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The mixed traffic flow of various types of vehicles at bus station is severe, which has an impact on the overall safety of traffic. Especially upstream of bus station, since buses need to change lane in order to stop at the bus station, it interacts with social vehicles. Thus, in this paper, a two-lane CA model considering the mixed traffic flow composing of buses, cars and nonmotorized vehicles upstream of a bus station is proposed. Through several field surveys, the movement characteristics of the vehicles are obtained and the basic parameters are calibrated. For comparison, five cases about bus stops are studied. Several indexes (i.e. parallel time, blind area dwell time, time to collision, potential collision energy) are analyzed to assess the safety upstream of the bus station. Four safety indices are used to examine, based on simulation findings, the impact of bus station on vehicle safety and the significance of establishing exclusive nonmotorized vehicle lanes and exclusive bus lanes. Finally, several safety-related recommendations for drivers and management are provided. These findings offer a theoretical basis for driver management and optimal design of bus stations. [ABSTRACT FROM AUTHOR]