31 results on '"Lerner, Jason T."'
Search Results
2. Electroencephalographic patterns during sleep in children with chromosome 15q11.2-13.1 duplications (Dup15q)
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Arkilo, Dimitrios, Devinsky, Orrin, Mudigoudar, Basanagoud, Boronat, Susana, Jennesson, Melanie, Sassower, Kenneth, Vaou, Okeanis Eleni, Lerner, Jason T, Jeste, Shafali Spurling, Luchsinger, Kadi, and Thibert, Ronald
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Medical Physiology ,Biomedical and Clinical Sciences ,Epilepsy ,Intellectual and Developmental Disabilities (IDD) ,Clinical Research ,Neurosciences ,Neurodegenerative ,Pediatric ,Sleep Research ,Brain Disorders ,2.1 Biological and endogenous factors ,Aetiology ,Neurological ,Adolescent ,Child ,Child ,Preschool ,Chromosome Aberrations ,Chromosome Disorders ,Chromosomes ,Chromosomes ,Human ,Pair 15 ,Delta Rhythm ,Electroencephalography ,Female ,Follow-Up Studies ,Humans ,Male ,Neurodevelopmental Disorders ,Retrospective Studies ,Seizures ,Sleep ,EEG patterns ,Dup15q syndrome ,Children ,Clinical Sciences ,Neurology & Neurosurgery ,Biological psychology ,Clinical and health psychology - Abstract
Our objective was to define the EEG features during sleep of children with neurodevelopmental disorders due to copy number gains of 15q11-q13 (Dup15q). We retrospectively reviewed continuous EEG recordings of 42 children with Dup15q (mean age: eight years, 32 with idic15), and data collected included background activity, interictal epileptiform discharges, sleep organization, and ictal activity. Three patterns were recognized: Pattern 1: Alpha–delta sleep was noted in 14 children (33%), not associated with any clinical changes. Pattern 2: Electrical status epilepticus in sleep was noted in 15 children (35%), all diagnosed with treatmentresistant epilepsy. Thirteen of the 15 children had clinical seizures. Pattern 3: Frequent bursts of high amplitude bifrontal predominant, paroxysmal fast activity (12–15 Hz) during non-REM sleep was noted in 15 children (35%). All 15 children had treatment-resistant epilepsy. This is the first report of electroencephalographic patterns during sleep of children with Dup15q reporting alpha-delta rhythms, CSWS, and high amplitude fast frequencies. Alpha-delta rhythms are described in children with dysautonomia and/or mood disorders and CSWS in children with developmental regression. The significance of these findings in cognitive function and epilepsy for the children in our cohort needs to be determined with follow-up studies.
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- 2016
3. Prospective observational study: Fast ripple localization delineates the epileptogenic zone
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Nariai, Hiroki, Hussain, Shaun A., Bernardo, Danilo, Fallah, Aria, Murata, Kristina K., Nguyen, Jimmy C., Rajaraman, Rajsekar R., Rao, Lekha M., Matsumoto, Joyce H., Lerner, Jason T., Salamon, Noriko, Elashoff, David, Sankar, Raman, and Wu, Joyce Y.
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- 2019
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4. Treatment of infantile spasms with very high dose prednisolone before high dose adrenocorticotropic hormone
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Hussain, Shaun A, Shinnar, Shlomo, Kwong, Grace, Lerner, Jason T, Matsumoto, Joyce H, Wu, Joyce Y, Shields, W Donald, and Sankar, Raman
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Clinical Trials and Supportive Activities ,Clinical Research ,Rare Diseases ,Pediatric ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,Adolescent ,Adrenocorticotropic Hormone ,Anticonvulsants ,Child ,Child ,Preschool ,Drug Administration Schedule ,Drug Therapy ,Combination ,Electroencephalography ,Female ,Humans ,Infant ,Male ,Monitoring ,Physiologic ,Prednisolone ,Spasms ,Infantile ,Treatment Outcome ,Hypsarrhythmia ,Corticotropin ,ACTHar ,Corticosteroids ,West syndrome ,Clinical Sciences ,Neurosciences ,Neurology & Neurosurgery - Abstract
PurposeThis study investigated the short-term response to a standardized hormonal therapy protocol for treatment of infantile spasms.MethodsTwenty-seven children with video electroencephalography (EEG)-confirmed infantile spasms received very high dose (8 mg/kg/day, max 60 mg/day) oral prednisolone for 2 weeks. Response (absence of both hypsarrhythmia and spasms) to prednisolone was ascertained by repeat overnight video-EEG. Responders were tapered over 2 weeks and nonresponders were immediately transitioned to high dose (150 IU/m(2)/day) intramuscular adrenocorticotropic hormone (ACTH) for two additional weeks. Response was again determined by overnight video-EEG after ACTH therapy.Key findingsSixty-three percent (17/27) of patients responded completely to prednisolone. Subsequently, 40% (4/10) of prednisolone nonresponders exhibited a complete response after an additional 2-week course with ACTH. Among 27 subjects with median follow-up of 13.5 months (interquartile range [IQR] 4.8-25.9), 12% (2/17) of prednisolone responders and 50% (2/4) of ACTH responders experienced a relapse between 2 and 9 months after initial response.SignificanceVery high dose prednisolone demonstrated significantly higher efficacy than previously reported for lower doses in prior studies. High dose ACTH may be superior to very high dose prednisolone, and in lieu of a definitive clinical trial, the choice between prednisolone and ACTH for initial treatment of infantile spasms remains controversial.
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- 2014
5. Subclinical early posttraumatic seizures detected by continuous EEG monitoring in a consecutive pediatric cohort
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Arndt, Daniel H, Lerner, Jason T, Matsumoto, Joyce H, Madikians, Andranik, Yudovin, Sue, Valino, Hannah, McArthur, David L, Wu, Joyce Y, Leung, Michelle, Buxey, Farzad, Szeliga, Conrad, Van Hirtum‐Das, Michele, Sankar, Raman, Brooks‐Kayal, Amy, and Giza, Christopher C
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Biomedical and Clinical Sciences ,Clinical Sciences ,Childhood Injury ,Traumatic Head and Spine Injury ,Brain Disorders ,Traumatic Brain Injury (TBI) ,Neurosciences ,Neurodegenerative ,Physical Injury - Accidents and Adverse Effects ,Clinical Research ,Pediatric ,Epilepsy ,Injuries and accidents ,Adolescent ,Anticonvulsants ,Brain Injuries ,Child ,Child ,Preschool ,Electroencephalography ,Epilepsies ,Partial ,Female ,Glasgow Coma Scale ,Humans ,Infant ,Male ,Monitoring ,Physiologic ,Prospective Studies ,Risk Factors ,Seizures ,Status Epilepticus ,Clinical neurophysiology ,Children ,ICU ,Neurology & Neurosurgery ,Clinical sciences - Abstract
PurposeTraumatic brain injury (TBI) is an important cause of morbidity and mortality in children, and early posttraumatic seizures (EPTS) are a contributing factor to ongoing acute damage. Continuous video-EEG monitoring (cEEG) was utilized to assess the burden of clinical and electrographic EPTS.MethodsEighty-seven consecutive, unselected (mild - severe), acute TBI patients requiring pediatric intensive care unit (PICU) admission at two academic centers were monitored prospectively with cEEG per established clinical TBI protocols. Clinical and subclinical seizures and status epilepticus (SE, clinical and subclinical) were assessed for their relation to clinical risk factors and short-term outcome measures.Key findingsOf all patients, 42.5% (37/87) had seizures. Younger age (p = 0.002) and injury mechanism (abusive head trauma - AHT, p < 0.001) were significant risk factors. Subclinical seizures occurred in 16.1% (14/87), while 6.9% (6/87) had only subclinical seizures. Risk factors for subclinical seizures included younger age (p < 0.001), AHT (p < 0.001), and intraaxial bleed (p < 0.001). SE occurred in 18.4% (16/87) with risk factors including younger age (p < 0.001), AHT (p < 0.001), and intraaxial bleed (p = 0.002). Subclinical SE was detected in 13.8% (12/87) with significant risk factors including younger age (p < 0.001), AHT (p = 0.001), and intraaxial bleed (p = 0.004). Subclinical seizures were associated with lower discharge King's Outcome Scale for Childhood Head Injury (KOSCHI) score (p = 0.002). SE and subclinical SE were associated with increased hospital length of stay (p = 0.017 and p = 0.041, respectively) and lower hospital discharge KOSCHI (p = 0.007 and p = 0.040, respectively).SignificancecEEG monitoring significantly improves detection of seizures/SE and is the only way to detect subclinical seizures/SE. cEEG may be indicated after pediatric TBI, particularly in younger children, AHT cases, and those with intraaxial blood on computerized tomography (CT).
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- 2013
6. Neurology
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Hartonian, Ivet, primary, Yoo, Jong W., additional, and Lerner, Jason T., additional
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- 2019
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7. Clinical profile of vigabatrin as monotherapy for treatment of infantile spasms.
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Lerner, Jason T, Salamon, Noriko, and Sankar, Raman
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infantile spasms ,monotherapy ,vigabatrin ,Neurology & Neurosurgery ,Clinical Sciences ,Neurosciences - Abstract
Vigabatrin, the first therapeutic agent to be approved by the Food and Drug Administration for the treatment of infantile spasms, as well as for adjunctive use in the treatment of refractory complex partial epilepsy, represents an important advance for patients with difficult-to-manage epilepsy. This review summarizes the complex history, chemistry, and pharmacology, as well as the clinical data leading to the approval of vigabatrin for infantile spasms in the US. The long path to its approval reflects the visual system and white matter toxicity concerns with this agent. This review provides a brief description of these concerns, and the regulatory safety monitoring and mitigation systems that have been put in place to enhance benefit over risk.
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- 2010
8. The Last Minute Review
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Naga, Osama, Lee, Kuk-Wha, Lerner, Jason T., Hartonian, Ivet, Bhatt, Rujuta R., Mahgerefteh, Joseph, Hsu, Daphne T., Goilav, Beatrice, Kukoyi-Maiyegun, Sitratullah Olawunmi, F. Mulne, Arlynn, Tonk, Vijay, Abdelgawad, Amr, and Naga, Osama, editor
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- 2015
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9. Pediatric Neurology
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Hartonian, Ivet, Bhatt, Rujuta R., Lerner, Jason T., and Naga, Osama, editor
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- 2015
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10. Development and validation of a seizure prediction model in critically ill children
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Yang, Amy, Arndt, Daniel H., Berg, Robert A., Carpenter, Jessica L., Chapman, Kevin E., Dlugos, Dennis J., Gallentine, William B., Giza, Christopher C., Goldstein, Joshua L., Hahn, Cecil D., Lerner, Jason T., Loddenkemper, Tobias, Matsumoto, Joyce H., Nash, Kendall B., Payne, Eric T., Sánchez Fernández, Iván, Shults, Justine, Topjian, Alexis A., Williams, Korwyn, Wusthoff, Courtney J., and Abend, Nicholas S.
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- 2015
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11. Traumatic Brain Injury in Children
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Lerner, Jason T., primary and Giza, Christopher C., additional
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- 2017
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12. Contributors
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Aaen, Gregory S., primary, Abend, Nicholas Scott, additional, Abou-Hamden, Amal, additional, Allen, Jeffrey C., additional, Amato, Anthony A., additional, Amlie-Lefond, Catherine, additional, Ashwal, Stephen, additional, Bailey, Russell C., additional, Bale, James F., additional, Banwell, Brenda, additional, Barañano, Kristin W., additional, Barkovich, A. James, additional, Barohn, Richard J., additional, Bartels, Ute K., additional, Bartnik-Olson, Brenda, additional, Barzilai, Ori, additional, Bassuk, Alexander, additional, Bearden, David R., additional, Ben-Sira, Liat, additional, Bernard, Timothy J., additional, Berry-Kravis, Elizabeth, additional, Beslow, Lauren A., additional, Biegel, Jaclyn A., additional, Billinghurst, Lori, additional, Birnbaum, Angela K., additional, Blackburn, Joanna S., additional, Bobowski, Nuala, additional, Boire, Adrienne, additional, Bönnemann, Carsten G., additional, Bonifacio, Sonia L., additional, Bonthius, Daniel J., additional, Borcherding, Breck, additional, Branchford, Brian R., additional, Brandsema, John, additional, Brennan, Kathryn M., additional, Brenton, J. Nicholas, additional, Brooks-Kayal, Amy R., additional, Brown, Lawrence W., additional, Buchalter, Jeffrey, additional, Camfield, Carol S., additional, Camfield, Peter R., additional, Campoy, Cristina, additional, Carpenter, Jessica L., additional, Chang, Taeun, additional, Chau, Vann, additional, Chi, Susan N., additional, Chiriboga, Claudia A., additional, Cho, Yoon-Jae, additional, Christian, Cindy W., additional, Chrestian, Nicholas, additional, Cilio, Maria Roberta, additional, Clark, Robin D., additional, Cohen, Bruce H., additional, Cohn, Ronald D., additional, Connolly, Anne M., additional, Constable, Todd, additional, Constantini, Shlomi, additional, Conway, Jeannine M., additional, Coulter, David L., additional, Cowan, Tina M., additional, Dale, Russell C., additional, Darbro, Benjamin, additional, Darras, Basil T., additional, Dastgir, Jahannaz, additional, De Meirleir, Linda, additional, De Vivo, Darryl C., additional, de Vries, Linda S., additional, Deisch, Jeremy K., additional, Deltenre, Paul, additional, Desai, Jay, additional, Descartes, Maria, additional, deVeber, Gabrielle, additional, Dhamne, Sameer C., additional, Diaz, Jullianne, additional, DiMauro, Salvatore, additional, Dobyns, William B., additional, Doherty, Dan, additional, Donner, Elizabeth J., additional, Dosenbach, Nico U.F., additional, Dowling, James J., additional, Drake, James M., additional, Ejerskov, Cecile, additional, Engel, Andrew G., additional, Enns, Gregory M., additional, Escolano-Margarit, María Victoria, additional, Etzion, Iris, additional, Fatemi, S. Ali, additional, Fehlings, Darcy L., additional, Feinberg, Michelle Lauren, additional, Ferriero, Donna M., additional, Filipek, Pauline A., additional, Finkel, Richard S., additional, Fisher, Paul G., additional, Flanigan, Kevin, additional, Foreman, Nicholas K., additional, Franco, Israel, additional, Frank, Yitzchak, additional, Fredrick, Douglas R., additional, Freeze, Hudson H., additional, Fuente-Mora, Cristina, additional, Furman, Joseph M., additional, Gallagher, Renata C., additional, Garel, Catherine, additional, Gertsch, Emily, additional, Gilbert, Donald L., additional, Gilles, Elizabeth E., additional, Giza, Christopher C., additional, Glaser, Carol A., additional, Glass, Hannah C., additional, Glauser, Tracy, additional, Glykys, Joseph, additional, Goldstein, Amy, additional, Gonorazky, Hernan Dario, additional, Gonzalez, Rodolfo, additional, Goodkin, Howard P., additional, Graham, John M., additional, Greninger, Alexander L., additional, Gronseth, Gary, additional, Gropman, Andrea L., additional, Grundy, Richard, additional, Guerrini, Renzo, additional, Gupta, Nalin, additional, Hahn, Jin S., additional, Hamblin, Milton H., additional, Hani, Abeer J., additional, Hanmantgad, Sharyu, additional, Harbert, Mary J., additional, Harini, Chellamani, additional, Harriott, Andrea M., additional, Heatwole, Chad, additional, Hershey, Andrew D., additional, Hirtz, Deborah G., additional, Holmes, Gregory L., additional, Holshouser, Barbara A., additional, Hurwitz, Kathleen A., additional, Hwang, Eugene, additional, Ichord, Rebecca N., additional, Jafar-Nejad, Paymaan, additional, Jain, Sejal V., additional, Jordan, Lori, additional, Kabbouche, Marielle A., additional, Kacperski, Joanne, additional, Kang, Peter B., additional, Kariannis, Matthias A., additional, Kaufmann, Horacio, additional, Kaye, Harper L., additional, Keating, Robert, additional, Kennedy, Colin R., additional, Khakoo, Yasmin, additional, Kirton, Adam, additional, Kissel, John T., additional, Knupp, Kelly G., additional, Korf, Bruce R., additional, Kossoff, Eric H., additional, Kothare, Sanjeev V., additional, Kupfer, Oren, additional, LaFrance, W. Curt, additional, Latal, Beatrice, additional, Leber, Steven M., additional, Lee, Jean-Pyo, additional, Leppik, Ilo E., additional, Lerman-Sagie, Tally, additional, Lerner, Jason T., additional, Leventer, Richard J., additional, Licht, Daniel J., additional, Lichter-Konecki, Uta, additional, Lidar, Zvi, additional, Liem, Djin Gie, additional, Loddenkemper, Tobias, additional, Long, Roger K., additional, Luc, Quyen N., additional, Mackay, Mark, additional, Majnemer, Annette, additional, Makhani, Naila, additional, Malinger, Gustavo, additional, Mandelbaum, David E., additional, Maricich, Stephen M., additional, Maski, Kiran P., additional, Mathur, Mudit, additional, Matthews, Dennis J., additional, McMahon, Kelly, additional, DeMara-Hoth, Megan B., additional, Mendelsohn, Bryce, additional, Mennella, Julie A., additional, Ment, Laura R., additional, Mercuri, Eugenio, additional, Michelson, David J., additional, Mikati, Mohamad A., additional, Mikhail, Fady M., additional, Miller, Steven Paul, additional, Milunsky, Jeff M., additional, Mink, Jonathan W., additional, Mirzaa, Ghayda M., additional, Mitchell, Wendy G., additional, Mohan, Michael A., additional, Mohassel, Payam, additional, Moharir, Mahendranath, additional, Monani, Umrao R., additional, Monje Deisseroth, Michelle, additional, Moodley, Manikum, additional, Mower, Andrew, additional, Moxley, Richard T., additional, Mueller, Sabine, additional, Muotri, Alysson R., additional, Nagamani, Sandesh C.S., additional, Narayanan, Mohan J., additional, Narayanan, Vinodh, additional, Nass, Ruth D., additional, Neul, Jeffrey L., additional, Nevo, Yoram, additional, Ng, Bobby G., additional, Nickels, Katherine C., additional, Nimmo, Graeme A.M., additional, Noetzel, Michael J., additional, Norcliffe-Kaufmann, Lucy, additional, Nordli, Douglas R., additional, Nowak-Göttl, Ulrike, additional, O'Brien, Hope L., additional, Oleszek, Joyce, additional, Oskoui, Maryam, additional, Paciorkowski, Alex R., additional, Packer, Roger J., additional, Packman, Seymour, additional, Palma, Jose-Alberto, additional, Pardo, Andrea C., additional, Parsons, Julie A., additional, Partridge, John Colin, additional, Pastores, Gregory M., additional, Patterson, Marc C., additional, Pearce, William J., additional, Pearl, Phillip L., additional, Penner, Melanie, additional, Percival, Leila, additional, Pereira, Marcia, additional, Pfister, Stefan M., additional, Phillips, John, additional, Plecko, Barbara, additional, Plioplys, Sigita, additional, Poduri, Annapurna, additional, Poisson, Sharon, additional, Pomeroy, Scott L., additional, Poretti, Andrea, additional, Powers, Scott W., additional, Pranzatelli, Michael R., additional, Przekop, Allison, additional, Rabie, Malcolm, additional, Rangasamy, Sampathkumar, additional, Raymond, Gerald V., additional, Reddy, Alyssa T., additional, Rendleman, Rebecca L., additional, Rho, Jong M., additional, Rodan, Lance H., additional, Roddy, Sarah M., additional, Rogers, Elizabeth E., additional, Rosenthal, Stephen M., additional, Rosman, N. Paul, additional, Ross, M. Elizabeth, additional, Rotenberg, Alexander, additional, Rust, Robert S., additional, Sanchez, Cheryl P., additional, Sanchez, Pedro, additional, Sánchez Fernández, Iván, additional, Sands, Tristan T., additional, Sanger, Terence D., additional, Sannagowdara, Kumar, additional, Scheinost, Dustin, additional, Scher, Mark S., additional, Schor, Nina F., additional, Schrauwen, Isabelle, additional, Segal, Michael M., additional, Seinfeld, Syndi, additional, Selcen, Duygu, additional, Seltzer, Laurie E., additional, Semrud-Clikeman, Margaret, additional, Shaw, Dennis W., additional, Shaywitz, Bennett A., additional, Shaywitz, Sally E., additional, Shellhaas, Renée A., additional, Sherr, Elliott H., additional, Sheth, Rita D., additional, Shevell, Michael I., additional, Shinnar, Shlomo, additional, Shofty, Ben, additional, Shu, Stanford K., additional, Shy, Michael E., additional, Silveira Moriyama, Laura, additional, Silvestri, Nicholas J., additional, Sims, Katherine B., additional, Singer, Harvey S., additional, Singhal, Nilika Shah, additional, Smith, Craig M., additional, Smith, Edward, additional, Smith, Stephen A., additional, Snyder, Evan Y., additional, Soul, Janet, additional, Spalink, Christy L., additional, Spencer, Karen A., additional, Stafstrom, Carl E., additional, Steinfeld, Robert, additional, Strober, Jonathan B., additional, Sullivan, Joseph, additional, Swaiman, Kenneth F., additional, Swoboda, Kathryn J., additional, Tate, Elizabeth D., additional, Tatum, William O., additional, Tein, Ingrid, additional, Tekulve, Kristyn, additional, Tenney, Jeffrey R., additional, Thiele, Elizabeth A., additional, Thompson-Stone, Robert, additional, Tochen, Laura, additional, Tormoehlen, Laura M., additional, Tran, Lily, additional, Trauner, Doris A., additional, Turnacioglu, Sinan O., additional, Ullrich, Nicole J., additional, Urion, David K., additional, Van Camp, Guy, additional, Van Hirtum-Das, Michèle, additional, van Karnebeek, Clara D.M., additional, Van Maldergem, Lionel, additional, Vanderver, Adeline, additional, Vitanza, Nicholas A., additional, von Rhein, Michael, additional, von Scheven, Emily, additional, Wagner, Ann, additional, Wainwright, Mark S., additional, Walker, Melissa A., additional, Walkup, John T., additional, Walsh, Laurence, additional, Walters-Sen, Lauren C., additional, Wang, Raymond Y., additional, Warner, Thomas T., additional, Whelan, Harry T., additional, Weinberg, Geoffrey A., additional, Wells, Elizabeth M., additional, Wheless, James W., additional, Wirrell, Elaine C., additional, Wisoff, Jeffrey H., additional, Wolf, Nicole I., additional, Wolfe, Gil I., additional, Wright, F. Virginia, additional, Wycliffe, Nathaniel D., additional, Yang, Michele L., additional, Yuskaitis, Christopher J., additional, Zoghbi, Huda Y., additional, and Zupanc, Mary L., additional
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- 2017
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13. Storage disorders
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Ekstrand, Jeffrey J., primary, Lerner, Jason T., additional, and Sankar, Raman, additional
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- 2016
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14. EEG Monitoring in Neonatal Epilepsies
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Rao, Lekha M., primary, Matsumoto, Joyce H., additional, Lerner, Jason T., additional, and Nuwer, Marc R., additional
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- 2015
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15. Hypsarrhythmia assessment exhibits poor interrater reliability: A threat to clinical trial validity
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Hussain, Shaun A., Kwong, Grace, Millichap, John J., Mytinger, John R., Ryan, Nicole, Matsumoto, Joyce H., Wu, Joyce Y., Lerner, Jason T., and Sankar, Raman
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- 2015
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16. Traumatic Brain Injury in Children
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Lerner, Jason T., primary and Giza, Christopher C., additional
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- 2012
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17. Contributors
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Abou-Hamden, Amal, primary, Amato, Anthony A., additional, Ashwal, Stephen, additional, Axelrod, Felicia B., additional, Bale, James F., additional, Banwell, Brenda, additional, Baranano, Kristin W., additional, Barkovich, A. James, additional, Barohn, Richard J., additional, Batshaw, Mark L., additional, Ben-Sira, Liat, additional, Birnbaum, Angela K., additional, Boustany, Rose-Mary N., additional, Brooks-Kayal, Amy, additional, Brown, Lawrence W., additional, Camfield, Carol S., additional, Camfield, Peter R., additional, Casselbrant, Margaretha L., additional, Chiriboga, Claudia A., additional, Christian, Susan L., additional, Cilio, Maria Roberta, additional, Connolly, Anne M., additional, Conway, Jeannine M., additional, Cornes, Susannah, additional, Coulter, David L., additional, Cowan, Tina M., additional, Das, Soma, additional, De Vivo, Darryl C., additional, de Vries, Linda S., additional, Desai, Jay, additional, Descartes, Maria, additional, deVeber, Gabrielle, additional, DiMauro, Salvatore, additional, Dobyns, William B., additional, Dong, Qing, additional, Drake, James M., additional, Duhaime, Ann-Christine, additional, du Plessis, Adre J., additional, El-Bitar, Mohamad K., additional, Enns, Gregory M., additional, Escolar, Diana M., additional, Evans, Owen B., additional, Fatemi, S. Ali, additional, Ferriero, Donna M., additional, Filipek, Pauline A., additional, Frank, Yitzchak, additional, Fredrick, Douglas R., additional, Freeze, Hudson H., additional, Friedman, Neil R., additional, Furman, Joseph M., additional, Garg, Bhuwan P., additional, Ghosh, Debabrata, additional, Gilles, Elizabeth E., additional, Giza, Christopher C., additional, Glaser, Carol A., additional, Gleeson, Joseph G., additional, Graham, John M., additional, Gressens, Pierre, additional, Guerrini, Renzo, additional, Gupta, Nalin, additional, Hahn, Jin S., additional, Harini, Chellamani, additional, Heatwole, Chad, additional, Hirtz, Deborah G., additional, Holmes, Gregory L., additional, Holshouser, Barbara A., additional, Ichord, Rebecca N., additional, Jafar-Nejad, Paymaan, additional, Jensen, Frances E., additional, Johnston, Michael V., additional, Jordan, Lori, additional, Khakoo, Yasmin, additional, Khasraw, Mustafa, additional, Kirton, Adam, additional, Kissel, John T., additional, Klein, Ophir, additional, Knupp, Kelly, additional, Korf, Bruce R., additional, Kotagal, Suresh, additional, Leber, Steven, additional, Leppik, Ilo E., additional, Lerman-Sagie, Tally, additional, Lerner, Jason T., additional, Leshner, Robert T., additional, Leventer, Richard J., additional, Lewis, Donald W., additional, Lewis, Paul F., additional, Lichter-Konecki, Uta, additional, Limperopoulos, Catherine, additional, Louie, Janice K., additional, Luc, Quyen N., additional, MacDonald, Tobey J., additional, Makhani, Naila, additional, Malinger, Gustavo, additional, Mandelbaum, David E., additional, Marcuccilli, Charles J., additional, Maricich, Stephen M., additional, Martin, Lee J., additional, Mennella, Julie A., additional, Ment, Laura R., additional, Michelson, David J., additional, Mikhail, Fady M., additional, Millen, Kathleen J., additional, Miller, Steven P., additional, Mink, Jonathan W., additional, Mirzaa, Ghayda, additional, Mitchell, Wendy G., additional, Moodley, Manikum, additional, Morton, Lawrence D., additional, Moxley, Richard T., additional, Muppidi, Srikanth, additional, Nash, Kendall, additional, Nass, Ruth, additional, Noetzel, Michael J., additional, Nordli, Douglas R., additional, Northington, Frances J., additional, Ouvrier, Robert, additional, Packer, Roger J., additional, Packman, Seymour, additional, Parsons, Julie A., additional, Partridge, John C., additional, Pastores, Gregory M., additional, Patterson, Marc C., additional, Pellock, John M., additional, Perkin, Ronald M., additional, Rapin, Isabelle, additional, Raymond, Gerald V., additional, Rendleman, Rebecca, additional, Rho, Jong M., additional, Roddy, Sarah M., additional, Rosenthal, Stephen M., additional, Rosman, N. Paul, additional, Ross, M. Elizabeth, additional, Rust, Robert S., additional, Sanchez-Lara, Pedro A., additional, Sanger, Terence D., additional, Sanmaneechai, Oranee, additional, Schaad, Urs B., additional, Scher, Mark S., additional, Schor, Nina F., additional, Segal, Michael M., additional, Shaywitz, Bennett A., additional, Shaywitz, Sally E., additional, Sherr, Elliott H., additional, Shevell, Michael I., additional, Shinnar, Shlomo, additional, Shu, Stanford K., additional, Silverstein, Faye S., additional, Singer, Harvey S., additional, Sladky, John T., additional, Smith, Stephen A., additional, Soul, Janet S., additional, Stafstrom, Carl E., additional, Strober, Jonathan B., additional, Sullivan, Joseph, additional, Swaiman, Kenneth F., additional, Sweney, Matthew T., additional, Swoboda, Kathryn J., additional, Täuber, Martin G., additional, Taylor, Donald A., additional, Tein, Ingrid, additional, Thiele, Elizabeth A., additional, Trauner, Doris A., additional, Tuchman, Roberto, additional, Vanderver, Adeline, additional, Hirtum-Das, Michéle Van, additional, Vedanarayanan, V. Venkataraman, additional, Vexler, Zinaida S., additional, Vezina, Gilbert, additional, Scheven, Emily von, additional, Wagner, Ann, additional, Wainwright, Mark S., additional, Walkup, John T., additional, Walsh, Laurence E., additional, Wang, Ching H., additional, Wheless, James W., additional, Wolf, Nicole I., additional, Wolfe, Gil I., additional, Wu, Yvonne W., additional, Wycliffe, Nathaniel D., additional, Yager, Jerome Y., additional, Zimmer, Jennifer A., additional, Zoghbi, Huda Y., additional, and Zupanc, Mary L., additional
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- 2012
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18. Electroencephalography monitoring in critically ill children: Current practice and implications for future study design
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Sánchez, Sarah M., Arndt, Daniel H., Carpenter, Jessica L., Chapman, Kevin E., Cornett, Karen M., Dlugos, Dennis J., Gallentine, William B., Giza, Christopher C., Goldstein, Joshua L., Hahn, Cecil D., Lerner, Jason T., Loddenkemper, Tobias, Matsumoto, Joyce H., McBain, Kristin, Nash, Kendall B., Payne, Eric, Fernández, Iván Sánchez, Shults, Justine, Williams, Korwyn, Yang, Amy, and Abend, Nicholas S.
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- 2013
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19. Chapter 12 Teratogenicity of Antiepileptic Drugs
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Sankar, Raman, primary and Lerner, Jason T., additional
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- 2008
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20. Electrographic Seizures after Convulsive Status Epilepticus in Children and Young Adults: A Retrospective Multicenter Study
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Fernández, Iván Sánchez, Abend, Nicholas S., Arndt, Daniel H., Carpenter, Jessica L., Chapman, Kevin E., Cornett, Karen M., Dlugos, Dennis J., Gallentine, William B., Giza, Christopher C., Goldstein, Joshua L., Hahn, Cecil D., Lerner, Jason T., Matsumoto, Joyce H., McBain, Kristin, Nash, Kendall B., Payne, Eric, Sánchez, Sarah M., Williams, Korwyn, and Loddenkemper, Tobias
- Published
- 2014
- Full Text
- View/download PDF
21. Assessment and surgical outcomes for mild type I and severe type II cortical dysplasia: A critical review and the UCLA experience
- Author
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Lerner, Jason T., Salamon, Noriko, Hauptman, Jason S., Velasco, Tonicarlo R., Hemb, Marta, Wu, Joyce Y., Sankar, Raman, Donald Shields, W., Engel, Jerome, Jr, Fried, Itzhak, Cepeda, Carlos, Andre, Veronique M., Levine, Michael S., Miyata, Hajime, Yong, William H., Vinters, Harry V., and Mathern, Gary W.
- Published
- 2009
- Full Text
- View/download PDF
22. 102 - Traumatic Brain Injury in Children
- Author
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Lerner, Jason T. and Giza, Christopher C.
- Published
- 2017
- Full Text
- View/download PDF
23. Conductive Plastic Electrodes Reduce EEG Artifact During Pediatric ECMO Therapy
- Author
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Matsumoto, Joyce H., primary, McArthur, David L., additional, Szeliga, Conrad W., additional, Lerner, Jason T., additional, Rao, Lekha M., additional, Hussain, Shaun A., additional, Wu, Joyce Y., additional, Nuwer, Marc R., additional, and Sankar, Raman, additional
- Published
- 2016
- Full Text
- View/download PDF
24. Perceived efficacy of cannabidiol-enriched cannabis extracts for treatment of pediatric epilepsy: A potential role for infantile spasms and Lennox–Gastaut syndrome
- Author
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Hussain, Shaun A., primary, Zhou, Raymond, additional, Jacobson, Catherine, additional, Weng, Julius, additional, Cheng, Emily, additional, Lay, Johnson, additional, Hung, Phoebe, additional, Lerner, Jason T., additional, and Sankar, Raman, additional
- Published
- 2015
- Full Text
- View/download PDF
25. Hypsarrhythmia assessment exhibits poor interrater reliability: A threat to clinical trial validity
- Author
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Hussain, Shaun A., primary, Kwong, Grace, additional, Millichap, John J., additional, Mytinger, John R., additional, Ryan, Nicole, additional, Matsumoto, Joyce H., additional, Wu, Joyce Y., additional, Lerner, Jason T., additional, and Sankar, Raman, additional
- Published
- 2014
- Full Text
- View/download PDF
26. Electrographic Seizures after Convulsive Status Epilepticus in Children and Young Adults: A Retrospective Multicenter Study
- Author
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Sánchez Fernández, Iván, primary, Abend, Nicholas S., additional, Arndt, Daniel H., additional, Carpenter, Jessica L., additional, Chapman, Kevin E., additional, Cornett, Karen M., additional, Dlugos, Dennis J., additional, Gallentine, William B., additional, Giza, Christopher C., additional, Goldstein, Joshua L., additional, Hahn, Cecil D., additional, Lerner, Jason T., additional, Matsumoto, Joyce H., additional, McBain, Kristin, additional, Nash, Kendall B., additional, Payne, Eric, additional, Sánchez, Sarah M., additional, Williams, Korwyn, additional, and Loddenkemper, Tobias, additional
- Published
- 2014
- Full Text
- View/download PDF
27. Treatment of infantile spasms with very high dose prednisolone before high dose adrenocorticotropic hormone
- Author
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Hussain, Shaun A., primary, Shinnar, Shlomo, additional, Kwong, Grace, additional, Lerner, Jason T., additional, Matsumoto, Joyce H., additional, Wu, Joyce Y., additional, Shields, W. Donald, additional, and Sankar, Raman, additional
- Published
- 2013
- Full Text
- View/download PDF
28. “Primary” leptomeningeal medulloblastoma
- Author
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Mehta, Rupal I., Cutler, Aaron R., Lasky, Joseph L., III, Yong, William H., Lerner, Jason T., Hirota, Brandon K., Salamon, Noriko, Mathern, Gary W., and Vinters, Harry V.
- Published
- 2009
- Full Text
- View/download PDF
29. Electrographic seizures in pediatric ICU patients: cohort study of risk factors and mortality.
- Author
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Abend, Nicholas S, Arndt, Daniel H, Carpenter, Jessica L, Chapman, Kevin E, Cornett, Karen M, Gallentine, William B, Giza, Christopher C, Goldstein, Joshua L, Hahn, Cecil D, Lerner, Jason T, Loddenkemper, Tobias, Matsumoto, Joyce H, McBain, Kristin, Nash, Kendall B, Payne, Eric, Sánchez, Sarah M, Fernández, Iván Sánchez, Shults, Justine, Williams, Korwyn, and Yang, Amy
- Published
- 2013
- Full Text
- View/download PDF
30. Clinical profile of vigabatrin as monotherapy for treatment of infantile spasms.
- Author
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Lerner, Jason T., Salamon, Noriko, and Sankar, Raman
- Published
- 2010
31. Teratogenicity of antiepileptic drugs: role of pharmacogenomics.
- Author
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Sankar R and Lerner JT
- Subjects
- Epilepsy drug therapy, Female, Humans, Pregnancy, Pregnancy Complications, Abnormalities, Drug-Induced etiology, Abnormalities, Drug-Induced genetics, Anticonvulsants adverse effects, Pharmacogenetics
- Abstract
The teratogenic potential of an antiepileptic drug is determined by the chemical attributes of the molecule under discussion and the genetic attributes of the host. The role of the hepatic mixed function oxidase system may be especially important in conferring teratogenic risk. However, systems such as epoxide hydrolase, glutathione reductase, and superoxide dismutase and other toxin scavenging systems may be important modifiers that lower the risk. Genetic variability in these systems is important in determining the type and severity of the final outcome. While our knowledge of these factors is incomplete, progress can be achieved by beginning to include these concepts in our discussion on the topic and by promoting research that may improve our ability to individualize the analysis of risk for a specific patient with regard to specific antiepileptic drugs. Such an approach will most likely involve DNA microchip technology and has the potential to overcome some of the limitations of pregnancy registries. Such an approach may also lead to novel interventions and therapeutics design to lower the teratogenic potential of pharmacologic treatment of epilepsy during conception.
- Published
- 2008
- Full Text
- View/download PDF
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