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Your search keyword '"Leung, Peter C. K."' showing total 944 results
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944 results on '"Leung, Peter C. K."'

10. A Lancet Commission on 70 years of women's reproductive, maternal, newborn, child, and adolescent health in China

Author

Qiao, Jie, Wang, Yuanyuan, Li, Xiaohong, Jiang, Fan, Zhang, Yunting, Ma, Jun, Song, Yi, Ma, Jing, Fu, Wei, Pang, Ruyan, Zhu, Zhaofang, Zhang, Jun, Qian, Xu, Wang, Linhong, Wu, Jiuling, Chang, Hsun-Ming, Leung, Peter C K, Mao, Meng, Ma, Duan, Guo, Yan, Qiu, Jie, Liu, Li, Wang, Haidong, Norman, Robert J, Lawn, Joy, Black, Robert E, Ronsmans, Carine, Patton, George, Zhu, Jun, Song, Li, and Hesketh, Therese

Published
2021
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11. Roles of bone morphogenetic proteins in endometrial remodeling during the human menstrual cycle and pregnancy.

Author

Wei, Daimin, Su, Yaxin, Leung, Peter C K, Li, Yan, and Chen, Zi-Jiang

Subjects
BONE morphogenetic proteins, MENSTRUAL cycle, PREGNANCY proteins, PREGNANCY complications, METRORRHAGIA, PREGNANCY, TECHNOLOGICAL innovations, TROPHOBLAST
Abstract

BACKGROUND During the human menstrual cycle and pregnancy, the endometrium undergoes a series of dynamic remodeling processes to adapt to physiological changes. Insufficient endometrial remodeling, characterized by inadequate endometrial proliferation, decidualization and spiral artery remodeling, is associated with infertility, endometriosis, dysfunctional uterine bleeding, and pregnancy-related complications such as preeclampsia and miscarriage. Bone morphogenetic proteins (BMPs), a subset of the transforming growth factor-β (TGF-β) superfamily, are multifunctional cytokines that regulate diverse cellular activities, such as differentiation, proliferation, apoptosis, and extracellular matrix synthesis, are now understood as integral to multiple reproductive processes in women. Investigations using human biological samples have shown that BMPs are essential for regulating human endometrial remodeling processes, including endometrial proliferation and decidualization. OBJECTIVE AND RATIONALE This review summarizes our current knowledge on the known pathophysiological roles of BMPs and their underlying molecular mechanisms in regulating human endometrial proliferation and decidualization, with the goal of promoting the development of innovative strategies for diagnosing, treating and preventing infertility and adverse pregnancy complications associated with dysregulated human endometrial remodeling. SEARCH METHODS A literature search for original articles published up to June 2023 was conducted in the PubMed, MEDLINE, and Google Scholar databases, identifying studies on the roles of BMPs in endometrial remodeling during the human menstrual cycle and pregnancy. Articles identified were restricted to English language full-text papers. OUTCOMES BMP ligands and receptors and their transduction molecules are expressed in the endometrium and at the maternal–fetal interface. Along with emerging technologies such as tissue microarrays, 3D organoid cultures and advanced single-cell transcriptomics, and given the clinical availability of recombinant human proteins and ongoing pharmaceutical development, it is now clear that BMPs exert multiple roles in regulating human endometrial remodeling and that these biomolecules (and their receptors) can be targeted for diagnostic and therapeutic purposes. Moreover, dysregulation of these ligands, their receptors, or signaling determinants can impact endometrial remodeling, contributing to infertility or pregnancy-related complications (e.g. preeclampsia and miscarriage). WIDER IMPLICATIONS Although further clinical trials are needed, recent advancements in the development of recombinant BMP ligands, synthetic BMP inhibitors, receptor antagonists, BMP ligand sequestration tools, and gene therapies have underscored the BMPs as candidate diagnostic biomarkers and positioned the BMP signaling pathway as a promising therapeutic target for addressing infertility and pregnancy complications related to dysregulated human endometrial remodeling. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Maternal high-fat-diet exposure is associated with elevated blood pressure and sustained increased leptin levels through epigenetic memory in offspring

Author

Lin, Xian-Hua, Gao, Ling, Tian, Shen, Klausen, Christian, Guo, Meng-Xi, Gao, Qian, Liu, Miao-E., Wang, Hui, Wu, Dan-Dan, Zhou, Cheng-Liang, Yang, Jing, Meng, Ye, Liu, Ye, Xu, Gu-Feng, Tan, Ya-Jing, Ullah, Kamran, Zhu, Yi-Min, Fraser, William D., Sheng, Jian-Zhong, Leung, Peter C. K., Muglia, Louis J., Wu, Yan-Ting, and Huang, He-Feng

Published
2021
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23. Primary specification of blastocyst trophectoderm by scRNA-seq: New insights into embryo implantation

Author

Liu, Dandan, primary, Chen, Yidong, additional, Ren, Yixin, additional, Yuan, Peng, additional, Wang, Nan, additional, Liu, Qiang, additional, Yang, Cen, additional, Yan, Zhiqiang, additional, Yang, Ming, additional, Wang, Jing, additional, Lian, Ying, additional, Yan, Jie, additional, Zhai, Fan, additional, Nie, Yanli, additional, Zhu, Xiaohui, additional, Chen, Yuan, additional, Li, Rong, additional, Chang, Hsun-Ming, additional, Leung, Peter C. K., additional, Qiao, Jie, additional, and Yan, Liying, additional

Published
2022
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36. Dysregulated BMP2 in the Placenta May Contribute to Early-Onset Preeclampsia by Regulating Human Trophoblast Expression of Extracellular Matrix and Adhesion Molecules

Author

Yi, Yuyin, Zhu, Hua, Klausen, Christian, Chang, Hsun-Ming, Inkster, Amy M., Terry, Jefferson, and Leung, Peter C. K.

Subjects
early-onset preeclampsia, 0303 health sciences, animal structures, QH301-705.5, fungi, mRNA-seq, BMP2 (bone morphogenetic protein 2), Cell Biology, trophoblast, Cell and Developmental Biology, 03 medical and health sciences, 0302 clinical medicine, embryonic structures, AMIGO, Biology (General), reproductive and urinary physiology, 030217 neurology & neurosurgery, Original Research, TGF-β superfamily, 030304 developmental biology, Developmental Biology
Abstract

Many pregnancy disorders, including early-onset preeclampsia (EOPE), are associated with defects in placental trophoblast cell invasion and differentiation during early placental development. Bone morphogenetic protein 2 (BMP2) belongs to the TGF-β superfamily and controls various physiological and developmental processes. However, the expression of BMP2 in the placenta and underlying molecular mechanisms of how BMP2 regulates trophoblast function remain unclear. In this study, we analyzed several publicly available microarray and RNA-seq datasets and revealed differences in expression of TGF-β superfamily members between gestational age-matched non-preeclamptic control and EOPE placentas. Importantly, BMP2 levels were significantly reduced in EOPE placentas compared with controls, and RNAscope in situ hybridization further demonstrated BMP2 expression was disrupted in EOPE placental villi. To explore the molecular mechanisms of BMP2-regulated early trophoblast differentiation, we examined BMP2 expression in first-trimester human placenta and found it to be localized to all subtypes of trophoblasts and the decidua. RNA-seq analysis on control and BMP2-treated primary human trophoblast cells identified 431 differentially expressed genes, including several canonical TGF-β/BMP signaling targets (BAMBI, ID1, INHBA, IGFBP3). Gene ontology annotations revealed that differentially expressed genes were involved in cell adhesion and extracellular matrix organization. Furthermore, we identified adhesion molecule with IgG-like domain 2 (AMIGO2) as a novel target for BMP2 that contributed to BMP2-induced trophoblast invasion and endothelial-like tube formation. Overall, our findings provide insight into the molecular processes controlled by BMP2 during early placental development that may contribute to the pathogenesis of EOPE.

Published
2021

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