Chun
- Abstract
Genomic and proteomic screens have identified numerous host factors of SARS-CoV-2, but efficient delineation of their molecular roles during infection remains a challenge. Here we use Perturb-seq, combining genetic perturbations with a single-cell readout, to investigate how inactivation of host factors changes the course of SARS-CoV-2 infection and the host response in human lung epithelial cells. Our high-dimensional data resolve complex phenotypes such as shifts in the stages of infection and modulations of the interferon response. However, only a small percentage of host factors showed such phenotypes upon perturbation. We further identified the NF-κB inhibitor IκBα (NFKBIA), as well as the translation factors EIF4E2 and EIF4H as strong host dependency factors acting early in infection. Overall, our study provides massively parallel functional characterization of host factors of SARS-CoV-2 and quantitatively defines their roles both in virus-infected and bystander cells.
- Published
- 2023
32. Evidence that CRISPR-Cas9 Y537S-mutant expressing breast cancer cells activate Yes-associated protein 1 to driving the conversion of normal fibroblasts into cancer-associated fibroblasts
- Author
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Gelsomino, Luca, Caruso, Amanda, Tasan, Emine, Leonetti, Adele Elisabetta, Malivindi, Rocco, Naimo, Giuseppina Daniela, Giordano, Francesca, Panza, Salvatore, Gu, Guowei, Perrone, Benedetta, Giordano, Cinzia, Mauro, Loredana, Nardo, Bruno, Filippelli, Gianfranco, Bonofiglio, Daniela, Barone, Ines, Fuqua, Suzanne A. W., Catalano, Stefania, and Andò, Sebastiano
- Published
- 2024
- Full Text
- View/download PDF
33. Perioperative management of antithrombotic therapy in elderly patients undergoing lumbar discectomy: a retrospective study on 163 patients
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Corazzelli, Giuseppe, Corvino, Sergio, Ricciardi, Francesco, Pizzuti, Valentina, Leonetti, Settimio, D’Elia, Alessandro, Santilli, Marco, Aloj, Fulvio, and Innocenzi, Gualtiero
- Published
- 2024
- Full Text
- View/download PDF
34. Development and validation of a new tool to estimate early mortality in patients with advanced cancer treated with immunotherapy
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De Giglio, Andrea, Leonetti, Alessandro, Comito, Francesca, Filippini, Daria Maria, Mollica, Veronica, Rihawi, Karim, Peroni, Marianna, Mazzaschi, Giulia, Ricciotti, Ilaria, Carosi, Francesca, Marchetti, Andrea, Rosellini, Matteo, Gagliano, Ambrogio, Favorito, Valentina, Nobili, Elisabetta, Gelsomino, Francesco, Melotti, Barbara, Marchese, Paola Valeria, Sperandi, Francesca, Di Federico, Alessandro, Buti, Sebastiano, Perrone, Fabiana, Massari, Francesco, Pantaleo, Maria Abbondanza, Tiseo, Marcello, and Ardizzoni, Andrea
- Published
- 2024
- Full Text
- View/download PDF
35. Effects of particulate matter (PM2.5) concentration and components on mortality in chronic kidney disease patients: a nationwide spatial–temporal analysis
- Author
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Leonetti, Alessia, Peansukwech, Udomlack, Charnnarong, Jain, Cha’on, Ubon, Suttiprapa, Sutas, and Anutrakulchai, Sirirat
- Published
- 2024
- Full Text
- View/download PDF
36. Posterolateral approaches to the thoracic spine for calcific disc herniation: is wider exposure always better?
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Corazzelli, Giuseppe, Di Noto, Giulio, Ciardo, Antonio, Colangelo, Manuel, Corvino, Sergio, Leonetti, Settimio, D’Elia, Alessandro, Ricciardi, Francesco, Bocchino, Andrea, Paolini, Sergio, Esposito, Vincenzo, and Innocenzi, Gualtiero
- Published
- 2024
- Full Text
- View/download PDF
37. Learning prevalent patterns of co-morbidities in multichronic patients using population-based healthcare data
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Seghieri, Chiara, Tortù, Costanza, Tricò, Domenico, and Leonetti, Simone
- Published
- 2024
- Full Text
- View/download PDF
38. Photonic Stochastic Emergent Storage for deep classification by scattering-intrinsic patterns
- Author
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Leonetti, Marco, Gosti, Giorgio, and Ruocco, Giancarlo
- Published
- 2024
- Full Text
- View/download PDF
39. Rough families, cluster points, and cores
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Leonetti, Paolo
- Subjects
Mathematics - General Topology - Abstract
We define the notion of ideal convergence for sequences $(x_n)$ with values in topological spaces $X$ with respect to a family $\{F_\eta: \eta \in X\}$ of subsets of $X$ with $\eta \in F_\eta$. Each set $F_\eta$ quantifies the degree of accuracy of the convergence toward $\eta$. After proving that this is really a new notion, we provide some properties of the set of limit points and characterize the latter through the ideal cluster points and the ideal core of $(x_n)$.
- Published
- 2023
40. The COMMOTIONS Urban Interactions Driving Simulator Study Dataset
- Author
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Srinivasan, Aravinda Ramakrishnan, Schumann, Julian, Wang, Yueyang, Lin, Yi-Shin, Daly, Michael, Solernou, Albert, Zgonnikov, Arkady, Leonetti, Matteo, Billington, Jac, and Markkula, Gustav
- Subjects
Computer Science - Human-Computer Interaction - Abstract
Accurate modelling of road user interaction has received lot of attention in recent years due to the advent of increasingly automated vehicles. To support such modelling, there is a need to complement naturalistic datasets of road user interaction with targeted, controlled study data. This paper describes a dataset collected in a simulator study conducted in the project COMMOTIONS, addressing urban driving interactions, in a state of the art moving base driving simulator. The study focused on two types of near-crash situations that can arise in urban driving interactions, and also collected data on human driver gap acceptance across a range of controlled gap sequences., Comment: 5 pages, 8 figures, 6 tables, data techincal description paper, Open Science Foundation - https://osf.io/eazg5/
- Published
- 2023
41. Subcommutativity of integrals and quasi-arithmetic means
- Author
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Glazowska, Dorota, Leonetti, Paolo, Matkowski, Janusz, and Tringali, Salvatore
- Subjects
Mathematics - Functional Analysis ,Mathematics - Classical Analysis and ODEs - Abstract
Let $(X, \mathscr{L}, \lambda)$ and $(Y, \mathscr{M}, \mu)$ be finite measure spaces for which there exist $A \in \mathscr{L}$ and $B \in \mathscr{M}$ with either $0 < \lambda(A) < 1 < \lambda(X)$ and $0 < \mu(B) < \mu(Y)$, or the other way around. In addition, let $I \subseteq \mathbb{R}$ be a non-empty open interval, and suppose that $f,g\colon I \to \mathbb{R}_{+}$ are homeo\-morphisms with $g$ increasing. We prove that the functional inequality $$ f^{-1}\!\left(\int_X f\!\left(g^{-1}\!\left(\int_Y g \circ h\;d\mu\right)\right)d \lambda\right)\! \le g^{-1}\!\left(\int_Y g\!\left(f^{-1}\!\left(\int_X f \circ h\;d\lambda\right)\right)d \mu\right) $$ is satisfied by every $\mathscr{L} \otimes \mathscr{M}$-measurable simple function $h: X \times Y \to I$ if and only if $f=a g^b$ for some $a,b \in \mathbb{R}_{+}$ with $b\ge 1$. An analogous characterization is given for probability spaces.
- Published
- 2023
42. Quantum-enhanced pattern recognition
- Author
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Ortolano, Giuseppe, Napoli, Carmine, Harney, Cillian, Pirandola, Stefano, Leonetti, Giuseppe, Boucher, Pauline, Losero, Elena, Genovese, Marco, and Ruo-Berchera, Ivano
- Subjects
Quantum Physics ,Physics - Optics - Abstract
The challenge of pattern recognition is to invoke a strategy that can accurately extract features of a dataset and classify its samples. In realistic scenarios this dataset may be a physical system from which we want to retrieve information, such as in the readout of optical classical memories. The theoretical and experimental development of quantum reading has demonstrated that the readout of optical memories can be dramatically enhanced through the use of quantum resources (namely entangled input-states) over that of the best classical strategies. However, the practicality of this quantum advantage hinges upon the scalability of quantum reading, and up to now its experimental demonstration has been limited to individual cells. In this work, we demonstrate for the first time quantum advantage in the multi-cell problem of pattern recognition. Through experimental realizations of digits from the MNIST handwritten digit dataset, and the application of advanced classical post-processing, we report the use of entangled probe states and photon-counting to achieve quantum advantage in classification error over that achieved with classical resources, confirming that the advantage gained through quantum sensors can be sustained throughout pattern recognition and complex post-processing. This motivates future developments of quantum-enhanced pattern recognition of bosonic-loss within complex domains.
- Published
- 2023
- Full Text
- View/download PDF
43. mTOR activation induces endolysosomal remodeling and nonclassical secretion of IL-32 via exosomes in inflammatory reactive astrocytes
- Author
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Kun Leng, Brendan Rooney, Frank McCarthy, Wenlong Xia, Indigo V. L. Rose, Sophie Bax, Marcus Chin, Saeed Fathi, Kari A. Herrington, Manuel Leonetti, Aimee Kao, Stephen P. J. Fancy, Joshua E. Elias, and Martin Kampmann
- Subjects
Astrocytes ,Inflammatory reactive astrocytes ,Neuroinflammation ,mTOR ,Endolysosomal system ,IL-32 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Astrocytes respond and contribute to neuroinflammation by adopting inflammatory reactive states. Although recent efforts have characterized the gene expression signatures associated with these reactive states, the cell biology underlying inflammatory reactive astrocyte phenotypes remains under-explored. Here, we used CRISPR-based screening in human iPSC-derived astrocytes to identify mTOR activation a driver of cytokine-induced endolysosomal system remodeling, manifesting as alkalinization of endolysosomal compartments, decreased autophagic flux, and increased exocytosis of certain endolysosomal cargos. Through endolysosomal proteomics, we identified and focused on one such cargo–IL-32, a disease-associated pro-inflammatory cytokine not present in rodents, whose secretion mechanism is not well understood. We found that IL-32 was partially secreted in extracellular vesicles likely to be exosomes. Furthermore, we found that IL-32 was involved in the polarization of inflammatory reactive astrocyte states and was upregulated in astrocytes in multiple sclerosis lesions. We believe that our results advance our understanding of cell biological pathways underlying inflammatory reactive astrocyte phenotypes and identify potential therapeutic targets.
- Published
- 2024
- Full Text
- View/download PDF
44. Effects of particulate matter (PM2.5) concentration and components on mortality in chronic kidney disease patients: a nationwide spatial–temporal analysis
- Author
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Alessia Leonetti, Udomlack Peansukwech, Jain Charnnarong, Ubon Cha’on, Sutas Suttiprapa, and Sirirat Anutrakulchai
- Subjects
Particulate Matter (PM2.5) ,Aerosol components ,Chronic kidney disease (CKD) ,Mortality ,Medicine ,Science - Abstract
Abstract Chronic kidney disease (CKD) is a major global public health issue and the leading cause of death in Thailand. This study investigated the spatial–temporal association between PM2.5 and its components (organic carbon, black carbon, dust, sulfate, and sea salt) and CKD mortality in Thailand from 2012 to 2021. The Modern-Era Retrospective analysis for Research and Application version 2 (MERRA-2), a NASA atmospheric satellite model, was assessed for the temporal data of PM2.5 concentration and aerosol components. Spatial resources of 77 provinces were integrated using the Geographical Information System (GIS). Multivariate Poisson regression and Bayesian inference analyses were conducted to explore the effects of PM2.5 on CKD mortality across the provinces. Our analysis included 718,686 CKD-related deaths, resulting in a mortality rate of 1107 cases per 100,000 population where was the highest rate in Northeast region. The average age of the deceased was 72.43 ± 13.10 years, with males comprising 50.46% of the cases. Adjusting for age, sex, underlying diseases, co-morbidities, CKD complications, replacement therapy, population density, and income, each 1 µg/m3 increase in PM2.5, black carbon, dust, sulfate, and organic carbon was significantly associated with increased CKD mortality across 77 provinces. Incidence rate ratios were 1.04 (95% CI 1.03–1.04) for PM2.5, 1.11 (95% CI 1.10–1.13) for black carbon, 1.24 (95% CI 1.22–1.25) for dust, 1.16 (95% CI 1.16–1.17) for sulfate, and 1.05 (95% CI 1.04–1.05) for organic carbon. These findings emphasize the significant impact of PM2.5 on CKD mortality and underscore the need for strategies to reduce PM emissions and manage CKD co-morbidities effectively.
- Published
- 2024
- Full Text
- View/download PDF
45. A size-dependent division strategy accounts for leukemia cell size heterogeneity
- Author
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Mattia Miotto, Simone Scalise, Marco Leonetti, Giancarlo Ruocco, Giovanna Peruzzi, and Giorgio Gosti
- Subjects
Astrophysics ,QB460-466 ,Physics ,QC1-999 - Abstract
Abstract Heterogeneity in the size distribution of cancer cell populations is linked to drug resistance and invasiveness. However, understanding how such heterogeneity arises is still damped by the difficulties of monitoring the proliferation at the typical timescales of mammalian cells. Here, we show how to infer the growth regime and division strategy of leukemia cell populations using live cell fluorescence labeling and flow cytometry in combination with an analytical model where cell growth and division rates depend on powers of the size. We found that the dynamics of the size distribution of Jurkat T-cells is reproduced by (i) a sizer-like division strategy, with (ii) division times following an Erlang distribution and (iii) fluctuations up to ten percent of the inherited fraction of size at division. Overall, our apparatus can be extended to other cell types and environmental conditions allowing for a comprehensive characterization of the growth and division model different cells adopt.
- Published
- 2024
- Full Text
- View/download PDF
46. Experimental investigation on the fatigue and fracture properties of a fine pearlitic rail steel
- Author
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D. Leonetti and B. Schotsman
- Subjects
r350ht rail steel ,fatigue crack growth ,rotating bending ,fracture toughness ,Mechanical engineering and machinery ,TJ1-1570 ,Structural engineering (General) ,TA630-695 - Abstract
This study reports an experimental investigation of the fatigue and fracture resistance of R350HT, a heat-treated pearlitic rail steel with refined microstructure used in rails. Monotonic tensile, rotating bending, linear elastic plane strain fracture toughness, and fatigue crack growth rate tests are presented. The results are used to outline the basic properties and are corroborated by fractographic investigation. This enables the identification of the dominant type of fracture. Regarding fatigue and fracture resistance, the investigated material shows similar properties as other pearlitic rail steels, such as R260. At room temperature, the dominating fracture is of brittle cleavage type, showing some ductile regions associated with pro-eutectoid.
- Published
- 2024
- Full Text
- View/download PDF
47. Nonoccurrence of Lavrentiev gap for a class of functionals with nonstandard growth
- Author
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De Filippis Filomena, Leonetti Francesco, and Treu Giulia
- Subjects
regularity ,minimizer ,variational ,integral ,lavrentiev ,phenomenon ,35b65 ,35j60 ,35j47 ,Analysis ,QA299.6-433 - Abstract
We consider the functional ℱ(u)≔∫Ωf(x,Du(x))dx,{\mathcal{ {\mathcal F} }}\left(u):= \mathop{\int }\limits_{\Omega }f\left(x,Du\left(x)){\rm{d}}x, where f(x,z)f\left(x,z) satisfies a (p,q)\left(p,q)-growth condition with respect to zz and can be approximated by means of a suitable sequence of functions. We consider BR⋐Ω{B}_{R}\hspace{0.33em}\Subset \hspace{0.33em}\Omega and the spaces X=W1,p(BR,RN)andY=W1,p(BR,RN)∩Wloc1,q(BR,RN).X={W}^{1,p}\left({B}_{R},{{\mathbb{R}}}^{N})\hspace{1.0em}\hspace{0.1em}\text{and}\hspace{0.1em}\hspace{1.0em}Y={W}^{1,p}\left({B}_{R},{{\mathbb{R}}}^{N})\cap {W}_{\hspace{0.1em}\text{loc}\hspace{0.1em}}^{1,q}\left({B}_{R},{{\mathbb{R}}}^{N}). We prove that the lower semicontinuous envelope of ℱ∣Y{\mathcal{ {\mathcal F} }}{| }_{Y} coincides with ℱ{\mathcal{ {\mathcal F} }} or, in other words, that the Lavrentiev term is equal to zero for any admissible function u∈W1,p(BR,RN)u\in {W}^{1,p}\left({B}_{R},{{\mathbb{R}}}^{N}). We perform the approximations by means of functions preserving the values on the boundary of BR{B}_{R}.
- Published
- 2024
- Full Text
- View/download PDF
48. Why do dogs wag their tails?
- Author
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Leonetti, Silvia, speaker, Hersh, Taylor A, speaker, and Clark, Fay, moderator
- Abstract
Have you ever wondered: “Why do dogs wag their tails and why do humans like it?" Domestic dogs may be "man's best friend": one-third of all households worldwide own one and our coexistence began around 35,000 years ago. However, many dog behaviours remain a scientific enigma. The rhythmic tail wagging of domestic dogs has always caught our attention. Through our intuition and a handful of scientific studies, we have attributed different meanings to this behaviour, leading to fragmented and conflicting answers. Here, we summarise existing research on the mechanisms, development, evolution and function of tail wagging in domestic dogs, highlighting where the results converge, diverge or do not exist. We propose investigating this behaviour from its evolutionary roots and we suggest two hypotheses to explain its increased occurrence and frequency in dogs compared to other canids. This behaviour could have arisen during the domestication process following two paths: a) as a by-product of selection for other traits, such as docility, or b) as a trait directly selected by humans who are attracted to repetitive and rhythmic movements. We invite testing these hypotheses through neuro-cognitive studies on both dogs and humans, thus shedding light not only on a key canine behavior but also on the evolutionary history of characteristic human traits, such as the propensity for rhythm.
- Published
- 2024
- Full Text
- View/download PDF
49. The electric and magnetic disordered Maxwell equations as eigenvalue problem
- Author
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Schirmacher, Walter, Franosch, Thomas, Leonetti, Marco, and Ruocco, Giancarlo
- Subjects
Physics - Optics ,Condensed Matter - Disordered Systems and Neural Networks - Abstract
We consider Maxwell's equations in a 3-dimensional material, in which both, the electric permittivity, as well as the magnetic permeability, fluctuate in space. Differently from all previous treatments of the disordered electromagnetic problem, we transform Maxwell's equations and the electric and magnetic fields in such a way that the linear operator in the resulting secular equations is manifestly Hermitian, in order to deal with a proper eigenvalue problem. As an application of our general formalism, we use an appropriate version of the Coherent-Potential approximation (CPA) to calculate the photon density of states and scattering-mean-free path. Applying standard localization theory, we find that in the presence of both electric and magnetic disorder the spectral range of Anderson localization appears to be much larger than in the case of electric (or magnetic) disorder only. Our result could explain the absence of experimental evidence of 3D Anderson localization of light (all the existing experiments has been performed with electric disorder only) and pave the way towards a successful search of this, up to now, elusive phenomenon.
- Published
- 2023
50. On the iterates of shifted Euler's function
- Author
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Leonetti, Paolo and Luca, Florian
- Subjects
Mathematics - Number Theory ,Mathematics - Dynamical Systems - Abstract
Let $\varphi$ be the Euler's function and fix an integer $k\ge 0$. We show that, for every initial value $x_1\ge 1$, the sequence of positive integers $(x_n)_{n\ge 1}$ defined by $x_{n+1}=\varphi(x_n)+k$ for all $n\ge 1$ is eventually periodic. Similarly, for every initial value $x_1,x_2\ge 1$, the sequence of positive integers $(x_n)_{n\ge 1}$ defined by $x_{n+2}=\varphi(x_{n+1})+\varphi(x_n)+k$ for all $n\ge 1$ is eventually periodic, provided that $k$ is even.
- Published
- 2023
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