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2. A direct comparison of mouse and human intestinal development using epithelial gene expression patterns

Author

Stanford, Amy H, Gong, Huiyu, Noonan, Mackenzie, Lewis, Angela N, Gong, Qingqing, Lanik, Wyatt E, Hsieh, Jonathan J, Lueschow, Shiloh R, Frey, Mark R, Good, Misty, and McElroy, Steven J

Subjects
Perinatal Period - Conditions Originating in Perinatal Period, Infant Mortality, Pediatric, Preterm, Low Birth Weight and Health of the Newborn, Clinical Research, Rare Diseases, Digestive Diseases, Aetiology, 2.1 Biological and endogenous factors, Oral and gastrointestinal, Reproductive health and childbirth, Animals, Enterocolitis, Necrotizing, Epithelium, ErbB Receptors, Gene Expression Profiling, Gene Expression Regulation, Developmental, Homeostasis, Humans, Intestinal Diseases, Intestines, Mice, Mice, Inbred C57BL, Paediatrics and Reproductive Medicine, Public Health and Health Services, Pediatrics
Abstract

BackgroundPreterm infants are susceptible to unique pathology due to their immaturity. Mouse models are commonly used to study immature intestinal disease, including necrotizing enterocolitis (NEC). Current NEC models are performed at a variety of ages, but data directly comparing intestinal developmental stage equivalency between mice and humans are lacking.MethodsSmall intestines were harvested from C57BL/6 mice at 3-4 days intervals from birth to P28 (n = 8 at each age). Preterm human small intestine samples representing 17-23 weeks of completed gestation were obtained from the University of Pittsburgh Health Sciences Tissue Bank, and at term gestation during reanastamoses after resection for NEC (n = 4-7 at each age). Quantification of intestinal epithelial cell types and messenger RNA for marker genes were evaluated on both species.ResultsOverall, murine and human developmental trends over time are markedly similar. Murine intestine prior to P10 is most similar to human fetal intestine prior to viability. Murine intestine at P14 is most similar to human intestine at 22-23 weeks completed gestation, and P28 murine intestine is most similar to human term intestine.ConclusionUse of C57BL/6J mice to model the human immature intestine is reasonable, but the age of mouse chosen is a critical factor in model development.

Published
2020

6. Microfluidic device facilitates in vitro modeling of human neonatal necrotizing enterocolitis-on-a-chip

Author

Lanik, Wyatt E., primary, Luke, Cliff J., additional, Nolan, Lila S., additional, Gong, Qingqing, additional, Frazer, Lauren C., additional, Rimer, Jamie M., additional, Gale, Sarah E., additional, Luc, Raymond, additional, Bidani, Shay S., additional, Sibbald, Carrie A., additional, Lewis, Angela N., additional, Mihi, Belgacem, additional, Agrawal, Pranjal, additional, Goree, Martin, additional, Maestas, Marlie M., additional, Hu, Elise, additional, Peters, David G., additional, and Good, Misty, additional

Published
2023
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7. Evaluation of the Neonatal Sequential Organ Failure Assessment and Mortality Risk in Preterm Infants with Necrotizing Enterocolitis

Author

Lewis, Angela N., primary, de la Cruz, Diomel, additional, Wynn, James L., additional, Frazer, Lauren C., additional, Yakah, William, additional, Martin, Camilia R., additional, Yang, Heeju, additional, Itriago, Elena, additional, Unger, Jana, additional, Hair, Amy B., additional, Miele, Jessica, additional, Sullivan, Brynne A., additional, Husain, Ameena, additional, and Good, Misty, additional

Published
2022
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10. Indole-3-Carbinol–Dependent Aryl Hydrocarbon Receptor Signaling Attenuates the Inflammatory Response in Experimental Necrotizing Enterocolitis

Author

Nolan, Lila S., primary, Mihi, Belgacem, additional, Agrawal, Pranjal, additional, Gong, Qingqing, additional, Rimer, Jamie M., additional, Bidani, Shay S., additional, Gale, Sarah E., additional, Goree, Martin, additional, Hu, Elise, additional, Lanik, Wyatt E., additional, Huang, Elizabeth, additional, Bando, Jennifer K., additional, Liu, Victoria, additional, Lewis, Angela N., additional, Bustos, Aiza, additional, Hodzic, Zerina, additional, Laury, Marie L., additional, and Good, Misty, additional

Published
2021
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11. Evaluation of the Neonatal Sequential Organ Failure Assessment and Mortality Risk in Preterm Infants With Late-Onset Infection

Author

Fleiss, Noa, primary, Coggins, Sarah A., additional, Lewis, Angela N., additional, Zeigler, Angela, additional, Cooksey, Krista E., additional, Walker, L. Anne, additional, Husain, Ameena N., additional, de Jong, Brenda S., additional, Wallman-Stokes, Aaron, additional, Alrifai, Mhd Wael, additional, Visser, Douwe H., additional, Good, Misty, additional, Sullivan, Brynne, additional, Polin, Richard A., additional, Martin, Camilia R., additional, and Wynn, James L., additional

Published
2021
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12. Microfluidic Device Facilitates Novel In Vitro Modeling of Human Neonatal Necrotizing Enterocolitis-on-a-Chip

Author

Lanik, Wyatt E., primary, Luke, Cliff J., additional, Nolan, Lila S., additional, Gong, Qingqing, additional, Rimer, Jamie M., additional, Gale, Sarah E., additional, Luc, Raymond, additional, Bidani, Shay S., additional, Sibbald, Carrie A., additional, Lewis, Angela N., additional, Mihi, Belgacem, additional, Agrawal, Pranjal, additional, Goree, Martin, additional, Maestas, Marlie, additional, Hu, Elise, additional, Peters, David G., additional, and Good, Misty, additional

Published
2020
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