1. A Rapidly Developing Nodule in a Patient With Hairy Cell Leukemia in Remission: Merkel Cell Carcinoma: A Case Report.
- Author
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Sachanas S, Stefanaki C, Marinos L, Yiakoumis X, Moschogiannis M, Koulieris E, Efstathopoulou M, and Pangalis GA
- Subjects
- Humans, Male, Skin Neoplasms pathology, Skin Neoplasms diagnosis, Remission Induction, Aged, Pentostatin therapeutic use, Biopsy, Leukemia, Hairy Cell pathology, Leukemia, Hairy Cell drug therapy, Leukemia, Hairy Cell diagnosis, Carcinoma, Merkel Cell pathology, Carcinoma, Merkel Cell diagnosis
- Abstract
Background/aim: Hairy cell leukemia (HCL) is a well-known lymphoproliferative disease with very effective treatment approaches primarily relying on purine analogues. However, these treatments are associated with profound and prolonged immunosuppression. Merkel cell carcinoma (MCC) is a rare and extremely aggressive skin tumor with an increased incidence in immunocompromised patients., Case Report: We report a case of a patient with HCL who was diagnosed with MCC, while in remission following retreatment with pentostatin, which induced a profound decrease in CD4 (+) T-cells., Conclusion: Our case provides further evidence supporting the hypothesis of a significant association between immunosuppression and MCC pathogenesis., (Copyright © 2024, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
- Published
- 2024
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