Search

Your search keyword '"Lewis, Claire A."' showing total 472 results
Start Over Author "Lewis, Claire A."
472 results on '"Lewis, Claire A."'

1. Analysis of SARS-CoV-2 antibody seroprevalence in Northern Ireland during 2020–2021

Author

Greene, Michelle K., Smyth, Peter, English, Andrew, McLaughlin, Joseph, Bucholc, Magda, Bailie, Janice, McCarroll, Julie, McDonnell, Margaret, Watt, Alison, Barnes, George, Lynch, Mark, Duffin, Kevan, Duffy, Gerard, Lewis, Claire, James, Jacqueline A., Stitt, Alan W., Ford, Tom, O'Kane, Maurice, Rai, Taranjit Singh, Bjourson, Anthony J., Cardwell, Christopher, Elborn, J Stuart, Gibson, David S., and Scott, Christopher J.

Published
2024
Full Text
View/download PDF

3. Empowering rangers through technology and innovation

Author

Cronin, Drew T., Benbow, Sophie, Bergl, Richard A., Bourgault, Liz, Caro, Lina, Dancer, Anthony, Davies, Alasdair, Joachim, Denton, Lewis, Claire, Lynam, Antony J., Maaz, Julio, Muntifering, Jeff, O'Donnell, Stephanie, Palmer, Jonathan, Slade, James, Spina Avino, Felipe, Stevens, Xia, and Wyatt, Alex

Abstract

Protected areas are key to biodiversity conservation and ranger-based monitoring, and law enforcement is the cornerstone upon which effective protected areas are built. Frontline practitioners, however, are often asked to protect large swathes of land or sea with limited resources, support, infrastructure, capacity, and/or training. Technology, when applied effectively and appropriately, has the capacity to empower practitioners, revolutionize ranger operations, improve ranger safety, and enhance wildlife protection and conservation outcomes. To do so, technology must be recognized, from the frontlines through to key decisionmakers, as a force multiplier, but only when it is fit for purpose, accessible, cost-effective, and supportive of rangers’ needs. In this paper we detail the general state of conservation technology and innovation within the ranger context and provide a series of detailed recommendations to help the Universal Ranger Support Alliance (URSA) meet the needs of rangers around the world, including: demystifying technology and clarifying what it can and cannot do, connecting the right technology with the right people and places, focusing technology development and investment on substantive improvements and support, broadening ranger familiarization with technology, building technology capacity in rangers, fostering greater community building and creating opportunities around technologies, engaging the technology sector to innovate and design technology to support rangers, and supporting technology as a complement to traditional knowledge and skills, rather than a replacement. These recommendations constitute an ambitious vision which cannot be delivered by URSA in isolation. Rather, we propose URSA leverages existing efforts to ensure rangers are supported around the world.

Published
2021

4. Targeting of a STING Agonist to Perivascular Macrophages in Prostate Tumors Delays Resistance to Androgen Deprivation Therapy

Author

Al-janabi, Haider, primary, Moyes, Katy, additional, Allen, Richard J, additional, Fisher, Matthew, additional, Crespo, Mateus, additional, Gurel, Bora, additional, Rescigno, Pasquale, additional, De Bono, Johann, additional, Nunns, Harry, additional, Bailey, Christopher, additional, Juncker-Jensen, Anna, additional, Muthana, Munitta, additional, Phillips, Wayne A, additional, Pearson, Helen, additional, Taplin, Mary-Ellen, additional, Brown, Janet E, additional, and Lewis, Claire E, additional

Published
2024
Full Text
View/download PDF

5. Factors influencing the design of a multiparticulate dosing device

Author

Lewis, Claire Jasmin

Subjects
618.92, RJ Pediatrics, RS Pharmacy and materia medica
Abstract

Paediatric specific medicines have become increasingly researched since the introduction of paediatric investigation plan requirements in 2007. Various dosage forms continue to be investigated for their appropriateness for children, including multiparticulates. Multiparticulates are currently available as tablets, capsules, sachets and medicated spoons/straws/syringes. These presentations offer limited dose flexibility with some only providing a single fixed dose. A device capable of repeated flexible multiparticulate dosing is therefore required to exploit the inherent flexibility of the dosage form and allow for patient-specific personalised dosing. This thesis takes a user-centered approach to conceptualise multiparticulate dosing devices through qualitative participatory design studies with user groups including children, caregivers and patients. Having explored User and Formulation requirements in terms of device design, a device specification has been generated with subsequent concept generation and mechanism prototyping. The research with users provided further understanding of the different contributors to ease of use, and highlighted the importance of device simplicity, accuracy and speed of use. Exploration of the concepts of self-administration and context of use with potential paediatric MP device users discovered that self-administration was more than a single step process. Caregivers also found it difficult to provide an age at which they would be happy for their child to self-administer and highlighted various influences upon their decision including child maturity, adult supervision and child familiarity with administration. A knowledge gap surrounding the use of mass-based mechanisms to determine multiparticulate dose has also been addressed. With new knowledge surrounding MP measurement and the mechanical specifications required for a personalised dosing device presented. A case study is presented, highlighting a possible application of multiparticulates and their dosing device in Cystic Fibrosis patients. This population was selected given their familiarity with a multiparticulate like dosage form as part of their pancreatic enzyme replacement therapy. This study demonstrates how the global device requirements (presented in this work) can be refined on a case-specific basis allowing for a refined, user-centered device specification. This work provides an industry road map for user engagement, acting as a platform for future multiparticulate dosing device design and development, guiding multiparticulate formulation design and ultimately advancing the field of personalised medicines and improving health outcomes (particularly of paediatric patients).

Published
2018

10. Analysis of SARS-CoV-2 Ig seroprevalence in Northern Ireland

Author

Greene, Michelle K, primary, Smyth, Peter, additional, English, Andrew, additional, McLaughlin, Joseph, additional, Bucholc, Magda, additional, Bailie, Janice, additional, McCarroll, Julie, additional, McDonnell, Margaret, additional, Watt, Alison, additional, Barnes, George, additional, Lynch, Mark, additional, Duffin, Kevan, additional, Duffy, Gerard, additional, Lewis, Claire, additional, James, Jacqueline A, additional, Ford, Tom, additional, O'Kane, Maurice, additional, Rai, Taranjit Singh, additional, Bjourson, Anthony J, additional, Cardwell, Christopher, additional, Elborn, J Stuart, additional, Gibson, David S, additional, and Scott, Christopher J, additional

Published
2023
Full Text
View/download PDF

11. Child and family social workers' experiences of working with parents who have intellectual disabilities

Author

Lewis, Claire

Subjects
150, BF Psychology
Abstract

An increasing number of adults with an intellectual disability (ID) are having children. However, research suggests that they face an increased risk of having their children freed for adoption. Although parenting interventions have been found to be effective for parents with ID, such services are rarely offered. Research suggests that multiple factors impact upon child and family social workers decision making in this area, including personal experiences and attitudes. It was therefore thought that exploring social workers’ experiences of parents with ID might enable a greater understanding of why parents with ID face this increased risk. Interviews were carried out with seven child and family social workers who had experience of working on safeguarding cases where at least one parent had an ID. Data were analysed using Interpretive Phenomenological Analysis and five super-ordinate themes were identified. These were: ‘feeling torn’ between parents and their children; experiencing a ‘power imbalance’ between themselves, parents and the local authority; feeling ‘hopeless’; having a sense of ‘pride’ in their work; and experiencing ‘barriers’. The results are discussed in the context of the increased risk parents with ID face of losing custody of their children. Recommendations are made regarding clinical practice and future research.

Published
2013

13. Non-canonical HIF-1 stabilization contributes to intestinal tumorigenesis

Author

Rohwer, Nadine, Jumpertz, Sandra, Erdem, Merve, Egners, Antje, Warzecha, Klaudia T., Fragoulis, Athanassios, Kühl, Anja A., Kramann, Rafael, Neuss, Sabine, Rudolph, Ines, Endermann, Tobias, Zasada, Christin, Apostolova, Ivayla, Gerling, Marco, Kempa, Stefan, Hughes, Russell, Lewis, Claire E., Brenner, Winfried, Malinowski, Maciej B., Stockmann, Martin, Schomburg, Lutz, Faller, William, Sansom, Owen J., Tacke, Frank, Morkel, Markus, and Cramer, Thorsten

Published
2019
Full Text
View/download PDF

14. Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models

Author

Keklikoglou, Ioanna, Cianciaruso, Chiara, Güç, Esra, Squadrito, Mario Leonardo, Spring, Laura M., Tazzyman, Simon, Lambein, Lore, Poissonnier, Amanda, Ferraro, Gino B., Baer, Caroline, Cassará, Antonino, Guichard, Alan, Iruela-Arispe, M. Luisa, Lewis, Claire E., Coussens, Lisa M., Bardia, Aditya, Jain, Rakesh K., Pollard, Jeffrey W., and De Palma, Michele

Published
2019
Full Text
View/download PDF

16. Extracytoplasmic stress response systems in S. Typhimurium

Author

Lewis, Claire

Subjects
579.344, Q Science (General)
Abstract

Salmonella species can cause wide-ranging disease from mild food-poisoning enteritis to a systemic, sometimes fatal typhoid infection. These bacteria have evolved to survive in different environments within and outside the host and do so through the regulation of differential gene expression following activation of certain stress response systems. In gram negative bacteria such as Salmonella, envelope stress responses (ESR) are response systems that target stresses affecting components of the cell envelope such as the periplasm and outer membrane proteins. The two best characterised ESRs are the RpoE stress response system and the CpxAR two-component signal transduction system. Two further ESRs, the BaeSR response and the phage shock response have also recently been identified. The intention of this thesis was to characterise the ESR systems of S. Typhimurium to widen our current knowledge of genes involved in these systems and their role in the pathogenesis of S. Typhimurium with the ultimate aim of identifying possible candidate vaccine genes that may be used in future therapeutics against Salmonella infection. Firstly, extensive mutagenesis and phenotypic analysis studies were undertaken to characterise genes thought to be members of the RpoE regulon. Study of the phage shock response was initiated through mutagenesis, characterisation and regulation studies. A microarray experiment was designed in collaboration with colleagues at the Sanger Centre to identify members of the S. Typhimurium CpxAR regulon, with several members of this regulon being characterised further. The structural components of HtrA, an important ESR protein in S. Typhimurium, were analysed and finally work within this thesis was involved in the investigation of potential overlaps between both the RpoE and CpxAR systems. This led to the establishment of preliminary studies to investigate the vaccine potential of the tol - pal genes in S. Typhimurium.

Published
2008

19. Supplementary Data from Macrophages Mediate the Antitumor Effects of the Oncolytic Virus HSV1716 in Mammary Tumors

Author

Kwan, Amy, primary, Winder, Natalie, primary, Atkinson, Emer, primary, Al-Janabi, Haider, primary, Allen, Richard J., primary, Hughes, Russell, primary, Moamin, Mohammed, primary, Louie, Rikah, primary, Evans, Dhanajay, primary, Hutchinson, Matthew, primary, Capper, Drew, primary, Cox, Katie, primary, Handley, Joshua, primary, Wilshaw, Adam, primary, Kim, Taewoo, primary, Tazzyman, Simon J., primary, Srivastava, Sanjay, primary, Ottewell, Penelope, primary, Vadakekolathu, Jayakumar, primary, Pockley, Graham, primary, Lewis, Claire E., primary, Brown, Janet E., primary, Danson, Sarah J., primary, Conner, Joe, primary, and Muthana, Munitta, primary

Published
2023
Full Text
View/download PDF

20. Data from Macrophages Mediate the Antitumor Effects of the Oncolytic Virus HSV1716 in Mammary Tumors

Author

Kwan, Amy, primary, Winder, Natalie, primary, Atkinson, Emer, primary, Al-Janabi, Haider, primary, Allen, Richard J., primary, Hughes, Russell, primary, Moamin, Mohammed, primary, Louie, Rikah, primary, Evans, Dhanajay, primary, Hutchinson, Matthew, primary, Capper, Drew, primary, Cox, Katie, primary, Handley, Joshua, primary, Wilshaw, Adam, primary, Kim, Taewoo, primary, Tazzyman, Simon J., primary, Srivastava, Sanjay, primary, Ottewell, Penelope, primary, Vadakekolathu, Jayakumar, primary, Pockley, Graham, primary, Lewis, Claire E., primary, Brown, Janet E., primary, Danson, Sarah J., primary, Conner, Joe, primary, and Muthana, Munitta, primary

Published
2023
Full Text
View/download PDF

23. Supplementary Figures S1-S7 from Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy

Author

Hughes, Russell, primary, Qian, Bin-Zhi, primary, Rowan, Charlotte, primary, Muthana, Munitta, primary, Keklikoglou, Ioanna, primary, Olson, Oakley C., primary, Tazzyman, Simon, primary, Danson, Sarah, primary, Addison, Christina, primary, Clemons, Mark, primary, Gonzalez-Angulo, Ana Maria, primary, Joyce, Johanna A., primary, De Palma, Michele, primary, Pollard, Jeffrey W., primary, and Lewis, Claire E., primary

Published
2023
Full Text
View/download PDF

29. Supplementary Table S1 from Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy

Author

Hughes, Russell, primary, Qian, Bin-Zhi, primary, Rowan, Charlotte, primary, Muthana, Munitta, primary, Keklikoglou, Ioanna, primary, Olson, Oakley C., primary, Tazzyman, Simon, primary, Danson, Sarah, primary, Addison, Christina, primary, Clemons, Mark, primary, Gonzalez-Angulo, Ana Maria, primary, Joyce, Johanna A., primary, De Palma, Michele, primary, Pollard, Jeffrey W., primary, and Lewis, Claire E., primary

Published
2023
Full Text
View/download PDF

31. Data from Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy

Author

Hughes, Russell, primary, Qian, Bin-Zhi, primary, Rowan, Charlotte, primary, Muthana, Munitta, primary, Keklikoglou, Ioanna, primary, Olson, Oakley C., primary, Tazzyman, Simon, primary, Danson, Sarah, primary, Addison, Christina, primary, Clemons, Mark, primary, Gonzalez-Angulo, Ana Maria, primary, Joyce, Johanna A., primary, De Palma, Michele, primary, Pollard, Jeffrey W., primary, and Lewis, Claire E., primary

Published
2023
Full Text
View/download PDF

33. Supplementary Figure 2 from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors

Author

Muthana, Munitta, primary, Giannoudis, Athina, primary, Scott, Simon D., primary, Fang, Hsin-Yu, primary, Coffelt, Seth B., primary, Morrow, Fiona J., primary, Murdoch, Craig, primary, Burton, Julian, primary, Cross, Neil, primary, Burke, Bernard, primary, Mistry, Roshna, primary, Hamdy, Freddie, primary, Brown, Nicola J., primary, Georgopoulos, Lindsay, primary, Hoskin, Peter, primary, Essand, Magnus, primary, Lewis, Claire E., primary, and Maitland, Norman J., primary

Published
2023
Full Text
View/download PDF

37. Supplementary Figure 4 from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors

Author

Muthana, Munitta, primary, Giannoudis, Athina, primary, Scott, Simon D., primary, Fang, Hsin-Yu, primary, Coffelt, Seth B., primary, Morrow, Fiona J., primary, Murdoch, Craig, primary, Burton, Julian, primary, Cross, Neil, primary, Burke, Bernard, primary, Mistry, Roshna, primary, Hamdy, Freddie, primary, Brown, Nicola J., primary, Georgopoulos, Lindsay, primary, Hoskin, Peter, primary, Essand, Magnus, primary, Lewis, Claire E., primary, and Maitland, Norman J., primary

Published
2023
Full Text
View/download PDF

39. Supplementary Figure Legends 1-5, Methods from Angiopoietin-2 Regulates Gene Expression in TIE2-Expressing Monocytes and Augments Their Inherent Proangiogenic Functions

Author

Coffelt, Seth B., primary, Tal, Andrea O., primary, Scholz, Alexander, primary, De Palma, Michele, primary, Patel, Sunil, primary, Urbich, Carmen, primary, Biswas, Subhra K., primary, Murdoch, Craig, primary, Plate, Karl H., primary, Reiss, Yvonne, primary, and Lewis, Claire E., primary

Published
2023
Full Text
View/download PDF

41. Supplementary Figure 1 from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors

Author

Muthana, Munitta, primary, Giannoudis, Athina, primary, Scott, Simon D., primary, Fang, Hsin-Yu, primary, Coffelt, Seth B., primary, Morrow, Fiona J., primary, Murdoch, Craig, primary, Burton, Julian, primary, Cross, Neil, primary, Burke, Bernard, primary, Mistry, Roshna, primary, Hamdy, Freddie, primary, Brown, Nicola J., primary, Georgopoulos, Lindsay, primary, Hoskin, Peter, primary, Essand, Magnus, primary, Lewis, Claire E., primary, and Maitland, Norman J., primary

Published
2023
Full Text
View/download PDF

44. Supplementary Figure 3 from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors

Author

Muthana, Munitta, primary, Giannoudis, Athina, primary, Scott, Simon D., primary, Fang, Hsin-Yu, primary, Coffelt, Seth B., primary, Morrow, Fiona J., primary, Murdoch, Craig, primary, Burton, Julian, primary, Cross, Neil, primary, Burke, Bernard, primary, Mistry, Roshna, primary, Hamdy, Freddie, primary, Brown, Nicola J., primary, Georgopoulos, Lindsay, primary, Hoskin, Peter, primary, Essand, Magnus, primary, Lewis, Claire E., primary, and Maitland, Norman J., primary

Published
2023
Full Text
View/download PDF

45. Supplementary Figure 5 from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors

Author

Muthana, Munitta, primary, Giannoudis, Athina, primary, Scott, Simon D., primary, Fang, Hsin-Yu, primary, Coffelt, Seth B., primary, Morrow, Fiona J., primary, Murdoch, Craig, primary, Burton, Julian, primary, Cross, Neil, primary, Burke, Bernard, primary, Mistry, Roshna, primary, Hamdy, Freddie, primary, Brown, Nicola J., primary, Georgopoulos, Lindsay, primary, Hoskin, Peter, primary, Essand, Magnus, primary, Lewis, Claire E., primary, and Maitland, Norman J., primary

Published
2023
Full Text
View/download PDF

46. Data from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors

Author

Muthana, Munitta, primary, Giannoudis, Athina, primary, Scott, Simon D., primary, Fang, Hsin-Yu, primary, Coffelt, Seth B., primary, Morrow, Fiona J., primary, Murdoch, Craig, primary, Burton, Julian, primary, Cross, Neil, primary, Burke, Bernard, primary, Mistry, Roshna, primary, Hamdy, Freddie, primary, Brown, Nicola J., primary, Georgopoulos, Lindsay, primary, Hoskin, Peter, primary, Essand, Magnus, primary, Lewis, Claire E., primary, and Maitland, Norman J., primary

Published
2023
Full Text
View/download PDF

47. Supplementary Figure Legends from Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy

Author

Hughes, Russell, primary, Qian, Bin-Zhi, primary, Rowan, Charlotte, primary, Muthana, Munitta, primary, Keklikoglou, Ioanna, primary, Olson, Oakley C., primary, Tazzyman, Simon, primary, Danson, Sarah, primary, Addison, Christina, primary, Clemons, Mark, primary, Gonzalez-Angulo, Ana Maria, primary, Joyce, Johanna A., primary, De Palma, Michele, primary, Pollard, Jeffrey W., primary, and Lewis, Claire E., primary

Published
2023
Full Text
View/download PDF

50. Technical note on the exploration of COVID-19 in autopsy material

Author

Humphries, Matthew Phillip, primary, Bingham, Victoria, additional, Abdullah Sidi, Fatima, additional, Craig, Stephanie, additional, Lara, Beatrize, additional, El-daly, Hesham, additional, O'Doherty, Nicole, additional, Maxwell, Perry, additional, Lewis, Claire, additional, McQuaid, Stephen, additional, Lyness, James, additional, James, Jacqueline, additional, Snead, David R J, additional, and Salto-Tellez, Manuel, additional

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results