67,110 results on '"Lewin, A"'
Search Results
2. Field-angle evolution of the superconducting and magnetic phases of UTe$_2$ around the $b$ axis
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Lewin, Sylvia K., Yu, Josephine J., Frank, Corey E., Graf, David, Chen, Patrick, Ran, Sheng, Eo, Yun Suk, Paglione, Johnpierre, Raghu, S., and Butch, Nicholas P.
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Condensed Matter - Superconductivity - Abstract
We experimentally determine the bounds of the magnetic-field-induced superconducting and magnetic phases near the crystalline $b$ axis of uranium ditelluride (UTe$_2$). By measuring the magnetoresistance as a function of rotation angle and field strength in magnetic fields as large as 41.5 T, we have studied these boundaries in three dimensions of magnetic field direction. The phase boundaries in all cases obey crystallographic symmetries and no additional symmetries, evidence against any symmetry-breaking quadrupolar or higher magnetic order. We find that the upper critical field of the zero-field superconducting state is well-described by an anisotropic mass model. In contrast, the angular boundaries of the $b$-axis-oriented field-reentrant superconducting phase are nearly constant as a function of field up to the metamagnetic transition, with anisotropy between the $ab$ and $bc$ planes that is comparable to the angular anisotropy of the metamagnetic transition itself. We discuss the relationship between the observed superconducting boundaries and the underlying $\mathbf{d}$ vector that represents the spin-triplet order parameter. Additionally, we report an unexplained normal-state feature in resistance and track its evolution as a function of field strength and angle., Comment: 17 pages, 16 figures
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- 2024
3. AGN STORM 2: X. The origin of the interband continuum delays in Mrk 817
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Netzer, Hagai, Goad, Michael R., Barth, Aaron J., Cackett, Edward M., Horne, Keith, Hu, Chen, Kara, Erin, Korista, Kirk T., Kriss, Gerard A., Lewin, Collin, Montano, John, Arav, Nahum, Behar, Ehud, Brotherton, Michael S., Chelouche, Doron, de Rosa, Gisella, Bonta, Elena Dalla, Dehghanian, Maryam, Ferland, Gary J., Fian, Carina, Homayouni, Yasaman, Ilic, Dragana, Kaspi, Shai, Kovacevic, Andjelka B., Landt, Hermine, Popovic, Luka C., Storchi-Bergmann, Thaisa, Wang, Jian-Min, and Zaidouni, Fatima
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Astrophysics - Astrophysics of Galaxies - Abstract
The local (z=0.0315) AGN Mrk 817, was monitored over more than 500 days with space-borne and ground-based instruments as part of a large international campaign AGN STORM 2. Here, we present a comprehensive analysis of the broad-band continuum variations using detailed modeling of the broad line region (BLR), several types of disk winds classified by their optical depth, and new numerical simulations. We find that diffuse continuum (DC) emission, with additional contributions from strong and broad emission lines, can explain the continuum lags observed in this source during high and low luminosity phases. Disk illumination by the variable X-ray corona contributes only a small fraction of the observed continuum lags. Our BLR models assume radiation pressure-confined clouds distributed over a distance of 2-122 light days. We present calculated mean-emissivity radii of many emission lines, and DC emission, and suggest a simple, transfer-function-dependent method that ties them to cross-correlation lag determinations. We do not find clear indications for large optical depth winds but identify the signature of lower column density winds. In particular, we associate the shortest observed continuum lags with a combination of tau(1 Ryd) approx. 2 wind and a partly shielded BLR. Even smaller optical depth winds may be associated with X-ray absorption features and with noticeable variations in the width and lags of several high ionization lines like HeII and CIV. Finally, we demonstrate the effect of torus dust emission on the observed lags in the i and z bands., Comment: 23 pages, 18 figures. Corrected typographical error in the title of the paper as it appeared in the Metadata
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- 2024
4. Characterisation of TOI-406 as showcase of the THIRSTEE program: A 2-planet system straddling the M-dwarf density gap
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Lacedelli, G., Pallè, E., Luque, R., Cadieux, C., Murphy, J. M. Akana, Murgas, F., Osorio, M. R. Zapatero, Tabernero, H. M., Collins, K. A., Watkins, C. N., L'Heureux, A., Doyon, R., Jankowski, D., Nowak, G., Artigau, È., Batalha, N. M., Bean, J. L., Bouchy, F., Brady, M., Martins, B. L. Canto, Carleo, I., Cointepas, M., Conti, D. M., Cook, N. J., Crossfield, I. J. M., Hernàndez, J. I. Gonzàlez, Lewin, P., Nari, N., Nielsen, L. D., Orell-Miquel, J., Parc, L., Schwarz, R. P., Srdoc, G., and Van Eylen, V.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
The exoplanet sub-Neptune population currently poses a conundrum. Are small-size planets volatile-rich cores without atmosphere, or are they rocky cores surrounded by H-He envelope? To test the different hypotheses from an observational point of view, a large sample of small-size planets with precise mass and radius measurements is the first necessary step. On top of that, much more information will likely be needed, including atmospheric characterisation and a demographic perspective on their bulk properties. We present the concept and strategy of THIRSTEE, a project which aims at shedding light on the composition of the sub-Neptune population across stellar types by increasing their number and improving the accuracy of bulk density measurements, as well as investigating their atmospheres and performing statistical, demographic analysis. We report the first results of the program, characterising a 2-planet system around the M dwarf TOI-406. We analyse TESS and ground-based photometry, together with ESPRESSO and NIRPS/HARPS RVs to derive the orbital parameters and investigate the internal composition of the 2 planets orbiting TOI-406, which have radii and masses of $R_b = 1.32 \pm 0.12 R_{\oplus}$, $M_b = 2.08_{-0.22}^{+0.23} M_{\oplus}$ and $R_c = 2.08_{-0.15}^{+0.16} R_{\oplus}$, $M_c = 6.57_{-0.90}^{+1.00} M_{\oplus}$, and periods of $3.3$ and $13.2$ days, respectively. Planet b is consistent with an Earth-like composition, while planet c is compatible with multiple internal composition models, including volatile-rich planets without H/He atmospheres. The 2 planets are located in 2 distinct regions in the mass-density diagram, supporting the existence of a density gap among small exoplanets around M dwarfs. With an equilibrium temperature of only 368 K, TOI-406 c stands up as a particularly interesting target for atmospheric characterisation with JWST in the low-temperature regime., Comment: 24 pages, 21 figures. SUBMITTED to A&A
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- 2024
5. AGN STORM 2. VII. A Frequency-resolved Map of the Accretion Disk in Mrk 817: Simultaneous X-ray Reverberation and UVOIR Disk Reprocessing Time Lags
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Lewin, Collin, Kara, Erin, Barth, Aaron J., Cackett, Edward M., De Rosa, Gisella, Homayouni, Yasaman, Horne, Keith, Kriss, Gerard A., Landt, Hermine, Gelbord, Jonathan, Montano, John, Arav, Nahum, Bentz, Misty C., Boizelle, Benjamin D., Bontà, Elena Dalla, Brotherton, Michael S., Dehghanian, Maryam, Ferland, Gary J., Fian, Carina, Goad, Michael R., Santisteban, Juan V. Hernández, Ilić, Dragana, Kaastra, Jelle, Kaspi, Shai, Korista, Kirk T., Kosec, Peter, Kovačević, Andjelka, Mehdipour, Missagh, Miller, Jake A., Netzer, Hagai, Neustadt, Jack M. M., Panagiotou, Christos, Partington, Ethan R., Popović, Luka Č., Sanmartim, David, Vestergaard, Marianne, Ward, Martin J., and Zaidouni, Fatima
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
X-ray reverberation mapping is a powerful technique for probing the innermost accretion disk, whereas continuum reverberation mapping in the UV, optical, and infrared (UVOIR) reveals reprocessing by the rest of the accretion disk and broad-line region (BLR). We present the time lags of Mrk 817 as a function of temporal frequency measured from 14 months of high-cadence monitoring from Swift and ground-based telescopes, in addition to an XMM-Newton observation, as part of the AGN STORM 2 campaign. The XMM-Newton lags reveal the first detection of a soft lag in this source, consistent with reverberation from the innermost accretion flow. These results mark the first simultaneous measurement of X-ray reverberation and UVOIR disk reprocessing lags$\unicode{x2013}$effectively allowing us to map the entire accretion disk surrounding the black hole. Similar to previous continuum reverberation mapping campaigns, the UVOIR time lags arising at low temporal frequencies are longer than those expected from standard disk reprocessing by a factor of 2-3. The lags agree with the anticipated disk reverberation lags when isolating short-timescale variability, namely timescales shorter than the H$\beta$ lag. Modeling the lags requires additional reprocessing constrained at a radius consistent with the BLR size scale inferred from contemporaneous H$\beta$-lag measurements. When we divide the campaign light curves, the UVOIR lags show substantial variations, with longer lags measured when obscuration from an ionized outflow is greatest. We suggest that, when the obscurer is strongest, reprocessing by the BLR elongates the lags most significantly. As the wind weakens, the lags are dominated by shorter accretion disk lags., Comment: 28 pages, 11 figures, 3 tables. Accepted for publication in the Astrophysical Journal
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- 2024
- Full Text
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6. The ground state energy is not always convex in the number of electrons
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Di Marino, Simone, Lewin, Mathieu, and Nenna, Luca
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Mathematical Physics ,Mathematics - Spectral Theory ,Physics - Chemical Physics - Abstract
We provide the first counter-example showing that the ground state energy of electrons in an external Coulomb potential is not always a convex function of the number of electrons. This property had been conjectured to hold for decades and it plays an important role in quantum chemistry. Our counter-example involves an external potential generated by six nuclei of small fractional charges, placed far away from each other. The ground state energy of 3 electrons is proved to be higher than the average of the energies for 2 and 4 electrons. In addition, we show that the nuclei can bind 2 or 4 electrons, but not 3. Although the conjecture remains open for real nuclei (of integer charges), our work sets some doubt on the validity of the energy convexity for general atoms and molecules., Comment: This paper is dedicated to Trygve Helgaker on the occasion of his 70th birthday
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- 2024
7. Developing Culturally Relevant Math and Science Items: Lessons Learned and Student Reactions. Research Report 2023-12
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ACT, Inc., Jeffrey T. Steedle, Cristina Anguiano-Carrasco, Nancy Lewin, and Jill McVey
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For this project, ACT developed math and science items that attempted to represent unique aspects of cultures, raise awareness of social justice issues, promote cultural learning, be authentic and relatable, be comprehensible, and represent people in positive, nonstereotypical ways. Creating culturally relevant items was a new challenge for ACT test developers, and it involved many rounds of review by diverse content experts. The developers learned that creating culturally relevant items is a more demanding process, but they all reported that it was a positive, enriching experience. During focus groups, high school students viewed the culturally relevant items alongside non--culturally relevant items measuring the same skills. The students expressed interest in seeing culturally relevant items on the ACT, and they reported learning about cultures from the items. However, many students expressed concern about the additional time required to answer longer items during a timed high-stakes assessment like the ACT.
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- 2023
8. A Neural Material Point Method for Particle-based Simulations
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Sharabi, Omer Rochman, Lewin, Sacha, and Louppe, Gilles
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Computer Science - Machine Learning - Abstract
Mesh-free Lagrangian methods are widely used for simulating fluids, solids, and their complex interactions due to their ability to handle large deformations and topological changes. These physics simulators, however, require substantial computational resources for accurate simulations. To address these issues, deep learning emulators promise faster and scalable simulations, yet they often remain expensive and difficult to train, limiting their practical use. Inspired by the Material Point Method (MPM), we present NeuralMPM, a neural emulation framework for particle-based simulations. NeuralMPM interpolates Lagrangian particles onto a fixed-size grid, computes updates on grid nodes using image-to-image neural networks, and interpolates back to the particles. Similarly to MPM, NeuralMPM benefits from the regular voxelized representation to simplify the computation of the state dynamics, while avoiding the drawbacks of mesh-based Eulerian methods. We demonstrate the advantages of NeuralMPM on several datasets, including fluid dynamics and fluid-solid interactions. Compared to existing methods, NeuralMPM reduces training times from days to hours, while achieving comparable or superior long-term accuracy, making it a promising approach for practical forward and inverse problems. A project page is available at https://neuralmpm.isach.be
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- 2024
9. BayesFBHborrow: An R Package for Bayesian borrowing for time-to-event data from a flexible baseline hazard
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Axillus, Sophia, Lewin, Alex, and Scott, Darren
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Statistics - Methodology ,Statistics - Applications ,Statistics - Computation - Abstract
There is currently a focus on statistical methods which can use external trial information to help accelerate the discovery, development and delivery of medicine. Bayesian methods facilitate borrowing which is "dynamic" in the sense that the similarity of the data helps to determine how much information is used. We propose a Bayesian semiparameteric model, which allows the baseline hazard to take any form through an ensemble average. We introduce priors to smooth the posterior baseline hazard improving both model estimation and borrowing characteristics. A "lump-and-smear" borrowing prior accounts for non-exchangable historical data and helps reduce the maximum type I error in the presence of prior-data conflict. In this article, we present BayesFBHborrow, an R package, which enables the user to perform Bayesian borrowing with a historical control dataset in a semiparameteric time-to-event model. User-defined hyperparameters smooth an ensemble averaged posterior baseline hazard. The model offers the specification of lump-and-smear priors on the commensurability parameter where the associated hyperparameters can be chosen according to the users tolerance for difference between the log baseline hazards. We demonstrate the performance of our Bayesian flexible baseline hazard model on a simulated and real world dataset.
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- 2024
10. AGN STORM 2: VIII. Investigating the Narrow Absorption Lines in Mrk 817 Using HST-COS Observations
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Dehghanian, Maryam, Arav, Nahum, Kriss, Gerard A., Mehdipour, Missagh, Byun, Doyee, Walker, Gwen, Sharma, Mayank, Barth, Aaron J., Bentz, Misty C., Boizelle, Benjamin D., Brotherton, Michael S., Cackett, Edward M., Bonta, Elena Dalla, De Rosa, Gisella, Ferland, Gary J., Fian, Carina, Filippenko, Alexei V., Gelbord, Jonathan, Goad, Michael R., Horne, Keith, Homayouni, Yasaman, Ilic, Dragana, Joner, Michael D., Kara, Erin A., Kaspi, Shai, Kochanek, Christopher S., Korista, Kirk T., Kosec, Peter, Kovacevic, Andjelka B., Landt, Hermine, Lewin, Collin, Partington, Ethan R., Popovic, Luka C., Proga, Daniel, Rogantini, Daniele, Siebert, Matthew R., Storchi-Bergmann, Thaisa, Vestergaard, Marianne, Waters, Timothy, Wang, Jian-Min, Zaidouni, Fatima, and Zu, Ying
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Astrophysics - Astrophysics of Galaxies - Abstract
We observed the Seyfert 1 galaxy Mrk817 during an intensive multi-wavelength reverberation mapping campaign for 16 months. Here, we examine the behavior of narrow UV absorption lines seen in HST/COS spectra, both during the campaign and in other epochs extending over 14 years. We conclude that while the narrow absorption outflow system (at -3750 km/s with FWHM=177 km/s) responds to the variations of the UV continuum as modified by the X-ray obscurer, its total column density (logNH =19.5 cm-2) did not change across all epochs. The adjusted ionization parameter (scaled with respect to the variations in the Hydrogen ionizing continuum flux) is log UH =-1.0. The outflow is located at a distance smaller than 38 parsecs from the central source, which implies a hydrogen density of nH > 3000 cm-3. The absorption outflow system only covers the continuum emission source and not the broad emission line region, which suggests that its transverse size is small (< 1e16 cm), with potential cloud geometries ranging from spherical to elongated along the line of sight., Comment: 18 pages, 12 Figures, Accepted for publication in ApJ
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- 2024
11. AGN STORM 2: IX. Studying the Dynamics of the Ionized Obscurer in Mrk 817 with High-resolution X-ray Spectroscopy
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Zaidouni, Fatima, Kara, Erin, Kosec, Peter, Mehdipour, Missagh, Rogantini, Daniele, Kriss, Gerard A., Behar, Ehud, Kaastra, Jelle, Barth, Aaron J., Cackett, Edward M., De Rosa, Gisella, Homayouni, Yasaman, Horne, Keith, Landt, Hermine, Arav, Nahum, Bentz, Misty C., Brotherton, Michael S., Bontà, Elena Dalla, Dehghanian, Maryam, Ferland, Gary J., Fian, Carina, Gelbord, Jonathan, Goad, Michael R., Buitrago, Diego H. González, Grier, Catherine J., Hall, Patrick B., Hu, Chen, Ilić, Dragana, Kaspi, Shai, Kochanek, Christopher S., Kovačević, Andjelka B., Kynoch, Daniel, Lewin, Collin, Montano, John, Netzer, Hagai, Neustadt, Jack M. M., Panagiotou, Christos, Partington, Ethan R., Plesha, Rachel, Popović, Luka Č., Proga, Daniel, Storchi-Bergmann, Thaisa, Sanmartim, David, Siebert, Matthew R., Signorini, Matilde, Vestergaard, Marianne, Waters, Tim, and Zu, Ying
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
We present the results of the XMM-Newton and NuSTAR observations taken as part of the ongoing, intensive multi-wavelength monitoring program of the Seyfert 1 galaxy Mrk 817 by the AGN Space Telescope and Optical Reverberation Mapping 2 (AGN STORM 2) Project. The campaign revealed an unexpected and transient obscuring outflow, never before seen in this source. Of our four XMM-Newton/NuSTAR epochs, one fortuitously taken during a bright X-ray state has strong narrow absorption lines in the high-resolution grating spectra. From these absorption features, we determine that the obscurer is in fact a multi-phase ionized wind with an outflow velocity of $\sim$5200 km s$^{-1}$, and for the first time find evidence for a lower ionization component with the same velocity observed in absorption features in the contemporaneous HST spectra. This indicates that the UV absorption troughs may be due to dense clumps embedded in diffuse, higher ionization gas responsible for the X-ray absorption lines of the same velocity. We observe variability in the shape of the absorption lines on timescales of hours, placing the variable component at roughly 1000 $R_g$ if attributed to transverse motion along the line of sight. This estimate aligns with independent UV measurements of the distance to the obscurer suggesting an accretion disk wind at the inner broad line region. We estimate that it takes roughly 200 days for the outflow to travel from the disk to our line of sight, consistent with the timescale of the outflow's column density variations throughout the campaign.
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- 2024
12. Magneto-electric decoupling in bismuth ferrite
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Dang, Thien Thanh, Heiniger-Schell, Juliana, Dubey, Astita, Gonçalves, João Nuno, Castillo, Marianela Escobar, Lewin, Daniil, Yap, Ian Chang Jie, Gerami, Adeleh Mokhles, Fathabad, Sobhan Mohammadi, Zyabkin, Dmitry, and Lupascu, Doru Constantin
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Condensed Matter - Materials Science - Abstract
It is still under intensive discussion, how magnetoelectric coupling actually occurs at the atomic scale in multiferroic BiFeO3. Nuclear solid-state techniques monitor local fields at the atomic scale. Using such an approach, we show that, contrary to our own expectation, ferroelectric and magnetic ordering in bismuth ferrite (BiFeO3 or BFO) decouple at the unit-cell level. Time differential perturbed angular correlation (TDPAC) data at temperatures below, close, and above the magnetic N\'eel temperature show that the coupling of the ferroelectric order to magnetization is completely absent at the bismuth site. It is common understanding that the antiferromagnetic order and the cycloidal ordering due to the Dzyaloshinskii-Moriya interaction generate a net zero magnetization of the sample cancelling any magnetoelectric effect at the macroscopic level. Our previous data show that a very large coupling of magnetic moment and electrical distortions arises on the magnetic sub-lattice (Fe-site). The oxygen octahedra around the iron site experience a large tilt due to the onset of magnetic ordering. Nevertheless, the Bi-containing complementary sub-lattice carrying the ferroelectric order is practically unaffected by this large structural change in its direct vicinity. The magnetoelectric coupling thus vanishes already at the unit cell level. These experimental results agree well with an ab-initio density functional theory (DFT) calculation., Comment: 23 pages, 14 figures
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- 2024
13. An Exploratory Study of an Online Vaccine Education Program in Middle-School Students to Promote Vaccine Acceptance
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Edward B. Lewin, Dawn M. Bellanti, Courtney C. Boyd, Walter A. Orenstein, and Joseph A. Bellanti
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Background: While vaccines have reduced the incidence of vaccine-preventable diseases, vaccine hesitancy threatens the re-emergence of childhood infectious diseases. Purpose: This randomized controlled study evaluated an online vaccine education program to advance vaccine acceptance among middle-school students. Methodology: Study participants were randomly assigned to an intervention group who viewed the VEP videos or to a comparison group who viewed a science-based video unrelated to vaccines. Results: Knowledge scores improved in both groups and more favorable shifts in vaccine-related beliefs and attitudes occurred in the intervention than in the comparison group. Conclusions: This program can be feasibly delivered via an online platform to middle school students, resulting in shifts in vaccine-related knowledge, beliefs and attitudes. Implications: Delivering evidence-based content to instruct about vaccine effectiveness and safety is an area in which school nurses have demonstrated an important role as a resource for patient education to promote vaccine advocacy.
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- 2024
- Full Text
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14. AT2018fyk: Candidate Tidal Disruption Event by a (Super)massive Black Hole Binary
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Wen, S., Jonker, P. G., Levan, A. J., Li, D., Stone, N. C., Zabludoff, A. I., Cao, Z., Wevers, T., Pasham, D. R., Lewin, C., and Kara, E.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
The tidal disruption event (TDE) AT2018fyk has unusual X-ray, UV, and optical light curves that decay over the first $\sim$600d, rebrighten, and decay again around 1200d. We explain this behavior as a one-off TDE associated with a massive black hole (BH) \emph{binary}. The sharp drop-offs from $t^{-5/3}$ power laws at around 600d naturally arise when one BH interrupts the debris fallback onto the other BH. The BH mass $M_\bullet$ derived from fitting X-ray spectra with a slim disk accretion model and, independently, from fitting the early UV/optical light curves, is smaller by two orders of magnitude than predicted from the $M_\bullet$--$\sigma_*$ host galaxy relation, suggesting that the debris is accreted onto the secondary, with fallback cut off by the primary. Furthermore, if the rebrightening were associated with the primary, it should occur around 5000d, not the observed 1200d. The secondary's mass and dimensionless spin is $M_{\bullet,{\rm s}}=2.7^{+0.5}_{-1.5} \times 10^5 M_\odot$ and $a_{\bullet,{\rm s}}>0.3$ (X-ray spectral fitting), while the primary's mass is $M_{\bullet,{\rm p}}=10^{7.7\pm0.4}M_\odot$ ($M_\bullet$-$\sigma_*$ relation). An intermediate mass BH secondary is consistent with the observed UV/optical light curve decay, i.e., the secondary's outer accretion disk is too faint to produce a detectable emission floor. The time of the first accretion cutoff constrains the binary separation to be $(6.7\pm 1.2) \times 10^{-3}~{\rm pc}$. X-ray spectral fitting and timing analysis indicate that the hard X-rays arise from a corona above the secondary's disk. The early UV/optical emission, suggesting a super-Eddington phase for the secondary, possibly originates from shocks arising from debris circularization., Comment: 5 tables, 7 figures
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- 2024
- Full Text
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15. Identifying Shopping Intent in Product QA for Proactive Recommendations
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Fetahu, Besnik, Cohen, Nachshon, Haramaty, Elad, Lewin-Eytan, Liane, Rokhlenko, Oleg, and Malmasi, Shervin
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Computer Science - Computation and Language - Abstract
Voice assistants have become ubiquitous in smart devices allowing users to instantly access information via voice questions. While extensive research has been conducted in question answering for voice search, little attention has been paid on how to enable proactive recommendations from a voice assistant to its users. This is a highly challenging problem that often leads to user friction, mainly due to recommendations provided to the users at the wrong time. We focus on the domain of e-commerce, namely in identifying Shopping Product Questions (SPQs), where the user asking a product-related question may have an underlying shopping need. Identifying a user's shopping need allows voice assistants to enhance shopping experience by determining when to provide recommendations, such as product or deal recommendations, or proactive shopping actions recommendation. Identifying SPQs is a challenging problem and cannot be done from question text alone, and thus requires to infer latent user behavior patterns inferred from user's past shopping history. We propose features that capture the user's latent shopping behavior from their purchase history, and combine them using a novel Mixture-of-Experts (MoE) model. Our evaluation shows that the proposed approach is able to identify SPQs with a high score of F1=0.91. Furthermore, based on an online evaluation with real voice assistant users, we identify SPQs in real-time and recommend shopping actions to users to add the queried product into their shopping list. We demonstrate that we are able to accurately identify SPQs, as indicated by the significantly higher rate of added products to users' shopping lists when being prompted after SPQs vs random PQs., Comment: Accepted at IronGraphs@ECIR'2024
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- 2024
16. SIFT-DBT: Self-supervised Initialization and Fine-Tuning for Imbalanced Digital Breast Tomosynthesis Image Classification
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Du, Yuexi, Hooley, Regina J., Lewin, John, and Dvornek, Nicha C.
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Electrical Engineering and Systems Science - Image and Video Processing ,Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Machine Learning - Abstract
Digital Breast Tomosynthesis (DBT) is a widely used medical imaging modality for breast cancer screening and diagnosis, offering higher spatial resolution and greater detail through its 3D-like breast volume imaging capability. However, the increased data volume also introduces pronounced data imbalance challenges, where only a small fraction of the volume contains suspicious tissue. This further exacerbates the data imbalance due to the case-level distribution in real-world data and leads to learning a trivial classification model that only predicts the majority class. To address this, we propose a novel method using view-level contrastive Self-supervised Initialization and Fine-Tuning for identifying abnormal DBT images, namely SIFT-DBT. We further introduce a patch-level multi-instance learning method to preserve spatial resolution. The proposed method achieves 92.69% volume-wise AUC on an evaluation of 970 unique studies., Comment: Accepted by IEEE ISBI 2024
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- 2024
17. A survey for variable stars with small telescopes: IX -- Evolution of Spot Properties on YSOs in IC5070
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Herbert, Carys, Froebrich, Dirk, Vanaverbeke, Siegfried, Scholz, Aleks, Eislöffel, Jochen, Urtly, Thomas, Walton, Ivan L., Wiersema, Klaas, Quinn, Nick J., Piehler, Georg, Aimar, Mario Morales, García, Rafael Castillo, Vanmunster, Tonny, Alfaro, Francisco C. Soldán, de la Cuesta, Faustino García, Licchelli, Domenico, Perez, Alex Escartin, Mañanes, Esteban Fernández, Ribes, Noelia Graciá, González, José Luis Salto, Futcher, Stephen R. L., Nelson, Tim, Dvorak, Shawn, Moździerski, Dawid, Kotysz, Krzysztof, Mikołajczyk, Przemysław, Fleming, George, Phillips, Mark, Vale, Tony, Dubois, Franky, Eggenstein, Heinz-Bernd, Heald, Michael A., Lewin, Pablo, OKeeffe, Derek, Popowicz, Adam, Bernacki, Krzysztof, Malcher, Andrzej, Lasota, Slawomir, Fiolka, Jerzy, Dustor, Adam, Percy, Stephen C., Devine, Pat, Patel, Aashini L., Dickers, Matthew D., Dover, Lord, Grozdanova, Ivana I., Urquhart, James S., and Lynch, Chris J. R.
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
We present spot properties on 32 periodic young stellar objects in IC 5070. Long term, $\sim$5 yr, light curves in the $V$, $R$, and $I$-bands are obtained through the HOYS (Hunting Outbursting Young Stars) citizen science project. These are dissected into six months long slices, with 3 months oversampling, to measure 234 sets of amplitudes in all filters. We fit 180 of these with reliable spot solutions. Two thirds of spot solutions are cold spots, the lowest is 2150 K below the stellar temperature. One third are warm spots that are above the stellar temperature by less than $\sim$2000 K. Cold and warm spots have maximum surface coverage values of 40 percent, although only 16 percent of warm spots are above 20 percent surface coverage as opposed to 60 percent of the cold spots. Warm spots are most likely caused by a combination of plages and low density accretion columns, most common on objects without inner disc excess emission in $K-W2$. Five small hot spot solutions have $<3$ percent coverage and are 3000 - 5000 K above the stellar temperature. These are attributed to accretion, and four of them occur on the same object. The majority of our objects are likely to be accreting. However, we observe very few accretion hot spots as either the accretion is not stable on our timescale or the photometry is dominated by other features. We do not identify cyclical spot behaviour on the targets. We additionally identify and discuss a number of objects that have interesting amplitudes, phase changes, or spot properties., Comment: Accepted for publication by MNRAS. 17 + 7 pages, 7 + 23 figures, 1 table
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- 2024
18. Building sustainable capacity to adopt, adapt or develop child health guidelines, Malawi, Nigeria and South Africa/Renforcement durable des capacites a adopter, adapter ou elaborer des lignes directrices sur la sante infantile en Afrique du Sud, au Malawi et au Nigeria/Creacion de capacidad sostenible para adoptar, adaptar o desarrollar directrices de salud infantil en Malawi, Nigeria y Sudafrica
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Kredo, Tamara, Durao, Solange, Effa, Emmanuel, Naude, Celeste, McCaul, Michael, Brand, Amanda, Lewin, Simon, Glenton, Claire, Munabi-Babigumira, Susan, Besnier, Elodie, Leong, Trudy D., Schmidt, Bey-Marie, Mbeye, Nyanyiwe, Hohlfeld, Ameer, Rohwer, Anke, Hafver, Tandekile Lubelwana, Delvaux, Nicolas, Nkonki, Lungiswa, Bango, Funeka, Thompson, Emma, and Cooper, Sara
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Decision-making -- Health aspects ,Evidence-based medicine -- Methods ,Medical screening -- Methods - Abstract
Problem Many national child health guidelines In Malawi, Nigeria and South Africa are outdated and score poorly on rigorous methods and stakeholder participation. Approach In line with the World Health Organization's (WHO) emphasis on local guideline contextualization, the Global Evidence-Local Adaptation (GELA) project supported multistakeholder processes to adapt evidence-informed recommendations for child health in Malawi, Nigeria and South Africa. The GELA project team convened national steering groups, which conducted structured, iterative priority-setting exercises to identify priority topics. We identified appropriate source guidelines by systematically searching and screening available guidelines. We then matched recommendations in potential source guidelines to the relevant questions, and assessed the guidelines for timeliness and quality. Drawing on WHO's guideline process, we applied the GRADE-ADOLOPMENT process to develop contextualized recommendations from existing guidelines. If no source guideline or reviews were identified, we conducted new evidence syntheses. Local setting Malawi, Nigeria and South Africa are countries with varying health priorities and systems, all transitioning to universal health coverage. Guideline structures differ between countries, with processes largely led from national health ministries. Relevant changes National guideline groups, supported by GELA researchers and government-academic partners, developed five contextually-tailored child health recommendations. For most of these recommendations, additional evidence was required to inform contextually appropriate national decision-making. Formal capacity-building and on-the-job learning enhanced the competencies of national contributors and researchers in evidence-informed decision-making. Lessons learnt Developing context-relevant recommendations requires considerable resources and time. Further investment in strengthening local capacity is needed for sustainable national guideline development. [phrase omitted] Probleme En Afrique du Sud, au Malawi et au Nigeria, de nombreuses lignes directrices nationales relatives a la sante infantile sont obsoletes et affichent de pietres resultats en termes de rigueur des methodes et d'implication des parties prenantes. Approche S'alignant sur l'importance accordee par l'Organisation mondiale de la Sante (OMS) a la contextualisation des lignes directrices locales, le projet Global Evidence - Local Adaptation (GELA) a apporte son soutien a divers processus de collaboration multilaterale afin d'adapter des recommandations sur la sante infantile etayees par des faits en Afrique du Sud, au Malawi et au Nigeria. L'equipe du projet GELA a constitue des groupes de pilotage nationaux, charges d'effectuer des exercices iteratifs et structures de definition des priorites afin de repertorier les principaux themes. Nous avons identifie des lignes directrices de reference en procedant a une recherche et une selection parmi celles disponibles. Ensuite, nous avons compare les recommandations de ces potentielles lignes directrices de reference avec les questions pertinentes, puis nous avons evalue leur qualite et leur actualite. En nous fondant sur le processus d'elaboration de lignes directrices de l'OMS, nous avons applique la methodologie GRADEADOLOPMENT pour formuler des recommandations contextualisees a partir de lignes directrices existantes. Si aucune analyse ni ligne directrice de reference n'avait pu etre degagee, nous etablissions de nouvelles syntheses de preuves. Environnement local L'Afrique du Sud, le Malawi et le Nigeria sont des pays aux priorites et systemes de sante variables, qui operent tous trois une transition vers une couverture sanitaire universelle. Les structures des lignes directrices different d'un pays a l'autre, les processus etant generalement menes par les Ministeres nationaux de la Sante. Changements significatifs Les groupes charges d'elaborer des lignes directrices nationales, avec l'aide des chercheurs GELA et des partenaires gouvernementaux et universitaires, ont emis cinq recommandations adaptees au contexte en matiere de sante infantile. Dans la plupart des cas, la prise de decisions nationales contextualisees necessitait des preuves supplementaires. Le programme de renforcement des capacites et l'apprentissage sur le terrain ont permis d'ameliorer les competences des chercheurs et contributeurs nationaux dans les processus decisionnels etayes par des faits. Lecons tirees Mettre au point des recommandations propres a chaque contexte demande du temps et des ressources considerables. D'autres investissements dans le renforcement des capacites locales sont indispensables pour perenniser le developpement national de lignes directrices. [phrase omitted] Situacion Muchas directrices nacionales de salud infantil en Malawi, Nigeria y Sudafrica estan obsoletas y obtienen una puntuacion baja respecto a los metodos rigurosos y la participacion de las partes interesadas. Enfoque En consonancia con el enfasis de la Organizacion Mundial de la Salud (OMS) en la contextualizacion local de las directrices, el proyecto Global Evidence-Local Adaptation (GELA) apoyo procesos multisectoriales para adaptar las recomendaciones basadas en la evidencia a la salud infantil en Malawi, Nigeria y Sudafrica. El equipo del proyecto GELA convoco a grupos directivos nacionales, que realizaron ejercicios estructurados e iterativos de fijacion de prioridades para identificar los temas prioritarios. Se identificaron las directrices fuente apropiadas mediante la busqueda sistematica y el analisis de las directrices disponibles. A continuacion, se compararon las recomendaciones de las posibles directrices fuente con las preguntas pertinentes y se evaluo la oportunidad y la calidad de las directrices. A partir del proceso de elaboracion de directrices de la OMS, se aplico el proceso GRADE-ADOLOPMENT para desarrollar recomendaciones contextualizadas partiendo de las directrices existentes. Si no se identificaba ninguna directriz o revision fuente, se realizaban nuevas sintesis de la evidencia. Marco regional Malawi, Nigeria y Sudafrica son paises con prioridades y sistemas sanitarios diversos, todos ellos en transicion hacia la cobertura sanitaria universal. Las estructuras de las directrices difieren de un pais a otro, y los procesos se dirigen en gran medida desde los ministerios de sanidad nacionales. Cambios importantes Los grupos nacionales de directrices, apoyados por investigadores del GELA y socios gubernamentales y academicos, elaboraron cinco recomendaciones de salud infantil adaptadas a cada contexto. Para la mayoria de estas recomendaciones, se necesitaron pruebas adicionales para fundamentar una toma de decisiones nacional adecuada al contexto. La capacitacion formal y el aprendizaje en el lugar de trabajo mejoraron las competencias de los colaboradores e investigadores nacionales en la toma de decisiones basada en evidencias. Lecciones aprendidas La elaboracion de recomendaciones adaptadas al contexto requiere recursos y tiempo considerables. Se necesita una mayor inversion en el fortalecimiento de la capacidad local para el desarrollo sostenible de directrices nacionales., Introduction Implementation of evidence-informed health guidelines tailored to the health system contexts of low- and middle-income countries is needed to improve health outcomes. Evidence-informed health guidelines are documents containing clinical, [...]
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19. Real-World Safety and Effectiveness of Dimethyl Fumarate in Patients with MS: Results from the ESTEEM Phase 4 and PROCLAIM Phase 3 Studies with a Focus on Older Patients
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Mao-Draayer, Yang, Bar-Or, Amit, Balashov, Konstantin, Foley, John, Smoot, Kyle, Longbrake, Erin E., Robertson, Derrick, Mendoza, Jason P., Lewin, James B., Everage, Nicholas, Božin, Ivan, Lyons, Jennifer, Mokliatchouk, Oksana, Bame, Eris, and Giuliani, Fabrizio
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- 2024
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20. JYNNEOS vaccine safety surveillance in the vaccine safety datalink during the 2022 mpox outbreak in the United States
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Duffy, Jonathan, Yih, W. Katherine, Walton, Kimp, DeSilva, Malini B., Glanz, Jason M., Hambidge, Simon J, Jackson, Lisa A., Klein, Nicola P., Lewin, Bruno J., Naleway, Allison L., Sundaram, Maria E., Maro, Judith C., and Weintraub, Eric
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- 2024
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21. Extended Monitoring for Transition to Oral Corticosteroids in Acute Severe Ulcerative Colitis May Be Unnecessarily Prolonging Length of Stay
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Ear, Sapphire, Cordero, James, McConnell, Ryan, Velayos, Fernando, Mahadevan, Uma, and Lewin, Sara
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- 2024
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22. Assisted Reproductive Technology During COVID-19: A Population-Based Study Of Pregnancy Outcomes
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Wei, Shu Qin, Luu, Thuy Mai, Ayoub, Aimina, Lewin, Antoine, and Auger, Nathalie
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- 2024
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23. The roles of the kynurenine pathway in COVID-19 neuropathogenesis
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Dehhaghi, Mona, Heydari, Mostafa, Panahi, Hamed Kazemi Shariat, Lewin, Sharon R., Heng, Benjamin, Brew, Bruce J., and Guillemin, Gilles J.
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- 2024
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24. Stillbirth rates following the change in definition of fetal mortality in Quebec
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Welsh, Golden, Ayoub, Aimina, Bilodeau-Bertrand, Marianne, Lewin, Antoine, and Auger, Nathalie
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- 2024
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25. Glutinleime im konstruktiven Holzbau als Alternative zu petrochemischen Klebstoffen
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Grunwald, Cordula, Vallée, Till, Schröder, Lewin, Steinberg, Thorben, Kösling, Stephanie, and Kolbe, Jana
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- 2024
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26. High-Field Superconducting Halo in UTe$_2$
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Lewin, Sylvia K., Czajka, Peter, Frank, Corey E., Salas, Gicela Saucedo, Yoon, Hyeok, Eo, Yun Suk, Paglione, Johnpierre, Nevidomskyy, Andriy H., Singleton, John, and Butch, Nicholas P.
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Condensed Matter - Superconductivity - Abstract
Heavy fermion UTe$_2$ is a promising candidate for topological superconductivity that also exhibits multiple high-field superconducting phases. The SC$_{\rm{FP}}$ phase has only been observed in off-axis magnetic fields in the $bc$ plane at fields greater than 40 teslas, a striking scale given its critical temperature of only 2 kelvins. Here, we extend measurements of this unique superconducting state outside of the $bc$ plane and reveal its core structure. The SC$_{\rm{FP}}$ phase is not confined to fields in the $bc$ plane and in fact wraps around the $b$ axis in a halo-like fashion. In other words, this superconducting state, which exists in fields above 73 teslas, is stabilized by a field component perpendicular to the magnetic easy axis. These remarkable field scales further underscore UTe$_2$'s unique magnetophilic superconducting tendencies and suggest an underlying pairing mechanism that is qualitatively distinct from known theories for field-enhanced superconductivity. Phenomenological modeling points to a two-component, non-unitary spin triplet order parameter with finite orbital momentum of the Cooper pairs as a natural explanation for the field-angle dependence of the upper critical field of the SC$_{\rm{FP}}$ phase., Comment: 7 pages, 3 figures
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27. A review of UTe$_2$ at high magnetic fields
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Lewin, Sylvia K., Frank, Corey E., Ran, Sheng, Paglione, Johnpierre, and Butch, Nicholas P.
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Condensed Matter - Superconductivity - Abstract
Uranium ditelluride (UTe$_2$) is recognized as a host material to unconventional spin-triplet superconductivity, but it also exhibits a wealth of additional unusual behavior at high magnetic fields. One of the most prominent signatures of the unconventional superconductivity is a large and anisotropic upper critical field that exceeds the paramagnetic limit. This superconductivity survives to 35 T and is bounded by a discontinuous magnetic transition, which itself is also field-direction-dependent. A different, reentrant superconducting phase emerges only on the high-field side of the magnetic transition, in a range of angles between the crystallographic $b$ and $c$ axes. This review discusses the current state of knowledge of these high-field phases, the high-field behavior of the heavy fermion normal state, and other phases that are stabilized by applied pressure., Comment: 34 pages, 12 figures
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- 2024
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28. Early Stages of Drop Coalescence
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Deblais, Antoine, Xie, Kaili, Lewin-Jones, Peter, Aarts, Dirk, Herrada, Miguel A., Eggers, Jens, Sprittles, James E., and Bonn, Daniel
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Physics - Fluid Dynamics ,Condensed Matter - Soft Condensed Matter - Abstract
Despite the large body of research on coalescence, firm agreement between experiment, theory, and computation has not been established for the very earliest times following the initial contact of two liquid volumes. Combining a range of experimental and computational modelling approaches, we have been able to elucidate the influence of the intervening gas, of the van der Waals forces and of thermal fluctuations on coalescence. For simple liquids, the gas influences both pre- and post-contact regimes, with a jump-to-contact the primary mode of merging. Subsequently, wave-like air pockets are observed. For a system with ultralow interfacial tension, that mimics nanodrop behaviour, the very first moments are governed by thermal fluctuations at the interfaces, with a nontrivial opening speed given by stochastic thermally driven motion.
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- 2024
29. A survey for variable young stars with small telescopes: VIII -- Properties of 1687 Gaia selected members in 21 nearby clusters
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Froebrich, Dirk, Scholz, Aleks, Campbell-White, Justyn, Vanaverbeke, Siegfried, Herbert, Carys, Eislöffel, Jochen, Urtly, Thomas, Long, Timothy P., Walton, Ivan L., Wiersema, Klaas, Quinn, Nick J., Rodda, Tony, González-Carballo, Juan-Luis, Aimar, Mario Morales, García, Rafael Castillo, Alfaro, Francisco C. Soldán, de la Cuesta, Faustino García, Licchelli, Domenico, Perez, Alex Escartin, González, José Luis Salto, Deldem, Marc, Futcher, Stephen R. L., Nelson, Tim, Dvorak, Shawn, Moździerski, Dawid, Kotysz, Krzysztof, Mikołajczyk, Przemysław, Fleming, George, Phillips, Mark, Vale, Tony, Öğmen, Yenal, Dubois, Franky, Rolfe, Samantha M., Campbell, David A., Eggenstein, Heinz-Bernd, Hambsch, Franz-Josef, Heald, Michael A., Lewin, Pablo, Rose, Adam C., Stone, Geoffrey, Crow, Martin Valentine, Dawes, Simon Francis, OKeeffe, Derek, Popowicz, Adam, Bernacki, Krzysztof, Malcher, Andrzej, Lasota, Slawomir, Fiolka, Jerzy, Dustor, Adam, Vajpayee, Amritanshu, Devine, Pat, Kolb, Matthias, Marquette, Jean-Baptiste, Ruppel, Gregg L., Crowson, Dan R., da Silva, Cledison Marcos, Michaud, Michel, Patel, Aashini L., Dickers, Matthew D., Dover, Lord, Grozdanova, Ivana I., Urquhart, James S., and Lynch, Chris J. R.
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
The Hunting Outbursting Young Stars (HOYS) project performs long-term, optical, multi-filter, high cadence monitoring of 25 nearby young clusters and star forming regions. Utilising Gaia DR3 data we have identified about 17000 potential young stellar members in 45 coherent astrometric groups in these fields. Twenty one of them are clear young groups or clusters of stars within one kiloparsec and they contain 9143 Gaia selected potential members. The cluster distances, proper motions and membership numbers are determined. We analyse long term (about 7yr) V, R, and I-band light curves from HOYS for 1687 of the potential cluster members. One quarter of the stars are variable in all three optical filters, and two thirds of these have light curves that are symmetric around the mean. Light curves affected by obscuration from circumstellar materials are more common than those affected by accretion bursts, by a factor of 2-4. The variability fraction in the clusters ranges from 10 to almost 100 percent, and correlates positively with the fraction of stars with detectable inner disks, indicating that a lot of variability is driven by the disk. About one in six variables shows detectable periodicity, mostly caused by magnetic spots. Two thirds of the periodic variables with disk excess emission are slow rotators, and amongst the stars without disk excess two thirds are fast rotators - in agreement with rotation being slowed down by the presence of a disk., Comment: accepted for publication in MNRAS, 1 table, 9 figures
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- 2024
30. Borrowing from historical control data in a Bayesian time-to-event model with flexible baseline hazard function
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Scott, Darren A. V. and Lewin, Alex
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Statistics - Methodology - Abstract
There is currently a focus on statistical methods which can use historical trial information to help accelerate the discovery, development and delivery of medicine. Bayesian methods can be constructed so that the borrowing is "dynamic" in the sense that the similarity of the data helps to determine how much information is used. In the time to event setting with one historical data set, a popular model for a range of baseline hazards is the piecewise exponential model where the time points are fixed and a borrowing structure is imposed on the model. Although convenient for implementation this approach effects the borrowing capability of the model. We propose a Bayesian model which allows the time points to vary and a dependency to be placed between the baseline hazards. This serves to smooth the posterior baseline hazard improving both model estimation and borrowing characteristics. We explore a variety of prior structures for the borrowing within our proposed model and assess their performance against established approaches. We demonstrate that this leads to improved type I error in the presence of prior data conflict and increased power. We have developed accompanying software which is freely available and enables easy implementation of the approach., Comment: Explanation of how to choose borrowing hyperparameters for the lump-and-smear prior
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31. Reversal of C9orf72 mutation-induced transcriptional dysregulation and pathology in cultured human neurons by allele-specific excision.
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Sachdev, Aradhana, Gill, Kamaljot, Sckaff, Maria, Birk, Alisha, Aladesuyi Arogundade, Olubankole, Brown, Katherine, Chouhan, Runvir, Issagholian-Lewin, Patrick, Patel, Esha, Watry, Hannah, Bernardi, Mylinh, Keough, Kathleen, Tsai, Yu-Chih, Smith, Alec, Conklin, Bruce, and Clelland, Claire
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ALS ,C9orf72 ,CRISPR ,FTD ,neurodegeneration ,Humans ,C9orf72 Protein ,Alleles ,Amyotrophic Lateral Sclerosis ,Frontotemporal Dementia ,Motor Neurons ,Mutation ,DNA Repeat Expansion ,Dipeptides - Abstract
Efforts to genetically reverse C9orf72 pathology have been hampered by our incomplete understanding of the regulation of this complex locus. We generated five different genomic excisions at the C9orf72 locus in a patient-derived induced pluripotent stem cell (iPSC) line and a non-diseased wild-type (WT) line (11 total isogenic lines), and examined gene expression and pathological hallmarks of C9 frontotemporal dementia/amyotrophic lateral sclerosis in motor neurons differentiated from these lines. Comparing the excisions in these isogenic series removed the confounding effects of different genomic backgrounds and allowed us to probe the effects of specific genomic changes. A coding single nucleotide polymorphism in the patient cell line allowed us to distinguish transcripts from the normal vs. mutant allele. Using digital droplet PCR (ddPCR), we determined that transcription from the mutant allele is upregulated at least 10-fold, and that sense transcription is independently regulated from each allele. Surprisingly, excision of the WT allele increased pathologic dipeptide repeat poly-GP expression from the mutant allele. Importantly, a single allele was sufficient to supply a normal amount of protein, suggesting that the C9orf72 gene is haplo-sufficient in induced motor neurons. Excision of the mutant repeat expansion reverted all pathology (RNA abnormalities, dipeptide repeat production, and TDP-43 pathology) and improved electrophysiological function, whereas silencing sense expression did not eliminate all dipeptide repeat proteins, presumably because of the antisense expression. These data increase our understanding of C9orf72 gene regulation and inform gene therapy approaches, including antisense oligonucleotides (ASOs) and CRISPR gene editing.
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- 2024
32. Vocal learning-associated convergent evolution in mammalian proteins and regulatory elements.
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Wirthlin, Morgan, Schmid, Tobias, Elie, Julie, Zhang, Xiaomeng, Kowalczyk, Amanda, Redlich, Ruby, Shvareva, Varvara, Rakuljic, Ashley, Ji, Maria, Bhat, Ninad, Kaplow, Irene, Schäffer, Daniel, Lawler, Alyssa, Wang, Andrew, Phan, BaDoi, Annaldasula, Siddharth, Brown, Ashley, Lu, Tianyu, Lim, Byung, Azim, Eiman, Clark, Nathan, Meyer, Wynn, Pond, Sergei, Chikina, Maria, Yartsev, Michael, Pfenning, Andreas, Andrews, Gregory, Armstrong, Joel, Bianchi, Matteo, Birren, Bruce, Bredemeyer, Kevin, Breit, Ana, Christmas, Matthew, Clawson, Hiram, Damas, Joana, Di Palma, Federica, Diekhans, Mark, Dong, Michael, Eizirik, Eduardo, Fan, Kaili, Fanter, Cornelia, Foley, Nicole, Forsberg-Nilsson, Karin, Garcia, Carlos, Gatesy, John, Gazal, Steven, Genereux, Diane, Goodman, Linda, Grimshaw, Jenna, Halsey, Michaela, Harris, Andrew, Hickey, Glenn, Hiller, Michael, Hindle, Allyson, Hubley, Robert, Hughes, Graham, Johnson, Jeremy, Juan, David, Karlsson, Elinor, Keough, Kathleen, Kirilenko, Bogdan, Koepfli, Klaus-Peter, Korstian, Jennifer, Kozyrev, Sergey, Lawless, Colleen, Lehmann, Thomas, Levesque, Danielle, Lewin, Harris, Li, Xue, Lind, Abigail, Lindblad-Toh, Kerstin, Mackay-Smith, Ava, Marinescu, Voichita, Marques-Bonet, Tomas, Mason, Victor, Meadows, Jennifer, Moore, Jill, Moreira, Lucas, Moreno-Santillan, Diana, Morrill, Kathleen, Muntané, Gerard, Murphy, William, Navarro, Arcadi, Nweeia, Martin, Ortmann, Sylvia, Osmanski, Austin, Paten, Benedict, Paulat, Nicole, Pollard, Katherine, Pratt, Henry, Ray, David, Reilly, Steven, Rosen, Jeb, and Ruf, Irina
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Animals ,Chiroptera ,Vocalization ,Animal ,Motor Cortex ,Chromatin ,Enhancer Elements ,Genetic ,Motor Neurons ,Larynx ,Epigenesis ,Genetic ,Genome ,Gene Expression Regulation ,Evolution ,Molecular ,Proteins ,Amino Acid Sequence ,Eutheria ,Machine Learning - Abstract
Vocal production learning (vocal learning) is a convergently evolved trait in vertebrates. To identify brain genomic elements associated with mammalian vocal learning, we integrated genomic, anatomical, and neurophysiological data from the Egyptian fruit bat (Rousettus aegyptiacus) with analyses of the genomes of 215 placental mammals. First, we identified a set of proteins evolving more slowly in vocal learners. Then, we discovered a vocal motor cortical region in the Egyptian fruit bat, an emergent vocal learner, and leveraged that knowledge to identify active cis-regulatory elements in the motor cortex of vocal learners. Machine learning methods applied to motor cortex open chromatin revealed 50 enhancers robustly associated with vocal learning whose activity tended to be lower in vocal learners. Our research implicates convergent losses of motor cortex regulatory elements in mammalian vocal learning evolution.
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- 2024
33. Drones: Both an emerging threat and asset for correctional facilities
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Anderson, Joel and Lewin, David
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Drone aircraft -- Safety and security measures ,Prisons -- Safety and security measures ,Law - Abstract
Prisons have a new tool and new security risk --drones. On one hand, drones, also referred to as unmanned aerial vehicles (UAVs), have proven a useful tool at prisons for [...]
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34. Identifying Shopping Intent in Product QA for Proactive Recommendations
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Fetahu, Besnik, Cohen, Nachshon, Haramaty, Elad, Lewin-Eytan, Liane, Rokhlenko, Oleg, Malmasi, Shervin, Ghosh, Ashish, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Boratto, Ludovico, editor, Malitesta, Daniele, editor, Marras, Mirko, editor, Medda, Giacomo, editor, Musto, Cataldo, editor, and Purificato, Erasmo, editor
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- 2025
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35. Development, Evaluation, and Long-Term Outcomes of Environmental Health and Land Reuse Training--Part 1: Developing Environmental Health and Land Reuse Trainings for the Environmental Health Workforce and Their Community Partners
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Berman, Laurel, Unkart, Sharon, Lewin, Michael, Labbo, Rebecca, Bare, Gina, Wooden, Alyssa, Erdal, Serap, Bing, Leann, Casteel, Sue, Amar, Onongoo, and Jones, Tracie
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Environmental health -- Training ,Land use -- Health aspects -- Environmental aspects -- United States ,Sanitarians -- Training ,Environmental issues ,Health - Abstract
This article is the first in a series of three that describes the development and delivery of the Environmental Health and Land Reuse (EHLR) Basic Training and the first pilot of the EHLR Immersion Training. The EHLR Basic Training is based on the 5-step Land Reuse Model from the Agency for Toxic Substances and Disease Registry (ATSDR). Through a collaboration with the National Environmental Health Association (NEHA), we developed the EHLR Basic Training in two modalities: virtual/live (maintained by ATSDR) and online/asynchronous (maintained by NEHA). The modules include: 1) Engaging With Your Community, 2) Evaluating Environmental and Health Risks, 3) Communicating Environmental and Health Risks, 4) Redesigning With Health in Mind, and 5) Measuring Success: Evaluating Environmental and Health Change. From June 2019-August 2022, ATSDR and NEHA delivered 10 EHLR Classroom Basic Trainings, launched the EHLR Online Basic Training, and developed the EHLR Immersion Training. We piloted the EHLR Immersion Training in July 2022, March 2023, and July 2023. Our participants included science, technology, engineering, and mathematics (STEM) students from Dine College who were in a Summer Intern Program; tribal environmental professionals; NEHA members in environmental health careers; and environmental professionals, students, and community members who were engaged in environmental work or environmental justice. We have learned that individual training modules can be used for specific learning needs among our participants. Perhaps more importantly, we have learned that undergraduate students and community members can and should be engaged in EHLR Training. The results of the evaluation and long-term follow-up of the EHLR Training will be presented in the second and third articles in this series. Keywords: brownfields, Navajo Nation, environmental health, land reuse, environmental training, tribal ecosystem knowledge, Background The definition of brownfields from the U.S. Congress (2002) refers to property of which the expansion, redevelopment, or reuse can be complicated by the presence or potential presence of [...]
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- 2024
36. Global evaluation of current and future threats to drylands and their vertebrate biodiversity
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Lewin, Amir, Murali, Gopal, Rachmilevitch, Shimon, and Roll, Uri
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- 2024
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37. Lymphopenia is Not the Primary Therapeutic Mechanism of Diroximel Fumarate in Relapsing–Remitting Multiple Sclerosis: Subgroup Analyses of the EVOLVE-MS-1 Study
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Singer, Barry A., Wray, Sibyl, Gudesblatt, Mark, Bumstead, Barbara, Ziemssen, Tjalf, Bonnell, Ashley, Scaramozza, Matthew, Levin, Seth, Shanmugasundaram, Mathura, Chen, Hailu, Mendoza, Jason P., Lewin, James B., and Shankar, Sai L.
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- 2024
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38. Diroximel Fumarate in Patients with Relapsing–Remitting Multiple Sclerosis: NEDA-3 After Re-Baselining in the Phase 3 EVOLVE-MS-1 Study
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Bowen, James D., Stulc, Jessica, Hunter, Samuel F., Chen, Hailu, Lewin, James B., Scaramozza, Matthew, Bozin, Ivan, and Then Bergh, Florian
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- 2024
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39. De-escalation of Disease-Modifying Therapy for People with Multiple Sclerosis Due to Safety Considerations: Characterizing 1-Year Outcomes in 25 People Who Switched from Ocrelizumab to Diroximel Fumarate
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Gudesblatt, Mark, Bumstead, Barbara, Buhse, Marijean, Zarif, Myassar, Morrow, Sarah A., Nicholas, Jacqueline A., Hancock, Laura M., Wilken, Jeffrey, Weller, Joanna, Scott, Nicole, Gocke, Anne, Lewin, James B., Kaczmarek, Olivia, Mendoza, Jason P., and Golan, Daniel
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- 2024
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40. Incidence of SARS-CoV-2 during the Omicron wave: Results of a longitudinal serosurvey in Québec, Canada
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Lewin, Antoine, Germain, Marc, Bazin, Renée, Grégoire, Yves, De Serres, Gaston, and Renaud, Christian
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- 2024
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41. How to get to the N – a call for interdisciplinary research on organic N utilization pathways by plants
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Holz, Maire, Lewin, Simon, Kolb, Steffen, Becker, Joscha N., and Bergmann, Joana
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- 2024
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42. BRCA1/2 mutation carriers vs the general breast cancer population (N = 799,986): 21-gene assay-based molecular characterization
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Yerushalmi, Rinat, Pomerantz, Adi, Lewin, Ron, Paluch-Shimon, Shani, Soussan-Gutman, Lior, Baehner, Frederick L., Voet, Hillary, Bareket-Samish, Avital, Kedar, Inbal, Goldberg, Yael, Peretz-Yablonski, Tamar, and Kadouri, Luna
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- 2024
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43. Suboptimal Imaging on Obstetric Ultrasound Should Prompt Early Referral for Fetal Echocardiography
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Chambers, Hailey N., Caris, Elizabeth, Conwell, Jeffrey, Edwards, Lindsay A., Hulse, J. Eddie, Lewin, Mark, Pinto, Nelangi M., Wolfe, Elana, and Arya, Bhawna
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- 2024
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44. Congenital anomalies during Covid-19: artifact of surveillance or a real TORCH?
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Auger, Nathalie, Arbour, Laura, Lewin, Antoine, Brousseau, Émilie, Healy-Profitós, Jessica, and Luu, Thuy Mai
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- 2024
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45. Problematic use of five different social networking sites is associated with depressive symptoms and loneliness
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Williams, McKain, Lewin, Kaitlin M., and Meshi, Dar
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- 2024
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46. Amplification, Resistance, and Kinetics of the Jaw Stretching Device (ARK-JSD): analysis of the force variation and implications for trismus therapy
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Charters, Emma, Cheng, Kai, Dunn, Masako, Luo, Aaron, Aung, Y. M., Lewin, Will, and Clark, Jonathan R.
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- 2024
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47. Classical Density Functional Theory: The Local Density Approximation
- Author
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Jex, Michal, Lewin, Mathieu, and Madsen, Peter
- Subjects
Mathematical Physics ,Condensed Matter - Statistical Mechanics - Abstract
We prove that the lowest free energy of a classical interacting system at temperature $T$ with a prescribed density profile $\rho(x)$ can be approximated by the local free energy $\int f_T(\rho(x))dx$, provided that $\rho$ varies slowly over sufficiently large length scales. A quantitative error on the difference is provided in terms of the gradient of the density. Here $f_T$ is the free energy per unit volume of an infinite homogeneous gas of the corresponding uniform density. The proof uses quantitative Ruelle bounds (estimates on the local number of particles in a large system), which are derived in an appendix.
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- 2023
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48. Variability as a predictor for the hard-to-soft state transition in GX 339-4
- Author
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Lucchini, Matteo, Have, Marina Ten, Wang, Jingyi, Homan, Jeroen, Kara, Erin, Adegoke, Oluwashina, Connors, Riley, Dauser, Thomas, Garcia, Javier, Mastroserio, Guglielmo, Ingram, Adam, van der Klis, Michiel, König, Ole, Lewin, Collin, Mallick, Labani, Nathan, Edward, O'Neill, Patrick, Panagiotou, Christos, Piotrowska, Joanna, and Uttley, Phil
- Subjects
Astrophysics - High Energy Astrophysical Phenomena - Abstract
During the outbursts of black hole X-ray binaries (BHXRBs), their accretion flows transition through several states. The source luminosity rises in the hard state, dominated by non-thermal emission, before transitioning to the blackbody-dominated soft state. As the luminosity decreases, the source transitions back into the hard state and fades to quiescence. This picture does not always hold, as $\approx$ 40$\%$ of the outbursts never leave the hard state. Identifying the physics that govern state transitions remains one of the outstanding open questions in black hole astrophysics. In this paper we present an analysis of archival RXTE data of multiple outbursts of GX 339-4. We compare the properties of the X-ray variability and time-averaged energy spectrum and demonstrate that the variability (quantified by the power spectral hue) systematically evolves $\approx$ 10-40 days ahead of the canonical state transition (quantified by a change in spectral hardness); no such evolution is found in hard state only outbursts. This indicates that the X-ray variability can be used to predict if and when the hard-to-soft state transition will occur. Finally, we find a similar behavior in ten outbursts of four additional BHXRBs with more sparse observational coverage. Based on these findings, we suggest that state transitions in BHXRBs might be driven by a change in the turbulence in the outer regions of the disk, leading to a dramatic change in variability. This change is only seen in the spectrum days to weeks later, as the fluctuations propagate inwards towards the corona., Comment: Accepted for publication in ApJ
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- 2023
49. Positive-density ground states of the Gross-Pitaevskii equation
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Lewin, Mathieu and Nam, Phan Thành
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Mathematical Physics ,Mathematics - Analysis of PDEs - Abstract
We consider the nonlinear Gross-Pitaevskii equation at positive density, that is, for a bounded solution not tending to 0 at infinity. We focus on infinite ground states, which are by definition minimizers of the energy under local perturbations. When the Fourier transform of the interaction potential takes negative values we prove the existence of a phase transition at high density, where the constant solution ceases to be a ground state. The analysis requires mixing techniques from elliptic PDE theory and statistical mechanics, in order to deal with a large class of interaction potentials., Comment: Revised version
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- 2023
50. Dynamical Architectures of S-type Transiting Planets in Binaries I: Target Selection using Hipparcos and Gaia proper motion anomalies
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Zhang, Jingwen, Weiss, Lauren M., Huber, Daniel, Jensen, Eric L. N., Brandt, Timothy D., Collins, Karen, Conti, Dennis M., Isaacson, Howard, Lewin, Pablo, Marino, Giuseppe, Massey, Bob, Murgas, Felipe, Palle, Enric, Radford, Don J., Relles, Howard M., Srdoc, Gregor, Stockdale, Chris, Tan, Thiam-Guan, and Wang, Gavin
- Subjects
Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
The effect of stellar multiplicity on planetary architecture and orbital dynamics provides an important context for exoplanet demographics. We present a volume-limited catalog up to 300 pc of 66 stars hosting planets and planet candidates from Kepler, K2 and TESS with significant Hipparcos-Gaia proper motion anomalies, which indicate the presence of companions. We assess the reliability of each transiting planet candidate using ground-based follow-up observations, and find that the TESS Objects of Interest (TOIs) with significant proper motion anomalies show nearly four times more false positives due to Eclipsing Binaries compared to TOIs with marginal proper motion anomalies. In addition, we find tentative evidence that orbital periods of planets orbiting TOIs with significant proper motion anomalies are shorter than those orbiting TOIs without significant proper motion anomalies, consistent with the scenario that stellar companions can truncate planet-forming disks. Furthermore, TOIs with significant proper motion anomalies exhibit lower Gaia differential velocities in comparison to field stars with significant proper motion anomalies, suggesting that planets are more likely to form in binary systems with low-mass substellar companions or stellar companions at wider separation. Finally, we characterize the three-dimensional architecture of LTT 1445 ABC using radial velocities, absolute astrometry from Gaia and Hipparcos, and relative astrometry from imaging. Our analysis reveals that LTT 1445 is a nearly flat system, with a mutual inclination of 2.88 deg between the orbit of BC around A and that of C around B. The coplanarity may explain why multiple planets around LTT 1445 A survive in the dynamically hostile environment of this system., Comment: 28 pages, 9 figures, published by AJ
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- 2023
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