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2. Effect of Scanning Method and Overlap Rate on the Microstructure and Properties of a Ni60-WC Composite Coating Laser Clad onto 45 Steel.

Author

Han, J., Li, B-Y., and Tian, X-Q.

Subjects
*COMPOSITE coating, *TRIBOLOGICAL ceramics, *WEAR resistance, *MICROSTRUCTURE, *STEEL, *ALLOY powders
Abstract

In order to solve the problem of insufficient hardness and friction wear performance of Ni-based coatings under certain extreme working conditions, this paper designs experiments from a process perspective to study the effects of laser scanning method and overlap rate on the microstructure and properties of laser clad Ni60-WC composite coatings. Unlike previous studies, this study considers the comprehensive effects of laser scanning method and overlap rate on coating performance for specific laser clad layers, rather than just one of them. The results show that the performance of the coating after fusion is the best in the single line scanning mode and the overlap rate is within the range of 30 to 35%. The maximum hardness of the laser clad coating can reach 1216 HV, which is 1.08 to 1.43 times the 850 to 1150 HV hardness of the Ni-WC coating reported so far. The wear resistance of the laser clad coating has also been improved to some extent. The results confirm the phenomenon of interactive influence between scanning mode and overlap rate in the laser cladding process, which will provide a new 4knowledge for optimizing laser cladding in the future. [ABSTRACT FROM AUTHOR]

Published
2024

3. Proton radiography of magnetic field produced by ultra-intense laser irradiating capacity-coil target

Author

Wang, W. W., Teng, J., Chen, J., Cai, H. B., He, S. K., Zhou, W. M., Shan, L. Q., Lu, F., Wu, Y. C., Hong, W., Liu, D. X., Bi, B., Zhang, F., Xue, F. B., Li, B. Y., Zhang, B., He, Y. L., He, W., Jiao, J. L., Dong, K. G., Zhang, F. Q., Deng, Z. G., Zhang, Z. M., Cui, B., Han, D., Zhou, K. N., Wang, X. D., Zhao, Z. Q., Cao, L. F., Zhang, B. H., He, X. T., and Gu, Y. Q.

Subjects
Physics - Plasma Physics, 68U20, I.6.8
Abstract

Ultra-intense ultra-short laser is firstly used to irradiate the capacity-coil target to generate magnetic field. The spatial structure and temporal evolution of huge magnetic fields were studied with time-gated proton radiography method. A magnetic flux density of 40T was measured by comparing the proton deflection and particle track simulations. Although the laser pulse duration is only 30fs, the generated magnetic field can last for over 100 picoseconds. The energy conversion efficiency from laser to magnetic field can reach as high as ~20%. The results indicate that tens of tesla (T) magnetic field could be produced in many ultra intense laser facilities around the world, and higher magnetic field could be produced by picosecond lasers., Comment: 5 pages, 5 figures

Published
2014

4. Accurate diagnosis of colorectal cancer based on histopathology images using artificial intelligence

Author

Wang, K. S., Yu, G., Xu, C., Meng, X. H., Zhou, J., Zheng, C., Deng, Z., Shang, L., Liu, R., Su, S., Zhou, X., Li, Q., Li, J., Wang, J., Ma, K., Qi, J., Hu, Z., Tang, P., Deng, J., Qiu, X., Li, B. Y., Shen, W. D., Quan, R. P., Yang, J. T., Huang, L. Y., Xiao, Y., Yang, Z. C., Li, Z., Wang, S. C., Ren, H., Liang, C., Guo, W., Li, Y., Xiao, H., Gu, Y., Yun, J. P., Huang, D., Song, Z., Fan, X., Chen, L., Yan, X., Li, Z., Huang, Z. C., Huang, J., Luttrell, J., Zhang, C. Y., Zhou, W., Zhang, K., Yi, C., Wu, C., Shen, H., Wang, Y. P., Xiao, H. M., and Deng, H. W.

Published
2021
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6. First-Principles Investigations on Structure Stability, Electronic and Optical Characterization of Hg(IO3)2 under Pressure.

Author

Li, B. Y. and Wang, M.

Abstract

We investigate the structural, electronic, and optical properties of Hg(IO3)2 under pressure within density-function theory. The crystal structure is fully relaxed, and the structural parameters are found to be well consistent with the experimental data. First-principles calculation provides considerable insight into the relationship between electronic structure and optical properties. The electronic band structure shows that the valence band maximum (VBM) and conduction band minimum (CBM) of monoclinic Hg(IO3)2 are mainly contributed by I 5p states with some Hg 5d and Hg 6s states, while the p-orbital contributions of O atom and Hg atom are very weak. Furthermore, the absorption, reflectivity, refractive index and extinction coefficient have been calculated using the imaginary part of the dielectric function. According to our work, we found that the optical properties of Hg(IO3)2 undergo a red shift with increasing pressure. [ABSTRACT FROM AUTHOR]

Published
2023
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9. Local climate adaptation and gene flow in the native range of two co-occurring fruit moths with contrasting invasiveness

Author

Cao, L-J, Li, B-Y, Chen, J-C, Zhu, J-Y, Hoffmann, AA, Wei, S-J, Cao, L-J, Li, B-Y, Chen, J-C, Zhu, J-Y, Hoffmann, AA, and Wei, S-J

Abstract

Invasive species pose increasing threats to global biodiversity and ecosystems. While previous studies have characterized successful invaders based on ecological traits, characteristics related to evolutionary processes have rarely been investigated. Here we compared gene flow and local adaptation using demographic analyses and outlier tests in two co-occurring moth pests across their common native range of China, one of which (the peach fruit moth, Carposina sasakii) has maintained its native distribution, while the other (the oriental fruit moth, Grapholita molesta) has expanded its range globally during the past century. We found that both species showed a pattern of genetic differentiation and an evolutionary history consistent with a common southwestern origin and northward expansion in their native range. However, for the noninvasive species, genetic differentiation was closely aligned with the environment, and there was a relatively low level of gene flow, whereas in the invasive species, genetic differentiation was associated with geography. Genome scans indicated stronger patterns of climate-associated loci in the noninvasive species. While strong local adaptation and reduced gene flow across its native range may have decreased the invasiveness of C. sasakii, this requires further validation with additional comparisons of invasive and noninvasive species across their native range.

Published
2021

17. Rhizobium sophorae, Rhizobium laguerreae, and two novel Rhizobium genospecies associated with Vicia sativa L. in Northwest China

Author

Zhang, J. J., Shang, Y. M., Peng, S. S., Chen, W. F., Wang, E. T., Lajudie, Philippe de, Li, B. Y., Guo, C., and Liu, C. Z.

Subjects
Rhizobium spp. nov, Vicia sativa, Rhizobium sophorae, food and beverages, Northwest China, Rhizobium laguerreae
Abstract

Aims To identify the rhizobia nodulating Vicia sativa in Northwestern China and to estimate their geographic distribution. Methods Rhizobia trapped with V. sativa plants from soils at six sites in the northwest of China were classified into genotypes by PCR-based restriction fragment length polymorphism (RFLP) of 16S-23S rRNA intergenic spacer (IGS) and 16S rRNA genes, and phylogenetic analyses of housekeeping (16S rRNA, recA, atpD) and symbiotic genes were performed for the representative strains. Soil physicochemical characteristics were recorded and canonical correlation analysis was performed to examine the correlations between soil features and distribution of rhizobial genotypes. Results A total of 202 rhizobial isolates were discriminated by RFLP analyses into 15 IGS types and a single 16S rRNA type, which were identified as Rhizobium by 16S rRNA gene phylogeny and as four clusters by multilocus sequence analysis (MLSA). Cluster 1 covering 86 strains and 7 IGS types prevalent in all sites was identified as Rhizobium laguerreae; cluster 2 was R. sophorae with 18 strains in 2 IGS types found in the site Q-GD. Each of cluster 3 and cluster 4 contained three IGS types representing two novel Rhizobium genospecies specific to Gansu Province and Shanxi Province, respectively. Four nodC phylogenetic clades were defined among the isolates. Conclusions R. sophorae, R. laguerreae, and two novel Rhizobium genospecies with diverse symbiotic genotypes are associated with Vicia sativa L. in Northwest China. Their biogeographic patterns are mainly directed by soil pH and salinity. This is the first study on the diversity of rhizobia nodulating Vicia sativa in China.

Published
2019

19. Mesorhizobium jarvisii sv. astragali as predominant microsymbiont for Astragalus sinicus L. in acidic soils, Xinyang, China

Author

Zhang, J. J., Shang, Y. M., Wang, E. T., Chen, W. F., Lajudie de, Philippe, Li, B. Y., Guo, C., Yang, X., Zheng, J. Q., and Liu, C. Z.

Subjects
Astragalus sinicus, Acidic soils, Mesorhizobium jarvisii, Xinyang
Abstract

Aims To identify the rhizobia nodulating Astragalus sinicus in the acid soils at Xinyang, China and to estimate the effects of fertilization strategies on the rhizobial community. Methods Soil samples were collected from treatments submitted to different fertilization strategies (chemical fertilizers, A. sinicus green manure, various input levels). Nodules obtained from the A. sinicus trapping plants grown in the soil samples were used for rhizobial isolation. The isolates were grouped into PCR-RFLP genotypes based on analyses of 16S rRNA gene and IGS, and representatives for each genotype were further subjected to phylogenetic analyses of housekeeping genes (16S rRNA gene, atpD, glnII, and rpoB), as well as symbiotic genes (nodC and nifH). Soil physicochemical characteristics were also estimated and redundancy analysis was performed to examine the relations between soil features and distribution of rhizobial genotypes across different fertilization treatments. Results A total of 257 rhizobial isolates were obtained and discriminated into 12 IGS types in a single 16S rRNA type by RFLP analyses. Further 16S rRNA gene sequence-based phylogeny and multilocus sequence analysis (MLSA) distinguished a minor group (10 strains, 4 IGS types) affiliated to Mesorhizobium huakuii and a main group (247 strains, 8 IGS types) to Mesorhizobium jarvisii, for which a novel symbiovar, sv. astragali, was described. The long-term input of A. sinicus green manure increased rhizobial diversity and modified rhizobial community structures, via the increase of organic matter and decrease of soil pH, available phosphate, available potassium, and total salt. Conclusions M. jarvisii sv. nov. astragali was the predominant microsymbiont of A. sinicus in the tested acidic soils. The long-term input of green manure modified the soil features, enhancing the genetic diversity of rhizobia associated with A. sinicus and alternating the rhizobial community structure.

Published
2018

21. Triton identification in the 6Li(n, t)4He reaction measurement with the grid ionization chamber at CSNS Back-n white neutron source

Author

Yi, H., primary, Zhao, Y., additional, Jiang, W., additional, Fan, R., additional, Li(b), Y., additional, Chen, Y., additional, Bai, H., additional, Jiang, H., additional, Cui, Z., additional, Zhang, G., additional, Cao, P., additional, Yu, T., additional, Zhou, L., additional, Ning, C., additional, Gu, M., additional, He, Y., additional, Sun, Z., additional, Tang, J., additional, Zhang, Q., additional, An, Q., additional, Bao, J., additional, Chen, Q., additional, Cheng, P., additional, Feng, C., additional, Guo, F., additional, Han, C., additional, Han, Z., additional, He, G., additional, Huang, H., additional, Huang, W., additional, Huang, X., additional, Ji, X., additional, Jing, H., additional, Kang, L., additional, Kang, M., additional, Li, B., additional, Li, Q., additional, Li, X., additional, Li(a), Y., additional, Liu, R., additional, Liu, S., additional, Liu, X., additional, Luan, G., additional, Ma, Y., additional, Pan, J., additional, Qi, B., additional, Ren, J., additional, Ruan, X., additional, Song, Z., additional, Sun, H., additional, Sun, X., additional, Tan, Z., additional, Tang, H., additional, Wang, P., additional, Wang, Q., additional, Wang, T., additional, Wang, Y., additional, Wang, Z., additional, Wen, J., additional, Wen, Z., additional, Wu, Q., additional, Wu, X., additional, Xie, L., additional, Yang, Y., additional, Yu, L., additional, Yu, Y., additional, Zhang, J., additional, Zhang, L., additional, Zhang, X., additional, Zhang, Y., additional, Zhang, Z., additional, Zhou, Z., additional, Zhu, D., additional, Zhu, K., additional, and Zhu, P., additional

Published
2019
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22. Multiple refugia from penultimate glaciations in East Asia demonstrated by phylogeography and ecological modelling of an insect pest

Author

Song, W, Cao, L-J, Li, B-Y, Gong, Y-J, Hoffmann, AA, Wei, S-J, Song, W, Cao, L-J, Li, B-Y, Gong, Y-J, Hoffmann, AA, and Wei, S-J

Abstract

BACKGROUND: Refugial populations in Quaternary glaciations are critical to understanding the evolutionary history and climatic interactions of many extant species. Compared with the well-studied areas of Europe and Northern America, refugia of species in eastern Asia remain largely unknown. Here, we investigated the phylogeographic history of a globally important insect pest, the oriental fruit moth Grapholita molesta, in its native range of China. RESULTS: Genetic structure analyses unveiled three distinct groups and a set of populations with admixture. Approximate Bayesian Computation (ABC) analyses support range expansion of this moth from southwest groups of Yunnan and Sichuan to northern and eastern China. A set of admixed populations was found around these two ancestral groups. This pattern of genetic structure points to two refugia located in the Yunnan region and Sichuan Basin. The split of the two refugia was dated to 329.2 thousand years ago in the penultimate glacial period. One of the lineages was exclusively found around the Sichuan Basin, indicating the formation of endemic populations in this refugium. Ecological niche model analysis suggested a shrinking distribution from the LIG period to the MID period in the Sichuan lineage but a wide and stable distribution in the other lineage. CONCLUSIONS: Our results for the first time suggest that Yunnan and Sichuan jointly served as two large-scale refugia in eastern Asia in Quaternary glaciations, helping to maintain genetic diversity overall.

Published
2018

23. Effect of CTCs and INHBA level on the effect and prognosis of different treatment methods for patients with early breast cancer.

Author

WANG, X.-Q., LIU, B., LI, B.-Y., WANG, T., and CHEN, D.-Q.

Abstract

OBJECTIVE: We aimed at investigating the changes in the number of circulating tumor cells (CTCs) in patients with early breast cancer (BCa) before and after different treatments, and the influence of INHBA expression on patients' therapy efficacy and prognosis prediction was also evaluated. PATIENTS AND METHODS: Treatment plans were formulated based on patient's condition and willingness. 160 patients with early BCa were divided into trastuzumab adjuvant group (80 cases) and surgery group (80 cases). The correlation between the number of CTCs and Inhibin, beta A (INHBA) level was assessed by Spearman correlation analysis. The cumulative survival curve was depicted using Kaplan-Meier method to evaluate the prognosis of patients in different groups. RESULTS: The number of detected CTCs and INHBA expression in the two groups were both reduced as compared with those before chemotherapy. After 3 months of treatment, CTCs and INHBA level in the surgical group were detected lower than those in the trastuzumab group. The number of CTCs was positively correlated with INHBA level. The overall survival rate of patients in the surgery group was remarkably higher than those in the adjuvant trastuzumab group. CONCLUSIONS: The CTCs in the peripheral blood of patients with early BCa showed a great relevance to INHBA expression, which may thus serve as predictors of treatment effect and prognosis of BCa patients in early stage. Meanwhile, we demonstrate that surgery should be the first choice for early BCa patients after chemotherapy. [ABSTRACT FROM AUTHOR]

Published
2020

24. Dexmedetomidine promotes the recovery of renal function and reduces the inflammatory level in renal ischemia-reperfusion injury rats through PI3K/Akt/HIF-1α signaling pathway.

Author

LI, B.-Y., LIU, Y., LI, Z.-H., AN, X.-L., XIAO, S.-S., LIU, G.-K., and ZHANG, J.

Abstract

OBJECTIVE: To evaluate the protective effect of dexmedetomidine (Dex) against renal ischemia-reperfusion injury (RIRI) in rats through the phosphatidylinositol 3-hydroxy kinase (PI3K)/protein kinase B (Akt)/hypoxia-inducible factor-1α (HIF-1α) signaling pathway. MATERIALS AND METHODS: (1) A Sprague-Dawley rat model of RIRI was established. Thirty rats were divided into Sham group, injury (RIRI) group, and Dex treatment (RIRI + Dex) group. Serum was collected to detect renal function-related indexes, and the levels of serum inflammatory factors were examined via enzyme-linked immunosorbent assay (ELISA). (2) The kidney tissues were separated, and the degree of tissue damage was determined using immunohistochemical staining. (3) Ribonucleic acids (RNAs) were extracted from tissues, and the mRNA levels of inflammatory factors were measured using quantitative reverse transcription-polymerase chain reaction (qRT-PCR). (4) The protein expressions of Akt, phosphorylated (p)-Akt, PI3K, p-PI3K, and HIF-1α were detected via Western blotting. RESULTS: Compared with those in RIRI group, the levels of blood urea nitrogen and creatinine declined (p<0.05), the synthesized mRNAs of inflammatory factors in the kidney tissues were reduced (p<0.05), the secreted serum inflammatory factors was also reduced (p<0.05), and the phosphorylation levels of Akt and PI3K and the HIF-1α level rose (p<0.05) in RIRI + Dex group. CONCLUSIONS: Dex promotes the recovery of renal function and reduces the inflammatory level in RIRI rats through the PI3K/Akt/HIF-1α signaling pathway. [ABSTRACT FROM AUTHOR]

Published
2020

25. Spectrum-tunable light source based on multi-sources

Author

Liu H.-X., Li B.-Y., Sun J.-X., Z Wan, Li X.-S., Ren J.-W., and Liu Z.-X.

Subjects
Physics, business.industry, Irradiance, Atomic and Molecular Physics, and Optics, Spectral line, Electronic, Optical and Magnetic Materials, law.invention, Integrating sphere, Optics, law, Calibration, Radiance, Black-body radiation, business, Radiometric calibration, Light-emitting diode, Remote sensing
Abstract

A spectrum-tunable integrating sphere light source based on a Light Emitting diode (LED) and basis sources was developed to eliminate the effect of spectral non-matching between calibration source and an on-orbit detecting target on the calibration accuracy of space optical remote sensor in a laboratory. The developed source was used to produce typical ground object spectra and to calibrate space optical remote sensors, which significantly diminishes the absolute radiometric calibration error caused by spectral non-matching mentioned above. Firstly, the affecting mechanism of the spectral non-matching on the absolute radiometric calibration accuracy of space optical remote sensor was analyzed. Then, the design scheme of the spectrum-tunable light source was given according to technical requirements. The scheme was mainly divided into four key issues: the determination of light source and design of spectral matching algorithm, the design of light source drive circuit and control system, the matching of target spectrum and spectral adjustment, and the optical-mechanical design of spectrum-tunable light source. In the end, the performance of calibrated spectrum-tunable light source was tested. The results show that the spectral non-matching errors of equi-energy spectrum and 6000 K blackbody spectrum are 6.37% and 8.76% respectively, the irradiance non-uniformity is 0.53%, the irradiance instability of the spectrum-tunable light source within 30 min is 0.03%, and the radiance angular non-uniformity of the spectrum-tunable light source within horizontally 30 is 0.80%. Moreover, it offers the spectral radiance above 0.07 W/(m2srnm) and the integral radiance in 410-900 nm of 58.3 W/(m2sr). These data all meet the design requirements of spectrum-tunable light sources.

Published
2014

26. Calibration Source of High Luminance with Integrating Sphere Based on Jones Method

Author

Li X.-S., Li B.-Y., Zhang H.-Z., Liu H.-X., Liu Z.-X., Sun J.-X., Gao J.-S., Ren J.-W., and Z Wan

Subjects
Radiation, Materials science, business.industry, Aperture, Condensed Matter Physics, Jones Method, Electronic, Optical and Magnetic Materials, Optics, Integrating sphere, Thermal, Calibration, Range (statistics), Radiance, business, Radiometric calibration, Remote sensing
Abstract

In order to meet the requirements of laboratory radiometric calibration for continually rising optical aperture of optical remote sensors, a calibration source of high luminance with integrating sphere was designed based on Jones method. The integrated radiance in the range of 400 nm to 900 nm was 6 800 W/(m2sr). The thermal design results indicated that the water-cooling method could meet the heat dissipation of the high luminance calibration source. The integrated radiance of the high luminance calibration source was 6 714 W/(m2sr) in the range of 400 nm to 900 nm. The temperature distribution of the integrating sphere made the calibration demands satisfied through water-cooling, which suggested that the calibration source of high luminance using integrating sphere based on Jones method could be used to engineering practice.

Published
2014

27. IS FOREST LANDSCAPE PATTERN MORE AFFECTED IN ROAD OVERLAP ZONE: EVIDENCE FROM AN UPSTREAM AREA OF THE MINJIANG RIVER OF FUJIAN PROVINCE IN THE SUBTROPICAL REGION OF CHINA.

Author

LIN, Y. Y., HU, X. S., LIN, M. S., QIU, R. Z., LIN, J. G., and LI, B. Y.

Subjects
LANDSCAPE ecology, ECOLOGICAL impact, ZONING, FOREST degradation
Abstract

Despite there is a rich literature base that strives to characterize and understand the influencing factors of landscape ecology, the fact that we still know very little about the ecological impact in the road overlap areas. Taking the upstream area of the Minjiang River of Fujian Province in China, as a case, quantitative landscape metrics were employed to analyze the forest landscape fragmentation and degradation associated with road networks in five zones, including the whole landscape (WL), non-road effect zone (NREZ), road effect zone (REZ), mono-road effect zone (MONREZ) and multi-road effect zone (MULREZ). Our findings showed that 5.4% of the forest landscape within the REZ experienced changes from 2007 to 2015, while only 4.1% in the NREZ. Landscape metrics also identified more scattered habitats in the REZ than in the NREZ. As a result, these leaded to more severe forest landscape degradation in the REZ. Notably, the outcomes showed that the landscape pattern in the MULREZ has been more affected by road networks than the REZ and the MONREZ. Furthermore, the growing rate of landscape degradation from 2007 to 2015 in the REZ was about 1.2 times higher of the NREZ. [ABSTRACT FROM AUTHOR]

Published
2020
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31. Patterns of genetic variation among geographic and host-plant associated populations of the peach fruit moth Carposina sasakii (Lepidoptera: Carposinidae)

Author

Wang, Y-Z, Li, B-Y, Hoffmann, AA, Cao, L-J, Gong, Y-J, Song, W, Zhu, J-Y, Wei, S-J, Wang, Y-Z, Li, B-Y, Hoffmann, AA, Cao, L-J, Gong, Y-J, Song, W, Zhu, J-Y, and Wei, S-J

Abstract

BACKGROUND: Populations of herbivorous insects may become genetically differentiated because of local adaptation to different hosts and climates as well as historical processes, and further genetic divergence may occur following the development of reproductive isolation among populations. Here we investigate the population genetic structure of the orchard pest peach fruit moth (PFM) Carposina sasakii (Lepidoptera: Carposinidae) in China, which shows distinct biological differences when characterized from different host plants. Genetic diversity and genetic structure were assessed among populations from seven plant hosts and nine regions using 19 microsatellite loci and a mitochondrial sequence. RESULTS: Strong genetic differentiation was found among geographical populations representing distinct geographical regions, but not in host-associated populations collected from the same area. Mantel tests based on microsatellite loci indicated an association between genetic differentiation and geographical distance, and to a lesser extent environmental differentiation. Approximate Bayesian Computation analyses supported the scenario that PFM likely originated from a southern area and dispersed northwards before the last glacial maximum during the Quaternary. CONCLUSIONS: Our analyses suggested a strong impact of geographical barriers and historical events rather than host plants on the genetic structure of the PFM; however, uncharacterized environmental factors and host plants may also play a role. Studies on adaptive shifts in this moth should take into account geographical and historical factors.

Published
2017

38. Physcion 8-O-β-glucopyranoside exhibits anti-growth and anti-metastatic activities in ovarian cancer by downregulating miR-25.

Author

XUE, C.-L., LIU, H.-G., LI, B.-Y., HE, S.-H., and YUE, Q.-F.

Abstract

OBJECTIVE: Ovarian cancer ranks 5th leading cause of cancer-related death in females worldwide. Physcion 8-O-β-glucopyranoside (PG) is an anthraquinone compound isolated from Rumex japonicus Houtt. This study aimed at investigating the effect of PG on ovarian cancer cells. PATIENTS AND METHODS: Cell viability was detected by CCK-8 assay. Colony formation assay evaluated whether PG could affect anchorage- independent growth. Whether PG affected cell cycle progression was examined by flow cytometry. The morphological changes caused by PG were visualized by microscopy. Apoptosis was quantitatively analyzed by flow cytometry. The effect of PG on cell migration and invasion was assessed by wound healing and transwell, respectively. The effect of PG on the expression of molecular markers was determined by Western blot. Microarray assay was performed to identify the potential target of PG. RESULTS: Results from the present study showed that PG decreased ovarian cancer cells viability. Colony formation assay also showed that PG suppressed the anchorage-independent growth of SKOV3 and OVCAR-3 cells. PG triggered cell cycle arrest at G1/G0 phase. The pro-apoptotic activity of PG was confirmed by flow cytometry, activation of caspase-3 and PARP, upregulation of Bax and downregulation of Bcl-2. The ability of PG to inhibit migration and invasion was evidenced by a decrease in wound healing and invasive cell number, as well as downregulation of MMP-2 and upregulation of TIMP-3. Microarray and qRT-PCR showed that miR-25 expression was downregulated by PG treatment. Moreover, our results indicated that the anti-cancer activities of PG were augmented by miR-25 knockdown and attenuated by ectopic miR-25 expression. CONCLUSIONS: PG exhibited anti-cancer activity in ovarian cancer by downregulating miR-25. [ABSTRACT FROM AUTHOR]

Published
2019

40. Angular and temperature dependence of depolarized and polarized Rayleigh–Brillouin spectra of poly(methylphenylsiloxane).

Author

Li, B. Y. and Wang, C. H.

Subjects
*TEMPERATURE, *BRILLOUIN scattering, *INTERFEROMETERS
Abstract

The angular and temperature dependence of polarized and depolarized Rayleigh–Brillouin spectra of poly(methylphenylsiloxane) is studied with a Fabry–Perot interferometer. Considerable dispersion is observed in the polarized spectrum. The dispersion is interpreted as arising from structural relaxation. In the depolarized spectrum, evolution from an overdamped spectrum to the one showing shifted side peaks due to transverse acoustic waves are observed. The frequency of the transverse acoustic wave is found to decrease with increasing temperature and becomes vanishingly small at high temperature. [ABSTRACT FROM AUTHOR]

Published
1989
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46. Paired δ13Ccarb and δ13Corg records of the Ordovician on the Yangtze platform, South China.

Author

Li, B.-Y., Zhang, D.-W., Pang, X.-Q., Gao, P., Zhu, D.-Y., Guo, K.-Z., and Zheng, T.-Y.

Subjects
*CARBON isotopes, *CARBON cycle, *ORDOVICIAN Period, *ORDOVICIAN stratigraphic geology, *ATMOSPHERIC carbon dioxide
Abstract

During the Ordovician, huge biological revolutions and environmental changes happened in Earth’s history, including the Great Ordovician Biodiversification Event, global cooling and so on, but the cause of these events remains controversial. Herein, we conducted a paired carbon isotopic analysis of carbonate (δ13Ccarb) and organic matter (δ13Corg) through the Ordovician in the Qiliao section on the Yangtze platform of South China. Our results showed that the δ13Ccarb trend of the Qiliao section can be correlated with local and global curves. The δ13Corg trend seems is less clear than the δ13Ccarb trend for stratigraphic correlations, but some δ13Corg positive excursions in the Middle and Upper Ordovician may be used for correlation studies. These carbon isotopic records may have global significance rather than local significance, revealing several fluctuations to the global carbon cycle during the Ordovician. Several known δ13Ccarb and δ13Corg negative and positive excursions have been recognised in this study, including the early Floian Negative Inorganic Carbon (δ13Ccarb) Excursion (EFNICE), as well as the early Floian Positive Organic Carbon (δ13Ccarb) Excursion, the mid-Darriwilian Inorganic Carbon (δ13Ccarb and δ13Corg) Excursion (MDICE), and the early Katian Guttenberg Inorganic Carbon (δ13Ccarb and δ13Corg) Excursion (GICE). These positive excursions and a smooth decline trend of δ13Corg values during the early to mid-Floian may imply multiple episodes of enhanced organic carbon burial that began at the early Floian stage, probably resulting in further decline in atmospheric pCO2 and then global cooling. [ABSTRACT FROM AUTHOR]

Published
2018
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48. The Relationship between Visual Field Global Indices and Retinal Nerve Fiber Layer Thickness in Healthy Myopes

Author

Yuan, Y.-Z. (Yuan-Zhi), Feng, C.-L. (Chen-Li), Li, B.-Y. (Bao-Yue), Shen, M.-Q. (Min-Qian), Chen, X.-P. (Xiu-Ping), Zhang, C.-H. (Chen-Hao), Dong, C.-Q. (Chun-Qiong), Yuan, F. (Fei), Yuan, Y.-Z. (Yuan-Zhi), Feng, C.-L. (Chen-Li), Li, B.-Y. (Bao-Yue), Shen, M.-Q. (Min-Qian), Chen, X.-P. (Xiu-Ping), Zhang, C.-H. (Chen-Hao), Dong, C.-Q. (Chun-Qiong), and Yuan, F. (Fei)

Abstract

The aim of the current study was to investigate the association between the thickness of the retinal nerve fiber layer (RNFL) and central visual field indices in otherwise healthy myopes. In total, 57 otherwise healthy subjects were cross-sectionally studied. General ophthalmic examinations, refractive measurements, RNFL thickness by spectral domain optical coherence tomography (OCT), and central visual fields were examined. Linear models were used to assess the associations. In this young and mid-aged population, the mean spherical equivalent was -4.79 (SD 1.66) and -4.59 (SD 1.88) diopters in the right and left eyes, respectively. Approximately 7% to 14% of the eyes showed the average RNFL thickness out of the normal range. The temporal RNFL was remarkably thicker, whereas the nasal RNFL was thinner. The higher the refractive error, the thinner the RNFL thickness. A thicker overall RNFL was significantly associated with decreased mean sensitivity and increased mean defect, and further adjustments for age, sex, refractive error, optic disk area, or ocular magnification did not change the association. Although nonpathologic myopia does not significantly affect central visual field global indices, its effects on the RNFL may be linked with performance on the central visual field test.

Published
2014
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50. Working principle analysis and control algorithm for bidirectional DC/DC converter.

Author

Li, B. Y., Xu, C., Lib, C., and Guan, Z.

Subjects
ELECTRIC potential, ELECTRON tube grids, DC-to-DC converters, ELECTRIC current converters, ON-chip charge pumps
Abstract

A bidirectional DC/DC converter is an important part of the DC micro grid system, playing a key role in the stable operation of the system and the coordinated distribution of power. To solve the problem of unstable busbar voltage when the energy transforms bidirectionally in the DC micro grid system, a control algorithm based on closed-loop proportion integral derivative was proposed in this study. The hardware cinarcuit of the bidirectiol DC/DC converter was designed in the DC micro grid energy storage system, and the characteristics of converter efficiency in charging mode and constant voltage output were studied by small-signal modeling of the bidirectional DC/DC converter in charging and discharging systems. Experimental data were used to prove the correctness of the theoretical analysis. The results demonstrate that the current-controlled precision changes steadily in the charging mode when the output voltage is constant and the charging current is adjustable in ranges between 1 A and 2 A. When the charging current is 2 A and the output voltage ranges from 24 V to 36 V, the change rate of the charging current undergoes stable changes. In the discharge mode, when the output voltage is stable, the converter conversion rate changes steadily. When the output voltage changes in the range between 32 V and 38 V, the bidirectional DC/DC circuit automatically switches over the work patterns and maintains the stability of the output voltage. This study achieves bidirectional transmission of energy by rational hardware design of a bidirectional DC/DC converter and improves the reliability of the DC micro grid energy storage system. The proposed method provides a good prospect of a control scheme for the bidirectional DC/DC converter to optimize practical engineering design. [ABSTRACT FROM AUTHOR]

Published
2017

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