Search

Li Fang,1,2 Chun-Hao Li,1,3 Qian Zhang,1,3 Tian-Jiao Jiang,1,3 Yuan Liu,1,2 Feng-Po Shi,1,3 Peng Yu,1,3 Liang Yu,1,3 Ai-Ping Chen,1,3 Tao Li,1,3 Yu-Zhu Wan,1,3 Li Shi1,3 1Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, Shandong, People’s Republic of China; 2Department of Otolaryngology Head & Neck Surgery, The Second People’s Hospital of Shenzhen, Shenzhen, Guangdong, People’s Republic of China; 3Department of Allergy, Shandong Second Provincial General Hospital, Jinan, Shandong, People’s Republic of ChinaCorrespondence: Tao Li; Yu-Zhu Wan, Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Duanxing West Road, Jinan, Shandong, 250033, People’s Republic of China, Tel +86 531 83086279 ; +86 531 83086280, Fax +86 531 87980304, Email ltwfmc@163.com; wanyuzhu001@126.comBackground: Mounting research indicates that brain-derived neurotrophic factor (BDNF), has great potential to increase neuro-hyperresponsiveness and airway resistance in airway allergic disease. The expression level of BDNF has been found to be notably elevated in lung/nasal lavage (NAL) fluid. However, the expression and position of BDNF in ciliated cells with allergic rhinitis remains unclear.Methods: Nasal mucosal cells were collected from patients with allergic rhinitis (AR) and mice which were performed under different allergen challenge time, then observed the expression and position of BDNF located in ciliated cells through the immunofluorescence staining. Nasal mucosa, serum and NAL fluid were collected also. The expression level of BDNF and IL-4/5/13 were detected by RT-PCR. The expressions of BDNF (in serum and NAL fluid), and total-IgE, ovalbumin sIgE (in serum) were detected by ELISA.Results: We found that MFI of BDNF in AR group’s ciliated cells was obviously lower than that in the control group, and a negative correlation was discovered between MFI and VAS

In pre-industrial Taiwan, an uxorilocal marriage, in which a man moved in with his bride's family, was a familial strategy used to continue family lineage and to enhance family farm labor. We examine the prevalence and circumstances in which a family would call in a man for one of their unmarried daughters. Using data from the Taiwan Historical Household Registers Database (THHRD) from 1906-1945, we identify the individual-level factors (including parental status, sibling status, household heads' occupations, and the capacity of the family labor force) and a community-level factor - the prevalence of uxorilocal marriages by region, which are predictive of uxorilocal marriages. Our analyses first show that women without siblings and women with only female siblings were more likely to adopt the uxorilocal form of marriage. In addition, the effects of siblings' status were moderated by the presence or absence of parents. For women without any male siblings with at least one parent, especially a father, residing in the household, the likelihood of having an uxorilocal marriage was higher than for those without any parents. Second, an uxorilocal marriage was less common in families with more young family members in the labor force to fulfill the manpower needed for farming. Third, uxorilocal marriage was more likely to occur in families living in the poorest socioeconomic conditions, especially those families in which household heads did not own land and had to sell their labor for agricultural production. Our findings imply that the adoption of uxorilocal marriage varied not only from place to place but also from time to time; it was conditioned by the modes and the means of labor production.

Sa-Hoe Lim,1,2 Chun-Hao Li,3 Young-Il Jeong,4 Woo-Youl Jang,1,2 Jin-Myung Choi,2 Shin Jung1,2 1Department of Neurosurgery, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Korea; 2Brain Tumor Research Laboratory, Chonnam National University Research Institute of Medical Sciences, Chonnam National University Hwasun Hospital, Hwasun, Korea; 3Department of Neurosurgery, Affiliated Hospital of Yanbian University, Yanji, Jilin 133000, People’s Republic of China; 4Biomedical Research Institute, Pusan National University Hospital, Pusan 602-739, Republic of KoreaCorrespondence: Shin JungDepartment of Neurosurgery, Chonnam National University Hwasun Hospital, 322, Seoyang-ro, Hwasun-eup, Hwasun-Gun, Jeollanam-do 519-763, Republic of KoreaTel +82-61-379-8588Fax +82-61-379-7181Email sjung@chonnam.ac.krBackground: Targeting radiosensitizer-incorporated nanoparticles to a tumor could allow for less normal tissue toxicity with more efficient drug release, thus improving the efficacy and safety of radiation treatment. The aim of this study was to improve tumor-specific delivery and bioavailability of a nanoparticle-mediated radiosensitizer in mouse brain tumor models.Methods: A pH-sensitive nanoparticle, chitoPEGAcHIS, was conjugated to recombinant peptide HVGGSSV that could bind to tax-interaction protein 1 (TIP-1) as a radiation-inducible receptor. Then the c-Jun N-terminal kinase (JNK) inhibitor, SP600125 was incorporated into this copolymer to fabricate a HVGGSSV-chitoPEGAcHIS-SP600125 (HVSP-NP) nanoradiosensitizer. In vitro and in vivo radiation treatment were performed using a Gamma Knife unit. The tumor targetability of HVSP-NP was estimated by optical bioluminescence. Synergistic therapeutic effects of radiation treatment and HVSP-NP were investigated in Lewis lung carcinoma (LLC) cell-bearing mouse brain tumor models.Results: The SP600125 JNK inhibitor effectively reduced DNA damage repair to irradiated LLC cells. A pH sensitivity assay i