192 results on '"Lewis, Keir E."'
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2. Quitting smoking improves two-year survival after a diagnosis of non-small cell lung cancer
- Author
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Gemine, Rachel E., Davies, Gareth R., Lanyon, Kirsty, Rees, Sarah E., Campbell, Ian, and Lewis, Keir E.
- Published
- 2023
- Full Text
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3. Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study
- Author
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Raman, Betty, McCracken, Celeste, Cassar, Mark P, Moss, Alastair J, Finnigan, Lucy, Samat, Azlan Helmy A, Ogbole, Godwin, Tunnicliffe, Elizabeth M, Alfaro-Almagro, Fidel, Menke, Ricarda, Xie, Cheng, Gleeson, Fergus, Lukaschuk, Elena, Lamlum, Hanan, McGlynn, Kevin, Popescu, Iulia A, Sanders, Zeena-Britt, Saunders, Laura C, Piechnik, Stefan K, Ferreira, Vanessa M, Nikolaidou, Chrysovalantou, Rahman, Najib M, Ho, Ling-Pei, Harris, Victoria C, Shikotra, Aarti, Singapuri, Amisha, Pfeffer, Paul, Manisty, Charlotte, Kon, Onn M, Beggs, Mark, O'Regan, Declan P, Fuld, Jonathan, Weir-McCall, Jonathan R, Parekh, Dhruv, Steeds, Rick, Poinasamy, Krisnah, Cuthbertson, Dan J, Kemp, Graham J, Semple, Malcolm G, Horsley, Alexander, Miller, Christopher A, O'Brien, Caitlin, Shah, Ajay M, Chiribiri, Amedeo, Leavy, Olivia C, Richardson, Matthew, Elneima, Omer, McAuley, Hamish J C, Sereno, Marco, Saunders, Ruth M, Houchen-Wolloff, Linzy, Greening, Neil J, Bolton, Charlotte E, Brown, Jeremy S, Choudhury, Gourab, Diar Bakerly, Nawar, Easom, Nicholas, Echevarria, Carlos, Marks, Michael, Hurst, John R, Jones, Mark G, Wootton, Daniel G, Chalder, Trudie, Davies, Melanie J, De Soyza, Anthony, Geddes, John R, Greenhalf, William, Howard, Luke S, Jacob, Joseph, Man, William D-C, Openshaw, Peter J M, Porter, Joanna C, Rowland, Matthew J, Scott, Janet T, Singh, Sally J, Thomas, David C, Toshner, Mark, Lewis, Keir E, Heaney, Liam G, Harrison, Ewen M, Kerr, Steven, Docherty, Annemarie B, Lone, Nazir I, Quint, Jennifer, Sheikh, Aziz, Zheng, Bang, Jenkins, R Gisli, Cox, Eleanor, Francis, Susan, Halling-Brown, Mark, Chalmers, James D, Greenwood, John P, Plein, Sven, Hughes, Paul J C, Thompson, A A Roger, Rowland-Jones, Sarah L, Wild, James M, Kelly, Matthew, Treibel, Thomas A, Bandula, Steven, Aul, Raminder, Miller, Karla, Jezzard, Peter, Smith, Stephen, Nichols, Thomas E, McCann, Gerry P, Evans, Rachael A, Wain, Louise V, Brightling, Christopher E, Neubauer, Stefan, Baillie, J K, Shaw, Alison, 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Beckett, P, Nanda, U, Daynes, E, Charalambou, A, Yousuf, A J, Lea, A, Prickett, A, Gooptu, Bibek, Hargadon, Beverley, Bourne, Charlotte, Christie, C, Edwardson, C, Lee, D, Baldry, E, Stringer, E, Woodhead, F, Mills, G, Arnold, H, Aung, H, Qureshi, I N, Finch, J, Skeemer, J, Hadley, K, Khunti, Kamlesh, Carr, Liesel, Ingram, L, Aljaroof, M, Bakali, M, Bakau, M, Baldwin, M, Bourne, Michelle, Pareek, Manish, Soares, M, Tobin, Martin, Armstrong, Natalie, Brunskill, Nigel, Goodman, N, Cairns, P, Haldar, Pranab, McCourt, P, Dowling, R, Russell, Richard, Diver, Sarah, Edwards, Sarah, Glover, Sarah, Parker, S, Siddiqui, Salman, Ward, T J C, Mcnally, T, Thornton, T, Yates, Tom, Ibrahim, W, Monteiro, Will, Thickett, D, Wilkinson, D, Broome, M, McArdle, P, Upthegrove, R, Wraith, D, Langenberg, C, Summers, C, Bullmore, E, Heeney, J L, Schwaeble, W, Sudlow, C L, Adeloye, D, Newby, D E, Rudan, I, Shankar-Hari, M, Thorpe, M, Pius, R, Walmsley, S, McGovern, A, Ballard, C, Allan, L, Dennis, J, Cavanagh, J, Petrie, J, O'Donnell, K, Spears, M, Sattar, N, MacDonald, S, Guthrie, E, Henderson, M, Guillen Guio, Beatriz, Zhao, Bang, Lawson, C, Overton, Charlotte, Taylor, Chris, Tong, C, Mukaetova-Ladinska, Elizabeta, Turner, E, Pearl, John E, Sargant, J, Wormleighton, J, Bingham, Michelle, Sharma, M, Steiner, Mike, Samani, Nilesh, Novotny, Petr, Free, Rob, Allen, R J, Finney, Selina, Terry, Sarah, Brugha, Terry, Plekhanova, Tatiana, McArdle, A, Vinson, B, Spencer, L G, Reynolds, W, Ashworth, M, Deakin, B, Chinoy, H, Abel, K, Harvie, M, Stanel, S, Rostron, A, Coleman, C, Baguley, D, Hufton, E, Khan, F, Hall, I, Stewart, I, Fabbri, L, Wright, L, Kitterick, P, Morriss, R, Johnson, S, Bates, A, Antoniades, C, Clark, D, Bhui, K, Channon, K M, Motohashi, K, Sigfrid, L, Husain, M, Webster, M, Fu, X, Li, X, Kingham, L, Klenerman, P, Miiler, K, Carson, G, Simons, G, Huneke, N, Calder, P C, Baldwin, D, Bain, S, Lasserson, D, Daines, L, Bright, E, Stern, M, Crisp, P, Dharmagunawardena, R, Reddington, A, Wight, A, Bailey, L, Ashish, A, Robinson, E, Cooper, J, Broadley, A, Turnbull, A, Brookes, C, Sarginson, C, Ionita, D, Redfearn, H, Elliott, K, Barman, L, Griffiths, L, Guy, Z, Gill, Rhyan, Nathu, Rashmita, Harris, Edward, Moss, P, Finnigan, J, Saunders, Kathryn, Saunders, Peter, Kon, S, Kon, Samantha S, O'Brien, Linda, Shah, K, Shah, P, Richardson, Emma, Brown, V, Brown, M, Brown, Jo, Brown, J, Brown, Ammani, Brown, Angela, Choudhury, N, Jones, S, Jones, H, Jones, L, Jones, I, Jones, G, Jones, Heather, Jones, Don, Davies, Ffyon, Davies, Ellie, Davies, Kim, Davies, Gareth, Davies, Gwyneth A, Howard, K, Porter, Julie, Rowland, J, Rowland, A, Scott, Kathryn, Singh, Suver, Singh, Claire, Thomas, S, Thomas, Caradog, Lewis, Victoria, Lewis, J, Lewis, D, Harrison, P, Francis, C, Francis, R, Hughes, Rachel Ann, Hughes, Joan, Hughes, A D, Thompson, T, Kelly, S, Smith, D, Smith, Nikki, Smith, Andrew, Smith, Jacqui, Smith, Laurie, Smith, Susan, Evans, Teriann, Evans, Ranuromanana I, Evans, D, Evans, R, Evans, H, and Evans, J
- Published
- 2023
- Full Text
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4. Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study
- Author
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Jackson, C, Stewart, I D, Plekhanova, T, Cunningham, P S, Hazel, A L, Al-Sheklly, B, Aul, R, Bolton, C E, Chalder, T, Chalmers, J D, Chaudhuri, N, Docherty, A B, Donaldson, G, Edwardson, C L, Elneima, O, Greening, N J, Hanley, N A, Harris, V C, Harrison, E M, Ho, L-P, Houchen-Wolloff, L, Howard, L S, Jolley, C J, Jones, M G, Leavy, O C, Lewis, K E, Lone, N I, Marks, M, McAuley, H J C, McNarry, M A, Patel, B, Piper-Hanley, K, Poinasamy, K, Raman, B, Richardson, M, Rivera-Ortega, P, Rowland-Jones, S L, Rowlands, A V, Saunders, R M, Scott, J T, Sereno, M, Shah, A M, Shikotra, A, Singapuri, A, Stanel, S C, Thorpe, M, Wootton, D G, Yates, T, Jenkins, G, Singh, S J, Man, W D-C, Brightling, C E, Wain, L V, Porter, J C, Thompson, R, Horsley, A, Molyneaux, P L, Evans, R A, Jones, S E, Rutter, M K, Blaikley, J F, Abel, K, Adamali, H, Adeloye, D, Adeyemi, O, Adrego, R, Aguilar Jimenez, L A, Ahmad, S, Ahmad Haider, N, Ahmed, R, Ahwireng, N, Ainsworth, M, Alamoudi, A, Ali, M, Aljaroof, M, All, AM, Allan, L, Allen, R J, Allerton, L, Allsop, L, Almeida, P, Altmann, D, Alvarez Corral, M, Amoils, S, Anderson, D, Antoniades, C, Arbane, G, Arias, A, Armour, C, Armstrong, L, Armstrong, N, Arnold, D, Arnold, H, Ashish, A, Ashworth, A, Ashworth, M, Aslani, S, Assefa-Kebede, H, Atkin, C, Atkin, P, Aung, H, Austin, L, Avram, C, Ayoub, A, Babores, M, Baggott, R, Bagshaw, J, Baguley, D, Bailey, L, Baillie, J K, Bain, S, Bakali, M, Bakau, M, Baldry, E, Baldwin, D, Baldwin, M, Ballard, C, Banerjee, A, Bang, B, Barker, R E, Barman, L, Barratt, S, Barrett, F, Basire, D, Basu, N, Bates, M, Bates, A, Batterham, R, Baxendale, H, Bayes, H, Beadsworth, M, Beckett, P, Beggs, M, Begum, M, Beirne, P, Bell, D, Bell, R, Bennett, K, Beranova, E, Bermperi, A, Berridge, A, Berry, C, Betts, S, Bevan, E, Bhui, K, Bingham, M, Birchall, K, Bishop, L, Bisnauthsing, K, Blaikely, J, Bloss, A, Bolger, A, Bonnington, J, Botkai, A, Bourne, C, Bourne, M, Bramham, K, Brear, L, Breen, G, Breeze, J, Briggs, A, Bright, E, Brill, S, Brindle, K, Broad, L, Broadley, A, Brookes, C, Broome, M, Brown, A, Brown, J, Brown, J S, Brown, M, Brown, V, Brugha, T, Brunskill, N, Buch, M, Buckley, P, Bularga, A, Bullmore, E, Burden, L, Burdett, T, Burn, D, Burns, G, Burns, A, Busby, J, Butcher, R, Butt, A, Byrne, S, Cairns, P, Calder, P C, Calvelo, E, Carborn, H, Card, B, Carr, C, Carr, L, Carson, G, Carter, P, Casey, A, Cassar, M, Cavanagh, J, Chablani, M, Chambers, R C, Chan, F, Channon, K M, Chapman, K, Charalambou, A, Checkley, A, Chen, J, Cheng, Y, Chetham, L, Childs, C, Chilvers, E R, Chinoy, H, Chiribiri, A, Chong-James, K, Choudhury, G, Choudhury, N, Chowienczyk, P, Christie, C, Chrystal, M, Clark, D, Clark, C, Clarke, J, Clohisey, S, Coakley, G, Coburn, Z, Coetzee, S, Cole, J, Coleman, C, Conneh, F, Connell, D, Connolly, B, Connor, L, Cook, A, Cooper, B, Cooper, J, Cooper, S, Copeland, D, Cosier, T, Coulding, M, Coupland, C, Cox, E, Craig, T, Crisp, P, Cristiano, D, Crooks, M G, Cross, A, Cruz, I, Cullinan, P, Cuthbertson, D, Daines, L, Dalton, M, Daly, P, Daniels, A, Dark, P, Dasgin, J, David, A, David, C, Davies, E, Davies, F, Davies, G, Davies, G A, Davies, K, Davies, M J, Dawson, J, Daynes, E, De Soyza, A, Deakin, B, Deans, A, Deas, C, Deery, J, Defres, S, Dell, A, Dempsey, K, Denneny, E, Dennis, J, Dewar, A, Dharmagunawardena, R, Diar-Bakerly, N, Dickens, C, Dipper, A, Diver, S, Diwanji, S N, Dixon, M, Djukanovic, R, Dobson, H, Dobson, S L, Donaldson, A, Dong, T, Dormand, N, Dougherty, A, Dowling, R, Drain, S, Draxlbauer, K, Drury, K, Dulawan, P, Dunleavy, A, Dunn, S, Dupont, C, Earley, J, Easom, N, Echevarria, C, Edwards, S, Edwardson, C, El-Taweel, H, Elliott, A, Elliott, K, Ellis, Y, Elmer, A, Evans, D, Evans, H, Evans, J, Evans, R, Evans, R I, Evans, T, Evenden, C, Evison, L, Fabbri, L, Fairbairn, S, Fairman, A, Fallon, K, Faluyi, D, Favager, C, Fayzan, T, Featherstone, J, Felton, T, Finch, J, Finney, S, Finnigan, J, Finnigan, L, Fisher, H, Fletcher, S, Flockton, R, Flynn, M, Foot, H, Foote, D, Ford, A, Forton, D, Fraile, E, Francis, C, Francis, R, Francis, S, Frankel, A, Fraser, E, Free, R, French, N, Fu, X, Fuld, J, Furniss, J, Garner, L, Gautam, N, Geddes, J R, George, J, George, P M, Gibbons, M, Gill, M, Gilmour, L, Gleeson, F, Glossop, J, Glover, S, Goodman, N, Goodwin, C, Gooptu, B, Gordon, H, Gorsuch, T, Greatorex, M, Greenhaff, P L, Greenhalf, W, Greenhalgh, A, Greenwood, J, Gregory, H, Gregory, R, Grieve, D, Griffin, D, Griffiths, L, Guerdette, A-M, Guillen Guio, B, Gummadi, M, Gupta, A, Gurram, S, Guthrie, E, Guy, Z, Henson, H, Hadley, K, Haggar, A, Hainey, K, Hairsine, B, Haldar, P, Hall, I, Hall, L, Halling-Brown, M, Hamil, R, Hancock, A, Hancock, K, Haq, S, Hardwick, H E, Hardy, E, Hardy, T, Hargadon, B, Harrington, K, Harris, E, Harrison, P, Hart, N, Harvey, A, Harvey, M, Harvie, M, Haslam, L, Havinden-Williams, M, Hawkes, J, Hawkings, N, Haworth, J, Hayday, A, Haynes, M, Hazeldine, J, Hazelton, T, Heaney, L G, Heeley, C, Heeney, J L, Heightman, M, Heller, S, Henderson, M, Hesselden, L, Hewitt, M, Highett, V, Hillman, T, Hiwot, T, Hoare, A, Hoare, M, Hockridge, J, Hogarth, P, Holbourn, A, Holden, S, Holdsworth, L, Holgate, D, Holland, M, Holloway, L, Holmes, K, Holmes, M, Holroyd-Hind, B, Holt, L, Hormis, A, Hosseini, A, Hotopf, M, Howard, K, Howell, A, Hufton, E, Hughes, A D, Hughes, J, Hughes, R, Humphries, A, Huneke, N, Hurditch, E, Hurst, J, Husain, M, Hussell, T, Hutchinson, J, Ibrahim, W, Ilyas, F, Ingham, J, Ingram, L, Ionita, D, Isaacs, K, Ismail, K, Jackson, T, Jacob, J, James, W Y, Jang, W, Jarman, C, Jarrold, I, Jarvis, H, Jastrub, R, Jayaraman, B, Jenkins, R G, Jezzard, P, Jiwa, K, Johnson, C, Johnson, S, Johnston, D, Jones, D, Jones, G, Jones, H, Jones, I, Jones, L, Jones, S, Jose, S, Kabir, T, Kaltsakas, G, Kamwa, V, Kanellakis, N, Kaprowska, S, Kausar, Z, Keenan, N, Kelly, S, Kemp, G, Kerr, S, Kerslake, H, Key, A L, Khan, F, Khunti, K, Kilroy, S, King, B, King, C, Kingham, L, Kirk, J, Kitterick, P, Klenerman, P, Knibbs, L, Knight, S, Knighton, A, Kon, O, Kon, S, Kon, S S, Koprowska, S, Korszun, A, Koychev, I, Kurasz, C, Kurupati, P, Laing, C, Lamlum, H, Landers, G, Langenberg, C, Lasserson, D, Lavelle-Langham, L, Lawrie, A, Lawson, C, Layton, A, Lea, A, Lee, D, Lee, J-H, Lee, E, Leitch, K, Lenagh, R, Lewis, D, Lewis, J, Lewis, V, Lewis-Burke, N, Li, X, Light, T, Lightstone, L, Lilaonitkul, W, Lim, L, Linford, S, Lingford-Hughes, A, Lipman, M, Liyanage, K, Lloyd, A, Logan, S, Lomas, D, Loosley, R, Lord, J M, Lota, H, Lovegrove, W, Lucey, A, Lukaschuk, E, Lye, A, Lynch, C, MacDonald, S, MacGowan, G, Macharia, I, Mackie, J, Macliver, L, Madathil, S, Madzamba, G, Magee, N, Magtoto, M M, Mairs, N, Majeed, N, Major, E, Malein, F, Malim, M, Mallison, G, Mandal, S, Mangion, K, Manisty, C, Manley, R, March, K, Marciniak, S, Marino, P, Mariveles, M, Marouzet, E, Marsh, S, Marshall, B, Marshall, M, Martin, J, Martineau, A, Martinez, L M, Maskell, N, Matila, D, Matimba-Mupaya, W, Matthews, L, Mbuyisa, A, McAdoo, S, McAllister-Williams, H, McArdle, A, McArdle, P, McAulay, D, McCann, G P, McCormick, J, McCormick, W, McCourt, P, McGarvey, L, McGhee, C, Mcgee, K, McGinness, J, McGlynn, K, McGovern, A, McGuinness, H, McInnes, I B, McIntosh, J, McIvor, E, McIvor, K, McLeavey, L, McMahon, A, McMahon, M J, McMorrow, L, Mcnally, T, McNarry, M, McNeill, J, McQueen, A, McShane, H, Mears, C, Megson, C, Megson, S, Mehta, P, Meiring, J, Melling, L, Mencias, M, Menzies, D, Merida Morillas, M, Michael, A, Miller, C, Milligan, L, Mills, C, Mills, G, Mills, N L, Milner, L, Misra, S, Mitchell, J, Mohamed, A, Mohamed, N, Mohammed, S, Monteiro, W, Moriera, S, Morley, A, Morrison, L, Morriss, R, Morrow, A, Moss, A J, Moss, P, Motohashi, K, Msimanga, N, Mukaetova-Ladinska, E, Munawar, U, Murira, J, Nanda, U, Nassa, H, Nasseri, M, Neal, A, Needham, R, Neill, P, Neubauer, S, Newby, D E, Newell, H, Newman, T, Newman, J, Newton-Cox, A, Nicholson, T, Nicoll, D, Nikolaidis, A, Nolan, C M, Noonan, M J, Norman, C, 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M, Ramos, A, Ramos, H, Rangeley, J, Rangelov, B, Ratcliffe, L, Ravencroft, P, Reddington, A, Reddy, R, Reddy, A, Redfearn, H, Redwood, D, Reed, A, Rees, M, Rees, T, Regan, K, Reynolds, W, Ribeiro, C, Richards, A, Richardson, E, Roberts, K, Robertson, E, Robinson, E, Robinson, L, Roche, L, Roddis, C, Rodger, J, Ross, A, Ross, G, Rossdale, J, Rostron, A, Rowe, A, Rowland, A, Rowland, J, Rowland, M J, Roy, K, Roy, M, Rudan, I, Russell, R, Russell, E, Saalmink, G, Sabit, R, Sage, E K, Samakomva, T, Samani, N, Sampson, C, Samuel, K, Samuel, R, Sanderson, A, Sapey, E, Saralaya, D, Sargent, J, Sarginson, C, Sass, T, Sattar, N, Saunders, K, Saunders, P, Saunders, L C, Savill, H, Saxon, W, Sayer, A, Schronce, J, Schwaeble, W, Scott, K, Selby, N, Semple, M G, Sewell, T A, Shah, K, Shah, P, Shankar-Hari, M, Sharma, M, Sharpe, C, Sharpe, M, Shashaa, S, Shaw, A, Shaw, K, Shaw, V, Sheikh, A, Shelton, S, Shenton, L, Shevket, K, Short, J, Siddique, S, Siddiqui, S, Sidebottom, J, Sigfrid, L, Simons, G, Simpson, J, Simpson, N, Singh, C, Sissons, D, Skeemer, J, Slack, K, Smith, A, Smith, D, Smith, S, Smith, J, Smith, L, Soares, M, Solano, T S, Solly, R, Solstice, A R, Soulsby, T, Southern, D, Sowter, D, Spears, M, Spencer, L G, Speranza, F, Stadon, L, Stanel, S, Steele, N, Steiner, M, Stensel, D, Stephens, G, Stephenson, L, Stern, M, Stimpson, R, Stockdale, S, Stockley, J, Stoker, W, Stone, R, Storrar, W, Storrie, A, Storton, K, Stringer, E, Strong-Sheldrake, S, Stroud, N, Subbe, C, Sudlow, C L, Suleiman, Z, Summers, C, Summersgill, C, Sutherland, D, Sykes, D L, Sykes, R, Talbot, N, Tan, A L, Tarusan, L, Tavoukjian, V, Taylor, A, Taylor, C, Taylor, J, Te, A, Tedd, H, Tee, C J, Teixeira, J, Tench, H, Terry, S, Thackray-Nocera, S, Thaivalappil, F, Thamu, B, Thickett, D, Thomas, C, Thomas, D C, Thomas, S, Thomas, A K, Thomas-Woods, T, Thompson, T, Thompson, A A R, Thornton, T, Thwaites, R S, Tilley, J, Tinker, N, Tiongson, G F, Tobin, M, Tomlinson, J, Tong, C, Toshner, M, Touyz, R, Tripp, K A, Tunnicliffe, E, Turnbull, A, Turner, E, Turner, S, Turner, V, Turner, K, Turney, S, Turtle, L, Turton, H, Ugoji, J, Ugwuoke, R, Upthegrove, R, Valabhji, J, Ventura, M, Vere, J, Vickers, C, Vinson, B, Wade, E, Wade, P, Wainwright, T, Wajero, L O, Walder, S, Walker, S, Wall, E, Wallis, T, Walmsley, S, Walsh, J A, Walsh, S, Warburton, L, Ward, T J C, Warwick, K, Wassall, H, Waterson, S, Watson, E, Watson, L, Watson, J, Weir McCall, J, Welch, C, Welch, H, Welsh, B, Wessely, S, West, S, Weston, H, Wheeler, H, White, S, Whitehead, V, Whitney, J, Whittaker, S, Whittam, B, Whitworth, V, Wight, A, Wild, J M, Wilkins, M, Wilkinson, D, Williams, B, Williams, N, Williams, J, Williams-Howard, S A, Willicombe, M, Willis, G, Willoughby, J, Wilson, A, Wilson, D, Wilson, I, Window, N, Witham, M, Wolf-Roberts, R, Wood, C, Woodhead, F, Woods, J, Wormleighton, J, Worsley, J, Wraith, D, Wrey Brown, C, Wright, C, Wright, L, Wright, S, Wyles, J, Wynter, I, Xu, M, Yasmin, N, Yasmin, S, Yip, K P, Young, B, Young, S, Young, A, Yousuf, A J, Zawia, A, Zeidan, L, Zhao, B, Zheng, B, Zongo, O, Jackson, Callum, Stewart, Iain D, Plekhanova, Tatiana, Cunningham, Peter S, Hazel, Andrew L, Al-Sheklly, Bashar, Aul, Raminder, Bolton, Charlotte E, Chalder, Trudie, Chalmers, James D, Chaudhuri, Nazia, Docherty, Annemarie B, Donaldson, Gavin, Edwardson, Charlotte L, Elneima, Omer, Greening, Neil J, Hanley, Neil A, Harris, Victoria C, Harrison, Ewen M, Ho, Ling-Pei, Houchen-Wolloff, Linzy, Howard, Luke S, Jolley, Caroline J, Jones, Mark G, Leavy, Olivia C, Lewis, Keir E, Lone, Nazir I, Marks, Michael, McAuley, Hamish J C, McNarry, Melitta A, Patel, Brijesh V, Piper-Hanley, Karen, Poinasamy, Krisnah, Raman, Betty, Richardson, Matthew, Rivera-Ortega, Pilar, Rowland-Jones, Sarah L, Rowlands, Alex V, Saunders, Ruth M, Scott, Janet T, Sereno, Marco, Shah, Ajay M, Shikotra, Aarti, Singapuri, Amisha, Stanel, Stefan C, Thorpe, Mathew, Wootton, Daniel G, Yates, Thomas, Gisli Jenkins, R, Singh, Sally J, Man, William D-C, Brightling, Christopher E, Wain, Louise V, Porter, Joanna C, Thompson, A A Roger, Horsley, Alex, Molyneaux, Philip L, Evans, Rachael A, Jones, Samuel E, Rutter, Martin K, and Blaikley, John F
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- 2023
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5. The Economic Potential of Smoking Cessation Interventions at the Point of Diagnosis of Non–Small Cell Lung Cancer
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Jones, Mari, Lowin, Julia, Sewell, Bernadette, Gemine, Rachel Elizabeth, Rees, Sarah Elizabeth, Lanyon, Kirsty, and Lewis, Keir E.
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- 2023
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6. Longitudinal study to assess impact of smoking at diagnosis and quitting on 1-year survival for people with non-small cell lung cancer
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Gemine, Rachel E., Ghosal, Robin, Collier, Gareth, Parry, Diane, Campbell, Ian, Davies, Gareth, Davies, Kathryn, and Lewis, Keir E.
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- 2019
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7. COVID-19 managed on respiratory wards and intensive care units: Results from the national COVID-19 outcome report in Wales from March 2020 to December 2021
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Barry, Simon M., primary, Davies, Gareth R., additional, Underwood, Jonathan, additional, Davies, Chris R., additional, and Lewis, Keir E., additional
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- 2024
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8. COPD patients
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Jiménez-Ruiz, Carlos A., primary and Lewis, Keir E., additional
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- 2021
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9. Lung cancer patients
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Gemine, Rachel E., primary, Haider, Syedah Aleena, additional, Ravara, Sofia Belo, additional, and Lewis, Keir E., additional
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- 2021
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10. Introduction: Supporting tobacco cessation – from health policy to health system reorientation and patient care
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Ravara, Sofia Belo, primary, Dağli, Elif, additional, Katsaounou, Paraskevi, additional, Lewis, Keir E., additional, and Pisinger, Charlotta, additional
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- 2021
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- View/download PDF
11. Optimising health systems to deliver tobacco-dependence treatment
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Lewis, Keir E., primary, Ravara, Sofia Belo, additional, Papadakis, Sophia, additional, Attar-Zadeh, Darush, additional, Hanafin, Joan, additional, Clancy, Luke, additional, Rasmussen, Mette, additional, Katsaounou, Paraskevi, additional, and Fu, Dongbo, additional
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- 2021
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12. Metabolomic-based biomarker discovery for non-invasive lung cancer screening: A case study
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O'Shea, Keiron, Cameron, Simon J.S., Lewis, Keir E., Lu, Chuan, and Mur, Luis A.J.
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- 2016
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13. The metabolomic detection of lung cancer biomarkers in sputum
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Cameron, Simon J.S., Lewis, Keir E., Beckmann, Manfred, Allison, Gordon G., Ghosal, Robin, Lewis, Paul D., and Mur, Luis A.J.
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- 2016
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14. Weekend admissions and mortality for major acute disorders across England and Wales: record linkage cohort studies
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Roberts, Stephen E., John, Ann, Lewis, Keir E., Brown, Jonathan, Lyons, Ronan A., and Williams, John G.
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- 2019
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15. Cohort Profile: Post-hospitalisation COVID-19 study (PHOSP-COVID)
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Elneima, Omer, primary, McAuley, Hamish J C, additional, Leavy, Olivia C, additional, Chalmers, James D, additional, Horsley, Alex, additional, Ho, Ling-Pei, additional, Marks, Michael, additional, Poinasamy, Krisnah, additional, Raman, Betty, additional, Shikotra, Aarti, additional, Singapuri, Amisha, additional, Sereno, Marco, additional, Harris, Victoria C, additional, Houchen-Wolloff, Linzy, additional, Saunders, Ruth M, additional, Greening, Neil J, additional, Richardson, Matthew, additional, Quint, Jennifer K, additional, Briggs, Andrew, additional, Docherty, Annemarie B, additional, Kerr, Steven, additional, Harrison, Ewen M, additional, Lone, Nazir I, additional, Thorpe, Mathew, additional, Heaney, Liam G, additional, Lewis, Keir E, additional, Aul, Raminder, additional, Beirne, Paul, additional, Bolton, Charlotte E, additional, Brown, Jeremy S, additional, Choudhury, Gourab, additional, Diar Bakerly, Nawar, additional, Easom, Nicholas, additional, Echevarria, Carlos, additional, Fuld, Jonathan, additional, Hart, Nick, additional, Hurst, John R, additional, Jones, Mark G, additional, Parekh, Dhruv, additional, Pfeffer, Paul, additional, Rahman, Najib M, additional, Rowland-Jones, Sarah L, additional, Thompson, AA Roger, additional, Jolley, Caroline, additional, Shah, Ajay M, additional, Wootton, Dan G, additional, Chalder, Trudie, additional, Davies, Melanie J, additional, De Soyza, Anthony, additional, Geddes, John R, additional, Greenhalf, William, additional, Heller, Simon, additional, Howard, Luke S, additional, Jacob, Joseph, additional, Jenkins, R Gisli, additional, Lord, Janet M, additional, Man, William D-C, additional, McCann, Gerry P, additional, Neubauer, Stefan, additional, Openshaw, Peter JM, additional, Porter, Joanna C, additional, Rowland, Matthew J, additional, Scott, Janet T, additional, Semple, Malcolm G, additional, Singh, Sally J, additional, Thomas, David C, additional, Toshner, Mark, additional, Sheikh, Aziz, additional, Brightling, Christopher E, additional, Wain, Louise V, additional, and Evans, Rachael A, additional
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- 2023
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16. Genomic and ecologic characteristics of the airway microbial-mucosal complex
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Cuthbertson, Leah, primary, Löber, Ulrike, additional, Ish-Horowicz, Jonathan S., additional, McBrien, Claire N., additional, Churchward, Colin, additional, Parker, Jeremy C., additional, Olanipekun, Michael T., additional, Burke, Conor, additional, O’Carroll, Orla, additional, Faul, John, additional, Davies, Gwyneth A., additional, Lewis, Keir E., additional, Hopkin, Julian M., additional, Creaser-Thomas, Joy, additional, Goshal, Robin, additional, Chung, Kian Fan, additional, Piatek, Stefan, additional, Willis-Owen, Saffron A.G., additional, Bartolomaeus, Theda U. P., additional, Birkner, Till, additional, Dwyer, Sarah, additional, Kumar, Nitin, additional, Turek, Elena M., additional, Musk, A. William, additional, Hui, Jenni, additional, Hunter, Michael, additional, James, Alan, additional, Dumas, Marc-Emmanuel, additional, Filippi, Sarah, additional, Cox, Michael J., additional, Lawley, Trevor D., additional, Forslund, Sofia K., additional, Moffatt, Miriam F., additional, and Cookson, William O.C., additional
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- 2022
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17. Mortality Improvements in Adult Patients Hospitalised with Community Acquired COVID-19 in Wales From March 2020 to December 2021
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Barry, Simon M, primary, Davies, Gareth R, additional, Davies, Chris R, additional, and Lewis, Keir E, additional
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- 2022
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18. Can smokers switch from a hospital-based to a community-based stop smoking service? An open-label, randomized trial comparing three referral schemes
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Lewis, Keir E., Durgan, Linda, Edwards, Victoria M., Dixon, Hazel, Whitehead, Carolyn, and Sykes, Robert N.
- Published
- 2009
19. Endothelial injury markers before and after nasal continuous positive airway pressure treatment for obstructive sleep apnoea hypopnoea syndrome
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Wilczynska, Maria, Rice, Samuel, Davies, Gareth, and Lewis, Keir E
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- 2014
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20. ‘I Live a Kind of Shadow Life’: Individual Experiences of COVID-19 Recovery and the Impact on Physical Activity Levels
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Shelley, James, primary, Hudson, Joanne, additional, Mackintosh, Kelly A., additional, Saynor, Zoe L., additional, Duckers, Jamie, additional, Lewis, Keir E., additional, Davies, Gwyneth A., additional, Berg, Ronan M. G., additional, and McNarry, Melitta A., additional
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- 2021
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21. Predictors of poor attendance at an outpatient pulmonary rehabilitation programme
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Sabit, Ramsey, Griffiths, Timothy L., Watkins, Alan J., Evans, Wendy, Bolton, Charlotte E., Shale, Dennis J., and Lewis, Keir E.
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- 2008
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22. ACCORD: A Multicentre, Seamless, Phase 2 Adaptive Randomisation Platform Study to Assess the Efficacy and Safety of Multiple Candidate Agents for the Treatment of COVID-19 in Hospitalised Patients: A structured summary of a study protocol for a randomised controlled trial
- Author
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Wilkinson, Tom, Dixon, Rupert, Page, Clive, Carroll, Miles, Griffiths, Gareth, Ho, Ling-Pei, De Soyza, Anthony, Felton, Timothy, Lewis, Keir E, Phekoo, Karen, Chalmers, James D, Gordon, Anthony, McGarvey, Lorcan, Doherty, Jillian, Read, Robert C, Shankar-Hari, Manu, Martinez-Alier, Nuria, O'Kelly, Michael, Duncan, Graeme, Walles, Roelize, Sykes, James, Summers, Charlotte, Singh, Dave, ACCORD Collaborators, NIHR, National Institute for Health Research, Summers, Charlotte [0000-0002-7269-2873], and Apollo - University of Cambridge Repository
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Letter ,Benzamides/therapeutic use ,medicine.medical_treatment ,Medicine (miscellaneous) ,Spike Glycoprotein, Coronavirus/antagonists & inhibitors ,law.invention ,platform study ,0302 clinical medicine ,Randomized controlled trial ,law ,Oxygen therapy ,Pharmacology (medical) ,030212 general & internal medicine ,Stage (cooking) ,1102 Cardiorespiratory Medicine and Haematology ,Randomized Controlled Trials as Topic ,Response rate (survey) ,lcsh:R5-920 ,master protocol ,Standard of Care ,phase II ,Antiviral Agents/adverse effects ,Hospitalization ,Pyrazines ,Benzamides ,Spike Glycoprotein, Coronavirus ,lcsh:Medicine (General) ,randomised ,Coronavirus Infections ,medicine.medical_specialty ,Blinding ,Randomization ,Pneumonia, Viral ,Antiviral Agents ,03 medical and health sciences ,Betacoronavirus ,General & Internal Medicine ,Internal medicine ,medicine ,Humans ,Pandemics ,Protocol (science) ,business.industry ,SARS-CoV-2 ,COVID-19 ,1103 Clinical Sciences ,Coronavirus Infections/drug therapy ,Pneumonia, Viral/drug therapy ,COVID-19 Drug Treatment ,Pyrazines/therapeutic use ,Cardiovascular System & Hematology ,Sample size determination ,business ,030217 neurology & neurosurgery - Abstract
Objectives Stage 1: To evaluate the safety and efficacy of candidate agents as add-on therapies to standard of care (SoC) in patients hospitalised with COVID-19 in a screening stage. Stage 2: To confirm the efficacy of candidate agents selected on the basis of evidence from Stage 1 in patients hospitalised with COVID-19 in an expansion stage. Trial design ACCORD is a seamless, Phase 2, adaptive, randomised controlled platform study, designed to rapidly test candidate agents in the treatment of COVID-19. Designed as a master protocol with each candidate agent being included via its own sub-protocol, initially randomising equally between each candidate and a single contemporaneous SoC arm (which can adapt into 2:1). Candidate agents currently include bemcentinib, MEDI3506, acalabrutinib, zilucoplan and nebulised heparin. For each candidate a total of 60 patients will be recruited in Stage 1. If Stage 1 provides evidence of efficacy and acceptable safety the candidate will enter Stage 2 where a total of approximately 126 patients will be recruited into each study arm sub-protocol. Enrollees and outcomes will not be shared across the Stages; the endpoint, analysis and sample size for Stage 2 may be adjusted based on evidence from Stage 1. Additional arms may be added as new potential candidate agents are identified via candidate agent specific sub-protocols. Participants The study will include hospitalised adult patients (≥18 years) with confirmed SARS-CoV-2 infection, the virus that causes COVID-19, that clinically meet Grades 3 (hospitalised – mild disease, no oxygen therapy), Grades 4 (hospitalised, oxygen by mask or nasal prongs) and 5 (hospitalised, non-invasive ventilation or high flow oxygen) of the WHO Working Group on the Clinical Characteristics of COVID-19 9-point category ordinal scale. Participants will be recruited from England, Northern Ireland, Wales and Scotland. Intervention and comparator Comparator is current standard of care (SoC) for the treatment of COVID-19. Current candidate experimental arms include bemcentinib, MEDI3506, acalabrutinib, zilucoplan and nebulised heparin with others to be added over time. Bemcentinib could potentially reduce viral infection and blocks SARS-CoV-2 spike protein; MEDI3506 is a clinic-ready anti-IL-33 monoclonal antibody with the potential to treat respiratory failure caused by COVID; acalabrutinib is a BTK inhibitor which is anti-viral and anti-inflammatory; zilucoplan is a complement C5 inhibitor which may block the severe inflammatory response in COVID-19 and; nebulised heparin has been shown to bind with the spike protein. ACCORD is linked with the UK national COVID therapeutics task force to help prioritise candidate agents. Main outcomes Time to sustained clinical improvement of at least 2 points (from randomisation) on the WHO 9-point category ordinal scale, live discharge from the hospital, or considered fit for discharge (a score of 0, 1, or 2 on the ordinal scale), whichever comes first, by Day 29 (this will also define the “responder” for the response rate analyses). Randomisation An electronic randomization will be performed by Cenduit using Interactive Response Technology (IRT). Randomisation will be stratified by baseline severity grade. Randomisation will proceed with an equal allocation to each arm and a contemporaneous SoC arm (e.g. 1:1 if control and 1 experimental arm; 1:1:1 if two experimental candidate arms etc) but will be reviewed as the trial progresses and may be changed to 2:1 in favour of the candidate agents. Blinding (masking) The trial is open label and no blinding is currently planned in the study. Numbers to be randomised (sample size) This will be in the order of 60 patients per candidate agent for Stage 1, and 126 patients for Stage 2. However, sample size re-estimation may be considered after Stage 1. It is estimated that up to 1800 patients will participate in the overall study. Trial Status Master protocol version ACCORD-2-001 - Master Protocol (Amendment 1) 22nd April 2020, the trial has full regulatory approval and recruitment is ongoing in the bemcentinib (first patient recruited 6/5/2020), MEDI3506 (first patient recruited 19/5/2020), acalabrutinib (first patient recruited 20/5/2020) and zilucoplan (first patient recruited 19/5/2020) candidates (and SoC). The recruitment dates of each arm will vary between candidate agents as they are added or dropped from the trial, but will have recruited and reported within a year. Trial registration EudraCT 2020-001736-95, registered 28th April 2020. Full protocol The full protocol (Master Protocol with each of the candidate sub-protocols) is attached as an additional file, accessible from the Trials website (Additional file 1). In the interest in expediting dissemination of this material, the familiar formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol.
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- 2020
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23. ‘I Live a Kind of Shadow Life’ : Individual Experiences of COVID-19 Recovery and the Impact on Physical Activity Levels
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Shelley, James, Hudson, Joanne, Mackintosh, Kelly A., Saynor, Zoe L., Duckers, Jamie, Lewis, Keir E., Davies, Gwyneth A., Berg, Ronan M. G., McNarry, Melitta A., Shelley, James, Hudson, Joanne, Mackintosh, Kelly A., Saynor, Zoe L., Duckers, Jamie, Lewis, Keir E., Davies, Gwyneth A., Berg, Ronan M. G., and McNarry, Melitta A.
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Understanding of strategies to support individuals recovering from coronavirus disease 2019 (COVID-19) is limited. ‘Long COVID’ is a multisystem disease characterised by a range of respiratory, gastrointestinal, cardiovascular, neurological, and musculoskeletal symptoms extending beyond 12 weeks. The aim of this study was to explore individuals’ experiences of recovering from COVID-19 to provide a better understanding of the acute and long-term impact of the disease on physical activity (PA). Individualised semi-structured interviews were conducted with 48 adults recovering from COVID-19 at 6–11 months post-infection. An inductive thematic analysis approach was used, reaching saturation at 14 interviews (10 female; 47 ± 7 years). Four overarching themes were identified: (i) Living with COVID-19, including managing activities of daily living; (ii) Dealing with the Unknown and self-management strategies; (iii) Re-introducing physical activity; and (iv) Challenges of returning to work. The return to PA, whether through activities of daily living, work or exercise, is often associated with the exacerbation of symptoms, presenting a range of challenges for individuals recovering from COVID-19. Individually tailored support is therefore required to address the unique challenges posed by COVID-19.
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- 2021
24. E-cigarettes, heated tobacco and other novel nicotine-containing products: a help to smokers or a public health threat?
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Ravara, Sofia Belo, Dağli, Elif, Katsaounou, Paraskevi, Lewis, Keir E., Pisinger, Charlotta, Vestbo, Jørgen, Ravara, Sofia Belo, Dağli, Elif, Katsaounou, Paraskevi, Lewis, Keir E., Pisinger, Charlotta, and Vestbo, Jørgen
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- 2021
25. ‘I Live a Kind of Shadow Life’:Individual Experiences of COVID‐19 Recovery and the Impact on Physical Activity Levels
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Shelley, James, Hudson, Joanne, Mackintosh, Kelly A., Saynor, Zoe L., Duckers, Jamie, Lewis, Keir E., Davies, Gwyneth A., Berg, Ronan M.G., McNarry, Melitta A., Shelley, James, Hudson, Joanne, Mackintosh, Kelly A., Saynor, Zoe L., Duckers, Jamie, Lewis, Keir E., Davies, Gwyneth A., Berg, Ronan M.G., and McNarry, Melitta A.
- Abstract
Understanding of strategies to support individuals recovering from coronavirus disease 2019 (COVID‐19) is limited. ‘Long COVID’ is a multisystem disease characterised by a range of respiratory, gastrointestinal, cardiovascular, neurological, and musculoskeletal symptoms extend-ing beyond 12 weeks. The aim of this study was to explore individuals’ experiences of recovering from COVID‐19 to provide a better understanding of the acute and long‐term impact of the disease on physical activity (PA). Individualised semi‐structured interviews were conducted with 48 adults recovering from COVID‐19 at 6–11 months post‐infection. An inductive thematic analysis approach was used, reaching saturation at 14 interviews (10 female; 47 ± 7 years). Four overarching themes were identified: i) Living with COVID‐19, including managing activities of daily living; ii) Dealing with the Unknown and self‐management strategies; iii) Re‐introducing physical activity; and iv) Challenges of returning to work. The return to PA, whether through activities of daily living, work or exercise, is often associated with the exacerbation of symptoms, presenting a range of challenges for individuals recovering from COVID‐19. Individually tailored support is therefore required to address the unique challenges posed by COVID‐19.
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- 2021
26. Pro-inflammatory effects of e-cigarette vapour condensate on human alveolar macrophages
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Scott, Aaron, Lugg, Sebastian T, Aldridge, Kerrie, Lewis, Keir E, Bowden, Allen, Mahida, Rahul Y, Grudzinska, Frances Susanna, Dosanjh, Davinder, Parekh, Dhruv, Foronjy, Robert, Sapey, Elizabeth, Naidu, Babu, and Thickett, David R
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Nicotine ,Cell Survival ,THP-1 Cells ,Apoptosis ,Complex Mixtures ,Electronic Nicotine Delivery Systems ,Antioxidants ,Necrosis ,macrophage biology ,Phagocytosis ,respiratory infection ,Macrophages, Alveolar ,oxidative stress ,Humans ,Protein Kinase Inhibitors ,Chemokine CCL2 ,Phosphoinositide-3 Kinase Inhibitors ,Inflammation ,Interleukin-6 ,Tumor Necrosis Factor-alpha ,Vaping ,Smoking ,Interleukin-8 ,Acetylcysteine ,Matrix Metalloproteinase 9 ,Gases ,Reactive Oxygen Species - Abstract
Objective Vaping may increase the cytotoxic effects of e-cigarette liquid (ECL). We compared the effect of unvaped ECL to e-cigarette vapour condensate (ECVC) on alveolar macrophage (AM) function. Methods AMs were treated with ECVC and nicotine-free ECVC (nfECVC). AM viability, apoptosis, necrosis, cytokine, chemokine and protease release, reactive oxygen species (ROS) release and bacterial phagocytosis were assessed. Results Macrophage culture with ECL or ECVC resulted in a dose-dependent reduction in cell viability. ECVC was cytotoxic at lower concentrations than ECL and resulted in increased apoptosis and necrosis. nfECVC resulted in less cytotoxicity and apoptosis. Exposure of AMs to a sub-lethal 0.5% ECVC/nfECVC increased ROS production approximately 50-fold and significantly inhibited phagocytosis. Pan and class one isoform phosphoinositide 3 kinase inhibitors partially inhibited the effects of ECVC/nfECVC on macrophage viability and apoptosis. Secretion of interleukin 6, tumour necrosis factor α, CXCL-8, monocyte chemoattractant protein 1 and matrix metalloproteinase 9 was significantly increased following ECVC challenge. Treatment with the anti-oxidant N-acetyl-cysteine (NAC) ameliorated the cytotoxic effects of ECVC/nfECVC to levels not significantly different from baseline and restored phagocytic function. Conclusions ECVC is significantly more toxic to AMs than non-vaped ECL. Excessive production of ROS, inflammatory cytokines and chemokines induced by e-cigarette vapour may induce an inflammatory state in AMs within the lung that is partly dependent on nicotine. Inhibition of phagocytosis also suggests users may suffer from impaired bacterial clearance. While further research is needed to fully understand the effects of e-cigarette exposure in humans in vivo, we caution against the widely held opinion that e-cigarettes are safe.
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- 2018
27. Relating Ventilatory Support and Drug Treatment Strategies to the Fundamental Pathophysiology in COVID-19 Illness
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Lewis, Keir E., primary, Stoll, Alexander, additional, Watts, Sarah, additional, and Kirkman, Emrys, additional
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- 2021
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28. Chapter 4 Pharmacological aids to smoking cessation
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Rees, Stuart, primary and Lewis, Keir E., additional
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- 2010
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29. Chapter 3 Helping individual smokers to stop
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Poole, Helen, primary, Dixon, Hazel, additional, and Lewis, Keir E., additional
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- 2010
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30. Chapter 2 The physiological and psychological effects of smoking
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Lewis, Keir E., primary
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- 2010
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31. Chapter 1 Epidemiology, the world tobacco epidemic
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Lewis, Keir E., primary
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- 2010
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32. Drugs that act on the respiratory tract
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Lewis, Keir E., primary and Davies, Gwyneth A., additional
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- 2010
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33. Chapter 9 Smoking cessation and pregnancy
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Einon, Cath, primary and Lewis, Keir E., additional
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- 2010
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34. Chapter 14 Smoking cessation and other medical illness
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Lewis, Keir E., primary
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- 2010
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35. Simple interventions improve re-attendance when treating the sleep apnoea syndrome
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Lewis, Keir E., Bartle, Iona E., Watkins, Alan J., Seale, Lisa, and Ebden, Philip
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- 2006
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36. Oxford Handbook of Clinical Diagnosis
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Llewelyn, Huw, primary, Ang, Hock Aun, additional, Lewis, Keir E, additional, and Al-Abdullah, Anees, additional
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- 2009
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37. The Noninvasive Ventilation Outcomes (NIVO) score: prediction of in-hospital mortality in exacerbations of COPD requiring assisted ventilation
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Hartley, Tom, primary, Lane, Nicholas D., additional, Steer, John, additional, Elliott, Mark W., additional, Sovani, Milind P., additional, Curtis, Helen Jane, additional, Fuller, Elizabeth R., additional, Murphy, Patrick B., additional, Shrikrishna, Dinesh, additional, Lewis, Keir E., additional, Ward, Neil R., additional, Turnbull, Chris D., additional, Hart, Nicholas, additional, and Bourke, Stephen C., additional
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- 2021
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38. Calcium-sensing receptor antagonists, calcilytics, prevent activation of human dendritic and epithelial cells by urban particulate matter
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Mansfield, Bethan, primary, Ho, Tzer-Ren, additional, Mudway, Ian, additional, Lugg, Sebastian. T, additional, Corrigan, Chris. J, additional, Ward, Jeremy P.T., additional, Thickett, David, additional, Prytherch, Zoe, additional, Scofield, Simon, additional, Kemp, Paul. J, additional, Lewis, Keir. E, additional, Mur, Luis. A, additional, Hawrylowicz, Catherine, additional, and Riccardi, Daniela, additional
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- 2020
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39. Metabolomics differentiate cancer from non-cancer pleural effusions based on steroid lipids and acyl carnitines
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Love, Katie, primary, da Costa, Ricardo MF, additional, Beckmann, Manfred, additional, Morley, Anna, additional, Bhatnagar, Rahul, additional, Maskell, Nick, additional, Mur, Luis AJ, additional, and Lewis, Keir E, additional
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- 2020
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40. Calcium-sensing receptor antagonism as a novel therapeutic for pulmonary fibrosis
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Wolffs, Kasope L., primary, Mansfield, Bethan, additional, Bruce, Richard T., additional, Huang, Ping, additional, Schepelmann, Martin, additional, Brennan, Sarah C, additional, Verckist, Line, additional, Adriaensen, Dirk, additional, De Araújo, Rachel Paes, additional, Mur, Luis A.J., additional, Attanoos, Richard, additional, Lewis, Keir E., additional, Ward, Jeremy P.T., additional, Corrigan, Christopher J., additional, Kemp, Paul J., additional, Hope-Gill, Benjamin D., additional, and Riccardi, Daniela, additional
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- 2020
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41. ERS Monograph 90: Supporting Tobacco Cessation
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Ravara, Sofia Belo, Dagli, Elif, Katsaounou, Paraskevi, Lewis, Keir E., Pisinger, Charlotta, Ravara, Sofia Belo, Dagli, Elif, Katsaounou, Paraskevi, Lewis, Keir E., and Pisinger, Charlotta
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- Tobacco use, Smoking cessation, Nicotine addiction--Treatment
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This Monograph provides a comprehensive overview of tobacco cessation, from health policy to patient care. Broad in scope, this state-of-the art collection is broken down into four sections: the changing landscape of the tobacco epidemic and challenges to curb it; treatment of tobacco dependence (pharmacotherapy, behavioural support); improving the care of patients with particular conditions who smoke (asthma, COPD, TB, cardiovascular diseases, etc.); and prevention. It also deals with some of the more controversial topics such as e-cigarettes and web applications. Readers will gain an understanding of how to implement smoking cessation into their everyday practice, but will also expand their knowledge about the policy and systems changes needed for population-wide smoking cessation.
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- 2021
42. Influence of long-term oxygen therapy on heart rate and QT time-series in hypoxic patients with chronic obstructive pulmonary disease
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Lewis, Michael J., Annandale, Joe, and Lewis, Keir E.
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- 2009
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43. Defining Metabolic Rewiring in Lung Squamous Cell Carcinoma
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De Araújo, Rachel Paes, Bertoni, Natália [UNESP], Seneda, Ana L. [UNESP], Felix, Tainara F. [UNESP], Carvalho, Márcio [UNESP], Lewis, Keir E., Hasimoto, Érica N. [UNESP], Beckmann, Manfred, Drigo, Sandra A. [UNESP], Reis, Patricia P. [UNESP], Mur, Luis A. J., Environmental and Rural Sciences (IBERS), Universidade Estadual Paulista (Unesp), Hywel Dda University Health Board, and Swansea University
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Lung squamous cell carcinoma ,Untargeted metabolites ,pathways ,lcsh:QR1-502 ,lung squamous cell carcinoma ,Flow infusion electrospray ionization high resolution mass spectrometry ,Pathways ,lcsh:Microbiology ,flow infusion electrospray ionization high resolution mass spectrometry ,untargeted metabolites - Abstract
Metabolomics based on untargeted flow infusion electrospray ionization high-resolution mass spectrometry (FIE-HRMS) can provide a snap-shot of metabolism in living cells. Lung Squamous Cell Carcinoma (SCC) is one of the predominant subtypes of Non-Small Cell Lung Cancers (NSCLCs), which usually shows a poor prognosis. We analysed lung SCC samples and matched histologically normal lung tissues from eight patients. Metabolites were profiled by FIE-HRMS and assessed using t-test and principal component analysis (PCA). Differentially accumulating metabolites were mapped to pathways using the mummichog algorithm in R, and biologically meaningful patterns were indicated by Metabolite Set Enrichment Analysis (MSEA). We identified metabolic rewiring networks, including the suppression of the oxidative pentose pathway and found that the normal tricarboxylic acid (TCA) cycle were decoupled from increases in glycolysis and glutamine reductive carboxylation. Well-established associated effects on nucleotide, amino acid and thiol metabolism were also seen. Novel aspects in SCC tissue were increased in Vitamin B complex cofactors, serotonin and a reduction of &gamma, aminobutyric acid (GABA). Our results show the value of FIE-HRMS as a high throughput screening method that could be exploited in clinical contexts.
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- 2019
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44. Excessive daytime sleepiness and driving: regulations for road safety
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Lewis, Keir E
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- 2004
45. Decision Rules for Diagnosis of Sleep Apnea
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Lewis, Keir E., Tsai, Willis H., Davies, Jan M., Flemons, Ward W., and MacArthur, Colin
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- 2004
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46. Somatostatin scan positive gastrinoma ocular metastasis
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LEWIS, KEIR E, ROGERS, PAUL B, HUNGERFORD, JOHN, BRITTON, KEITH E, and PLOWMAN, P NICHOLAS
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- 1999
47. Evaluation of FTIR Spectroscopy as a diagnostic tool for lung cancer using sputum
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Wills John, Lloyd Amanda J, Bayliss Sion, Ghosal Robin, Lewis Keir E, Lewis Paul D, Godfrey Ruth, Kloer Philip, and Mur Luis AJ
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Survival time for lung cancer is poor with over 90% of patients dying within five years of diagnosis primarily due to detection at late stage. The main objective of this study was to evaluate Fourier transform infrared spectroscopy (FTIR) as a high throughput and cost effective method for identifying biochemical changes in sputum as biomarkers for detection of lung cancer. Methods Sputum was collected from 25 lung cancer patients in the Medlung observational study and 25 healthy controls. FTIR spectra were generated from sputum cell pellets using infrared wavenumbers within the 1800 to 950 cm-1 "fingerprint" region. Results A panel of 92 infrared wavenumbers had absorbances significantly different between cancer and normal sputum spectra and were associated with putative changes in protein, nucleic acid and glycogen levels in tumours. Five prominent significant wavenumbers at 964 cm-1, 1024 cm-1, 1411 cm-1, 1577 cm-1 and 1656 cm-1 separated cancer spectra from normal spectra into two distinct groups using multivariate analysis (group 1: 100% cancer cases; group 2: 92% normal cases). Principal components analysis revealed that these wavenumbers were also able to distinguish lung cancer patients who had previously been diagnosed with breast cancer. No patterns of spectra groupings were associated with inflammation or other diseases of the airways. Conclusions Our results suggest that FTIR applied to sputum might have high sensitivity and specificity in diagnosing lung cancer with potential as a non-invasive, cost-effective and high-throughput method for screening. Trial Registration ClinicalTrials.gov: NCT00899262
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- 2010
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48. Lung cancer: a new frontier for microbiome research and clinical translation
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Mur, Luis AJ, primary, Huws, Sharon A, additional, Cameron, Simon JS, additional, Lewis, Paul D, additional, and Lewis, Keir E, additional
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- 2018
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49. New horizons in tobacco control and alternative sources of inhaling tobacco: World No Tobacco Day
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Lewis, Keir E., primary
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- 2018
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50. Development of an algorithm for determining smoking status and behaviour over the life course from UK electronic primary care records
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Atkinson, Mark D., Kennedy, Jonathan I., John, Ann, Lewis, Keir E., Lyons, Ronan A., and Brophy, Sinead T.
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Adult ,Aged, 80 and over ,Male ,Wales ,Adolescent ,Primary Health Care ,Health Policy ,Health Behavior ,Smoking ,Health Informatics ,Smoking cessation ,Data linkage ,Middle Aged ,Young Adult ,Prevalence ,Electronic Health Records ,Humans ,Smoking status ,Female ,Medical Record Linkage ,SAIL databank ,Algorithms ,Research Article ,Aged - Abstract
Background Patients’ smoking status is routinely collected by General Practitioners (GP) in UK primary health care. There is an abundance of Read codes pertaining to smoking, including those relating to smoking cessation therapy, prescription, and administration codes, in addition to the more regularly employed smoking status codes. Large databases of primary care data are increasingly used for epidemiological analysis; smoking status is an important covariate in many such analyses. However, the variable definition is rarely documented in the literature. Methods The Secure Anonymised Information Linkage (SAIL) databank is a repository for a national collection of person-based anonymised health and socio-economic administrative data in Wales, UK. An exploration of GP smoking status data from the SAIL databank was carried out to explore the range of codes available and how they could be used in the identification of different categories of smokers, ex-smokers and never smokers. An algorithm was developed which addresses inconsistencies and changes in smoking status recording across the life course and compared with recorded smoking status as recorded in the Welsh Health Survey (WHS), 2013 and 2014 at individual level. However, the WHS could not be regarded as a “gold standard” for validation. Results There were 6836 individuals in the linked dataset. Missing data were more common in GP records (6%) than in WHS (1.1%). Our algorithm assigns ex-smoker status to 34% of never-smokers, and detects 30% more smokers than are declared in the WHS data. When distinguishing between current smokers and non-smokers, the similarity between the WHS and GP data using the nearest date of comparison was κ = 0.78. When temporal conflicts had been accounted for, the similarity was κ = 0.64, showing the importance of addressing conflicts. Conclusions We present an algorithm for the identification of a patient’s smoking status using GP self-reported data. We have included sufficient details to allow others to replicate this work, thus increasing the standards of documentation within this research area and assessment of smoking status in routine data. Electronic supplementary material The online version of this article (doi:10.1186/s12911-016-0400-6) contains supplementary material, which is available to authorized users.
- Published
- 2017
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