306 results on '"Lesche, Ralf"'
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2. Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling
3. Targeting fatty acid oxidation via Acyl-CoA binding protein hinders glioblastoma invasion
4. Identification of a neural development gene expression signature in colon cancer stem cells reveals a role for EGR2 in tumorigenesis
5. RNA sequencing of long-term label-retaining colon cancer stem cells identifies novel regulators of quiescence
6. Identification of Small Molecules that Modulate Mutant p53 Condensation
7. Dual targeting of the androgen receptor and PI3K/AKT/mTOR pathways in prostate cancer models improves antitumor efficacy and promotes cell apoptosis
8. Targeting the aryl hydrocarbon receptor (AhR) with BAY 2416964: a selective small molecule inhibitor for cancer immunotherapy
9. A new molecular classification to drive precision treatment strategies in primary Sjögren’s syndrome
10. Novel YAP1/TAZ pathway inhibitors identified through phenotypic screening with potent anti-tumor activity via blockade of GGTase-I / Rho-GTPase signaling
11. The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies
12. Live-Specific Deletion of Negative Regulator Pten Results in Fatty Liver and Insulin Hypersensitivity
13. A Sensitized Genetic System for the Analysis of Murine B Lymphocyte Signal Transduction Pathways Dependent on Bruton's Tyrosine Kinase
14. PTEN Modulates Cell Cycle Progression and Cell Survival by Regulating Phosphatidylinositol 3,4,5-Trisphosphate and Akt/Protein Kinase B Signaling Pathway
15. Abstract 6089: Identification of novel YAP/TAZ pathway regulators in the triple-negative breast cancer cell line MDA-MB231 using single-cell CRISPR screening
16. Supplemental Tables S1-3 from Preclinical Efficacy of the Novel Monocarboxylate Transporter 1 Inhibitor BAY-8002 and Associated Markers of Resistance
17. Supplementary Figure S3 from EZH2 Inhibition Blocks Multiple Myeloma Cell Growth through Upregulation of Epithelial Tumor Suppressor Genes
18. Data from Preclinical Efficacy of the Novel Monocarboxylate Transporter 1 Inhibitor BAY-8002 and Associated Markers of Resistance
19. Supplementary Methods from Preclinical Efficacy of the Novel Monocarboxylate Transporter 1 Inhibitor BAY-8002 and Associated Markers of Resistance
20. Data from EZH2 Inhibition Blocks Multiple Myeloma Cell Growth through Upregulation of Epithelial Tumor Suppressor Genes
21. Supplementary Tables S1 from EZH2 Inhibition Blocks Multiple Myeloma Cell Growth through Upregulation of Epithelial Tumor Suppressor Genes
22. Supplementary Table S4 from Identification and Validation of Colorectal Neoplasia–Specific Methylation Markers for Accurate Classification of Disease
23. Supplementary Materials and Methods and Figure Legends from EZH2 Inhibition Blocks Multiple Myeloma Cell Growth through Upregulation of Epithelial Tumor Suppressor Genes
24. Figures S1-S5 from Preclinical Efficacy of the Novel Monocarboxylate Transporter 1 Inhibitor BAY-8002 and Associated Markers of Resistance
25. Supplementary Data from DNA Methylation Markers Predict Outcome in Node-Positive, Estrogen Receptor-Positive Breast Cancer with Adjuvant Anthracycline-Based Chemotherapy
26. Data from DNA Methylation Markers Predict Outcome in Node-Positive, Estrogen Receptor-Positive Breast Cancer with Adjuvant Anthracycline-Based Chemotherapy
27. Supplementary Figures 1-3 from Genetic Background Controls Tumor Development in Pten-Deficient Mice
28. Functional diversity of inhibitors tackling the differentiation blockage of MLL-rearranged leukemia
29. Comparative Proteomic and Transcriptomic Analysis of the Impact of Androgen Stimulation and Darolutamide Inhibition
30. Preclinical evaluation of BAY 1075553, a novel 18F-labelled inhibitor of prostate-specific membrane antigen for PET imaging of prostate cancer
31. Comparative Proteomic and Transcriptomic Analysis of the Impact of Androgen Stimulation and Darolutamide Inhibition.
32. Development of a Diagnostic Microarray Assay to Assess the Risk of Recurrence of Prostate Cancer Based on PITX2 DNA Methylation
33. Discovery and Characterization of the Potent and Highly Selective 1,7-Naphthyridine-Based Inhibitors BAY-091 and BAY-297 of the Kinase PIP4K2A
34. Abstract 1008: Comparative proteomics and transcriptomics analysis of the impact of androgen stimulation and darolutamide inhibition in a prostate cancer model
35. Integrative Analysis Reveals a Molecular Stratification of Systemic Autoimmune Diseases
36. A new molecular classification to drive precision treatment strategies in primary Sjögren's syndrome.
37. Integrative Analysis Reveals a Molecular Stratification of Systemic Autoimmune Diseases.
38. Prognostic significance of methylated RASSF1A and PITX2 genes in blood- and bone marrow plasma of breast cancer patients
39. DNA hypermethylation of PITX2 is a marker of poor prognosis in untreated lymph node-negative hormone receptor-positive breast cancer patients
40. The prognostic value of Stathmin-1, S100A2, and SYK proteins in ER-positive primary breast cancer patients treated with adjuvant tamoxifen monotherapy: an immunohistochemical study
41. Integrative Analysis Reveals a Molecular Stratification of Systemic Autoimmune Diseases
42. RNA-Sequencing of Long-Term Label-Retaining Colon Cancer Stem Cells Identifies Novel Regulators of Quiescence
43. Identification of a Nervous System Gene Expression Signature in Colon Cancer Stem Cells Reveals a Role for Neural Crest RegulatorsEGR2andSOX2in Tumorigenesis
44. Genome-wide whole blood transcriptome profiling in a large European cohort of systemic sclerosis patients
45. An elevated polyclonal free light chain level reflects a strong interferon signature in patients with systemic autoimmune diseases
46. DNA Methylation Analysis
47. Aberrant Methylation of the Eyes Absent 4 Gene in Ulcerative Colitis–Associated Dysplasia
48. DNA Methylation Analysis: Providing New Insight into Human Disease
49. Contributors
50. Quantitative DNA Methylation Profiling on a High-Density Oligonucleotide Microarray
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