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26 results on '"Leyendecker, Pierre"'

1. Factors associated with coinfections in invasive aspergillosis: a retrospective cohort study

Author

Addeo, Pietro Francesco, Astruc, Dominique, Baldacini, Mathieu, Bilger, Karin, Chenard, Marie-Pierrette, Collange, Olivier, Degot, Tristan, Dhif, Nadia, Dicop, Elise, Fafi-Kremer, Samira, Fornecker, Luc-Matthieu, Fuseau, Charline, Guillot, Max, Harlay, Mary-Line, Janssen-Langenstein, Ralf, Jaulhac, Benoît, Kaeuffer, Charlotte, Kessler, Romain, Kummerlen, Christine, Laplace, Annegret, Launoy, Anne, Lioure, Bruno, Merdji, Hamid, Mertes, Paul-Michel, Natarajan-Ame, Shanti, Nisand, Gabriel, Porzio, Michele, Pottecher, Julien, Roche, Anne-Claude, Schenck-Dhif, Maleka, Sonntag, Cécile, Toussaint, Elise, Zilliox, Anne, Danion, François, Duval, Céline, Séverac, François, Bachellier, Philippe, Candolfi, Ermanno, Castelain, Vincent, Clere-Jehl, Raphaël, Denis, Julie, Dillenseger, Laurence, Epailly, Eric, Gantzer, Justine, Guffroy, Blandine, Hansmann, Yves, Herbrecht, Jean-Etienne, Letscher-Bru, Valérie, Leyendecker, Pierre, Le Van Quyen, Pauline, Ludes, Pierre-Olivier, Morel, Guillaume, Moulin, Bruno, Paillard, Catherine, Renaud-Picard, Benjamin, Sabou, Marcela, Schneider, Francis, Solis, Morgane, Talagrand-Reboul, Emilie, Veillon, Francis, Ledoux, Marie-Pierre, Simand, Célestine, and Herbrecht, Raoul

Published
2021
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4. SARS-CoV-2 Pneumonia in Hospitalized Asthmatic Patients Did Not Induce Severe Exacerbation

Author

Grandbastien, Manon, Piotin, Anays, Godet, Julien, Abessolo-Amougou, Ines, Ederlé, Carole, Enache, Irina, Fraisse, Philippe, Tu Hoang, Thi Cam, Kassegne, Loic, Labani, Aissam, Leyendecker, Pierre, Manien, Louise, Marcot, Christophe, Pamart, Guillaume, Renaud-Picard, Benjamin, Riou, Marianne, Doyen, Virginie, Kessler, Romain, Fafi-Kremer, Samira, Metz-Favre, Carine, Khayath, Naji, and de Blay, Frédéric

Published
2020
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10. Factors associated with coinfections in invasive aspergillosis: a retrospective cohort study

Author

Danion, François, primary, Duval, Céline, additional, Séverac, François, additional, Bachellier, Philippe, additional, Candolfi, Ermanno, additional, Castelain, Vincent, additional, Clere-Jehl, Raphaël, additional, Denis, Julie, additional, Dillenseger, Laurence, additional, Epailly, Eric, additional, Gantzer, Justine, additional, Guffroy, Blandine, additional, Hansmann, Yves, additional, Herbrecht, Jean-Etienne, additional, Letscher-Bru, Valérie, additional, Leyendecker, Pierre, additional, Le Van Quyen, Pauline, additional, Ludes, Pierre-Olivier, additional, Morel, Guillaume, additional, Moulin, Bruno, additional, Paillard, Catherine, additional, Renaud-Picard, Benjamin, additional, Roche, Anne-Claude, additional, Sabou, Marcela, additional, Schneider, Francis, additional, Solis, Morgane, additional, Talagrand-Reboul, Emilie, additional, Veillon, Francis, additional, Ledoux, Marie-Pierre, additional, Simand, Célestine, additional, Herbrecht, Raoul, additional, Addeo, Pietro Francesco, additional, Astruc, Dominique, additional, Baldacini, Mathieu, additional, Bilger, Karin, additional, Chenard, Marie-Pierrette, additional, Collange, Olivier, additional, Degot, Tristan, additional, Dhif, Nadia, additional, Dicop, Elise, additional, Fafi-Kremer, Samira, additional, Fornecker, Luc-Matthieu, additional, Fuseau, Charline, additional, Guillot, Max, additional, Harlay, Mary-Line, additional, Janssen-Langenstein, Ralf, additional, Jaulhac, Benoît, additional, Kaeuffer, Charlotte, additional, Kessler, Romain, additional, Kummerlen, Christine, additional, Laplace, Annegret, additional, Launoy, Anne, additional, Lioure, Bruno, additional, Merdji, Hamid, additional, Mertes, Paul-Michel, additional, Natarajan-Ame, Shanti, additional, Nisand, Gabriel, additional, Porzio, Michele, additional, Pottecher, Julien, additional, Schenck-Dhif, Maleka, additional, Sonntag, Cécile, additional, Toussaint, Elise, additional, and Zilliox, Anne, additional

Published
2021
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11. COVID-19 in Patients with Cancer: A Retrospective Study of 212 Cases from a FrenchSARS-CoV-2 Cluster During the First Wave of theCOVID-19 Pandemic

Author

Martin, Sophie, primary, Kaeuffer, Charlotte, additional, Leyendecker, Pierre, additional, Tuzin, Nicolas, additional, Tazi, Youssef, additional, Schaff-Wendling, Frédérique, additional, Kleinheny, Tiffanie, additional, Husson-Wetzel, Stéphanie, additional, Pamart, Guillaume, additional, Limacher, Jean-Marc, additional, Clerc, Olivier, additional, Dicop, Elise, additional, Kurtz, Jean-Emmanuel, additional, Barthélémy, Philippe, additional, and Gantzer, Justine, additional

Published
2021
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12. Clinical characteristics and risk factors associated with severe COVID-19: prospective analysis of 1,045 hospitalised cases in North-Eastern France, March 2020

Author

Kaeuffer, Charlotte, Le Hyaric, Coralie, Fabacher, Thibaut, Mootien, Joy, Dervieux, Benjamin, Ruch, Yvon, Hugerot, Antonin, Zhu, Yves-Jean, Pointurier, Valentin, Clere-Jehl, Raphael, Greigert, Valentin, Kassegne, Loic, Lefebvre, Nicolas, Gallais, Floriane, Meyer, Nicolas, Hansmann, Yves, Hinschberger, Olivier, Danion, François, Merdji, Hamid, Mertes, Paul-Michel, Oulehri, Walid, Tacquard, Charles, Collange, Olivier, Ludes, Pierre-Olivier, Diemunsch, Sophie, Schneider, Francis, Lemmet, Thomas, Damour, Anne-Sophie, Behr, Martin, Le Borgne, Pierrick, Chatelus, Emmanuel, Felten, Renaud, Zecchi, Adrien, Maitrepierre, Flavie, Terrade, Jean-Edouard, Boehn, Louis, Zulfiqar, Abrar Ahmad, Guffroy, Aurélien, Poindron, Vincent, Lescuyer, Sylvain, Schmitt, Elise, Waechter, Cédric, Ronde-Oustau, Cécile, De Blay, Frédéric, Fraisse, Philippe, Perrin, Peggy, Keller, Nicolas, Pontvianne, Mary, De Marcillac, Fanny, Deruelle, Philippe, Legris, Marie-Laure, Wehr, Mégane, Zeyons, Floriane, Von Hunolstein, Jean-Jacques, Leyendecker, Pierre, Ohana, Mickael, Labani, Aissam, Risser, Clémence, Goetsch, Thibaut, Leclerc Du Sablon, Noémie, Ehret, Marion, Vinee, Frederic, Bernard, Myriam, Koch, Clémence, Waegell, Arnaud, Dormegny, Léa, Daguet, Alexandra, Deboscker, Stéphanie, Lavigne, Thierry, Fafi-Kremer, Samira, Velay, Aurélie, Solis, Morgane, Wendling, Marie-Josée, Delagreverie, Héloïse, Benotmane, Ilies, Dicop, Elise, Martzolff, Lionel, and Oudeville, Pierre

Subjects
Male, Epidemiology, coronavirus, Comorbidity, 030204 cardiovascular system & hematology, Severity of Illness Index, law.invention, Patient Admission, 0302 clinical medicine, Risk Factors, law, Medicine, Prospective Studies, 030212 general & internal medicine, Prospective cohort study, Aged, 80 and over, Age Factors, Middle Aged, Intensive care unit, Intensive Care Units, outcome, Absolute neutrophil count, Female, France, Coronavirus Infections, Adult, medicine.medical_specialty, Adolescent, Pneumonia, Viral, Young Adult, 03 medical and health sciences, Sex Factors, death, Virology, Internal medicine, Diabetes mellitus, Humans, Obesity, Pandemics, Aged, Inflammation, business.industry, Research, Public Health, Environmental and Occupational Health, COVID-19, Odds ratio, medicine.disease, Survival Analysis, Dyspnea, business, Body mass index, Kidney disease
Abstract

Background In March 2020, the COVID-19 outbreak was declared a pandemic by the World Health Organization. Aim Our objective was to identify risk factors predictive of severe disease and death in France. Methods In this prospective cohort study, we included patients ≥ 18 years old with confirmed COVID-19, hospitalised in Strasbourg and Mulhouse hospitals (France), in March 2020. We respectively compared patients who developed severe disease (admission to an intensive care unit (ICU) or death) and patients who died, to those who did not, by day 7 after hospitalisation. Results Among 1,045 patients, 424 (41%) had severe disease, including 335 (32%) who were admitted to ICU, and 115 (11%) who died. Mean age was 66 years (range: 20–100), and 612 (59%) were men. Almost 75% of patients with body mass index (BMI) data (n = 897) had a BMI ≥ 25 kg/m2 (n = 661). Independent risk factors associated with severe disease were advanced age (odds ratio (OR): 1.1 per 10-year increase; 95% CrI (credible interval): 1.0–1.2), male sex (OR: 2.1; 95% CrI: 1.5–2.8), BMI of 25–29.9 kg/m2 (OR: 1.8; 95% CrI: 1.2–2.7) or ≥ 30 (OR: 2.2; 95% CrI: 1.5–3.3), dyspnoea (OR: 2.5; 95% CrI: 1.8–3.4) and inflammatory parameters (elevated C-reactive protein and neutrophil count, low lymphocyte count). Risk factors associated with death were advanced age (OR: 2.7 per 10-year increase; 95% CrI: 2.1–3.4), male sex (OR: 1.7; 95% CrI: 1.1–2.7), immunosuppression (OR: 3.8; 95% CrI: 1.6–7.7), diabetes (OR: 1.7; 95% CrI: 1.0–2.7), chronic kidney disease (OR: 2.3; 95% CrI: 1.3–3.9), dyspnoea (OR: 2.1; 95% CrI: 1.2–3.4) and inflammatory parameters. Conclusions Overweightedness, obesity, advanced age, male sex, comorbidities, dyspnoea and inflammation are risk factors for severe COVID-19 or death in hospitalised patients. Identifying these features among patients in routine clinical practice might improve COVID-19 management.

Published
2020
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15. Acute Pulmonary Embolism in Patients with COVID-19 at CT Angiography and Relationship to d-Dimer Levels

Author

Léonard-Lorant, Ian, primary, Delabranche, Xavier, additional, Séverac, François, additional, Helms, Julie, additional, Pauzet, Coralie, additional, Collange, Olivier, additional, Schneider, Francis, additional, Labani, Aissam, additional, Bilbault, Pascal, additional, Molière, Sébastien, additional, Leyendecker, Pierre, additional, Roy, Catherine, additional, and Ohana, Mickaël, additional

Published
2020
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18. COVID‐19 in Patients with Cancer: A Retrospective Study of 212 Cases from a French SARS‐CoV‐2 Cluster During the First Wave of the COVID‐19 Pandemic.

Author

Martin, Sophie, Kaeuffer, Charlotte, Leyendecker, Pierre, Tuzin, Nicolas, Tazi, Youssef, Schaff‐Wendling, Frédérique, Kleinheny, Tiffanie, Husson‐Wetzel, Stéphanie, Pamart, Guillaume, Limacher, Jean‐Marc, Clerc, Olivier, Dicop, Elise, Kurtz, Jean‐Emmanuel, Barthélémy, Philippe, and Gantzer, Justine

Subjects
TUMOR treatment, RESEARCH, COVID-19, RETROSPECTIVE studies, MEDICAL cooperation, CANCER patients, RADIOTHERAPY, COVID-19 pandemic, IMMUNOTHERAPY
Abstract

We describe a large series of patients with solid tumors in an early COVID‐19 cluster in the eastern part of France. From February to May 2020, this multicenter retrospective study enrolled 212 patients with cancer under treatment or on follow‐up for any type of malignant solid tumor and positive for SARS‐CoV‐2. The mortality rate was 30%. Patients with gastrointestinal cancers were identified as a subset of more vulnerable patients; immunotherapy and radiotherapy within 3 months from COVID‐19 diagnosis were risk factors for death. The reported data support the essential need to be proactive and weigh the risks of morbidity from COVID‐19 against the magnitude of benefits of intended cancer therapies during this pandemic. Implications for Practice: This article supports the essential need to be proactive (treatment delay or modification) in oncology in the setting of pandemic. This study identified patients with gastrointestinal cancers as a more vulnerable subset of patients with cancer and found that immunotherapy and radiotherapy within 3 months from COVID‐19 diagnosis to be risk factors for death. The reported data indicate the necessity of weighing the risks of morbidity from COVID‐19 against the magnitude of benefits of intended cancer therapies in any future wave of COVID‐19. In the light of a local experience in an area of France, this article describes disease characteristics, management, and outcomes in patients with cancer and confirmed or highly suspected COVID‐19. [ABSTRACT FROM AUTHOR]

Published
2021
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20. Prospective evaluation of ultra-low-dose contrast-enhanced 100-kV abdominal computed tomography with tin filter: effect on radiation dose reduction and image quality with a third-generation dual-source CT system

Author

Leyendecker, Pierre, primary, Faucher, Vanina, additional, Labani, Aissam, additional, Noblet, Vincent, additional, Lefebvre, François, additional, Magotteaux, Paul, additional, Ohana, Mickaël, additional, and Roy, Catherine, additional

Published
2018
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21. Automatic tube voltage selection on a 320-slice CT scan for parenchymal phase exploration: a trade-off between image quality and dose reduction

Author

Leyendecker, Pierre

Subjects
Computer Applications-General, Radiation safety, genetic structures, Computer applications, Radioprotection / Radiation dose, Dosimetric comparison, Radiation physics, CT
Abstract

Aims and objectives Methods and materials Results Conclusion Personal information References, Aims and objectives: Within the past years, multiple techniques for radiation dose reduction have been developed such as automatic tube current modulation (ATCM), reduced tube voltage based on patient size and iterative reconstruction algorithms (1,2). CT settings like...

Published
2017
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22. Automatic tube voltage selection on a 320-slice CT-scan: a strategy to reduce the iodine load in routine contrast-enhanced CT? - a retrospective and a phantom study

Author

Leyendecker, Pierre

Subjects
Contrast agent-other, Oncology, Computer applications, Contrast agents, CT
Abstract

Purpose Methods and materials Results Conclusion Personal information References, Purpose: CT acquisition with lower tube potential has been used, especially in pediatric patients or smaller adults (1) primarly, toreduce the radiation dosewithout impairing image quality. Mean radiation dose reduction of nearly 20-25% for CTA (2–4) and...

Published
2017
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