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1. Risk factors affecting the feeding site predilection of ticks on cattle in Ghana

Author

Addo, Seth Offei, Bentil, Ronald Essah, Mosore, Mba-tihssommah, Behene, Eric, Adinkrah, Julian, Tagoe, Janice, Yeboah, Clara, Baako, Bernice Olivia Ama, Atibila, Dorcas, Kwarteng, Sandra Abankwa, Poku-Asante, Kwaku, Owusu-Darbo, Ellis, Asoala, Victor, Mingle, Daniel Lartei, Nyarko, Edward Owusu, Fox, Anne T., Letizia, Andrew G., William, II, Joseph Diclaro, Nimo-Paintsil, Shirley, Harwood, James F., and Dadzie, Samuel Kweku

Published
2024
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3. Sepsis endotypes identified by host gene expression across global cohorts

Author

Chenoweth, Josh G., Brandsma, Joost, Striegel, Deborah A., Genzor, Pavol, Chiyka, Elizabeth, Blair, Paul W., Krishnan, Subramaniam, Dogbe, Elliot, Boakye, Isaac, Fogel, Gary B., Tsalik, Ephraim L., Woods, Christopher W., Owusu-Ofori, Alex, Oppong, Chris, Oduro, George, Vantha, Te, Letizia, Andrew G., Beckett, Charmagne G., Schully, Kevin L., and Clark, Danielle V.

Published
2024
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4. Gene expression signatures in blood from a West African sepsis cohort define host response phenotypes

Author

Chenoweth, Josh G., Colantuoni, Carlo, Striegel, Deborah A., Genzor, Pavol, Brandsma, Joost, Blair, Paul W., Krishnan, Subramaniam, Chiyka, Elizabeth, Fazli, Mehran, Mehta, Rittal, Considine, Michael, Cope, Leslie, Knight, Audrey C., Elayadi, Anissa, Fox, Anne, Hertzano, Ronna, Letizia, Andrew G., Owusu-Ofori, Alex, Boakye, Isaac, Aduboffour, Albert A., Ansong, Daniel, Biney, Eno, Oduro, George, Schully, Kevin L., and Clark, Danielle V.

Published
2024
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5. Mapping disease regulatory circuits at cell-type resolution from single-cell multiomics data

Author

Chen, Xi, Wang, Yuan, Cappuccio, Antonio, Cheng, Wan-Sze, Zamojski, Frederique Ruf, Nair, Venugopalan D., Miller, Clare M., Rubenstein, Aliza B., Nudelman, German, Tadych, Alicja, Theesfeld, Chandra L., Vornholt, Alexandria, George, Mary-Catherine, Ruffin, Felicia, Dagher, Michael, Chawla, Daniel G., Soares-Schanoski, Alessandra, Spurbeck, Rachel R., Ndhlovu, Lishomwa C., Sebra, Robert, Kleinstein, Steven H., Letizia, Andrew G., Ramos, Irene, Fowler, Jr, Vance G., Woods, Christopher W., Zaslavsky, Elena, Troyanskaya, Olga G., and Sealfon, Stuart C.

Published
2023
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6. Applying next generation sequencing to detect tick-pathogens in Dermacentor nuttalli, Ixodes persulcatus, and Hyalomma asiaticum collected from Mongolia

Author

Matulis, Graham A., Sakolvaree, Jira, Boldbaatar, Bazartseren, Cleary, Nora, Takhampunya, Ratree, Poole-Smith, B. Katherine, Lilak, Abigail A., Altantogtokh, Doniddemberel, Tsogbadrakh, Nyamdorj, Chanarat, Nitima, Youngdech, Nittayaphon, Lindroth, Erica J., Fiorenzano, Jodi M., Letizia, Andrew G., and von Fricken, Michael E.

Published
2023
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7. Multi-omics of NET formation and correlations with CNDP1, PSPB, and L-cystine levels in severe and mild COVID-19 infections

Author

Bramer, Lisa M., Hontz, Robert D., Eisfeld, Amie J., Sims, Amy C., Kim, Young-Mo, Stratton, Kelly G., Nicora, Carrie D., Gritsenko, Marina A., Schepmoes, Athena A., Akasaka, Osamu, Koga, Michiko, Tsutsumi, Takeya, Nakamura, Morio, Nakachi, Ichiro, Baba, Rie, Tateno, Hiroki, Suzuki, Shoji, Nakajima, Hideaki, Kato, Hideaki, Ishida, Kazunari, Ishii, Makoto, Uwamino, Yoshifumi, Mitamura, Keiko, Paurus, Vanessa L., Nakayasu, Ernesto S., Attah, Isaac K., Letizia, Andrew G., Waters, Katrina M., Metz, Thomas O., Corson, Karen, Kawaoka, Yoshihiro, Gerbasi, Vincent R., Yotsuyanagi, Hiroshi, and Iwatsuki-Horimoto, Kiyoko

Published
2023
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9. Retrospective Genomic Characterization of a 2017 Dengue Virus Outbreak, Burkina Faso

Author

Letizia, Andrew G., Pratt, Catherine B., Wiley, Michael R., Fox, Anne T., Mosore, Mba, Agbodzi, Bright, Yeboah, Clara, Kumordjie, Selassie, Paola, Nicholas Di, Assana, Kone Cisse, Coulidiaty, David, Ouedraogo, Casimir, Bonney, Joseph H. Kofi, Ampofo, William, Tarnagda, Zekiba, and Sangare, Lassana

Subjects
Epidemics -- Causes of -- Burkina Faso, Dengue -- Causes of, Dengue viruses -- Identification and classification -- Genetic aspects -- Distribution, Company distribution practices, Health
Abstract

Dengue virus (DENV), the causative agent of dengue fever, is a mosquitoborne single-stranded RNA virus from the genus Flavivirus, often defined as 4 related serotypes (DENV-1, DENV-2, DENV-3, and DENV-4) [...]

Published
2022
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10. Informing the Need for a SARS-CoV-2 Booster Based Upon the Immune Responses among Young Healthy Adults to Variants Circulating in Late 2023

Author

Nguyen, Huy C, primary, Lal, Kerri G, additional, Balinsky, Corey A, additional, Hontz, Robert D, additional, Lin, Jin, additional, Beye, Matthew J, additional, Smith, Lauren, additional, Pan, Li, additional, Cheng, Ying, additional, Fox, Isabella, additional, Lizewski, Stephen E, additional, Foo, Hayley S, additional, Krebs, Shelly J, additional, Sun, Peifang, additional, and Letizia, Andrew G, additional

Published
2024
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11. Author Correction: Mapping disease regulatory circuits at cell-type resolution from single-cell multiomics data

Author

Chen, Xi, Wang, Yuan, Cappuccio, Antonio, Cheng, Wan-Sze, Zamojski, Frederique Ruf, Nair, Venugopalan D., Miller, Clare M., Rubenstein, Aliza B., Nudelman, German, Tadych, Alicja, Theesfeld, Chandra L., Vornholt, Alexandria, George, Mary-Catherine, Ruffin, Felicia, Dagher, Michael, Chawla, Daniel G., Soares-Schanoski, Alessandra, Spurbeck, Rachel R., Ndhlovu, Lishomwa C., Sebra, Robert, Kleinstein, Steven H., Letizia, Andrew G., Ramos, Irene, Fowler, Jr, Vance G., Woods, Christopher W., Zaslavsky, Elena, Troyanskaya, Olga G., and Sealfon, Stuart C.

Published
2023
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12. Asymptomatic or symptomatic SARS-CoV-2 infection plus vaccination confers increased adaptive immunity to variants of concern

Author

Sun, Peifang, Ramos, Irene, Coelho, Camila H., Grifoni, Alba, Balinsky, Corey A., Vangeti, Sindhu, Tarke, Alison, Bloom, Nathaniel I., Jani, Vihasi, Jakubski, Silvia J., Boulifard, David A., Cooper, Elizabeth, Goforth, Carl W., Marayag, Jan, Marrone, Amethyst, Nunez, Edgar, White, Lindsey, Porter, Chad K., Sugiharto, Victor A., Schilling, Megan, Mahajan, Avinash S., Beckett, Charmagne, Sette, Alessandro, Sealfon, Stuart C., Crotty, Shane, and Letizia, Andrew G.

Published
2022
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14. Clinical evaluation of the BioFire Global Fever Panel for the identification of malaria, leptospirosis, chikungunya, and dengue from whole blood: a prospective, multicentre, cross-sectional diagnostic accuracy study

Author

Manabe, Yukari C, Betz, Joshua, Jackson, Olivia, Asoala, Victor, Bazan, Isabel, Blair, Paul W, Chang, Aileen, Chusri, Sarunyou, Crump, John A, Edgel, Kimberly A, Faix, Dennis J, Fernandez, Stefan, Fox, Anne T, Garcia, Jose A, Grogl, Max, Hansen, Erin A, Heang, Vireak, House, Stacey L, Jongsakul, Krisada, Kaburise, Michael B, Klungthong, Chonticha, Lamorde, Mohammed, Letizia, Andrew G, Lorenzana, Ivette, Luy, Malen, Maro, Vanance P, Mores, Christopher N, Myers, Christopher A, Oduro, Abraham R, Parham, Leda, Porzucek, Abigail J, Prouty, Michael, Rabiger, David S, Rubach, Matthew P, Siles, Crystyan, Silva, Maria, Ukachu, Chinaka, Waitumbi, John N, Phillips, Cynthia L, and Jones, Brian W

Published
2022
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17. Informing the Need for a SARS-CoV-2 Booster Based on the Immune Responses Among Young Healthy Adults to Variants Circulating in Late 2023.

Author

Nguyen, Huy C, Lal, Kerri G, Balinsky, Corey A, Hontz, Robert D, Lin, Jin, Beye, Matthew J, Smith, Lauren, Pan, Li, Cheng, Ying, Fox, Isabella, Lizewski, Stephen E, Foo, Hayley S, Krebs, Shelly J, Sun, Peifang, and Letizia, Andrew G

Subjects
IMMUNOLOGIC memory, SARS-CoV-2, SARS-CoV-2 Omicron variant, IMMUNE response, ANTIBODY formation
Abstract

Background COVID-19 remains a global public health challenge due to new immune-evasive SARS-CoV-2 variants and heterogeneous immunity. Methods In this cross-sectional study, we evaluated the adaptive immune responses in US active duty personnel who completed a COVID-19 primary vaccine series and had heterogenous SARS-CoV-2 vaccination and infection histories to 3 previously dominant variants (ancestral, Delta, BA.5) and 3 circulating variants (XBB.1.5, EG.5, and BA.2.86) in late 2023. Analyses were based on the most recent exposure in terms of timing (within or beyond 12 months) and type (vaccine or infection). Results Significant reduction was observed in binding antibodies, neutralization antibodies, memory B cells, and CD8+ T cells against circulating variants when compared with previous variants. The reduction in antibody response was more pronounced in those whose most recent exposure was >12 months from enrollment. In contrast, the CD4+ T-cell response was largely consistent across all tested variants. The type of most recent exposure was not a significant factor in determining the magnitude of current immune responses. Conclusions Administration of the XBB.1.5-based booster is likely to enhance cross-reactive humoral responses against SARS-CoV-2 circulating lineages. Ongoing surveillance of immune responses to emerging variants is needed for informing vaccine composition and timing. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Dry Swabs and Dried Saliva as Alternative Samples for SARS-CoV-2 Detection in Remote Areas in Lao PDR.

Author

Sibounheuang, Bountoy, Boutthasavong, Latsaniphone, Chommanam, Danoy, Phommasone, Koukeo, Panapruksachat, Siribun, Praphasiri, Viladeth, Bouttavong, Sengvong, Sisavath, Hongkham, Christy, Nathaniel C V, Letizia, Andrew G, Mayxay, Mayfong, Vongsouvath, Manivanh, Ashley, Elizabeth A, and Dubot-Pérès, Audrey

Subjects
RESOURCE-limited settings, SARS-CoV-2 Omicron variant, SARS-CoV-2, FILTER paper, RAPID tooling
Abstract

Background Surveillance of SARS-CoV-2 circulation is mainly based on real-time reverse transcription–polymerase chain reaction, which requires laboratory facilities and cold chain for sample transportation. This is difficult to achieve in remote rural areas of resource-limited settings. The use of dried blood spots shipped at room temperature has shown good efficiency for the detection of arboviral RNA. Using a similar approach, we conducted a study at 3 provincial hospitals in Laos to compare the detection of SARS-CoV-2 from neat and dried spot samples. Methods Between January 2022 and March 2023, patients with respiratory symptoms were recruited. Nasopharyngeal/oropharyngeal swabs in virus transport medium (VTM), dry swabs, saliva, and dried saliva spotted on filter paper were collected. All samples were tested by SARS-CoV-2 real-time reverse transcription–polymerase chain reaction. Results In total, 479 participants were included. The VTM samples tested positive for 288 (60.1%). High positive percent agreements were observed for dry swab (84.8%; 95% CI, 80.2%–88.8%) and saliva (89.2%; 95% CI, 85.1%–92.6%) as compared with VTM. There was a loss of sensitivity when saliva was dried on filter paper (73.6%; 95% CI, 68.1%–78.6%) as compared with saliva. SARS-CoV-2 variant (Delta or Omicron) had no significant impact on the performance of the different sample types. Conclusions Our findings suggest that dry swabs could be a good alternative for sample collection and permit easy shipping at ambient temperature for subsequent viral SARS-CoV-2 RNA purification and molecular investigation. This is a useful tool to consider for a rapid implementation of large-scale surveillance of SARS-CoV-2 in remote areas, which could be extrapolated to other respiratory targets during routine surveillance or in the case of a novel emerging pandemic. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Clinical Presentation, Risk Factors, and Comparison of Laboratory Diagnostics for Seasonal Influenza Virus Among Cambodians From 2007 to 2020

Author

Rachmat, Agus, primary, Kelly, Gerard C, additional, Tran, Long Khanh, additional, Christy, Nathaniel, additional, Supaprom, Chonthida, additional, Heang, Vireak, additional, Dul, Sokha, additional, Garcia-Rivera, Jose A, additional, Prom, Satharath, additional, Sopheab, Heng, additional, Brooks, John S, additional, Sutherland, Ian J, additional, Corson, Karen S, additional, and Letizia, Andrew G, additional

Published
2024
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21. SARS-CoV-2 Outbreak Dynamics in an Isolated US Military Recruit Training Center With Rigorous Prevention Measures

Author

Lizewski, Rhonda A., Sealfon, Rachel S. G., Park, Sang Woo, Smith, Gregory R., Porter, Chad K., Gonzalez-Reiche, Ana S., Ge, Yongchao, Miller, Clare M., Goforth, Carl W., Pincas, Hanna, Termini, Michael S., Ramos, Irene, Nair, Venugopalan D., Lizewski, Stephen E., Alshammary, Hala, Cer, Regina Z., Chen, Hua Wei, George, Mary-Catherine, Arnold, Catherine E., Glang, Lindsay A., Long, Kyle A., Malagon, Francisco, Marayag, Jan J., Nunez, Edgar, Rice, Gregory K., Santa Ana, Ernesto, Schilling, Megan A., Smith, Darci R., Sugiharto, Victor A., Sun, Peifang, van de Guchte, Adriana, Khan, Zenab, Dutta, Jayeeta, Vangeti, Sindhu, Voegtly, Logan J., Weir, Dawn L., Metcalf, C. Jessica E., Troyanskaya, Olga G., Bishop-Lilly, Kimberly A., Grenfell, Bryan T., van Bakel, Harm, Letizia, Andrew G., and Sealfon, Stuart C.

Published
2022
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22. SARS-CoV-2 seropositivity and subsequent infection risk in healthy young adults: a prospective cohort study

Author

Letizia, Andrew G, Ge, Yongchao, Vangeti, Sindhu, Goforth, Carl, Weir, Dawn L, Kuzmina, Natalia A, Balinsky, Corey A, Chen, Hua Wei, Ewing, Dan, Soares-Schanoski, Alessandra, George, Mary-Catherine, Graham, William D, Jones, Franca, Bharaj, Preeti, Lizewski, Rhonda A, Lizewski, Stephen E, Marayag, Jan, Marjanovic, Nada, Miller, Clare M, Mofsowitz, Sagie, Nair, Venugopalan D, Nunez, Edgar, Parent, Danielle M, Porter, Chad K, Santa Ana, Ernesto, Schilling, Megan, Stadlbauer, Daniel, Sugiharto, Victor A, Termini, Michael, Sun, Peifang, Tracy, Russell P, Krammer, Florian, Bukreyev, Alexander, Ramos, Irene, and Sealfon, Stuart C

Published
2021
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23. Chikungunya viruses containing the A226V mutation detected retrospectively in Cameroon form a new geographical subclade

Author

Agbodzi, Bright, Yousseu, Francine Berlange Sado, Simo, Fredy Brice Nemg, Kumordjie, Selassie, Yeboah, Clara, Mosore, Mba-Tihssommah, Bentil, Ronald E., Prieto, Karla, Colston, Sophie M., Attram, Naiki, Nimo-Paintsil, Shirley, Fox, Anne T., Bonney, Joseph H.K., Ampofo, William, Coatsworth, Heather G., Dinglasan, Rhoel R., Wolfe, David M., Wiley, Michael R., Demanou, Maurice, and Letizia, Andrew G.

Published
2021
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24. SARS-CoV-2 Seropositivity among US Marine Recruits Attending Basic Training, United States, Spring-Fall 2020

Author

Letizia, Andrew G., Ge, Yongchao, Goforth, Carl W., Weir, Dawn L., Lizewski, Rhonda, Lizewski, Stephen, Soares-Schanoski, Alessandra, Vangeti, Sindhu, Marjanovic, Nada, Sealfon, Stuart C., and Ramos, Irene

Subjects
Prevalence studies (Epidemiology), Health
Abstract

Coronavirus disease (COVID-19) cases are increasing in young adults (1). In some instances, prevalence among younger adults exceeds that of older adults (2). Younger adults often have a paucisymptomatic or [...]

Published
2021
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25. First Molecular Identification of Rickettsia aeschlimannii and Rickettsia africae in Ticks from Ghana

Author

Tagoe, Janice A., primary, Addo, Seth O., additional, Mosore, Mba-tihssommah, additional, Bentil, Ronald E., additional, Agbodzi, Bright, additional, Behene, Eric, additional, Ladzekpo, Danielle, additional, Addae, Charlotte A., additional, Nimo-Painstil, Shirley, additional, Fox, Anne T., additional, Bimi, Langbong, additional, Dafeamekpor, Courage, additional, Richards, Allen L., additional, Letizia, Andrew G., additional, Diclaro, Joseph W., additional, and Dadzie, Samuel K., additional

Published
2024
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26. Clinical and Functional Assessment of SARS-CoV-2 Sequelae Among Young Marines

Author

Porter, Chad K., primary, Beckett, Charmagne, additional, Cooper, Elizabeth, additional, White, Lindsey, additional, Wallace, David, additional, Jakubski, Silvia, additional, Boulifard, David, additional, Schilling, Megan, additional, Sun, Peifang, additional, Marayag, Jan, additional, Marrone, Amethyst, additional, Nunez Hernandez, Edgar, additional, Vangeti, Sindhu, additional, Miller, Clare, additional, Ge, Yongchao, additional, Ramos, Irene, additional, Goforth, Carl, additional, Sealfon, Stuart C., additional, and Letizia, Andrew G., additional

Published
2024
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27. Nucleocapsid (NP) with NP-Specific IgG Induce M2b Macrophages (HLA-DRHighCCR7-CD86 ), Which Contribute to the Hyperproduction of IL-10 and L-6, in Severe and Critical COVID‐19 Patients

Author

Kang, Su Yeon, primary, Yoo, Jeong Rae, additional, Heo, Sang Taek, additional, Pack, Yejin, additional, Bae, EunJin, additional, Kim, Yuna, additional, Kim, Sung Hye, additional, Kim, Misun, additional, Kim, Miyeon, additional, Song, Yoon-Jae, additional, Hwang, Daehee, additional, Jung, Jaehun, additional, Lee, Jacob, additional, Kim, Sung-Han, additional, Lee, Kyung-Mi, additional, Letizia, Andrew G., additional, and Lee, Keunhwa, additional

Published
2024
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29. Informing the need for a SARS-CoV-2 booster based upon the immune response among young, healthy adults to variants circulating during late 2023

Author

Nguyen, Huy C., primary, Lal, Kerri G., additional, Balinsky, Corey A., additional, Smith, Lauren, additional, Pan, Li, additional, Cheng, Ying, additional, Fox, Isabella, additional, Hontz, Robert D., additional, Lizewski, Stephen E., additional, Foo, Hayley S., additional, Krebs, Shelly J., additional, Sun, Peifang, additional, and Letizia, Andrew G., additional

Published
2023
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30. Whole genome sequencing of outbreak strains from 2017 to 2018 reveals an endemic clade of dengue 1 virus in Cameroon

Author

Agbodzi, Bright, primary, Sado Yousseu, Francine Berlange, additional, Nemg Simo, Fredy Brice, additional, Kumordjie, Selassie, additional, Yeboah, Clara, additional, Mosore, Mba-Tihssommah, additional, Bentil, Ronald E., additional, Coatsworth, Heather G., additional, Attram, Naiki, additional, Nimo-Paintsil, Shirley, additional, Fox, Anne T., additional, Bonney, Joseph H. K., additional, Ampofo, William, additional, Dinglasan, Rhoel R., additional, Sanders, Terrel, additional, Wiley, Michael R., additional, Demanou, Maurice, additional, and Letizia, Andrew G., additional

Published
2023
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31. Antibodies to S2 domain of SARS-CoV-2 spike protein in Moderna mRNA vaccinated subjects sustain antibody-dependent NK cell-mediated cell cytotoxicity against Omicron BA.1

Author

Balinsky, Corey A., primary, Jiang, Le, additional, Jani, Vihasi, additional, Cheng, Ying, additional, Zhang, Zhiwen, additional, Belinskaya, Tatyana, additional, Qiu, Qi, additional, Long, Tran Khanh, additional, Schilling, Megan A., additional, Jenkins, Sarah A., additional, Corson, Karen S., additional, Martin, Nicholas J., additional, Letizia, Andrew G., additional, Hontz, Robert D., additional, and Sun, Peifang, additional

Published
2023
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32. Coinfection of Malaria and Bacterial Pathogens among Acute Febrile Patients in Selected Clinics in Ghana

Author

Tagoe, Janice N. A., primary, Yeboah, Clara, additional, Behene, Eric, additional, Kumordjie, Selassie, additional, Nimo-Paintsil, Shirley, additional, Attram, Naiki, additional, Nyarko, Edward O., additional, Carroll, John Ayite, additional, Fox, Anne T., additional, Watters, Chaselynn, additional, Koram, Kwadwo, additional, Anang, Abraham Kwabena, additional, Sanders, Terrel, additional, and Letizia, Andrew G., additional

Published
2023
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33. Deep phenotyping of the lipidomic response in COVID‐19 and non‐COVID‐19 sepsis

Author

Meng, Hu, primary, Sengupta, Arjun, additional, Ricciotti, Emanuela, additional, Mrčela, Antonijo, additional, Mathew, Divij, additional, Mazaleuskaya, Liudmila L., additional, Ghosh, Soumita, additional, Brooks, Thomas G., additional, Turner, Alexandra P., additional, Schanoski, Alessa Soares, additional, Lahens, Nicholas F., additional, Tan, Ai Wen, additional, Woolfork, Ashley, additional, Grant, Greg, additional, Susztak, Katalin, additional, Letizia, Andrew G., additional, Sealfon, Stuart C., additional, Wherry, E. John, additional, Laudanski, Krzysztof, additional, Weljie, Aalim M., additional, Meyer, Nuala J., additional, and FitzGerald, Garret A., additional

Published
2023
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34. Prospective Assessment of SARS-CoV-2 Seroconversion (PASS) study: an observational cohort study of SARS-CoV-2 infection and vaccination in healthcare workers

Author

Jackson-Thompson, Belinda M., Goguet, Emilie, Laing, Eric D., Olsen, Cara H., Pollett, Simon, Hollis-Perry, K. Monique, Maiolatesi, Santina E., Illinik, Luca, Ramsey, Kathleen F., Reyes, Anatalio E., Alcorta, Yolanda, Wong, Mimi A., Davies, Julian, Ortega, Orlando, Parmelee, Edward, Lindrose, Alyssa R., Moser, Matthew, Graydon, Elizabeth, Letizia, Andrew G., Duplessis, Christopher A., Ganesan, Anuradha, Pratt, Kathleen P., Malloy, Allison M., Scott, David W., Anderson, Stephen K., Snow, Andrew L., Dalgard, Clifton L., Powers, III, John H., Tribble, David, Burgess, Timothy H., Broder, Christopher C., and Mitre, Edward

Published
2021
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35. Lassa virus circulating in Liberia: a retrospective genomic characterisation

Author

Wiley, Michael R, Fakoli, Lawrence, Letizia, Andrew G, Welch, Stephen R, Ladner, Jason T, Prieto, Karla, Reyes, Daniel, Espy, Nicole, Chitty, Joseph A, Pratt, Catherine B, Di Paola, Nicholas, Taweh, Fahn, Williams, Desmond, Saindon, Jon, Davis, William G, Patel, Ketan, Holland, Mitchell, Negrón, Daniel, Ströher, Ute, Nichol, Stuart T, Sozhamannan, Shanmuga, Rollin, Pierre E, Dogba, John, Nyenswah, Tolbert, Bolay, Fatorma, Albariño, César G, Fallah, Mosoka, and Palacios, Gustavo

Published
2019
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36. First Whole Genome Sequencing of Crimean–Congo Hemorrhagic Fever Virus (CCHFV) in Tick Species within Ghana

Author

Bentil, Ronald Essah, primary, Addo, Seth Offei, additional, Mosore, Mba-tihssommah, additional, Kumordjie, Selassie, additional, Yeboah, Clara, additional, Agbodzi, Bright, additional, Behene, Eric, additional, Tagoe, Janice, additional, Baako, Bernice Olivia Ama, additional, Asoala, Victor, additional, Ampadu, Richard Osei, additional, Mingle, Daniel Lartei, additional, Nyarko, Edward O., additional, Fox, Anne T., additional, Letizia, Andrew G., additional, Diclaro, Joseph William, additional, Sanders, Terrel, additional, Oduro, Daniel, additional, Nimo-Paintsil, Shirley C., additional, Harwood, James, additional, and Dadzie, Samuel Kweku, additional

Published
2023
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37. Whole genome analysis and antimicrobial resistance of Neisseria gonorrhoeae isolates from Ghana

Author

Agbodzi, Bright, primary, Duodu, Samuel, additional, Dela, Helena, additional, Kumordjie, Selassie, additional, Yeboah, Clara, additional, Behene, Eric, additional, Ocansey, Karen, additional, Yanney, Jennifer N., additional, Boateng-Sarfo, George, additional, Kwofie, Samuel Kojo, additional, Egyir, Beverly, additional, Colston, Sophie M., additional, Miranda, Hugo V., additional, Watters, Chaselynn, additional, Sanders, Terrel, additional, Fox, Anne T., additional, Letizia, Andrew G., additional, Wiley, Michael R., additional, and Attram, Naiki, additional

Published
2023
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38. Antibodies to S2 domain of SARS-CoV-2 spike protein in Moderna mRNA vaccinated subjects sustain antibodydependent NK cell-mediated cell cytotoxicity against Omicron BA.1.

Author

Balinsky, Corey A., Jiang, Le, Jani, Vihasi, Cheng, Ying, Zhang, Zhiwen, Belinskaya, Tatyana, Qiu, Qi, Long, Tran Khanh, Schilling, Megan A., Jenkins, Sarah A., Corson, Karen S., Martin, Nicholas J., Letizia, Andrew G., Hontz, Robert D., and Sun, Peifang

Subjects
SARS-CoV-2 Omicron variant, KILLER cells, CELL-mediated cytotoxicity, ANTIBODY-dependent cell cytotoxicity, SARS-CoV-2, BACTERIAL vaccines, BCG vaccines
Abstract

Vaccination with the primary two-dose series of SARS-CoV-2 mRNA protects against infection with the ancestral strain, and limits the presentation of severe disease after re-infection by multiple variants of concern (VOC), including Omicron, despite the lack of a strong neutralizing response to these variants. We compared antibody responses in serum samples collected from mRNA-1273 (Moderna) vaccinated subjects to identify mechanisms of immune escape and cross-protection. Using pseudovirus constructs containing domain-specific amino acid changes representative of Omicron BA.1, combined with domain competition and RBD-antibody depletion, we showed that RBD antibodies were primarily responsible for virus neutralization and variant escape. Antibodies to NTD played a less significant role in antibody neutralization but acted along with RBD to enhance neutralization. S2 of Omicron BA.1 had no impact on neutralization escape, suggesting it is a less critical domain for antibody neutralization; however, it was as capable as S1 at eliciting IgG3 responses and NK-cell mediated, antibody-dependent cell cytotoxicity (ADCC). Antibody neutralization and ADCC activities to RBD, NTD, and S1 were all prone to BA.1 escape. In contrast, ADCC activities to S2 resisted BA.1 escape. In conclusion, S2 antibodies showed potent ADCC function and resisted Omicron BA.1 escape, suggesting that S2 contributes to cross-protection against Omicron BA.1. In line with its conserved nature, S2 may hold promise as a vaccine target against future variants of SARS-CoV-2. [ABSTRACT FROM AUTHOR]

Published
2023
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39. Deep Phenotyping of the Lipidomic Response in COVID and non-COVID Sepsis

Author

Meng, Hu, Sengupta, Arjun, Ricciotti, Emanuela, Mrčela, Antonijo, Mathew, Divij, Mazaleuskaya, Liudmila L., Ghosh, Soumita, Brooks, Thomas G., Turner, Alexandra P., Schanoski, Alessa Soares, Lahens, Nicholas F., Tan, Ai Wen, Woolfork, Ashley, Grant, Greg, Susztak, Katalin, Letizia, Andrew G., Sealfon, Stuart C., Wherry, E. John, Laudanski, Krzysztof, Weljie, Aalim M., Meyer, Nuala B., and FitzGerald, Garret A.

Subjects
Article
Abstract

Lipids may influence cellular penetrance by pathogens and the immune response that they evoke. Here we find a broad based lipidomic storm driven predominantly by secretory (s) phospholipase A (2) (sPLA (2) ) dependent eicosanoid production occurs in patients with sepsis of viral and bacterial origin and relates to disease severity in COVID-19. Elevations in the cyclooxygenase (COX) products of arachidonic acid (AA), PGD (2) and PGI (2) , and the AA lipoxygenase (LOX) product, 12-HETE, and a reduction in the high abundance lipids, ChoE 18:3, LPC-O-16:0 and PC-O-30:0 exhibit relative specificity for COVID-19 amongst such patients, correlate with the inflammatory response and link to disease severity. Linoleic acid (LA) binds directly to SARS-CoV-2 and both LA and its di-HOME products reflect disease severity in COVID-19. AA and LA metabolites and LPC-O-16:0 linked variably to the immune response. These studies yield prognostic biomarkers and therapeutic targets for patients with sepsis, including COVID-19. An interactive purpose built interactive network analysis tool was developed, allowing the community to interrogate connections across these multiomic data and generate novel hypotheses.

Published
2023

40. Etiology and risk factors for diarrheal disease amongst rural and peri-urban populations in Cambodia, 2012–2018

Author

Kelly, Gerard C., primary, Rachmat, Agus, additional, Hontz, Robert D., additional, Sklar, Marvin J., additional, Tran, Long Khanh, additional, Supaprom, Chonthida, additional, Luy, Malen, additional, Lina, Sin, additional, Gregory, Michael J., additional, Sopheab, Heng, additional, Brooks, John S., additional, Sutherland, Ian W., additional, Corson, Karen S., additional, and Letizia, Andrew G., additional

Published
2023
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41. Antibody Responses to the SARS-CoV-2 Ancestral Strain and Omicron Variants in Moderna mRNA-1273 Vaccinated Active-Duty U.S. Navy Sailors and Marines

Author

Sun, Peifang, primary, Balinsky, Corey A, additional, Jiang, Le, additional, Jani, Vihasi, additional, Long, Tran Khanh, additional, Cheng, Ying, additional, Serote, Mary Ann, additional, Smith, Andrew B, additional, Fears, Burnetta F, additional, Gatrell, Stephanie K, additional, Sugiharto, Victor, additional, Chen, Huawei, additional, Zhang, Zhiwen, additional, Belinskaya, Tatyana, additional, Qiu, Qi, additional, Graham, William D, additional, Schilling, Megan A, additional, Jones, Anthony R, additional, Corson, Karen S, additional, Martin, Nicholas J, additional, Letizia, Andrew G, additional, and Hontz, Robert D, additional

Published
2023
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42. Blood RNA alternative splicing events as diagnostic biomarkers for infectious disease

Author

Zhang, Zijun, primary, Sauerwald, Natalie, additional, Cappuccio, Antonio, additional, Ramos, Irene, additional, Nair, Venugopalan D., additional, Nudelman, German, additional, Zaslavsky, Elena, additional, Ge, Yongchao, additional, Gaitas, Angelo, additional, Ren, Hui, additional, Brockman, Joel, additional, Geis, Jennifer, additional, Ramalingam, Naveen, additional, King, David, additional, McClain, Micah T., additional, Woods, Christopher W., additional, Henao, Ricardo, additional, Burke, Thomas W., additional, Tsalik, Ephraim L., additional, Goforth, Carl W., additional, Lizewski, Rhonda A., additional, Lizewski, Stephen E., additional, Weir, Dawn L., additional, Letizia, Andrew G., additional, Sealfon, Stuart C., additional, and Troyanskaya, Olga G., additional

Published
2023
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43. A Preliminary Study to Compare Recombinase Polymerase Amplification-Lateral Flow and Quantitative PCR in the Detection of Cutaneous Leishmania in Communities from the Volta Region of Ghana

Author

Yeboah, Clara, primary, Mosore, Mba-Tihssommah, additional, Attram, Naiki, additional, Shelite, Thomas R., additional, Akuffo, Richard A., additional, Addo, Seth O., additional, Behene, Eric, additional, Agbodzi, Bright, additional, Bentil, Ronald E., additional, Fox, Anne T., additional, Wilson, Michael, additional, Boakye, Daniel, additional, Letizia, Andrew G., additional, Melby, Peter C., additional, and Travi, Bruno L., additional

Published
2023
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44. Clinical Manifestations of COVID-19 are Driven by High Levels of Anti-Nucleocapsid Igg, Il-10, Il-6, and Ifn-Γ and Low Levels of Nucleocapsid and Tgf-Β

Author

Lee, Keunhwa, primary, Yoo, Jeong Rae, additional, Kang, Su Yeon, additional, Heo, Sang Taek, additional, Bae, EunJin, additional, Kim, Yuna, additional, Kim, Sung Hye, additional, Kim, Misun, additional, Kim, Miyeon, additional, Song, Yoon-Jae, additional, Hwang, Daehee, additional, Lee, Kyung-Mi, additional, Kim, Sung-Han, additional, and Letizia, Andrew G., additional

Published
2023
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45. Bartonella Species in Cambodia, Ghana, Laos, and Peru: Results from Vector and Serosurveys

Author

Mullins, Kristin, primary, Canal, Enrique, additional, Ouch, Pidor, additional, Prasetyo, Didot, additional, Tagoe, Janice, additional, Attram, Naiki, additional, Yeboah, Clara, additional, Kumordjie, Selassi, additional, Fox, Anne, additional, Letizia, Andrew G., additional, Rachlin, Audrey, additional, Nguyen, Hung Manh, additional, Robinson, Matthew T., additional, Vongsouvath, Manivanh, additional, Davong, Viengmon, additional, Maxay, Mayfong, additional, Simons, Mark P., additional, Caranci, Angela, additional, Newton, Paul N., additional, Richards, Allen L., additional, and Farris, Christina M., additional

Published
2023
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46. Serum Fc-Mediated Monocyte Phagocytosis Activity Is Stable for Several Months after SARS-CoV-2 Asymptomatic and Mildly Symptomatic Infection

Author

Vangeti, Sindhu, primary, Periasamy, Sivakumar, additional, Sun, Peifang, additional, Balinsky, Corey A., additional, Mahajan, Avinash S., additional, Kuzmina, Natalia A., additional, Soares-Schanoski, Alessandra, additional, Cooper, Elizabeth, additional, Beckett, Charmagne, additional, Marayag, Jan, additional, Marrone, Amethyst, additional, Nunez, Edgar, additional, Ge, Yongchao, additional, Porter, Chad K., additional, Goforth, Carl W., additional, Lizewski, Stephen E., additional, Lizewski, Rhonda, additional, Jani, Vihasi, additional, Sugiharto, Victor A., additional, Schilling, Megan, additional, Yu, Xuechen B., additional, Marjanovic, Nada, additional, George, Mary Catherine, additional, Bukreyev, Alexander, additional, Sealfon, Stuart C., additional, Letizia, Andrew G., additional, and Ramos, Irene, additional

Published
2022
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47. Mapping disease regulatory circuits at cell-type resolution from single-cell multiomics data

Author

Chen, Xi, primary, Wang, Yuan, additional, Cappuccio, Antonio, additional, Cheng, Wan-Sze, additional, Zamojski, Frederique Ruf, additional, Nair, Venugopalan, additional, Miller, Clare M, additional, Rubenstein, Aliza, additional, Nudelman, German, additional, Tadych, Alicja, additional, Theesfield, Chandra, additional, Vornholt, Alexandria, additional, George, Mary-Catherine, additional, Ruffin, Felicia, additional, Dagher, Michael, additional, Chawla, Daniel, additional, Soares-Schanoski, Alessandra, additional, Spurbeck, Rachel R., additional, Ndhlovu, Lishomwa C., additional, Sebra, Robert, additional, Kleinstein, Steven, additional, Letizia, Andrew G., additional, Ramos, Irene, additional, Fowler, Vance G., additional, Woods, Christopher W., additional, Zaslavsky, Elena, additional, Troyanskaya, Olga G., additional, and Sealfon, Stuart C., additional

Published
2022
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48. Pre-infection antiviral innate immunity contributes to sex differences in SARS-CoV-2 infection

Author

Sauerwald, Natalie, primary, Zhang, Zijun, additional, Ramos, Irene, additional, Nair, Venugopalan D., additional, Soares-Schanoski, Alessandra, additional, Ge, Yongchao, additional, Mao, Weiguang, additional, Alshammary, Hala, additional, Gonzalez-Reiche, Ana S., additional, van de Guchte, Adriana, additional, Goforth, Carl W., additional, Lizewski, Rhonda A., additional, Lizewski, Stephen E., additional, Amper, Mary Anne S., additional, Vasoya, Mital, additional, Seenarine, Nitish, additional, Guevara, Kristy, additional, Marjanovic, Nada, additional, Miller, Clare M., additional, Nudelman, German, additional, Schilling, Megan A., additional, Sealfon, Rachel S.G., additional, Termini, Michael S., additional, Vangeti, Sindhu, additional, Weir, Dawn L., additional, Zaslavsky, Elena, additional, Chikina, Maria, additional, Wu, Ying Nian, additional, Van Bakel, Harm, additional, Letizia, Andrew G., additional, Sealfon, Stuart C., additional, and Troyanskaya, Olga G., additional

Published
2022
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49. Additional file 1 of Clinical and epidemiologic evaluation of a 2020 chikungunya outbreak in Cambodia

Author

Rachmat, Agus, Kelly, Gerard C., Hontz, Robert D., Supaprom, Chonthida, Heang, Vireak, Hip, Phireak, Garcia-Rivera, Jose A., Prom, Satharath, Chhea, Chhorvann, Sutherland, Ian W., Corson, Karen S., and Letizia, Andrew G.

Abstract

Additional file 1. Summary data of CHIKV laboratory testing results and analysis of symptoms observed as proportions of CHIKV positive and CHIKV negative study subjects. Further data summarizing CHIKV laboratory testing results and analysis of symptoms observed as proportions of CHIKV positive and CHIKV negative study subjects.

Published
2023
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50. Molecular characterization of haemagglutinin genes of influenza B viruses circulating in Ghana during 2016 and 2017

Author

Yakubu, Alhassan Mohammed, primary, Aryee, Nii Ayite, additional, Bonney, Evelyn Yayra, additional, Kotey, Erasmus Nikoi, additional, Bonney, Joseph Humphrey Kofi, additional, Wiley, Michael R., additional, Pratt, Catherine B., additional, Ababio, Grace Korkor, additional, Nimo-Paintsil, Shieley, additional, Puplampu, Naiki, additional, Attoh, Seth, additional, Fatchu, Raymond D., additional, Nyarko, Edward Owusu, additional, Fox, Anne, additional, Watters, Chaselynn M., additional, Sanders, Terrel, additional, Letizia, Andrew G., additional, and Ampofo, William Kwabena, additional

Published
2022
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