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1. Immigrants’ health empowerment and access to health coverage in France: A stepped wedge randomised controlled trial

Author

Desgrées du Loû, Annabel, Derche, Nicolas, Gubert, Flore, Mbiribindi, Romain, Melchior, Maria, principal coordinators, Andrianirina, Ny Sata, Bousmah, Marwân-al-Qays, Carillon, Séverine, Comblon, Virginie, Coulibaly, Karna, Delbe, Angèle, Ebongue, Jacques, Notemi, Ruth Foundje, Gaywahali, Charles, Gosselin, Anne, Kohou, Veroska, Lert, France, Lusilu-Voza, Jean, Lutonadio, Belinda, Nyemeck, Yves, Mbiribindi, Patricia, Miatti, Thierry, Ngueya, Jean-Paul, Ravalihasy, Andrainolo, Ridde, Valéry, Senne, Jean-Noël, Sissoko, Oumar, Taéron, Corinne, Tess, Faya, and Zoumenou, Iris

Published
2023
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2. Depression and loneliness among Sub-Saharan immigrants living in the greater Paris area: results from the MAKASI empowerment stepped wedge cluster randomised controlled trial.

Author

Gonçalves Tasca, Bianca, Bousmah, Marwân-al-Qays, Coulibaly, Karna, Gosselin, Anne, Ravalihasy, Andrainolo, Desgrées du Loû, Annabel, Melchior, Maria, Derche, Nicolas, Gubert, Flore, Mbiribindi, Romain, Andrianirina, Ny Sata, Carillon, Séverine, Comblon, Virginie, Delbe, Angèle, Ebongue, Jacques, Notemi, Ruth Foundje, Gaywahali, Charles, Kohou, Veroska, Lert, France, and Lusilu-Voza, Jean

Subjects
SUB-Saharan Africans, CLUSTER randomized controlled trials, COVID-19 pandemic, NONGOVERNMENTAL organizations, METROPOLITAN areas
Abstract

Purpose: The MAKASI intervention aimed to empower Sub-Saharan African immigrants living in precarious situations in the Paris metropolitan area. Because there are factors specifically related to immigration that may increase the risk for common mental disorders, the present study aimed to examine participants' levels of depression and loneliness and analyze the effect of the intervention on depression and loneliness. Methods: The MAKASI study was designed as a stepped wedge cluster randomized trial. Study participants were recruited through an outreach program led by a nongovernmental organization and randomly assigned to two clusters, with an intervention delay of 3 months between them. Participants were assessed for 6 months after inclusion and the effect of the intervention on depression and loneliness was assessed using generalized linear mixed models. The study was conducted from 2018 to 2021 and took in consideration whether being interviewed during one of the Covid-19 confinement had an effect on the results. Results: Between 2018 and 2021 a total of 821 subjects participated in the Makasi study. High levels of depression and loneliness were found in the study population. We found no effect of the intervention on depression [95% CI 0.77 to 2.40]. Similarly, no effect of the intervention was found on loneliness [95% CI 0.87 to 2.54]. Conclusions: The intervention tested did not appear to improve the level of depression and loneliness among participants. However, the high prevalence of mental and emotional problems in the study population suggests a public health crisis among immigrants in the greater Paris area. Clinical Trial Registration Number: Trial registration Clinicaltrials.gov, NCT04468724 (July 13, 2020). [ABSTRACT FROM AUTHOR]

Published
2024
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3. Facilitating the access to HIV testing at lower costs: "To the laboratory without prescription" (ALSO), a pilot intervention to expand HIV testing through medical laboratories in France.

Author

Champenois, Karen, Sawras, Victoire, Ngoh, Pamela, Bouvet de la Maisonneuve, Philippe, Valbousquet, Julie, Annequin, Margot, Gatseva, Yoana, Michels, David, Lydié, Nathalie, Maguet, Charlotte, Aïna, Elodie, Le Hô, Erwann, Plenel, Eve, Touitou, Irit, Deuffic-Burban, Sylvie, Lert, France, and Pugliese, Pascal

Subjects
DIAGNOSIS of HIV infections, HETEROSEXUAL men, BUSINESS hours, CITIES & towns, HEALTH insurance, MEDICAL laboratories
Abstract

Background: A pilot HIV testing programme, Au Labo sans Ordo (ALSO; "to the laboratory without prescription") was implemented in two French Fast-Track Cities Initiative areas from 07/2019 to 12/2020. ALSO aimed to remove barriers to HIV testing by providing free testing with widespread access through all laboratories, extended opening hours, and no prescription requirements. Objectives: Assessing the ALSO programme in terms of testing activity, user characteristics, and costs, compared to other HIV testing offers. Methods: Laboratories and STI clinics reported the monthly numbers of tests performed and positive tests. Two short surveys were carried out 12 months apart in people who sought HIV testing. In each offer, the mean costs of HIV testing have been estimated according to negative or positive results using a microcosting approach. Results: During the study period, 214/264 laboratories reported performing 38,941 ALSO tests that accounted for 7.2% of laboratory HIV testing activity. Positivity rates of ALSO and prescribed tests were similar (2.2/1000) but lower than that in STI clinics (6.0/1000). Heterosexual men, and individuals with multiple sexual partners, poor health insurance and few visits to GPs were more likely to use the ALSO offer than tests upon prescription. Compared to ALSO, STI clinic users were younger, more exposed to HIV and with a less favourable socio-economic situation. ALSO had low costs: €13 for a negative test, €163 for a positive test and €5,388 to identify an HIV-positive person (versus €9,068 in STI clinics and €20,126 with prescribed tests). Conclusion: ALSO has attracted users less likely to visit STI clinics or to seek a prescribed test, particularly heterosexual men. Activities, user profiles and costs suggested the complementarity of the HIV testing offers and the relevance of making them coexist. French health authorities have decided to maintain and expand this programme to complement existing HIV testing offers. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Development of a risk prediction score for screening for HBV, HCV and HIV among migrants in France: results from a multicentre observational study (STRADA study)

Author

Duracinsky, Martin, primary, Yaya, Issifou, additional, Yombo-Kokule, Lisa, additional, Bessonneau, Pascal, additional, Thonon, Frédérique, additional, Rousset-Torrente, Olivia, additional, Roudot-Thoraval, Françoise, additional, Lert, France, additional, Zucman, David, additional, and Chassany, Olivier, additional

Published
2024
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5. On-demand pre-exposure prophylaxis with tenofovir disoproxil fumarate plus emtricitabine among men who have sex with men with less frequent sexual intercourse: a post-hoc analysis of the ANRS IPERGAY trial

Author

Aboulker, Jean-Pierre, Bajos, Nathalie, Baril, Jean-Guy, Besnier, Michel, Binesse, Johan, Carette, Diane, Cattin, Grégoire, Chéret, Antoine, Chidiac, Christian, Choucair, Elias, Delfraissy, Jean-François, Demoulin, Baptiste, Diallo, Alpha, Durant-Zaleski, Isabelle, Doré, Véronique, Etien, Nicolas, Euphrasie, Françoise, Fonsart, Julien, Foubert, Valérie, Gibowski, Séverine, Girard, Gabriel, Guillon, Brigitte, Le Mestre, Soizic, Lert, France, Leturque, Nicolas, Lorente, Nicolas, Mennecier, Anaïs, Morin, Michel, Netzer, Emmanuelle, Otis, Joanne, Pasquet, Armelle, Peytavin, Gilles, Pialoux, Gilles, Préau, Marie, Rabian, Cécile, Rozenbaum, Willy, Sagaon-Teyssier, Luis, Saïdi, Yacine, Saouzanet, Marine, Simon, Marie-Christine, Suzan-Monti, Marie, Thompson, David, Timsit, Julie, Trottier, Benoît, Wainberg, Mark, Antoni, Guillemette, Tremblay, Cécile, Delaugerre, Constance, Charreau, Isabelle, Cua, Eric, Rojas Castro, Daniela, Raffi, François, Chas, Julie, Huleux, Thomas, Spire, Bruno, Capitant, Catherine, Cotte, Laurent, Meyer, Laurence, and Molina, Jean-Michel

Published
2020
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7. Targeted HIV Screening in Eight Emergency Departments: The DICI-VIH Cluster-Randomized Two-Period Crossover Trial

Author

Duchêne, Gaëlle, Jegou, Carole, Adnet, Frédéric, Bouchaud, Olivier, Alloui, Chakib, Jauneau, Christine, Troisvallets, Didier, Vandemeulebroucke, Eric, Fossoux, Nadia, Raphaël, Maurice, Vincent-Cassy, Christophe, Quertainmont, Yann, Goujard, Cécile, Pallier, Coralie, Vega, Aglavène, Renaud, Bertrand, Salmon, Dominique, Krivine, Anne, Bastide, Théophile, Galichon, Bertrand, Plaisance, Patrick, Morgand, Marjolaine, Maylin, Sarah, Bercot, Béatrice, Campa, Pauline, Valin, Nadia, Boukli, Narjis, Morand-Joubert, Laurence, Verbrugghe, Rachel, Dautheville, Sandrine, Ray, Patrick, Lebrette, Marie-Gisèle, Amiel, Corinne, Lancien, Cécile, Doumenc, Benoit, Khuong, Marie-Aude, Gros, Isabelle, Mutuon, Pierre, d’Almeida, Kayigan, Fromentin, Hélène, Martin, Maria, Cossé, Charlotte, Burnet, Espérie, Leblanc, Judith, Hejblum, Gilles, Costagliola, Dominique, Durand-Zaleski, Isabelle, Lert, France, de Truchis, Pierre, Verbeke, Geert, Rousseau, Alexandra, Piquet, Hélène, Simon, François, Pateron, Dominique, Simon, Tabassome, and Crémieux, Anne-Claude

Published
2018
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8. Universal test and treat and the HIV epidemic in rural South Africa: a phase 4, open-label, community cluster randomised trial

Author

Bärnighausen, Till, Herbst, Kobus, Iwuji, Collins, Makowa, Thembisa, Naidu, Kevi, Newell, Marie-Louise, Okesola, Nonhlanhla, de Oliveira, Tulio, Pillay, Deenan, Rochat, Tamsen, Tanser, Frank, Viljoen, Johannes, Zuma, Thembelihle, McGrath, Nuala, Balestre, Eric, Dabis, François, Karcher, Sophie, Orne-Gliemann, Joanna, Plazy, Melanie, Prague, Mélanie, Thiébaut, Rodolphe, Tiendrebeogo, Thierry, Boyer, Sylvie, Donfouet, Hermann, Gosset, Andrea, March, Laura, Protopopescu, Camelia, Spire, Bruno, Calmy, Alexandra, Larmarange, Joseph, Inghels, Maxime, Diallo, Hassimiou, Calvez, Vincent, Derache, Anne, Marcelin, Anne-Geneviève, Dray-Spira, Rosemary, Lert, France, El Farouki, Kamal, Lessells, Richard, Freedberg, Kenneth, Imrie, John, Chaix, Marie-Laure, Newell, Colin, Hontelez, Jan, Bazin, Brigitte, Rekacewicz, Claire, Iwuji, Collins C, Thiebaut, Rodolphe, Dreyer, Jaco, and De Oliveira, Tulio

Published
2018
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11. Effect of isoniazid preventive therapy on risk of death in west African, HIV-infected adults with high CD4 cell counts: long-term follow-up of the Temprano ANRS 12136 trial

Author

Badje, Anani, Moh, Raoul, Gabillard, Delphine, Guéhi, Calixte, Kabran, Mathieu, Ntakpé, Jean-Baptiste, Le Carrou, Jérôme, Kouame, Gérard-Menan, Ouattara, Eric, Messou, Eugène, Anzian, Amani, Minga, Albert, Gnokoro, Joachim, Gouesse, Patrice, Emieme, Arlette, Toni, Thomas-d'Aquin, Rabe, Cyprien, Sidibé, Baba, Nzunetu, Gustave, Dohoun, Lambert, Abo, Yao, Kamagate, Synali, Amon, Solange, Kouame, Amadou-Barenson, Koua, Aboli, Kouamé, Emmanuel, Daligou, Marcelle, Hawerlander, Denise, Ackoundzé, Simplice, Koule, Serge, Séri, Jonas, Ani, Alex, Dembélé, Fassery, Koné, Fatoumata, Oyebi, Mykayila, Mbakop, Nathalie, Makaila, Oyewole, Babatunde, Carolle, Babatunde, Nathaniel, Bleoué, Gisèle, Tchoutedjem, Mireille, Kouadio, Alain-Claude, Sena, Ghislaine, Yededji, Sahinou-Yediga, Karcher, Sophie, Rouzioux, Christine, Kouame, Abo, Assi, Rodrigue, Bakayoko, Alima, Domoua, Serge-K., Deschamps, Nina, Aka, Kakou, N'Dri-Yoman, Thérèse, Salamon, Roger, Journot, Valérie, Ahibo, Hughes, Ouassa, Timothée, Ménan, Hervé, Inwoley, André, Ndja, Ben-Ahoussi, Adou, Blandine, Kanga, Constance, Aoussi, Eba, Bissagnene, Emmanuel, Ba-Gomis, Olivier, Zike, Yves-Alain, Akakpo, Claude, Sassan-Morokro, Madeleine, Mobio, Max, Doféré, Bamba, Mesmin, Koman, Attia, Alain, Mahassadi, Alassane, Horo, Apollinaire, Oussou, Armel, Chaix, Marie-Laure, Peytavin, Gilles, Koné, Mariatou, N'Guessan, Kouamé, Fassassi, Raïmi, Niangoran, Serge, Desgrées-du-Loû, Annabel, Lert, France, Dray Spira, Rosemary, Jean, Kevin, Konan, Romuald, Bohoussou, Franck, Yao-Yapi, Cyril, N'guessan-Koffi, Larissa, Siloué, Bertine, Cissé, Adoulaye, Aboua, Adrienne, Konan, Sylvie, Kouamé, Antoine, N'Chot, Celestin, Amani, Elvis, Clouet, Gwenaëlle, Debono, Bruno, Chêne, Geneviève, Dosso, Mireille, Girard, Pierre-Marie, Jarlier, Vincent, Masumbuko, Jean-Marie, Perronne, Christian, Sow, Papa-Salif, Danel, Christine, Eholié, Serge-Paul, Anglaret, Xavier, Carrou, Jérôme Le, Kouame, Gérard M, Yao, Abo, Domoua, Serge K, Menan, Hervé, and Eholié, Serge P

Published
2017
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12. Efficacy, safety, and effect on sexual behaviour of on-demand pre-exposure prophylaxis for HIV in men who have sex with men: an observational cohort study

Author

Meyer, L, Capitant, C, Charreau, I, Netzer, E, Leturque, N, Binesse, J, Foubert, V, Saouzanet, M, Euphrasie, F, Carette, D, Guillon, B, Saïdi, Y, Aboulker, J P, Spire, B, Suzan, M, Cattin, G, Demoulin, B, Sagaon-Teyssier, L, Lorente, N, Doré, V, Choucair, E, Le Mestre, S, Mennecier, A, Etien, N, Simon, M C, Diallo, A, Gibowski, S, Delfraissy, J F, Thompson, D, Sas, J, Pankovitch, J, Klein, M, Anis, A, Molina, Jean-Michel, Wainberg, Mark A, Trottier, Benoit, Tremblay, Cécile, Baril, Jean-Guy, Pialoux, Gilles, Cotte, Laurent, Chéret, Antoine, Pasquet, Armelle, Cua, Eric, Besnier, Michel, Rozenbaum, Willy, Chidiac, Christian, Delaugerre, Constance, Bajos, Nathalie, Timsit, Julie, Peytavin, Gilles, Fonsart, Julien, Durand-Zaleski, Isabelle, Meyer, Laurence, Aboulker, Jean-Pierre, Spire, Bruno, Suzan-Monti, Marie, Girard, Gabriel, Castro, Daniela Rojas, Préau, Marie, Morin, Michel, Thompson, David, Capitant, Catherine, Mennecier, Anaïs, Choucair, Elias, Doré, Véronique, Simon, Marie-Christine, Charreau, Isabelle, Otis, Joanne, Lert, France, Diallo, Alpha, Gibowski, Séverine, Rabian, Cecile, Chas, Julie, Tremblay, Cecile, Rojas-Castro, Daniela, Bernaud, Camille, Pintado, Claire, Sagaon-Teyssier, Luis, Mestre, Soizic Le, Ponscarme, Diane, and Doré, Veronique

Published
2017
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13. Drastic Reduction in Time to Controlled Viral Load in People With Human Immunodeficiency Virus in France, 2009–2019: A Longitudinal Cohort Study.

Author

Cuzin, Lise, Morisot, Adeline, Allavena, Clotilde, Lert, France, Pugliese, Pascal, and Group, the Dat'AIDS Study

Subjects
DIAGNOSIS of HIV infections, HIV prevention, HIV-positive persons, HIV infections, KRUSKAL-Wallis Test, VIRAL load, ANTIRETROVIRAL agents, MEDICAL care, FISHER exact test, KAPLAN-Meier estimator, CHI-squared test, DESCRIPTIVE statistics, DATA analysis software, LONGITUDINAL method
Abstract

Background Aspirational targets to end AIDS by 2030 include having 95% of people with human immunodeficiency virus (HIV; PWH) diagnosed, 95% treated, and 95% with controlled viral load (VL). Our objective was to describe, using a large French prospective cohort, the median transition times through the cascade of care between 2009 and 2019. Methods We analyzed patients whose first HIV diagnosis was made between 1 January 2009 and 31 December 2019. Using the Kaplan–Meier method, we estimated the time to linkage to care (from HIV diagnosis to first biological assessment), to treatment (date of first antiretroviral therapy [ART] prescription), and to controlled VL (first value <200 copies/mL). Analyses were disaggregated by time periods and patients' characteristics. Censoring date was 31 December 2021. Results Among the 16 864 patients linked to care since 2009, the median [Q1; Q3] time from HIV diagnosis to controlled VL decreased from 254 [127–745] to 73 [48–132] days in 2009–2011 and 2018–2019, respectively. Transition times from linkage to care to first ART decreased from 67 [17; 414] in 2009–2011 to 13 [5; 26] days in 2018–2019, and from ART to controlled VL from 83 [35; 130] in 2009–2011 to 38 [28; 90] days in 2018–2019. Differences were observed depending on patients' characteristics. Conclusions We describe drastic reductions in transition time through the cascade of care, allowing reduction in the transmission period following each new infection. Delayed diagnosis remains the main obstacle to ending AIDS in the next decade. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Disclosure of HIV Status Beyond Sexual Partners by People Living with HIV in France: A Call for Help? Results from the National Cross-Sectional Survey ANRS-VESPA2

Author

Marcellin, Fabienne, Suzan-Monti, Marie, Vilotitch, Antoine, Sagaon-Teyssier, Luis, Mora, Marion, Dray-Spira, Rosemary, Préau, Marie, Lert, France, Spire, Bruno, Lert, France, Spire, Bruno, Carrieri, Maria Patrizia, Dray-Spira, Rosemary, Hamelin, Christine, Lorente, Nicolas, Préau, Marie, Suzan-Monti, Marie, Marcellin, Fabienne, Duracinsky, Martin, The ANRS VESPA2 Study Group, and with the collaboration of Marion Mora

Published
2017
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21. Implementation and effectiveness of a linkage to HIV care intervention in rural South Africa (ANRS 12249 TasP trial)

Author

Plazy, Mélanie, Diallo, Adama, Hlabisa, Thabile, Okesola, Nonhlanhla, Iwuji, Collins, Herbst, Kobus, Boyer, Sylvie, Lert, France, Mcgrath, Nuala, Pillay, Deenan, Dabis, François, Larmarange, Joseph, Orne-Gliemann, Joanna, Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Global Health in the Global South (GHiGS), Institut de Recherche pour le Développement (IRD)- Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Africa Health Research Institute [Durban/Mtubatuba] (AHRI), University of Sussex, University of Brighton, Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, University of Southampton, University College of London [London] (UCL), Centre population et développement (CEPED - UMR_D 196), Institut de Recherche pour le Développement (IRD)-Université Paris Cité (UPCité), Santé, vulnérabilités et relations de genre au sud (SAGESUD - ERL Inserm U1244), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre population et développement (CEPED - UMR_D 196), Institut de Recherche pour le Développement (IRD)-Université Paris Cité (UPCité)-Institut de Recherche pour le Développement (IRD)-Université Paris Cité (UPCité), and ANRS, BMGF

Subjects
Multidisciplinary, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Abstract

Background Timely linkage to care and ART initiation is critical to decrease the risks of HIV-related morbidity, mortality and HIV transmission, but is often challenging. We report on the implementation and effectiveness of a linkage-to-care intervention in rural KwaZulu-Natal, South Africa. Methods In the ANRS 12249 TasP trial on Universal Testing and Treatment (UTT) implemented between 2012–2016, resident individuals ≥16 years were offered home-based HIV testing every six months. Those ascertained to be HIV-positive were referred to trial clinics. Starting May 2013, a linkage-to-care intervention was implemented in both trial arms, consisting of tracking through phone calls and/or home visits to “re-refer” people who had not linked to care to trial clinics within three months of the first home-based referral. Fidelity in implementing the planned intervention was described using Kaplan-Meier estimation to compute conditional probabilities of being tracked and of being re-referred by the linkage-to-care team. Effect of the intervention on time to linkage-to-care was analysed using a Cox regression model censored for death, migration, and end of data follow-up. Results Among the 2,837 individuals (73.7% female) included in the analysis, 904 (32%) were tracked at least once, and 573 of them (63.4%) were re-referred. Probabilities of being re-referred was 17% within six months of first referral and 31% within twelve months. Compared to individuals not re-referred by the intervention, linkage-to-care was significantly higher among those with at least one re-referral through phone call (adjusted hazard ratio [aHR] = 1.82; 95% confidence interval [95% CI] = 1.47–2.25), and among those with re-referral through both phone call and home visit (aHR = 3.94; 95% CI = 2.07–7.48). Conclusions Phone calls and home visits following HIV testing were challenging to implement, but appeared effective in improving linkage-to-care amongst those receiving the intervention. Such patient-centred strategies should be part of UTT programs to achieve the UNAIDS 95-95-95 targets.

Published
2023
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22. Changes in kidney function among men having sex with men starting on demand tenofovir disoproxil fumarate – emtricitabine for HIV pre‐exposure prophylaxis

Author

Liegeon, Geoffroy, Antoni, Guillemette, Pialoux, Gilles, Capitant, Catherine, Cotte, Laurent, Charreau, Isabelle, Tremblay, Cécile, Cua, Eric, Senneville, Eric, Raffi, François, Meyer, Laurence, Molina, Jean?Michel, Meyer, L, Capitant, C, Charreau, I, Netzer, E, Leturque, N, Binesse, J, Foubert, V, Saouzanet, M, Euphrasie, F, Carette, D, Guillon, B, Saïdi, Y, Aboulker, J P., Spire, B, Suzan, M, Cattin, G, Demoulin, B, Sagaon?Teyssier, L, Lorente, N, Doré, V, Choucair, E, Le Mestre, S, Mennecier, A, Etien, N, Simon, M C., Diallo, A, Gibowski, S, Delfraissy, J F., Thompson, D, Sas, J, Pankovitch, J, Klein, M, Anis, A, Wainberg, Mark A., Trottier, Benoit, Baril, Jean?Guy, Chéret, Antoine, Pasquet, Armelle, Hall, Nolwenn, Rozenbaum, Willy, Chidiac, Christian, Delaugerre, Constance, Bajos, Nathalie, Timsit, Julie, Peytavin, Gilles, Fonsart, Julien, Durand?Zaleski, Isabelle, Aboulker, Jean?Pierre, Spire, Bruno, Suzan?Monti, Marie, Girard, Gabriel, Castro, Daniela Rojas, Préau, Marie, Morin, Michel, Thompson, David, Mennecier, Anaïs, Choucair, Elias, Doré, Véronique, Simon, Marie?Christine, Otis, Joanne, Lert, France, Diallo, Alpha, Gibowski, Séverine, and Rabian, Cecile

Subjects
MSM (Men who have sex with men) -- Health aspects, Tenofovir -- Patient outcomes, Glomerular filtration rate -- Testing, Emtricitabine -- Patient outcomes, HIV infection -- Prevention, Health
Abstract

: Introduction: Daily pre‐exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) is associated with a small but statistically significant decrease in estimated glomerular filtration rate (eGFR). We assessed the renal safety of on‐demand PrEP with TDF/FTC in HIV‐1 uninfected men. Methods: We used data from the randomized double‐blind placebo‐controlled ANRS‐IPERGAY trial and its open‐label extension conducted between February 2012 and June 2016 among HIV‐uninfected MSM starting on‐demand PrEP. Using linear mixed model, we evaluated the mean eGFR decline from baseline over time and determined risks factors associated with eGFR decline during the study. Results: During the blind phase, with a median follow‐up of 9.4 months, the mean decline slope of eGFR from baseline was −0.88 and −1.53 mL/min/1.73 m[sup.2] per year in the placebo (n = 201) and the TDF/FTC group (n = 198) respectively, with a slope difference of 0.65 mL/min/1.73 m[sup.2] per year (p = 0.27). Including both phases, 389 participants started on‐demand TDF/FTC with a median follow‐up of 19.2 months and a mean decline of eGFR from baseline of −1.14 mL/min/1.73 m[sup.2] per year (p < 0.001). The slope of eGFR reduction was not significantly different in participants with baseline eGFR ≤ 90 mL/min/1.73 m[sup.2] (p = 0.44), age >40 years (p = 0.24) or hypertension (p = 0.21). There was a dose‐response relationship between recent tenofovir exposure and lower eGFR when considering the number of pills taken in the two months prior the visit (eGFR difference of −0.88 mL/min/1.73 m[sup.2] between >15 pills/month vs. ≤15 pills/month, p < 0.01) or plasma tenofovir concentrations at the visit (eGFR difference compared to ≤2 ng/mL: >2 to ≤10ng/mL: −0.98 mL/min/1.73 m[sup.2], >10 to ≤40ng/mL: −1.28 mL/min/1.73 m[sup.2], >40 ng/mL: −1.82 mL/min/1.73 m[sup.2], p < 0.001). Three participants discontinued TDF/FTC for eGFR < 60 mL/min/1.73 m[sup.2] during the OLE phase. No case of Fanconi syndrome was reported. Conclusions: The renal safety of on‐demand PrEP with TDF/FTC was good. The overall reduction and intermittent exposure to TDF/FTC may explain this good renal safety., Introduction Pre‐exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate (TDF) – emtricitabine (FTC) raises a lot of expectations to hamper HIV epidemic due to its high effectiveness to prevent HIV acquisition [...]

Published
2020
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23. Transmission of SARS-CoV-2 during indoor clubbing events: A clustered randomized, controlled, multicentre trial protocol

Author

Bouillé, Jeanne Goupil De, Nguyen, Liem Binh Luong, Crepey, Pascal, Garlantezec, Ronan, Doré, Véronique, Dumas, Audrey, Mechlia, Mohamed Ben, Tattevin, Pierre, Gaudart, Jean, Spire, Bruno, Lert, France, Yazdanpanah, Yazdan, Delaugerre, Constance, Noret, Marion, Zeggagh, Jeremy, Group, The Itoc Study, École des Hautes Études en Santé Publique [EHESP] (EHESP), Département Méthodes quantitatives en santé publique (METIS), Centre de Recherches sur l'Action Politique en Europe (ARENES), Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut d'Études Politiques [IEP] - Rennes-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Abstract

International audience; Introduction: The SARS-CoV-2 pandemic led to the implementation of several non-pharmaceutical interventions (NPIs), from closings of bars and restaurants to curfews and lockdowns. Vaccination campaigns started hoping it could efficiently alleviate NPI. The primary objective of the “Indoor Transmission of COVID-19” (ITOC) study is to determine among a fully vaccinated population the relative risk of SARS-CoV-2 transmission during one indoor clubbing event. Secondary objectives are to assess the transmission of other respiratory viruses, risk exposure, and attitudes toward COVID-19 vaccination, health pass, and psychological impact of indoor club closing.Methods and analysis: Four thousand four hundred healthy volunteers aged 18–49 years and fully vaccinated will be included in Paris region. The intervention is an 8-hour indoor clubbing event with no masks, no social distance, maximum room capacity, and ventilation. A reservation group of up to 10 people will recruit participants, who will be randomized 1:1 to either the experimental group (2,200 volunteers in two venues with capacities of 1,000 people each) or the control group (2,200 volunteers asked not to go to the club). All participants will provide a salivary sample on the day of the experiment and 7 days later. They also will answer several questionnaires. Virological analyses include polymerase chain reaction (PCR) of salivary samples and air of the venue, investigating SARS-CoV-2 and 18 respiratory viruses.Ethics and dissemination: Ethical clearance was first obtained in France from the institutional review board (Comité de Protection des Personnes Ile de France VII - CPP), and the trial received clearance from the French National Agency for Medicines and Health Products (Agence National de Sécurité du Médicament - ANSM). The trial is supported and approved by The Agence Nationale Recherche sur le SIDA, les hépatites et maladies émergences (ANRS-MIE). Positive, negative, and inconclusive results will be published in peer-reviewed scientific journals.

Published
2022
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24. Transmission of SARS-CoV-2 during indoor clubbing events: A clustered randomized, controlled, multicentre trial protocol

Author

Goupil de Bouillé, Jeanne, primary, Luong Nguyen, Liem Binh, additional, Crépey, Pascal, additional, Garlantezec, Ronan, additional, Doré, Véronique, additional, Dumas, Audrey, additional, Ben Mechlia, Mohamed, additional, Tattevin, Pierre, additional, Gaudart, Jean, additional, Spire, Bruno, additional, Lert, France, additional, Yazdanpanah, Yazdan, additional, Delaugerre, Constance, additional, Noret, Marion, additional, and Zeggagh, Jeremy, additional

Published
2022
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33. Parcours

Author

Desgrées du Loû, Annabel, primary and Lert, France, additional

Published
2017
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34. Childhood Sexual Abuse and Adult Sexual Health among Indigenous Kanak Women and Non-Kanak Women of New Caledonia

Author

Hamelin, Christine, Salomon, Christine, Cyr, Diane, Gueguen, Alice, and Lert, France

Abstract

Objectives: Few studies have addressed the long-term consequences of adverse childhood experiences among women in Oceania, in particular among indigenous women. This paper aims to report prevalences of childhood sexual abuse (CSA) and to asses the negative sexual health consequences in adulthood by comparing indigenous Kanak to non-Kanak women in New Caledonia. Methods: Data come from a population survey on violence against women and health. Face-to-face interviews were conducted in 2002-2003 with adult women randomly selected from the electoral list. Separate models for Kanak (n = 329) and non-Kanak women (n = 426) were performed. Regression models adjusted for relevant socio-demographics factors were conducted to estimate the odds ratios for the associations between childhood sexual abuse and adult sexual health outcomes. Results: A non-significant difference between Kanak (11.8%) and non-Kanak women (14.4%) was found for the prevalence of CSA. Among Kanak women, CSA increases the risk of sexually transmitted infections, of non-desired sexual intercourse with an intimate partner and of experience of adult sexual violence. However, use of modern contraception as an adult was more frequent among CSA Kanak victims, as compared to other Kanak women. Among non-Kanak women, only abortion appeared significantly associated with CSA. Conclusions and Practice implications: The findings show that in all ethnic communities of New Caledonia, a history of child sexual abuse is not rare among women. They also shed light on the long-term consequences of CSA, suggesting that the effect of CSA may differ according to ethnic membership and subsequent social stratification and gender norms. Efforts to break the silence around violence against girls and establish a stronger foundation are required in New Caledonia. Prevention programs on violence against women and sexual health that take into account the cultural and social heterogeneity are needed. (Contains 3 tables.)

Published
2010
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35. Temporal trends of population viral suppression in the context of Universal Test and Treat: the ANRS 12249 TasP trial in rural South Africa

Author

Larmarange, Joseph, Diallo, Mamadou H., Mcgrath, Nuala, Iwuji, Collins, Plazy, Mélanie, Thiébaut, Rodolphe, Tanser, Frank, Bärnighausen, Till, Orne?Gliemann, Joanna, Pillay, Deenan, Dabis, François, Barnighausen, Till, Herbst, Kobus, Makowa, Thembisa, Naidu, Kevi, Okesola, Nonhlanhla, Oliveira, Tulio, Rochat, Tamsen, Viljoen, Johannes, Zuma, Thembelihle, Balestre, Eric, Dabis, Francois, Karcher, Sophie, Plazy, Melanie, Prague, Melanie, Thiebaut, Rodolphe, Tiendrebeogo, Thierry, Boyer, Sylvie, Donfouet, Hermann, Gosset, Andrea, March, Laura, Protopopescu, Camelia, Spire, Bruno, Calvez, Vincent, Derache, Anne, Marcelin, Anne?Genevieve, Dray?Spira, Rosemary, Lert, France, Farouki, Kamal El, Chaix, Marie?Laure, Bazin, Brigitte, Rekacewicz, Claire, Imrie, John, Lessells, Richard, Newell, Colin, Newell, Marie?Louise, Calmy, Alexandra, Freedberg, Kenneth, and Hontelez, Jan

Subjects
Time trends (Statistics) -- Analysis, Antiviral agents -- Dosage and administration, Immunosuppression -- Patient outcomes, HIV infection -- Risk factors -- Prevention, Health
Abstract

: Introduction: The universal test‐and‐treat (UTT) strategy aims to maximize population viral suppression (PVS), that is, the proportion of all people living with HIV (PLHIV) on antiretroviral treatment (ART) and virally suppressed, with the goal of reducing HIV transmission at the population level. This article explores the extent to which temporal changes in PVS explain the observed lack of association between universal treatment and cumulative HIV incidence seen in the ANRS 12249 TasP trial conducted in rural South Africa. Methods: The TasP cluster‐randomized trial (2012 to 2016) implemented six‐monthly repeat home‐based HIV counselling and testing (RHBCT) and referral of PLHIV to local HIV clinics in 2 × 11 clusters opened sequentially. ART was initiated according to national guidelines in control clusters and regardless of CD4 count in intervention clusters. We measured residency status, HIV status, and HIV care status for each participant on a daily basis. PVS was computed per cluster among all resident PLHIV (≥16, including those not in care) at cluster opening and daily thereafter. We used a mixed linear model to explore time patterns in PVS, adjusting for sociodemographic changes at the cluster level. Results: 8563 PLHIV were followed. During the course of the trial, PVS increased significantly in both arms (23.5% to 46.2% in intervention, +22.8, p < 0.001; 26.0% to 44.6% in control, +18.6, p < 0.001). That increase was similar in both arms (p = 0.514). In the final adjusted model, PVS increase was most associated with increased RHBCT and the implementation of local trial clinics (measured by time since cluster opening). Contextual changes (measured by calendar time) also contributed slightly. The effect of universal ART (trial arm) was positive but limited. Conclusions: PVS was improved significantly but similarly in both trial arms, explaining partly the null effect observed in terms of cumulative HIV incidence between arms. The PVS gains due to changes in ART‐initiation guidelines alone are relatively small compared to gains obtained by strategies to maximize testing and linkage to care. The achievement of the 90‐90‐90 targets will not be met if the operational and implementational challenges limiting access to care and treatment, often context‐specific, are not properly addressed. Clinical trial number: NCT01509508 (clinicalTrials.gov)/DOH‐27‐0512‐3974 (South African National Clinical Trials Register)., Introduction Antiretroviral treatment (ART), when taken early has several benefits, both in terms of morbidity and mortality and in terms of reduction in HIV sexual transmission. Mathematical modelling work suggested [...]

Published
2019
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36. Distribution of HIV self-tests by men who have sex with men attending a French sexual health centre: results of the OTO study

Author

Gosset, Daniel, primary, Plathey, Marine, additional, Lert, France, additional, Lasry, Stéphane, additional, Jedrzejewski, Thibaut, additional, Gazalet, Philippe, additional, L'Yavanc, Thomas, additional, Pierre, Nadège, additional, Kachal, Abdessamad, additional, Frémondière, Marc, additional, Ohayon, Michel, additional, and Palich, Romain, additional

Published
2022
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38. Les violences sexuelles envers les femmes immigrées d’Afrique subsaharienne après la migration en France

Author

Pannetier, Julie, Ravalihasy, Andrainolo, Desgrées du Loû, Annabel, Lert, France, Lydié, Nathalie, and Groupe PARCOURS

Subjects
Cultural Studies, SOCIAL_PRECARIOUSNESS, Health (social science), WOMEN'S_STATUS, LIVING_CONDITIONS, FEMALE_MIGRATION, FRANCE, AFRICAN_IMMIGRATION, AIDS, REFUGEES, SEXUAL_VIOLENCE, ASYLUM, 10. No inequality, Demography
Abstract

L’enquête Parcours réalisée en 2012-2013 dans des établissements de santé en Île-de-France permet d’étudier les violences sexuelles que les femmes immigrées originaires d’Afrique subsaharienne ont subies après leur migration et d’examiner le contexte social de leur survenue. L’insécurité résidentielle et administrative accroît ces violences sexuelles. Un tiers des femmes séropositives pour le VIH a été infecté après la migration, et rapporte quatre fois plus souvent avoir été victime de rapports sexuels forcés que les femmes non infectées.

Published
2020
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50. Profiles of the ALSO program users, a a free hiv testing supply in walk-in medical labs in france

Author

Champenois, Karen, Annequin, Margot, Ngoh, Paméla, Touitou, Irit, Lert, France, Bouvet de la Maisonneuve, Philippe, Valbousquet, Julie, Le Hô, Erwan, Lydie, Nathalie, Plenel, Ève, Pugliese, Pascal, Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Vers Paris sans sida [Paris], Corevih Paca Est, Centre Hospitalier Universitaire de Nice (CHU Nice), Objectif sida zéro [Nice], Santé publique France - French National Public Health Agency [Saint-Maurice, France], Groupe ALSO ((« Au labo sans ordo ») : Laurence Dauffy, Laurence Dumondin et les équipes de l’Assurance maladie de Paris, Gwenaelle Tasset et les équipes de l’Assurance maladie des Alpes-Maritimes, Anne-Claire Haye, Gérard Ughetto et les équipes du Service médical de l’Assurance maladie, Florence Orsini, Said Oumeddour et la sous-direction de prévention et promotion de la santé de l’Assurance maladie, Jean-Claude Azoulay et l’URPS Biologie Île-de-France (IDF), Boris Loquet, Jean-Marc Dubertrand et l’URPS Biologie Paca, les présidents et présidentes, ainsi que les techniciens et techniciennes d’études cliniques des Corevih Paca-Est, IDF Sud, IDF Nord, IDF Centre et IDF Ouest, Christophe Caissotti (Corevih Paca-Est), Frédéric Goyet, Corinne Chouraqui (Agence régionale de santé Île-de-France), Anne Souyris (Ville de Paris)., and Annequin, Margot

Subjects
CeGIDD, Dépistage, Public STI clinic, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Testing, HIV, VIH, Medical laboratory, Laboratoire de biologie médicale, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Abstract

Introduction – Since July 1st, 2019, the “Au labo sans ordo” (ALSO) program offers a free HIV testing solution, without prescription, in any walk-in medical laboratory in Paris and the Alpes-Maritimes. This article describes the ALSO program users’ profile and compares their characteristics to those of the persons who get tested for HIV in labs with a prescription or in public STI clinics.Methods – A cross-sectional survey was conducted on the week of November 18-23, 2019 in 240 medicallaboratories and 11 public STI clinics in both regions. An anonymous self-administered questionnaire wasproposed to every adult who got tested for HIV. Two logistic regression models were used to compare ALSO users to (1) prescription test users and (2) STI clinics clients.Results – 3,144 questionnaires were analyzed (295 ALSO users, 2,138 prescriptions test users and 711 STI clinics clients). Compared to people with a prescribed test, ALSO attracted more heterosexual men (42% vs 28%), better established socially but quite far from care (32% vs 21% see a doctor ≤ once a year), with multiple sexual partners (60% vs 49%). Public STI clinics attracted a younger population (42% vs 21%, Introduction – Depuis le 1er juillet 2019, le programme « Au labo sans ordo » (ALSO) offre, à Paris et dans les Alpes-Maritimes, un dépistage du VIH sans ordonnance et sans frais dans tous les laboratoires de biologie médicale de ville. Cet article décrit les usagers du programme ALSO et compare leurs caractéristiques à celles des personnes qui ont recours au dépistage du VIH en laboratoire sur prescription médicale ou en CeGIDD.Méthodes – Une étude transversale a été menée la semaine du 18 au 23 novembre 2019 dans 240 laboratoires et 11 CeGIDD, dans les deux départements. Un autoquestionnaire anonyme était proposé par le personnel d’accueil aux personnes majeures qui réalisaient un test VIH. Deux modèles de régression logistique ont permis de comparer les usagers ALSO aux personnes avec (1) un test prescrit ; (2) un dépistage en CeGIDD.Résultats – L’analyse portait sur 3 144 questionnaires (295 usagers ALSO, 2 138 personnes avec un testprescrit et 711 usagers des CeGIDD). Comparativement aux personnes avec un test prescrit, ALSO attiraitdavantage d’hommes hétérosexuels (42% vs 28%), bien insérés socialement mais assez éloignés du soin(32% vs 21% consultaient ≤1 fois/an), multipartenaires (60% vs 49%). Les CeGIDD touchaient une population plus jeune (42% vs 21%

Published
2020

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