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24 results on '"Li, Dize"'

4. A Dual‐Antioxidative Coating on Transmucosal Component of Implant to Repair Connective Tissue Barrier for Treatment of Peri‐Implantitis

Author

Li, Dize, primary, Tan, Xi, additional, Zheng, Liwen, additional, Tang, Han, additional, Hu, Shanshan, additional, Zhai, Qiming, additional, Jing, Xuan, additional, Liang, Panpan, additional, Zhang, Yuxin, additional, He, Qingqing, additional, Jian, Guangyu, additional, Fan, Dongqi, additional, Ji, Ping, additional, Chen, Tao, additional, and Zhang, Hongmei, additional

Published
2023
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10. Highly elastic and self-healing nanostructured gelatin/clay colloidal gels with osteogenic capacity for minimally invasive and customized bone regeneration

Author

Dou, Zhenzhen, primary, Tang, Han, additional, Chen, Kaiwen, additional, Li, Dize, additional, Ying, Qiwei, additional, Mu, Zhixiang, additional, An, Chuanfeng, additional, Shao, Fei, additional, Zhang, Yang, additional, Zhang, Yonggang, additional, Bai, Haoliang, additional, Zheng, Guoshuang, additional, Zhang, Lijun, additional, Chen, Tao, additional, and Wang, Huanan, additional

Published
2023
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14. A Logic‐Based Diagnostic and Therapeutic Hydrogel with Multistimuli Responsiveness to Orchestrate Diabetic Bone Regeneration

Author

Li, Dize, primary, Chen, Kaiwen, additional, Tang, Han, additional, Hu, Shanshan, additional, Xin, Liangjing, additional, Jing, Xuan, additional, He, Qingqing, additional, Wang, Si, additional, Song, Jinlin, additional, Mei, Li, additional, Cannon, Richard D., additional, Ji, Ping, additional, Wang, Huanan, additional, and Chen, Tao, additional

Published
2022
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20. Effects of Programmed Local Delivery from a Micro/Nano‐Hierarchical Surface on Titanium Implant on Infection Clearance and Osteogenic Induction in an Infected Bone Defect

Author

Li, Dize, primary, Li, Yihan, additional, Shrestha, Annie, additional, Wang, Si, additional, Wu, Qingqing, additional, Li, Lingjie, additional, Guan, Chao, additional, Wang, Chao, additional, Fu, Tiwei, additional, Liu, Wenzhao, additional, Huang, Yuanding, additional, Ji, Ping, additional, and Chen, Tao, additional

Published
2019
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21. Strontium Ranelate Incorporated Enzyme-Cross-Linked Gelatin Nanoparticle/Silk Fibroin Aerogel for Osteogenesis in OVX-Induced Osteoporosis

Author

Li, Dize, primary, Chen, Kaiwen, additional, Duan, Lian, additional, Fu, Tiwei, additional, Li, Jiao, additional, Mu, Zhixiang, additional, Wang, Si, additional, Zou, Qin, additional, Chen, Li, additional, Feng, Yangyingfan, additional, Li, Yihan, additional, Zhang, Hongmei, additional, Wang, Huanan, additional, Chen, Tao, additional, and Ji, Ping, additional

Published
2019
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24. Catechol-Modified and MnO 2 -Nanozyme-Reinforced Hydrogel with Improved Antioxidant and Antibacterial Capacity for Periodontitis Treatment.

Author

Hu S, Wang L, Li J, Li D, Zeng H, Chen T, Li L, and Xiang X

Subjects
Anti-Bacterial Agents administration & dosage, Anti-Bacterial Agents pharmacology, Antioxidants administration & dosage, Antioxidants pharmacology, Bacteria drug effects, Animals, Rats, Rats, Sprague-Dawley, Bone Regeneration drug effects, Biofilms drug effects, Reactive Oxygen Species metabolism, Periodontitis drug therapy, Hydrogels administration & dosage, Hydrogels chemical synthesis, Hydrogels pharmacology
Abstract

Periodontitis is an inflammatory disease characterized by tooth loss and alveolar bone resorption. Bacteria are the original cause of periodontitis, and excess reactive oxygen species (ROS) encourage and intensify inflammation. In this study, a mussel-inspired and MnO 2 NPs-reinforced adhesive hydrogel capable of alleviating periodontitis with improved antibacterial and antioxidant abilities was developed. The hydrogel was created by combining polyvinyl alcohol (PVA), 3,4-dihydroxy-d-phenylalanine (DOPA), and MnO 2 nanoparticles (NPs) (named PDMO hydrogel). The hydrogel was demonstrated to be able to scavenge various free radicals (including total ROS─O 2 •- and OH • ) and relieve the hypoxia in an inflammatory microenvironment by scavenging excess ROS and generating O 2 due to its superoxide dismutase (SOD)/catalase (CAT)-like activity. Besides, under 808 nm near-infrared (NIR) light, the photothermal performance of the PDMO hydrogel displayed favorable antibacterial and antibiofilm effects toward Escherichia coli , Staphylococcus aureus , and Porphyromonas gingivalis (up to nearly 100% antibacterial rate). Furthermore, the PDMO hydrogel exhibited favorable therapeutic efficacy in alleviating gingivitis in Sprague-Dawley rats, even comparable to or better than the commercial PERIO. In addition, in the periodontitis models, the PDMO2 group showed the height of the residual alveolar bone and the smallest shadow area of low density among other groups, indicating the positive role of the PDMO2 hydrogel in bone regeneration. Finally, the biosafety of the PDMO hydrogel was comprehensively investigated, and the hydrogel was demonstrated to have good biocompatibility. Therefore, the developed PDMO hydrogel provided an effective solution to resolve biofilm recolonization and oxidative stress in periodontitis and could be a superior candidate for local drug delivery system in the clinical management of periodontitis with great potential for future clinical translation.

Published
2023
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