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4. Report on the Human Genome Initiative

10. The isolation of CpG islands from human chromosomal regions 11q13 and Xp22 by segregation of partlymelted molecules.

11. Separation of random fragments of DNA according to properties of their sequences.

12. Attachment of a 40-base-pair G + C-rich sequence (GC-clamp) to genomic DNA fragments by the polymerase chain reaction results in improved detection of single-base changes.

13. Preferential isolation of DNA fragments associated with CpG islands.

20. Intramolecular DNA melting between stable helical segments: melting theory and metastable states.

21. A mitochondrial DNA deletion in normally aging and in Alzheimer brain tissue.

22. Comprehensive screening of the human KRAS2 gene for sequence variants.

24. The effects of lithium, rubidium, cesium and magnesium ions on the close packing of persistence-length DNA fragments.

25. Comprehensive detection of single base changes in human genomic DNA using denaturing gradient gel electrophoresis and a GC clamp.

26. Chromosomal analogues: long-range order in psi-condensed DNA.

28. Modification of the melting properties of duplex DNA by attachment of a GC-rich DNA sequence as determined by denaturing gradient gel electrophoresis.

30. Scaling of the equilibrium sedimentation distribution in dense DNA solutions.

33. Small RNA.

34. Length-independent separation of DNA restriction fragments in two-dimensional gel electrophoresis.

36. Detection of single base substitutions in total genomic DNA.

37. Nearly all single base substitutions in DNA fragments joined to a GC-clamp can be detected by denaturing gradient gel electrophoresis.

38. The structure of psi DNA.

41. A general method for saturation mutagenesis of cloned DNA fragments.

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