224 results on '"Leveque, Vincent"'
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2. NTP-mediated nucleotide excision activity of hepatitis C virus RNA-dependent RNA polymerase
3. Redox properties of human manganese superoxide dismutase and active-site mutants
4. 2′- and 4′-Modified Ribonucleoside Analogs Can Inhibit All Four Serotypes of Dengue Virus in Human Primary Dendritic Cells as Competitive Inhibitors and Non-obligatory Chain Terminators: 29
5. Multiple replacements of glutamine 143 in human manganese superoxide dismutase: effects on structure, stability, and catalysis
6. The Requirement of HCV NS3 Oligomerization for RNA Helicase Activity is RNA Substrate Dependent: 15
7. Information Security
8. Role of tryptophan 161 in catalysis by human manganese superoxide dismutase
9. 2′-Deoxy-nucleoside Analogs can be Potent Dual Inhibitors of HCV and HIV Replication with Selectivity against Human Polymerases: 16
10. HCV RNA Helicase Requirement for NS3 Oligomerization is Substrate-dependent: Characterization of RNA Substrates with Different Double Strand Lengths and RNA Binding-dependent Inhibition: 19
11. Different Incorporation Efficiencies for Nucleotide Analogs During HCV Polymerase RNA Synthesis Initiation and Elongation Phases: 18
12. Design and Characterization of R1626, A Prodrug of the HCV Replication Inhibitor R1479 (4′-Azidocytidine) With Enhanced Oral Bioavailability: 21
13. Novel 4′-Azido-2′-Deoxy-Nucleoside Analogs are Potent Inhibitors of NS5B-Dependent HCV Replication: 22
14. Characterization of the Intracellular Metabolism of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methyl-Cytidine and the Inhibition of HCV Polymerase NS5B by its 5′-Triphosphate Species: 23
15. R1479 is a Highly Selective Inhibitor of NS5B-dependent HCV Replication and Does Not Inhibit Human DNA and RNA Polymerases: 24
16. Synthesis and Anti-HCV Activity of 4′-Substituted Ribonucleosides: 22
17. How to find a consultant
18. High-Throughput and Sensitive Quantification of Circulating Tumor DNA by Microfluidic-Based Multiplex PCR and Next-Generation Sequencing
19. Abstract 2740: High-throughput and sensitive quantification of circulating tumor DNA
20. OA20.01 Tumor Mutation Burden (TMB) is Associated with Improved Efficacy of Atezolizumab in 1L and 2L+ NSCLC Patients
21. Atezolizumab in combination with bevacizumab enhances antigen-specific T-cell migration in metastatic renal cell carcinoma
22. Abstract 2651: Clinical activity and immune correlates from a phase Ib study evaluating atezolizumab (anti-PDL1) in combination with FOLFOX and bevacizumab (anti-VEGF) in metastatic colorectal carcinoma
23. Abstract A017: PD-L1 as a predictive biomarker for atezolizumab (MPDL3280A; anti-PDL1) in non-small cell lung cancer (NSCLC)
24. Abstract POSTER-THER-1441: Biomarker evaluation of phase 1 clinical trials of antibody-drug conjugates (ADCs) in platinum resistant ovarian cancer
25. Cyclic amide bioisosterism: Strategic application to the design and synthesis of HCV NS5B polymerase inhibitors
26. Non-nucleoside inhibitors of HCV polymerase NS5B. Part 4: Structure-based design, synthesis, and biological evaluation of benzo[d]isothiazole-1,1-dioxides
27. Non-nucleoside inhibitors of HCV polymerase NS5B. Part 3: Synthesis and optimization studies of benzothiazine-substituted tetramic acids
28. Non-nucleoside inhibitors of HCV polymerase NS5B. Part 2: Synthesis and structure–activity relationships of benzothiazine-substituted quinolinediones
29. Non-nucleoside inhibitors of HCV NS5B polymerase. Part 1: Synthetic and computational exploration of the binding modes of benzothiadiazine and 1,4-benzothiazine HCV NS5b polymerase inhibitors
30. 3-Hydroxyisoquinolines as inhibitors of HCV NS5b RNA-dependent RNA polymerase
31. Discovery of N-[4-[6-tert-Butyl-5-methoxy-8-(6-methoxy-2-oxo-1H-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a Potent Inhibitor of the Hepatitis C Virus NS5B Polymerase
32. Discovery of a Novel Series of Potent Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B
33. De Novo Fragment Design: A Medicinal Chemistry Approach to Fragment-Based Lead Generation
34. Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors
35. Assembly, Purification, and Pre-steady-state Kinetic Analysis of Active RNA-dependent RNA Polymerase Elongation Complex
36. The hepatitis C virus NS5A inhibitor (BMS-790052) alters the subcellular localization of the NS5A non-structural viral protein
37. Assembly and Pre‐steady‐state Kinetic Analysis of the Hepatitis C Virus RNA Polymerase Elongation Complex
38. Slow Binding Inhibition and Mechanism of Resistance of Non-nucleoside Polymerase Inhibitors of Hepatitis C Virus
39. Silibinin (Legalon-SIL) Inhibits HCV Replication In Vitro
40. The Design, Synthesis, and Antiviral Activity of Monofluoro and Difluoro Analogues of 4′-Azidocytidine against Hepatitis C Virus Replication: The Discovery of 4′-Azido-2′-deoxy-2′-fluorocytidine and 4′-Azido-2′-dideoxy-2′,2′-difluorocytidine
41. Design, synthesis, and antiviral properties of 4′-substituted ribonucleosides as inhibitors of hepatitis C virus replication: The discovery of R1479
42. The Design, Synthesis, and Antiviral Activity of 4′-Azidocytidine Analogues against Hepatitis C Virus Replication: The Discovery of 4′-Azidoarabinocytidine
43. Selected Replicon Variants with Low-Level In Vitro Resistance to the Hepatitis C Virus NS5B Polymerase Inhibitor PSI-6130 Lack Cross-Resistance with R1479
44. 2′-Deoxy-4′-azido Nucleoside Analogs Are Highly Potent Inhibitors of Hepatitis C Virus Replication Despite the Lack of 2′-α-Hydroxyl Groups
45. Characterization of the Metabolic Activation of Hepatitis C Virus Nucleoside Inhibitor β-d-2′-Deoxy-2′-fluoro-2′-C-methylcytidine (PSI-6130) and Identification of a Novel Active 5′-Triphosphate Species
46. In vitro selected Con1 subgenomic replicons resistant to 2′-C-Methyl-Cytidine or to R1479 show lack of cross resistance
47. Selection and Characterization of Replicon Variants Dually Resistant to Thumb- and Palm-Binding Nonnucleoside Polymerase Inhibitors of the Hepatitis C Virus
48. Inhibition of native hepatitis C virus replicase by nucleotide and non-nucleoside inhibitors
49. Potent Anti-tumor Effects of an Active Site Mutant of Human Manganese-Superoxide Dismutase
50. Defending against eavesdropping & malicious modifications
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