398 results on '"Leynaert, B"'
Search Results
2. Augmentation de la prévalence de l’asthme chez le jeune enfant en France
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Delmas, M.-C., Guignon, N., Leynaert, B., Moisy, M., Marguet, C., and Fuhrman, C.
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- 2017
- Full Text
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3. Early life exposures contributing to accelerated lung function decline in adulthood - a follow-up study of 11,000 adults from the general population
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Kirkeleit, J, Riise, T, Wielscher, M, Accordini, S, Carsin, A-E, Dratva, J, Franklin, KA, Garcia-Aymerich, J, Jarvis, D, Leynaert, B, Lodge, CJ, Real, FG, Schlunssen, V, Corsico, AG, Heinrich, J, Holm, M, Janson, C, Benediktsdottir, B, Jogi, R, Dharmage, SC, Jarvelin, M-R, Svanes, C, Kirkeleit, J, Riise, T, Wielscher, M, Accordini, S, Carsin, A-E, Dratva, J, Franklin, KA, Garcia-Aymerich, J, Jarvis, D, Leynaert, B, Lodge, CJ, Real, FG, Schlunssen, V, Corsico, AG, Heinrich, J, Holm, M, Janson, C, Benediktsdottir, B, Jogi, R, Dharmage, SC, Jarvelin, M-R, and Svanes, C
- Abstract
BACKGROUND: We aimed to assess whether exposure to risk factors in early life from conception to puberty continue to contribute to lung function decline later in life by using a pooled cohort comprising approx. 11,000 adults followed for more than 20 years and with up to three lung function measurements. METHODS: Participants (20-68 years) in the ECRHS and NFBC1966 cohort studies followed in the periods 1991-2013 and 1997-2013, respectively, were included. Mean annual decline in maximum forced expired volume in 1 s (FEV1) and forced vital capacity (FVC) were main outcomes. Associations between early life risk factors and change in lung function were estimated using mixed effects linear models adjusted for sex, age, FEV1, FVC and height at baseline, accounting for personal smoking. FINDINGS: Decline in lung function was accelerated in participants with mothers that smoked during pregnancy (FEV1 2.3 ml/year; 95% CI: 0.7, 3.8) (FVC 2.2 ml/year; 0.2, 4.2), with asthmatic mothers (FEV1 2.6 ml/year; 0.9, 4.4) (FEV1/FVC 0.04 per year; 0.04, 0.7) and asthmatic fathers (FVC 2.7 ml/year; 0.5, 5.0), and in women with early menarche (FVC 2.4 ml/year; 0.4, 4.4). Personal smoking of 10 pack-years contributed to a decline of 2.1 ml/year for FEV1 (1.8, 2.4) and 1.7 ml/year for FVC (1.3, 2.1). Severe respiratory infections in early childhood were associated with accelerated decline among ever-smokers. No effect-modification by personal smoking, asthma symptoms, sex or cohort was found. INTERPRETATION: Mothers' smoking during pregnancy, parental asthma and early menarche may contribute to a decline of FEV1 and FVC later in life comparable to smoking 10 pack-years. FUNDING: European Union's Horizon 2020; Research Council of Norway; Academy of Finland; University Hospital Oulu; European Regional Development Fund; Spanish Ministry of Science and Innovation; Generalitat de Catalunya.
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- 2023
4. Residential greenspace and lung function decline over 20 years in a prospective cohort: the ECRHS study
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Markevych, I., Zhao, T., Fuertes, E., Marcon, A., Dadvand, P., Vienneau, D., Garcia Aymerich, J., Nowak, D., de Hoogh, K., Jarvis, D., Abramson, M. J., Accordini, S., Amaral, A. F., Bentouhami, H., Jacobsen Bertelsen, R., Boudier, A., Bono, R., Bowatte, G., Casas, L., Dharmage, S. C., Forsberg, B., Gislason, T., Gnesi, M., Holm, M., Jacquemin, B., Janson, C., Jogi, R., Johannessen, A., Keidel, D., Leynaert, B., Maldonado Perez, J. A., Marchetti, P., Migliore, E., Martínez-Moratalla, J., Orru, H., Pin, I., Potts, J., Probst-Hensch, N., Ranzi, A., Sánchez-Ramos, J. L., Siroux, V., Soussan, D., Sunyer, J., Urrutia Landa, I., Villani, S., and Heinrich, J.
- Subjects
Green space ,FEV1 ,Arbetsmedicin och miljömedicin ,Spirometry ,Respiratory Medicine and Allergy ,Occupational Health and Environmental Health ,ECRHS ,FVC ,Nature ,Lungmedicin och allergi - Abstract
BACKGROUND: The few studies that have examined associations between greenspace and lung function in adulthood have yielded conflicting results and none have examined whether the rate of lung function decline is affected. OBJECTIVE: We explored the association between residential greenspace and change in lung function over 20 years in 5559 adults from 22 centers in 11 countries participating in the population-based, international European Community Respiratory Health Survey. METHODS: Forced expiratory volume in 1 s (FEV(1)) and forced vital capacity (FVC) were measured by spirometry when participants were approximately 35 (1990-1994), 44 (1999-2003), and 55 (2010-2014) years old. Greenness was assessed as the mean Normalized Difference Vegetation Index (NDVI) in 500 m, 300 m, and 100 m circular buffers around the residential addresses at the time of lung function measurement. Green spaces were defined as the presence of agricultural, natural, or urban green spaces in a circular 300 m buffer. Associations of these greenspace parameters with the rate of lung function change were assessed using adjusted linear mixed effects regression models with random intercepts for subjects nested within centers. Sensitivity analyses considered air pollution exposures. RESULTS: A 0.2-increase (average interquartile range) in NDVI in the 500 m buffer was consistently associated with a faster decline in FVC (-1.25 mL/year [95% confidence interval: -2.18 to -0.33]). These associations were especially pronounced in females and those living in areas with low PM(10) levels. We found no consistent associations with FEV(1) and the FEV(1)/FVC ratio. Residing near forests or urban green spaces was associated with a faster decline in FEV(1), while agricultural land and forests were related to a greater decline in FVC. CONCLUSIONS: More residential greenspace was not associated with better lung function in middle-aged European adults. Instead, we observed slight but consistent declines in lung function parameters. The potentially detrimental association requires verification in future studies.
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- 2023
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5. Household use of green and home-made cleaning products, wipe form and asthma
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Pacheco da Silva, E, primary, Sit, G, additional, Goldberg, M, additional, Leynaert, B, additional, Nadif, R, additional, Ribet, C, additional, Roche, N, additional, Zins, M, additional, Varraso, R, additional, Dumas, O, additional, and Le Moual, N, additional
- Published
- 2022
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6. Maternal diet during pregnancy with allergic and respiratory profiles in children
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Delvert, R, primary, Charles, M, additional, Dumas, O, additional, Leynaert, B, additional, Nadif, R, additional, Plancoulaine, S, additional, Raherison, C, additional, Sedki, M, additional, Varraso, R, additional, De Lauzon-Guillain, B, additional, and Bédard, A, additional
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- 2022
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7. Dwelling visible mould exposure increased asthma symptom score in the CONSTANCES cohort
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TSIAVIA, T, primary, Fréalle, E, additional, Bex, V, additional, Dumas, O, additional, Goldberg, M, additional, Le Moual, N, additional, Ribet, C, additional, Roche, N, additional, Savouré, M, additional, Varraso, R, additional, Zins, M, additional, Leynaert, B, additional, Orsi*, L, additional, and Nadif*, R, additional
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- 2022
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8. Longitudinal association between healthy diet and change in asthma symptom in elderly women
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Ait-hadad, W, primary, Bédard, A, additional, Chanoine, S, additional, Dumas, O, additional, Laouali, N, additional, Lemoual, N, additional, Leynaert, B, additional, Macdonald, C, additional, Siroux, V, additional, Boutron-Ruault, M, additional, and Varraso, R, additional
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- 2022
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9. Influence of asthma on ARIA classification of allergic rhinitis in the French population-based cohort Constances
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Savouré, M, primary, Bousquet, J, additional, Leynaert, B, additional, Goldberg, M, additional, Zins, M, additional, Jacquemin, B, additional, and Nadif, R, additional
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- 2022
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10. 388 - Caractérisation longitudinale des logements français selon plusieurs cohortes micro-organismes : la cohorte ELFE
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Khan, S., primary, Leynaert, B., additional, Rocchi, S., additional, Marguet, C., additional, Deschildre, A., additional, Scherer, E., additional, Reboux, G., additional, Delmas, M-C., additional, Dufourg, M-N., additional, Charles, M-A., additional, Divaret-Chauveau, A., additional, Millon, L., additional, and Raherison, C., additional
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- 2022
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11. The effects of growing up on a farm on adult lung function and allergic phenotypes: an international population-based study
- Author
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Campbell, B, Raherison, C, Lodge, C J, Lowe, A J, Gislason, T, Heinrich, J, Sunyer, J, Gómez Real, F, Norbäck, D, Matheson, M C, Wjst, M, Dratva, J, de Marco, R, Jarvis, D, Schlünssen, V, Janson, C, Leynaert, B, Svanes, C, and Dharmage, S C
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- 2017
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12. Occupation and adult onset of rhinitis in the general population
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Radon, K, Gerhardinger, U, Schulze, A, Zock, J-P, Norback, D, Toren, K, Jarvis, D, Held, L, Heinrich, J, Leynaert, B, Nowak, D, and Kogevinas, M
- Published
- 2008
13. The risk of respiratory symptoms on allergen exposure increases with increasing specific IgE levels
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Olivieri, M., Heinrich, J., Schlünssen, V., Antó, J. M., Forsberg, B., Janson, C., Leynaert, B., Norback, D., Sigsgaard, T., Svanes, C., Tischer, C., Villani, S., Jarvis, D., and Verlato, G.
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- 2016
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14. The coexistence of asthma and COPD: risk factors, clinical history and lung function trajectories
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Marcon, A, Locatelli, F, Dharmage, SC, Svanes, C, Heinrich, J, Leynaert, B, Burney, P, Corsico, A, Caliskan, G, Calciano, L, Gislason, T, Janson, C, Jarvis, D, Jogi, R, Lytras, T, Malinovschi, A, Probst-Hensch, N, Toren, K, Casas, L, Verlato, G, Garcia-Aymerich, J, Accordini, S, Marcon, A, Locatelli, F, Dharmage, SC, Svanes, C, Heinrich, J, Leynaert, B, Burney, P, Corsico, A, Caliskan, G, Calciano, L, Gislason, T, Janson, C, Jarvis, D, Jogi, R, Lytras, T, Malinovschi, A, Probst-Hensch, N, Toren, K, Casas, L, Verlato, G, Garcia-Aymerich, J, and Accordini, S
- Abstract
Patients with concomitant features of asthma and chronic obstructive pulmonary disease (COPD) have a heavy disease burden.Using data collected prospectively in the European Community Respiratory Health Survey, we compared the risk factors, clinical history and lung function trajectories from early adulthood to late sixties of middle-aged subjects with asthma+COPD (n=179), past (n=263) or current (n=808) asthma alone, COPD alone (n=111) or none of these (n=3477).Interview data and pre-bronchodilator forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were obtained during three clinical examinations in 1991-1993, 1999-2002 and 2010-2013. Disease status was classified in 2010-2013, when the subjects were aged 40-68 years, according to the presence of fixed airflow obstruction (post-bronchodilator FEV1/FVC below the lower limit of normal), a lifetime history of asthma and cumulative exposure to tobacco or occupational inhalants. Previous lung function trajectories, clinical characteristics and risk factors of these phenotypes were estimated.Subjects with asthma+COPD reported maternal smoking (28.2%) and respiratory infections in childhood (19.1%) more frequently than subjects with COPD alone (20.9% and 14.0%, respectively). Subjects with asthma+COPD had an impairment of lung function at age 20 years that tracked over adulthood, and more than half of them had asthma onset in childhood. Subjects with COPD alone had the highest lifelong exposure to tobacco smoking and occupational inhalants, and they showed accelerated lung function decline during adult life.The coexistence between asthma and COPD seems to have its origins earlier in life compared to COPD alone. These findings suggest that prevention of this severe condition, which is typical at older ages, should start in childhood.
- Published
- 2021
15. The association of asthma, nasal allergies, and positive skin prick tests with obesity, leptin, and adiponectin
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Newson, R. B., Jones, M., Forsberg, B., Janson, C., Bossios, A., Dahlen, S.-E., Toskala, E. M., Al-Kalemji, A., Kowalski, M. L., Rymarczyk, B., Salagean, E. M., van Drunen, C. M., Bachert, C., Wehrend, T., Krämer, U., Mota-Pinto, A., Burney, P., Leynaert, B., and Jarvis, D.
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- 2014
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16. Lung function changes over eight years and testosterone markers in both sexes: UK Biobank
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Lenoir, A, Fuertes, E, Gómez Real, F, Leynaert, B, Van der Plaat, D, and Jarvis, D
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respiratory system ,respiratory tract diseases - Abstract
Higher levels of testosterone have been associated with better lung function in cross-sectional population-based studies. The role of testosterone on lung function in women, and on lung function decline in men or women is unclear. We studied 5,114 men and 5,467 women in UK Biobank with high-quality spirometry at baseline (2006-10) and 8.4 years later. We studied cross-sectional associations of total testosterone (TT), calculated free testosterone (cFT), free androgen index (FAI) and sex-hormone binding globulin (SHBG) with FEV1, FVC and FEV1/FVC using linear regression and associations of baseline markers with lung function decline using linear mixed effects regression. Men with higher levels of TT had higher FEV1 (27.56 ml per interquartile range (IQR) increase TT, 95%CI 5.43 to 49.68) and FVC (48.06 ml, 95%CI 22.07 to 74.06) at baseline. Higher cFT levels were associated with higher FEV1 and FVC among physically active men only. In women, higher FAI and cFT levels were associated with lower lung function at baseline, and higher levels of TT, cFT and FAI were associated with slightly attenuated FEV1 and FVC decline. Higher levels of SHBG were associated with better lung function in both sexes but slightly accelerated decline in men. In this population-based sample, higher levels of TT were associated with better lung function in men and higher levels of cFT with better lung function in physically active men. A small attenuation of lung function decline with higher levels of TT, cFT and FAI was seen in women only.
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- 2020
17. Early menarche is associated with lower adult lung function: A longitudinal cohort study from the first to sixth decade of life.
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Leynaert B., Frith P.A., Giles G.G., Thomas P.S., Gomez Real F., Campbell B., Simpson J.A., Bui D.S., Lodge C.J., Lowe A.J., Matheson M.C., Bowatte G., Burgess J.A., Hamilton G.S., Dharmage S.C., Perret J.L., Walters E.H., Abramson M.J., Jarvis D., Garcia-Aymerich J., Mishra G., Johns D.P., Leynaert B., Frith P.A., Giles G.G., Thomas P.S., Gomez Real F., Campbell B., Simpson J.A., Bui D.S., Lodge C.J., Lowe A.J., Matheson M.C., Bowatte G., Burgess J.A., Hamilton G.S., Dharmage S.C., Perret J.L., Walters E.H., Abramson M.J., Jarvis D., Garcia-Aymerich J., Mishra G., and Johns D.P.
- Abstract
Background and objective: Early menarche is increasing in prevalence worldwide, prompting clinical and public health interest on its links with pulmonary function. We aimed to investigate the relationship between early menarche and lung function in middle age. Method(s): The population-based Tasmanian Longitudinal Health Study (born 1961; n = 8583), was initiated in 1968. The 5th Decade follow-up data (mean age: 45 years) included age at menarche and complex lung function testing. The 6th Decade follow-up (age: 53 years) repeated spirometry and gas transfer factor. Multiple linear regression and mediation analyses were performed to determine the association between age at menarche and adult lung function and investigate biological pathways, including the proportion mediated by adult-attained height. Result(s): Girls reporting an early menarche (<12 years) were measured to be taller with greater lung function at age 7 years compared with those reporting menarche >=12 years. By 45 years of age, they were shorter and had lower post-bronchodilator (BD) forced expiratory volume in 1 s (adjusted mean difference: -133 mL; 95% CI: -233, -33), forced vital capacity (-183 mL; 95% CI: -300, -65) and functional residual capacity (-168 mL; 95% CI: -315, -21). Magnitudes of spirometric deficits were similar at age 53 years. Forty percent of these total effects were mediated through adult-attained height. Conclusion(s): Early menarche was associated with reduced adult lung function. This is the first study to investigate post-BD outcomes and quantify the partial role of adult height in this association.Copyright © 2019 Asian Pacific Society of Respirology
- Published
- 2020
18. Low serum DHEA-S is associated with impaired lung function in women
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Pesce, G, Triebner, K, van der Plaat, DA, Courbon, D, Hustad, S, Sigsgaard, T, Nowak, D, Heinrich, J, Anto, JM, Dorado-Arenas, S, Martinez-Moratalla, J, Gullon-Blanco, JA, Sanchez-Ramos, JL, Raherison, C, Pin, I, Demoly, P, Gislason, T, Toren, K, Forsberg, B, Lindberg, E, Zemp, E, Jogi, R, Probst-Hensch, N, Dharmage, SC, Jarvis, D, Garcia-Aymerich, J, Marcon, A, Gomez-Real, F, Leynaert, B, Pesce, G, Triebner, K, van der Plaat, DA, Courbon, D, Hustad, S, Sigsgaard, T, Nowak, D, Heinrich, J, Anto, JM, Dorado-Arenas, S, Martinez-Moratalla, J, Gullon-Blanco, JA, Sanchez-Ramos, JL, Raherison, C, Pin, I, Demoly, P, Gislason, T, Toren, K, Forsberg, B, Lindberg, E, Zemp, E, Jogi, R, Probst-Hensch, N, Dharmage, SC, Jarvis, D, Garcia-Aymerich, J, Marcon, A, Gomez-Real, F, and Leynaert, B
- Abstract
BACKGROUND: Emerging evidence suggests that androgens and estrogens have a role in respiratory health, but it is largely unknown whether levels of these hormones can affect lung function in adults from the general population. This study investigated whether serum dehydroepiandrosterone sulfate (DHEA-S), a key precursor of both androgens and estrogens in peripheral tissues, was related to lung function in adult women participating in the European Community Respiratory Health Survey (ECRHS). METHODS: Lung function and serum DHEA-S concentrations were measured in n = 2,045 and n = 1,725 women in 1999-2002 and in 2010-2013, respectively. Cross-sectional associations of DHEA-S levels (expressed as age-adjusted z-score) with spirometric outcomes were investigated, adjusting for smoking habits, body mass index, menopausal status, and use of corticosteroids. Longitudinal associations of DHEA-S levels in 1999-2002 with incidence of restrictive pattern and airflow limitation in 2010-2013 were also assessed. FINDINGS: Women with low DHEA-S (z-score<-1) had lower FEV1 (% of predicted, adjusted difference: -2.2; 95%CI: -3.5 to -0.9) and FVC (-1.7; 95%CI: -2.9 to -0.5) and were at a greater risk of having airflow limitation and restrictive pattern on spirometry than women with higher DHEA-S levels. In longitudinal analyses, low DHEA-S at baseline was associated with a greater incidence of airflow limitation after an 11-years follow-up (incidence rate ratio, 3.43; 95%CI: 1.91 to 6.14). INTERPRETATION: Low DHEA-S levels in women were associated with impaired lung function and a greater risk of developing airflow limitation later in adult life. Our findings provide new evidence supporting a role of DHEA-S in respiratory health. FUNDING: EU H2020, grant agreement no.633212.
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- 2020
19. Early menarche is associated with lower adult lung function: A longitudinal cohort study from the first to sixth decade of life
- Author
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Campbell, B, Simpson, JA, Bui, DS, Lodge, CJ, Lowe, AJ, Matheson, MC, Bowatte, G, Burgess, JA, Hamilton, GS, Leynaert, B, Gomez Real, F, Thomas, PS, Giles, GG, Frith, PA, Johns, DP, Mishra, G, Garcia-Aymerich, J, Jarvis, D, Abramson, MJ, Walters, EH, Perret, JL, Dharmage, SC, Campbell, B, Simpson, JA, Bui, DS, Lodge, CJ, Lowe, AJ, Matheson, MC, Bowatte, G, Burgess, JA, Hamilton, GS, Leynaert, B, Gomez Real, F, Thomas, PS, Giles, GG, Frith, PA, Johns, DP, Mishra, G, Garcia-Aymerich, J, Jarvis, D, Abramson, MJ, Walters, EH, Perret, JL, and Dharmage, SC
- Abstract
BACKGROUND AND OBJECTIVE: Early menarche is increasing in prevalence worldwide, prompting clinical and public health interest on its links with pulmonary function. We aimed to investigate the relationship between early menarche and lung function in middle age. METHODS: The population-based Tasmanian Longitudinal Health Study (born 1961; n = 8583), was initiated in 1968. The 5th Decade follow-up data (mean age: 45 years) included age at menarche and complex lung function testing. The 6th Decade follow-up (age: 53 years) repeated spirometry and gas transfer factor. Multiple linear regression and mediation analyses were performed to determine the association between age at menarche and adult lung function and investigate biological pathways, including the proportion mediated by adult-attained height. RESULTS: Girls reporting an early menarche (<12 years) were measured to be taller with greater lung function at age 7 years compared with those reporting menarche ≥12 years. By 45 years of age, they were shorter and had lower post-bronchodilator (BD) forced expiratory volume in 1 s (adjusted mean difference: -133 mL; 95% CI: -233, -33), forced vital capacity (-183 mL; 95% CI: -300, -65) and functional residual capacity (-168 mL; 95% CI: -315, -21). Magnitudes of spirometric deficits were similar at age 53 years. Forty percent of these total effects were mediated through adult-attained height. CONCLUSION: Early menarche was associated with reduced adult lung function. This is the first study to investigate post-BD outcomes and quantify the partial role of adult height in this association.
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- 2020
20. Body mass index and weight change are associated with adult lung function trajectories: the prospective ECRHS study
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Peralta, GP, Marcon, A, Carsin, A-E, Abramson, MJ, Accordini, S, Amaral, AFS, Anto, JM, Bowatte, G, Burney, P, Corsico, A, Demoly, P, Dharmage, S, Forsberg, B, Fuertes, E, Garcia-Larsen, V, Gislason, T, Gullon, J-A, Heinrich, J, Holm, M, Jarvis, DL, Janson, C, Jogi, R, Johannessen, A, Leynaert, B, Rovira, JM-M, Nowak, D, Probst-Hensch, N, Raherison, C, Sanchez-Ramos, J-L, Sigsgaard, T, Siroux, V, Squillacioti, G, Urrutia, I, Weyler, J, Zock, J-P, Garcia-Aymerich, J, Peralta, GP, Marcon, A, Carsin, A-E, Abramson, MJ, Accordini, S, Amaral, AFS, Anto, JM, Bowatte, G, Burney, P, Corsico, A, Demoly, P, Dharmage, S, Forsberg, B, Fuertes, E, Garcia-Larsen, V, Gislason, T, Gullon, J-A, Heinrich, J, Holm, M, Jarvis, DL, Janson, C, Jogi, R, Johannessen, A, Leynaert, B, Rovira, JM-M, Nowak, D, Probst-Hensch, N, Raherison, C, Sanchez-Ramos, J-L, Sigsgaard, T, Siroux, V, Squillacioti, G, Urrutia, I, Weyler, J, Zock, J-P, and Garcia-Aymerich, J
- Abstract
BACKGROUND: Previous studies have reported an association between weight increase and excess lung function decline in young adults followed for short periods. We aimed to estimate lung function trajectories during adulthood from 20-year weight change profiles using data from the population-based European Community Respiratory Health Survey (ECRHS). METHODS: We included 3673 participants recruited at age 20-44 years with repeated measurements of weight and lung function (forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1)) in three study waves (1991-93, 1999-2003, 2010-14) until they were 39-67 years of age. We classified subjects into weight change profiles according to baseline body mass index (BMI) categories and weight change over 20 years. We estimated trajectories of lung function over time as a function of weight change profiles using population-averaged generalised estimating equations. RESULTS: In individuals with normal BMI, overweight and obesity at baseline, moderate (0.25-1 kg/year) and high weight gain (>1 kg/year) during follow-up were associated with accelerated FVC and FEV1 declines. Compared with participants with baseline normal BMI and stable weight (±0.25 kg/year), obese individuals with high weight gain during follow-up had -1011 mL (95% CI -1.259 to -763) lower estimated FVC at 65 years despite similar estimated FVC levels at 25 years. Obese individuals at baseline who lost weight (<-0.25 kg/year) exhibited an attenuation of FVC and FEV1 declines. We found no association between weight change profiles and FEV1/FVC decline. CONCLUSION: Moderate and high weight gain over 20 years was associated with accelerated lung function decline, while weight loss was related to its attenuation. Control of weight gain is important for maintaining good lung function in adult life.
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- 2020
21. Describing the status of reproductive ageing simply and precisely: A reproductive ageing score based on three questions and validated with hormone levels
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Triebner, K, Johannessen, A, Svanes, C, Leynaert, B, Benediktsdottir, B, Demoly, P, Dharmage, SC, Franklin, KA, Heinrich, J, Holm, M, Jarvis, D, Lindberg, E, Rovira, JMM, Agirre, NM, Sanchez-Ramos, JL, Schlunssen, V, Skulstad, SM, Hustad, S, Rodriguez, FJ, Real, FG, Triebner, K, Johannessen, A, Svanes, C, Leynaert, B, Benediktsdottir, B, Demoly, P, Dharmage, SC, Franklin, KA, Heinrich, J, Holm, M, Jarvis, D, Lindberg, E, Rovira, JMM, Agirre, NM, Sanchez-Ramos, JL, Schlunssen, V, Skulstad, SM, Hustad, S, Rodriguez, FJ, and Real, FG
- Published
- 2020
22. T2 Effect of testosterone and sex hormone-binding globulin on lung function: a Mendelian randomisation study
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van der Plaat, DA, primary, Lenoir, A, additional, Dharmage, S, additional, Gómez Real, F, additional, Jarvis, D, additional, Minelli, C, additional, and Leynaert, B, additional
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- 2021
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23. Risk factors of new-onset asthma in adults: a population-based international cohort study
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Antó, J. M., Sunyer, J., Basagaña, X., Garcia-Esteban, R., Cerveri, I., de Marco, R., Heinrich, J., Janson, C., Jarvis, D., Kogevinas, M., Kuenzli, N., Leynaert, B., Svanes, C., Wjst, M., Gislason, T., and Burney, P.
- Published
- 2010
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24. Risk factors of adverse reactions to food in German adults
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Soost, S., Leynaert, B., Almqvist, C., Edenharter, G., Zuberbier, T., and Worm, M.
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- 2009
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25. Geographical distribution of atopic rhinitis in the European Community Respiratory Health Survey I*
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Bousquet, P.-J., Leynaert, B., Neukirch, F., Sunyer, J., Janson, C. M., Anto, J., Jarvis, D., and Burney, P.
- Published
- 2008
26. Important research questions in allergy and related diseases: nonallergic rhinitis: a GA2LEN paper
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Bousquet, J., Fokkens, W., Burney, P., Durham, S. R., Bachert, C., Akdis, C. A., Canonica, G. W., Dahlen, S.-E., Zuberbier, T., Bieber, T., Bonini, S., Bousquet, P. J., Brozek, J. L., Cardell, L.-O., Crameri, R., Custovic, A., Demoly, P., van Wijk, R. G., Gjomarkaj, M., Holland, C., Howarth, P., Humbert, M., Johnston, S. L., Kauffmann, F., Kowalski, M. L., Lambrecht, B., Lehmann, S., Leynaert, B., Lodrup-Carlsen, K., Mullol, J., Niggemann, B., Nizankowska-Mogilnicka, E., Papadopoulos, N., Passalacqua, G., Schünemann, H. J., Simon, H.-U., Todo-Bom, A., Toskala, E., Valenta, R., Wickman, M., and Zock, J. P.
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- 2008
27. Quality-of-life and asthma-severity in general population asthmatics: results of the ECRHS II study
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Siroux, V., Boudier, A., Anto, J. M., Cazzoletti, L., Accordini, S., Alonso, J., Cerveri, I., Corsico, A., Gulsvik, A., Jarvis, D., de Marco, R., Marcon, A., Marques, E. A., Bugiani, M., Janson, C., Leynaert, B., and Pin, I.
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- 2008
28. The socio-economic burden of asthma is substantial in Europe
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Accordini, S., Corsico, A., Cerveri, I., Gislason, D., Gulsvik, A., Janson, C., Jarvis, D., Marcon, A., Pin, I., Vermeire, P., Almar, E., Bugiani, M., Cazzoletti, L., Duran-Tauleria, E., Jõgi, R., Marinoni, A., Martínez-Moratalla, J., Leynaert, B., and de Marco, R.
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- 2008
29. The association of asthma, atopy and lung function with hormone replacement therapy and surgical cessation of menstruation in a population-based sample of English women
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Jarvis, D. and Leynaert, B.
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- 2008
30. Impact of gender on asthma in childhood and adolescence: a GA2LEN review
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Almqvist, C., Worm, M., and Leynaert, B.
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- 2008
31. Time and age trends in smoking cessation in Europe
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Pesce, G, Marcon, A, Calciano, L, Perret, JL, Abramson, MJ, Bono, R, Bousquet, J, Fois, AG, Janson, C, Jarvis, D, Jogi, R, Leynaert, B, Nowak, D, Schlunssen, V, Urrutia-Landa, I, Verlato, G, Villani, S, Zuberbier, T, Minelli, C, Accordini, S, Boezen, M, Elger, B, Gleditsch, BA, Heijmans, B, Romieu, I, Thompson, J, Commission of the European Communities, Salvy-Córdoba, Nathalie, Physiopathologie et Epidémiologie des Maladies Respiratoires (PHERE (UMR_S_1152 / U1152)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), University Hospital of Verona, Università degli studi di Verona = University of Verona (UNIVR), University of Melbourne, Monash University [Melbourne], Università degli studi di Torino = University of Turin (UNITO), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Università degli Studi di Sassari = University of Sassari [Sassari] (UNISS), Uppsala University Hospital, MRC Centre for Molecular Microbiology and Infection [Imperial College, London] (CMBI), Imperial College London, University of Tartu, Ludwig Maximilian University [Munich] (LMU), Aarhus University Hospital, Galdakao Hospital, Università degli Studi di Pavia = University of Pavia (UNIPV), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), University of Verona (UNIVR), University of Turin, University of Sassari, Università degli Studi di Pavia, Groningen Research Institute for Asthma and COPD (GRIAC), and Life Course Epidemiology (LCE)
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Male ,Pulmonology ,IMPACT ,medicine.medical_treatment ,Maternal Health ,Tobacco Smoking / epidemiology ,Social Sciences ,RELAPSE ,[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,Geographical Locations ,Habits ,INITIATION ,0302 clinical medicine ,Elderly ,Quality of life ,Pregnancy ,Smoking Habits ,Medicine and Health Sciences ,Medicine ,Psychology ,Public and Occupational Health ,030212 general & internal medicine ,Young adult ,PREDICTORS ,0303 health sciences ,Multidisciplinary ,Tobacco control ,food and beverages ,Obstetrics and Gynecology ,Public Health, Global Health, Social Medicine and Epidemiology ,Middle Aged ,3. Good health ,PREVALENCE ,Europe ,Multidisciplinary Sciences ,ALLERGIC RHINITIS ,Age trends, Ageing Lungs in European Cohorts (ALEC) study, Europe, smoking cessation, time trends ,Science & Technology - Other Topics ,Female ,Public Health ,Europe / epidemiology ,Research Article ,Adult ,medicine.medical_specialty ,Tobacco Control ,Smoking Cessation / statistics & numerical data ,Adolescent ,Substance-Related Disorders ,General Science & Technology ,Science ,Health Promotion ,Age trends ,03 medical and health sciences ,Young Adult ,Age Distribution ,Sex Factors ,Public Health, Tobacco Control, Tobacco Smoking, Smoking Cessation, Time Trends, Pregnancy ,Mental Health and Psychiatry ,MD Multidisciplinary ,Tobacco Smoking ,Humans ,Risk factor ,030304 developmental biology ,time trends ,Behavior ,Science & Technology ,business.industry ,Public health ,Biology and Life Sciences ,Smoking Related Disorders ,Retrospective cohort study ,ADULTS ,Ageing Lungs in European Cohorts (ALEC) study ,smoking cessation ,Young Adults ,Health Care ,Retrospective studies ,Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi ,Health promotion ,Age Groups ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,People and Places ,Quality of Life ,Smoking cessation ,Women's Health ,[SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,ASTHMA ,Population Groupings ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,business ,Demography - Abstract
BackgroundSmoking is the main risk factor for most of the leading causes of death. Cessation is the single most important step that smokers can take to improve their health. With the aim of informing policy makers about decisions on future tobacco control strategies, we estimated time and age trends in smoking cessation in Europe between 1980 and 2010.MethodsData on the smoking history of 50,228 lifetime smokers from 17 European countries were obtained from six large population-based studies included in the Ageing Lungs in European Cohorts (ALEC) consortium. Smoking cessation rates were assessed retrospectively, and age trends were estimated for three decades (1980-1989, 1990-1999, 2000-2010). The analyses were stratified by sex and region (North, East, South, West Europe).ResultsOverall, 21,735 subjects (43.3%) quit smoking over a total time-at-risk of 803,031 years. Cessation rates increased between 1980 and 2010 in young adults (16-40 years), especially females, from all the regions, and in older adults (41-60 years) from North Europe, while they were stable in older adults from East, South and West Europe. In the 2000s, the cessation rates for men and women combined were highest in North Europe (49.9 per 1,000/ year) compared to the other regions (range: 26.5-32.7 per 1,000/ year). A sharp peak in rates was observed for women around the age of 30, possibly as a consequence of pregnancy-related smoking cessation. In most regions, subjects who started smoking before the age of 16 were less likely to quit than those who started later.ConclusionsOur findings suggest an increasing awareness on the detrimental effects of smoking across Europe. However, East, South and West European countries are lagging behind North Europe, suggesting the need to intensify tobacco control strategies in these regions. Additional efforts should be made to keep young adolescents away from taking up smoking, as early initiation could make quitting more challenging during later life.
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- 2019
- Full Text
- View/download PDF
32. Eczema, atopy and allergen exposure in adults: a population-based study
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Harrop, J., Chinn, S., Verlato, G., Olivieri, M., Norbäck, D., Wjst, M., Janson, C., Zock, J.-P., Leynaert, B., Gislason, D., Ponzio, M., Villani, S., Carosso, A., Svanes, C., Heinrich, J., and Jarvis, D.
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- 2007
33. Association of lung function decline with the heme oxygenase-1 gene promoter microsatellite polymorphism in a general population sample. Results from the European Community Respiratory Health Survey (ECRHS), France
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Guénégou, A, Leynaert, B, Bénessiano, J, Pin, I, Demoly, P, Neukirch, F, Boczkowski, J, and Aubier, M
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- 2006
34. Factors responsible for differences between asymptomatic subjects and patients presenting an IgE sensitization to allergens. A GA2LEN project
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Bousquet, J., Anto, J. M., Bachert, C., Bousquet, P. J., Colombo, P., Crameri, R., Daëron, M., Fokkens, W., Leynaert, B., Lahoz, C., Maurer, M., Passalacqua, G., Valenta, R., van Hage, M., and Van Ree, R.
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- 2006
35. Serum carotenoids, vitamins A and E, and 8 year lung function decline in a general population
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Guénégou, A, Leynaert, B, Pin, I, Le Moël, G, Zureik, M, and Neukirch, F
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- 2006
36. Fruit and vegetable intakes and asthma in the E3N study
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Romieu, I, Varraso, R, Avenel, V, Leynaert, B, Kauffmann, F, and Clavel-Chapelon, F
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- 2006
37. Maternal atopy and changes in parity
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Sunyer, J., Antó, J. M., Plana, E., Janson, C., Jarvis, D., Kony, S., Omenaas, E. R., Svanes, C., Wjst, M., and Leynaert, B.
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- 2005
38. Determinants of fractional exhaled nitric oxide in healthy men and women from the European Community Respiratory Health Survey III
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Nerpin, E., Olivieri, M., Gislason, T., Olin, A. C., Nielsen, R., Johannessen, A., Ferreira, D. S., Marcon, A., Cazzoletti, L., Accordini, S., Pin, I., Corsico, A., Demoly, P., Weyler, J., Nowak, D., Jõgi, R., Forsberg, Bertil, Zock, J.P., Sigsgaard, T., Heinric, J., Bono, R., Leynaert, B., Jarvis, D., Janson, C., Malinovschi, A., Nerpin, E., Olivieri, M., Gislason, T., Olin, A. C., Nielsen, R., Johannessen, A., Ferreira, D. S., Marcon, A., Cazzoletti, L., Accordini, S., Pin, I., Corsico, A., Demoly, P., Weyler, J., Nowak, D., Jõgi, R., Forsberg, Bertil, Zock, J.P., Sigsgaard, T., Heinric, J., Bono, R., Leynaert, B., Jarvis, D., Janson, C., and Malinovschi, A.
- Abstract
Introduction: The fractional exhaled nitric oxide (FENO) is a marker for type 2 inflammation used in diagnostics and management of asthma. In order to use FENO as a reliable biomarker, it is important to investigate factors that influence FENO in healthy individuals. Men have higher levels of FENO than women, but it is unclear whether determinants of FENO differ by sex. Objective: To identify determinants of FENO in men and women without lung diseases. Method: FENO was validly measured in 3,881 healthy subjects that had answered the main questionnaire of the European Community Respiratory Health Survey III without airways or lung disease Results: Exhaled NO levels were 21.3% higher in men compared with women p<0.001. Being in the upper age quartile (60.3–67.6 years) men had 19.2 ppb (95% CI: 18.3, 20.2) higher FENO than subjects in the lowest age quartile (39.7–48.3 years) p=0.02. Women in the two highest age quartiles (54.6–60.2 and 60.3–67.6 years) had 15.4 ppb (14.7, 16.2), p=0.03 and 16.4 ppb (15.6, 17.1), p=<0.001 higher FENO, compared with the lowest age quartile. Height was related to 8% higher FENO level in men (p<0.001) and 5% higher FENO levels in women (p=0.008). Men who smoked had 37% lower FENO levels and women had 30% lower levels compared with never‐smokers (p<0.001 for both). Men and women sensitized to both grass and perennial allergens had higher FENO levels compared with non‐sensitized subjects 26% and 29%, p<0.001 for both. Conclusion & Clinical Relevance: FENO levels were higher in men than women. Similar effects of current smoking, height, and IgE sensitization were found in both sexes. FENO started increasing at lower age in women than in men, suggesting that interpretation of FENO levels in adults aged over 50 years should take into account age and sex.
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- 2019
- Full Text
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39. Snoring and nocturnal reflux: association with lung function decline and respiratory symptoms
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Emilsson, OI, Hagg, SA, Lindberg, E, Franklin, KA, Toren, K, Benediktsdottir, B, Aspelund, T, Real, FG, Leynaert, B, Demoly, P, Sigsgaard, T, Perret, J, Malinovschi, A, Jarvis, D, Garcia-Aymerich, J, Gislason, T, Janson, C, Emilsson, OI, Hagg, SA, Lindberg, E, Franklin, KA, Toren, K, Benediktsdottir, B, Aspelund, T, Real, FG, Leynaert, B, Demoly, P, Sigsgaard, T, Perret, J, Malinovschi, A, Jarvis, D, Garcia-Aymerich, J, Gislason, T, and Janson, C
- Abstract
INTRODUCTION: The study aim was to examine the association of snoring and nocturnal gastro-oesophageal reflux (nGOR) with respiratory symptoms and lung function, and if snoring and/or nGOR associated with a steeper decline in lung function. METHODS: Data from the third visit of the European Community Respiratory Health Survey (ECRHS) was used for cross-sectional analysis. Pre- and post-bronchodilator spirometry was performed, and information on sleep, nGOR and respiratory symptoms was collected (n=5715). Habitual snoring and nGOR were assessed by questionnaire reports. Pre-bronchodilator spirometry from ECRHS I, II and III (20 years follow-up) were used to analyse lung function changes by multivariate regression analysis. RESULTS: Snoring and nGOR were independently associated with a higher prevalence of wheeze, chest tightness, breathlessness, cough and phlegm. The prevalence of any respiratory symptom was 79% in subjects with both snoring and nGOR versus 56% in those with neither (p<0.001). Subjects with both snoring and nGOR had more frequent exacerbations (adjusted prevalence 32% versus 19% among "no snoring, no nGOR", p=0.003). Snoring but not nGOR was associated with a steeper decline in forced expiratory volume in 1 s over 10 years after adjusting for confounding factors (change in % predicted -5.53, versus -4.58 among "no snoring", p=0.04) and forced vital capacity (change in % predicted -1.94, versus -0.99 among "no snoring", p=0.03). CONCLUSIONS: Adults reporting both habitual snoring and nGOR had more respiratory symptoms and more frequent exacerbations of these symptoms. Habitual snoring was associated with a steeper decline in lung function over time.
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- 2019
40. Time and age trends in smoking cessation in Europe
- Author
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Manzoli, L, Pesce, G, Marcon, A, Calciano, L, Perret, JL, Abramson, MJ, Bono, R, Bousquet, J, Fois, AG, Janson, C, Jarvis, D, Jogi, R, Leynaert, B, Nowak, D, Schlunssen, V, Urrutia-Landa, I, Verlato, G, Villani, S, Zuberbier, T, Minelli, C, Accordini, S, Boezen, M, Elger, B, Gleditsch, BA, Heijmans, B, Romieu, I, Thompson, J, Manzoli, L, Pesce, G, Marcon, A, Calciano, L, Perret, JL, Abramson, MJ, Bono, R, Bousquet, J, Fois, AG, Janson, C, Jarvis, D, Jogi, R, Leynaert, B, Nowak, D, Schlunssen, V, Urrutia-Landa, I, Verlato, G, Villani, S, Zuberbier, T, Minelli, C, Accordini, S, Boezen, M, Elger, B, Gleditsch, BA, Heijmans, B, Romieu, I, and Thompson, J
- Abstract
BACKGROUND: Smoking is the main risk factor for most of the leading causes of death. Cessation is the single most important step that smokers can take to improve their health. With the aim of informing policy makers about decisions on future tobacco control strategies, we estimated time and age trends in smoking cessation in Europe between 1980 and 2010. METHODS: Data on the smoking history of 50,228 lifetime smokers from 17 European countries were obtained from six large population-based studies included in the Ageing Lungs in European Cohorts (ALEC) consortium. Smoking cessation rates were assessed retrospectively, and age trends were estimated for three decades (1980-1989, 1990-1999, 2000-2010). The analyses were stratified by sex and region (North, East, South, West Europe). RESULTS: Overall, 21,735 subjects (43.3%) quit smoking over a total time-at-risk of 803,031 years. Cessation rates increased between 1980 and 2010 in young adults (16-40 years), especially females, from all the regions, and in older adults (41-60 years) from North Europe, while they were stable in older adults from East, South and West Europe. In the 2000s, the cessation rates for men and women combined were highest in North Europe (49.9 per 1,000/year) compared to the other regions (range: 26.5-32.7 per 1,000/year). A sharp peak in rates was observed for women around the age of 30, possibly as a consequence of pregnancy-related smoking cessation. In most regions, subjects who started smoking before the age of 16 were less likely to quit than those who started later. CONCLUSIONS: Our findings suggest an increasing awareness on the detrimental effects of smoking across Europe. However, East, South and West European countries are lagging behind North Europe, suggesting the need to intensify tobacco control strategies in these regions. Additional efforts should be made to keep young adolescents away from taking up smoking, as early initiation could make quitting more challenging during later li
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- 2019
41. Association of bronchial hyperresponsiveness and lung function with C-reactive protein (CRP): a population based study
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Kony, S, Zureik, M, Driss, F, Neukirch, C, Leynaert, B, and Neukirch, F
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- 2004
42. Increase in diagnosed asthma but not in symptoms in the European Community Respiratory Health Survey
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Chinn, S, Jarvis, D, Burney, P, Luczynska, C, Ackermann-Liebrich, U, Antó, J M, Cerveri, I, de Marco, R, Gislason, T, Heinrich, J, Janson, C, Künzli, N, Leynaert, B, Neukirch, F, Schouten, J, Sunyer, J, Svanes, C, Vermeire, P, and Wjst, M
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- 2004
43. An international survey of chronic obstructive pulmonary disease in young adults according to GOLD stages
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de Marco, R, Accordini, S, Cerveri, I, Corsico, A, Sunyer, J, Neukirch, F, Künzli, N, Leynaert, B, Janson, C, Gislason, T, Vermeire, P, Svanes, C, Anto, J M, and Burney, P
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- 2004
44. Body Mass Index, Change in Body Silhouette, and Risk of Asthma in the E3N Cohort Study
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Romieu, I., Avenel, V., Leynaert, B., Kauffmann, F., and Clavel-Chapelon, F.
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- 2003
45. Mould exposure in indoor environments: The French ANSES recommendations to reinforce measures for preventing mould growth and the impact on human health
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Keirsbulck, Marion, Aschan-Leygonie, Christina, Bayeux, Thomas, Bex, Valerie, Boulanger, Gabrielle, Bretagne, Stéphane, Caillaud, D., Colleville, A-C., Fourneau, C., Frealle, Emilie, Ginestet, Stéphane, Lecoq, Laetitia, Leynaert, B., Nadif, Rachel, F., Oswald, Reboux, Gabriel, Roussel, S., Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Environnement, Ville, Société (EVS), École normale supérieure de Lyon (ENS de Lyon)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université Lumière - Lyon 2 (UL2)-Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-École Nationale des Travaux Publics de l'État (ENTPE)-École nationale supérieure d'architecture de Lyon (ENSAL)-Centre National de la Recherche Scientifique (CNRS), Service de parasitologie [Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Laboratoire Matériaux et Durabilité des constructions (LMDC), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT), Université Grenoble Alpes - UFR Médecine (UGA UFRM), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Physiopathologie et Epidemiologie de l'Insuffisance Respiratoire, Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Chrono-environnement (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Environnement Ville Société (EVS), Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-École nationale supérieure d'architecture de Lyon (ENSAL)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-École Nationale des Travaux Publics de l'État (ENTPE)-Université Jean Monnet [Saint-Étienne] (UJM)-Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université Lumière - Lyon 2 (UL2)-École normale supérieure - Lyon (ENS Lyon), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS), Body, Salima, Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-École nationale supérieure d'architecture de Lyon (ENSAL)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), École normale supérieure - Lyon (ENS Lyon)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet [Saint-Étienne] (UJM)-École Nationale des Travaux Publics de l'État (ENTPE)-École nationale supérieure d'architecture de Lyon (ENSAL)-Centre National de la Recherche Scientifique (CNRS), Institut National des Sciences Appliquées (INSA)-Université Fédérale Toulouse Midi-Pyrénées-Institut National des Sciences Appliquées (INSA)-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées
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[SHS] Humanities and Social Sciences ,ComputingMilieux_MISCELLANEOUS ,[SHS]Humanities and Social Sciences - Abstract
International audience
- Published
- 2018
46. Trends in smoking initiation in Europe over 40 years: A retrospective cohort study
- Author
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Niaura, R, Marcon, A, Pesce, G, Calciano, L, Bellisario, V, Dharmage, SC, Garcia-Aymerich, J, Gislason, T, Heinrich, J, Holm, M, Janson, C, Jarvis, D, Leynaert, B, Matheson, MC, Pirina, P, Svanes, C, Villani, S, Zuberbier, T, Minelli, C, Accordini, S, Niaura, R, Marcon, A, Pesce, G, Calciano, L, Bellisario, V, Dharmage, SC, Garcia-Aymerich, J, Gislason, T, Heinrich, J, Holm, M, Janson, C, Jarvis, D, Leynaert, B, Matheson, MC, Pirina, P, Svanes, C, Villani, S, Zuberbier, T, Minelli, C, and Accordini, S
- Abstract
BACKGROUND: Tobacco consumption is the largest avoidable health risk. Understanding changes of smoking over time and across populations is crucial to implementing health policies. We evaluated trends in smoking initiation between 1970 and 2009 in random samples of European populations. METHODS: We pooled data from six multicentre studies involved in the Ageing Lungs in European Cohorts consortium, including overall 119,104 subjects from 17 countries (range of median ages across studies: 33-52 years). We estimated retrospectively trends in the rates of smoking initiation (uptake of regular smoking) by age group, and tested birth cohort effects using Age-Period-Cohort (APC) modelling. We stratified all analyses by sex and region (North, East, South, West Europe). RESULTS: Smoking initiation during late adolescence (16-20 years) declined for both sexes and in all regions (except for South Europe, where decline levelled off after 1990). By the late 2000s, rates of initiation during late adolescence were still high (40-80 per 1000/year) in East, South, and West Europe compared to North Europe (20 per 1000/year). Smoking initiation rates during early adolescence (11-15 years) showed a marked increase after 1990 in all regions (except for North European males) but especially in West Europe, where they reached 40 per 1000/year around 2005. APC models supported birth cohort effects in the youngest cohorts. CONCLUSION: Smoking initiation is still unacceptably high among European adolescents, and increasing rates among those aged 15 or less deserve attention. Reducing initiation in adolescents is fundamental, since youngsters are particularly vulnerable to nicotine addiction and tobacco adverse effects.
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- 2018
47. A three-generation study on the association of tobacco smoking with asthma
- Author
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Accordini, S, Calciano, L, Johannessen, A, Portas, L, Benediktsdottir, B, Bertelsen, RJ, Braback, L, Carsin, A-E, Dharmage, SC, Dratva, J, Forsberg, B, Real, FG, Heinrich, J, Holloway, JW, Holm, M, Janson, C, Jogi, R, Leynaert, B, Malinovschi, A, Marcon, A, Martinez-Moratalla Rovira, J, Raherison, C, Luis Sanchez-Ramos, J, Schlunssen, V, Bono, R, Corsico, AG, Demoly, P, Dorado Arenas, S, Nowak, D, Pin, I, Weyler, J, Jarvis, D, Svanes, C, Accordini, S, Calciano, L, Johannessen, A, Portas, L, Benediktsdottir, B, Bertelsen, RJ, Braback, L, Carsin, A-E, Dharmage, SC, Dratva, J, Forsberg, B, Real, FG, Heinrich, J, Holloway, JW, Holm, M, Janson, C, Jogi, R, Leynaert, B, Malinovschi, A, Marcon, A, Martinez-Moratalla Rovira, J, Raherison, C, Luis Sanchez-Ramos, J, Schlunssen, V, Bono, R, Corsico, AG, Demoly, P, Dorado Arenas, S, Nowak, D, Pin, I, Weyler, J, Jarvis, D, and Svanes, C
- Abstract
BACKGROUND: Mothers' smoking during pregnancy increases asthma risk in their offspring. There is some evidence that grandmothers' smoking may have a similar effect, and biological plausibility that fathers' smoking during adolescence may influence offspring's health through transmittable epigenetic changes in sperm precursor cells. We evaluated the three-generation associations of tobacco smoking with asthma. METHODS: Between 2010 and 2013, at the European Community Respiratory Health Survey III clinical interview, 2233 mothers and 1964 fathers from 26 centres reported whether their offspring (aged ≤51 years) had ever had asthma and whether it had coexisted with nasal allergies or not. Mothers and fathers also provided information on their parents' (grandparents) and their own asthma, education and smoking history. Multilevel mediation models within a multicentre three-generation framework were fitted separately within the maternal (4666 offspring) and paternal (4192 offspring) lines. RESULTS: Fathers' smoking before they were 15 [relative risk ratio (RRR) = 1.43, 95% confidence interval (CI): 1.01-2.01] and mothers' smoking during pregnancy (RRR = 1.27, 95% CI: 1.01-1.59) were associated with asthma without nasal allergies in their offspring. Grandmothers' smoking during pregnancy was associated with asthma in their daughters [odds ratio (OR) = 1.55, 95% CI: 1.17-2.06] and with asthma with nasal allergies in their grandchildren within the maternal line (RRR = 1.25, 95% CI: 1.02-1.55). CONCLUSIONS: Fathers' smoking during early adolescence and grandmothers' and mothers' smoking during pregnancy may independently increase asthma risk in offspring. Thus, risk factors for asthma should be sought in both parents and before conception. FUNDING: European Union (Horizon 2020, GA-633212).
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- 2018
48. Leisure-time vigorous physical activity is associated with better lung function: the prospective ECRHS study
- Author
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Fuertes, E, Carsin, A-E, Anto, JM, Bono, R, Corsico, AG, Demoly, P, Gislason, T, Gullon, J-A, Janson, C, Jarvis, D, Heinrich, J, Holm, M, Leynaert, B, Marcon, A, Martinez-Moratalla, J, Nowak, D, Erquicia, SP, Probst-Hensch, NM, Raherison, C, Raza, W, Real, FG, Russell, M, Sanchez-Ramos, JL, Weyler, J, Aymerich, JG, Fuertes, E, Carsin, A-E, Anto, JM, Bono, R, Corsico, AG, Demoly, P, Gislason, T, Gullon, J-A, Janson, C, Jarvis, D, Heinrich, J, Holm, M, Leynaert, B, Marcon, A, Martinez-Moratalla, J, Nowak, D, Erquicia, SP, Probst-Hensch, NM, Raherison, C, Raza, W, Real, FG, Russell, M, Sanchez-Ramos, JL, Weyler, J, and Aymerich, JG
- Abstract
OBJECTIVE: We assessed associations between physical activity and lung function, and its decline, in the prospective population-based European Community Respiratory Health Survey cohort. METHODS: FEV1 and FVC were measured in 3912 participants at 27-57 years and 39-67 years (mean time between examinations=11.1 years). Physical activity frequency and duration were assessed using questionnaires and used to identify active individuals (physical activity ≥2 times and ≥1 hour per week) at each examination. Adjusted mixed linear regression models assessed associations of regular physical activity with FEV1 and FVC. RESULTS: Physical activity frequency and duration increased over the study period. In adjusted models, active individuals at the first examination had higher FEV1 (43.6 mL (95% CI 12.0 to 75.1)) and FVC (53.9 mL (95% CI 17.8 to 89.9)) at both examinations than their non-active counterparts. These associations appeared restricted to current smokers. In the whole population, FEV1 and FVC were higher among those who changed from inactive to active during the follow-up (38.0 mL (95% CI 15.8 to 60.3) and 54.2 mL (95% CI 25.1 to 83.3), respectively) and who were consistently active, compared with those consistently non-active. No associations were found for lung function decline. CONCLUSION: Leisure-time vigorous physical activity was associated with higher FEV1 and FVC over a 10-year period among current smokers, but not with FEV1 and FVC decline.
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- 2018
49. Airway responsiveness to methacholine and incidence of COPD: an international prospective cohort study
- Author
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Marcon, A, Locatelli, F, Keidel, D, Beckmeyer-Borowko, AB, Cerveri, I, Dharmage, SC, Fuertes, E, Garcia-Aymerich, J, Heinrich, J, Imboden, M, Janson, C, Johannessen, A, Leynaert, B, Erquicia, SP, Pesce, G, Schaffner, E, Svanes, C, Urrutia, I, Jarvis, D, Probst-Hensch, NM, Accordini, S, Marcon, A, Locatelli, F, Keidel, D, Beckmeyer-Borowko, AB, Cerveri, I, Dharmage, SC, Fuertes, E, Garcia-Aymerich, J, Heinrich, J, Imboden, M, Janson, C, Johannessen, A, Leynaert, B, Erquicia, SP, Pesce, G, Schaffner, E, Svanes, C, Urrutia, I, Jarvis, D, Probst-Hensch, NM, and Accordini, S
- Abstract
BACKGROUND: It has been debated, but not yet established, whether increased airway responsiveness can predict COPD. Recognising this link may help in identifying subjects at risk. OBJECTIVE: We studied prospectively whether airway responsiveness is associated with the risk of developing COPD. METHODS: We pooled data from two multicentre cohort studies that collected data from three time points using similar methods (European Community Respiratory Health Survey and Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults). We classified subjects (median age 37 years, 1st-3rd quartiles: 29-44) by their level of airway responsiveness using quintiles of methacholine dose-response slope at the first examination (1991-1994). Then, we excluded subjects with airflow obstruction at the second examination (1999-2003) and analysed incidence of COPD (postbronchodilator FEV1/FVC below the lower limit of normal) at the third examination (2010-2014) as a function of responsiveness, adjusting for sex, age, education, body mass index, history of asthma, smoking, occupational exposures and indicators of airway calibre. RESULTS: We observed 108 new cases of COPD among 4205 subjects during a median time of 9 years. Compared with the least responsive group (incidence rate 0.6 per 1000/year), adjusted incidence rate ratios for COPD ranged from 1.79 (95% CI 0.52 to 6.13) to 8.91 (95% CI 3.67 to 21.66) for increasing airway responsiveness. Similar dose-response associations were observed between smokers and non-smokers, and stronger associations were found among subjects without a history of asthma or asthma-like symptoms. CONCLUSIONS: Our study suggests that increased airway responsiveness is an independent risk factor for COPD. Further research should clarify whether early treatment in patients with high responsiveness can slow down disease progression.
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- 2018
50. Body silhouettes as a tool to reflect obesity in the past
- Author
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Vinciguerra, M, Lonnebotn, M, Svanes, C, Igland, J, Franklin, KA, Accordini, S, Benediktsdottir, B, Bentouhami, H, Blanco, JAG, Bono, R, Corsicoll, A, Demoly, P, Dharmage, S, Dorado Arenas, S, Garcia, J, Heinrich, J, Holm, M, Janson, C, Jarvis, D, Leynaert, B, Martinez-Moratalla, J, Nowak, D, Pin, I, Raherison-Semjen, C, Luis Sanchez-Ramos, J, Schlunssen, V, Skulstad, SM, Dratva, J, Real, FG, Vinciguerra, M, Lonnebotn, M, Svanes, C, Igland, J, Franklin, KA, Accordini, S, Benediktsdottir, B, Bentouhami, H, Blanco, JAG, Bono, R, Corsicoll, A, Demoly, P, Dharmage, S, Dorado Arenas, S, Garcia, J, Heinrich, J, Holm, M, Janson, C, Jarvis, D, Leynaert, B, Martinez-Moratalla, J, Nowak, D, Pin, I, Raherison-Semjen, C, Luis Sanchez-Ramos, J, Schlunssen, V, Skulstad, SM, Dratva, J, and Real, FG
- Abstract
Life course data on obesity may enrich the quality of epidemiologic studies analysing health consequences of obesity. However, achieving such data may require substantial resources. We investigated the use of body silhouettes in adults as a tool to reflect obesity in the past. We used large population-based samples to analyse to what extent self-reported body silhouettes correlated with the previously measured (9-23 years) body mass index (BMI) from both measured (European Community Respiratory Health Survey, N = 3 041) and self-reported (Respiratory Health In Northern Europe study, N = 3 410) height and weight. We calculated Spearman correlation between BMI and body silhouettes and ROC-curve analyses for identifying obesity (BMI ≥30) at ages 30 and 45 years. Spearman correlations between measured BMI age 30 (±2y) or 45 (±2y) and body silhouettes in women and men were between 0.62-0.66 and correlations for self-reported BMI were between 0.58-0.70. The area under the curve for identification of obesity at age 30 using body silhouettes vs previously measured BMI at age 30 (±2y) was 0.92 (95% CI 0.87, 0.97) and 0.85 (95% CI 0.75, 0.95) in women and men, respectively; for previously self-reported BMI, 0.92 (95% CI 0.88, 0.95) and 0.90 (95% CI 0.85, 0.96). Our study suggests that body silhouettes are a useful epidemiological tool, enabling retrospective differentiation of obesity and non-obesity in adult women and men.
- Published
- 2018
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