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30 results on '"Li, Fengkai"'

6. Microbiota enterotoxigenic Bacteroides fragilis-secreted BFT-1 promotes breast cancer cell stemness and chemoresistance through its functional receptor NOD1

Author

Ma, Wei, primary, Zhang, Lu, additional, Chen, Weilong, additional, Chang, Zhaoxia, additional, Tu, Juchuanli, additional, Qin, Yuanyuan, additional, Yao, Yuwen, additional, Dong, Mengxue, additional, Ding, Jiajun, additional, Li, Siqin, additional, Li, Fengkai, additional, Deng, Qiaodan, additional, Yang, Yifei, additional, Feng, Tingting, additional, Zhang, Fanrong, additional, Shao, Xiying, additional, He, Xueyan, additional, Zhang, Lixing, additional, Hu, Guohong, additional, Liu, Quentin, additional, Jiang, Yi-Zhou, additional, Zhu, Shu, additional, Xiao, Zhi, additional, Su, Dan, additional, Liu, Tong, additional, and Liu, Suling, additional

Published
2024
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9. Supplementary Figures from Retinoblastoma Inactivation Induces a Protumoral Microenvironment via Enhanced CCL2 Secretion

Author

Li, Fengkai, primary, Kitajima, Shunsuke, primary, Kohno, Susumu, primary, Yoshida, Akiyo, primary, Tange, Shoichiro, primary, Sasaki, Soichiro, primary, Okada, Nobuhiro, primary, Nishimoto, Yuuki, primary, Muranaka, Hayato, primary, Nagatani, Naoko, primary, Suzuki, Misa, primary, Masuda, Sayuri, primary, Thai, Tran C., primary, Nishiuchi, Takumi, primary, Tanaka, Tomoaki, primary, Barbie, David A., primary, Mukaida, Naofumi, primary, and Takahashi, Chiaki, primary

Published
2023
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10. Data from Retinoblastoma Inactivation Induces a Protumoral Microenvironment via Enhanced CCL2 Secretion

Author

Li, Fengkai, primary, Kitajima, Shunsuke, primary, Kohno, Susumu, primary, Yoshida, Akiyo, primary, Tange, Shoichiro, primary, Sasaki, Soichiro, primary, Okada, Nobuhiro, primary, Nishimoto, Yuuki, primary, Muranaka, Hayato, primary, Nagatani, Naoko, primary, Suzuki, Misa, primary, Masuda, Sayuri, primary, Thai, Tran C., primary, Nishiuchi, Takumi, primary, Tanaka, Tomoaki, primary, Barbie, David A., primary, Mukaida, Naofumi, primary, and Takahashi, Chiaki, primary

Published
2023
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11. Supplementary Table 2 from Retinoblastoma Inactivation Induces a Protumoral Microenvironment via Enhanced CCL2 Secretion

Author

Li, Fengkai, primary, Kitajima, Shunsuke, primary, Kohno, Susumu, primary, Yoshida, Akiyo, primary, Tange, Shoichiro, primary, Sasaki, Soichiro, primary, Okada, Nobuhiro, primary, Nishimoto, Yuuki, primary, Muranaka, Hayato, primary, Nagatani, Naoko, primary, Suzuki, Misa, primary, Masuda, Sayuri, primary, Thai, Tran C., primary, Nishiuchi, Takumi, primary, Tanaka, Tomoaki, primary, Barbie, David A., primary, Mukaida, Naofumi, primary, and Takahashi, Chiaki, primary

Published
2023
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12. Supplementary Table 1 from Retinoblastoma Inactivation Induces a Protumoral Microenvironment via Enhanced CCL2 Secretion

Author

Li, Fengkai, primary, Kitajima, Shunsuke, primary, Kohno, Susumu, primary, Yoshida, Akiyo, primary, Tange, Shoichiro, primary, Sasaki, Soichiro, primary, Okada, Nobuhiro, primary, Nishimoto, Yuuki, primary, Muranaka, Hayato, primary, Nagatani, Naoko, primary, Suzuki, Misa, primary, Masuda, Sayuri, primary, Thai, Tran C., primary, Nishiuchi, Takumi, primary, Tanaka, Tomoaki, primary, Barbie, David A., primary, Mukaida, Naofumi, primary, and Takahashi, Chiaki, primary

Published
2023
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16. Ccl3 enhances docetaxel chemosensitivity in breast cancer by triggering proinflammatory macrophage polarization

Author

Sheng, Dandan, primary, Ma, Wei, additional, Zhang, Rui, additional, Zhou, Lei, additional, Deng, Qiaodan, additional, Tu, Juchuanli, additional, Chen, Weilong, additional, Zhang, Fuchuang, additional, Gao, Nailong, additional, Dong, Mengxue, additional, Wang, Dong, additional, Li, Fengkai, additional, Liu, Yin, additional, He, Xueyan, additional, Duan, Shengzhong, additional, Zhang, Lixing, additional, Liu, Tong, additional, and Liu, Suling, additional

Published
2022
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17. The germline factor DDX4 contributes to the chemoresistance of small cell lung cancer cells

Author

Noyes, Christopher, primary, Kitajima, Shunsuke, additional, Li, Fengkai, additional, Suita, Yusuke, additional, Miriyala, Saradha, additional, Isaac, Shakson, additional, Ahsan, Nagib, additional, Knelson, Erik, additional, Vajdi, Amir, additional, Tani, Tetsuo, additional, Thai, Tran C., additional, Xu, Derek, additional, Murai, Junko, additional, Tapinos, Nikos, additional, Takahashi, Chiaki, additional, Barbie, David A., additional, and Yajima, Mamiko, additional

Published
2022
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19. 「Retinoblastoma inactivation induces a protumoral microenvironment via enhanced CCL2 secretion」

Author

Li, Fengkai

Abstract

第18回 高安賞最優秀論文賞受賞 Cancer Res. 2019 Aug 1; 79 (15): 3903-3915. 令和元年8月掲載 Fengkai Li, Shunsuke Kitajima, Susumu Kohno, Akiyo Yoshida, Shoichiro Tange, Soichiro Sasaki, Nobuhiro Okada, Yuuki Nishimoto, Hayato Muranaka, Naoko Nagatani, Misa Suzuki, Sayuri Masuda, Tran C. Thai, Takumi Nishiuchi, Tomoaki Tanaka, David A. Barbie, Naofumi Mukaida, and Chiaki Takahashi

Published
2020

24. Retinoblastoma Inactivation Induces a Protumoral Microenvironment via Enhanced CCL2 Secretion

Author

Li, Fengkai, primary, Kitajima, Shunsuke, additional, Kohno, Susumu, additional, Yoshida, Akiyo, additional, Tange, Shoichiro, additional, Sasaki, Soichiro, additional, Okada, Nobuhiro, additional, Nishimoto, Yuuki, additional, Muranaka, Hayato, additional, Nagatani, Naoko, additional, Suzuki, Misa, additional, Masuda, Sayuri, additional, Thai, Tran C., additional, Nishiuchi, Takumi, additional, Tanaka, Tomoaki, additional, Barbie, David A., additional, Mukaida, Naofumi, additional, and Takahashi, Chiaki, additional

Published
2019
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26. MicroRNA-140 mediates RB tumor suppressor function to control stem cell-like activity through interleukin-6

Author

Yoshida, Akiyo, primary, Kitajima, Shunsuke, additional, Li, Fengkai, additional, Cheng, Chaoyang, additional, Takegami, Yujiro, additional, Kohno, Susumu, additional, Wan, Yuan Song, additional, Hayashi, Naoyuki, additional, Muranaka, Hayato, additional, Nishimoto, Yuuki, additional, Nagatani, Naoko, additional, Nishiuchi, Takumi, additional, Thai, Tran C, additional, Suzuki, Sawako, additional, Nakao, Shinji, additional, Tanaka, Tomoaki, additional, Hirose, Osamu, additional, Barbie, David A., additional, and Takahashi, Chiaki, additional

Published
2017
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27. Undifferentiated State Induced by Rb-p53 Double Inactivation in Mouse Thyroid Neuroendocrine Cells and Embryonic Fibroblasts

Author

Kitajima, Shunsuke, primary, Kohno, Susumu, additional, Kondoh, Atsushi, additional, Sasaki, Nobunari, additional, Nishimoto, Yuuki, additional, Li, Fengkai, additional, Abdallah Mohammed, Mohammed Salah, additional, Muranaka, Hayato, additional, Nagatani, Naoko, additional, Suzuki, Misa, additional, Kido, Yukiharu, additional, and Takahashi, Chiaki, additional

Published
2015
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29. STUDY ON THE PREPARATION OF COLUMN-CELL AND ITS INFLUENCE ON MECHANICAL PROPERTIES BY DEEP DRAWING.

Author

LI Fengkai, DENG Anzhong, RONG Xiang, CHEN Ke, and LI Haonan

Subjects
MECHANICAL behavior of materials, DEEP drawing (Metalwork), STAINLESS steel, MATERIAL plasticity, COMPUTER simulation
Abstract

A thin-walled semi-ellipsoidal shell unit was designed. The column-cell was prepared by deep drawing process and the forming process was numerically simulated. The influence of deep drawing on the wall thickness and pre-strain of the column-cell cell was discussed, the effect of pre-strain on mechanical properties of 0Cr18Ni9 stainless steel and T2 copper was also intensively studied. The results show that the deep drawing process will cause wall thickness of the column-cell to be thinner, and the longer the deep drawing distance is, the thinner the thickness is; The longer the thickness is, the greater the flow stress under the same strain, and the smaller the elongation after breaking for the same metal sheet material; The pre-strain distribution of the sheet material after deep drawing is significantly uneven, and larger plastic strain is produced at deeper parts. Under the same deep drawing condition, the maximum pre-strain of T2 copper column-cell was significantly higher than that of 0Cr18Ni9 stainless steel. And the pre-strain has significant effect on the plastic deformation ability of the metal material. When the pre-strain increases, the yield strength of the material increases and the elongation at break decreases. [ABSTRACT FROM AUTHOR]

Published
2017

30. IL1R2 Blockade Alleviates Immunosuppression and Potentiates Anti-PD-1 Efficacy in Triple-Negative Breast Cancer.

Author

Xia J, Zhang L, Peng X, Tu J, Li S, He X, Li F, Qiang J, Dong H, Deng Q, Liu C, Xu J, Zhang R, Liu Q, Hu G, Liu C, Jiang YZ, Shao ZM, Chen C, and Liu S

Subjects
Animals, Mice, Humans, Female, Immune Checkpoint Inhibitors pharmacology, Immune Checkpoint Inhibitors therapeutic use, CD8-Positive T-Lymphocytes immunology, Tumor Microenvironment immunology, Tumor Microenvironment drug effects, Tumor-Associated Macrophages immunology, Tumor-Associated Macrophages metabolism, Tumor-Associated Macrophages drug effects, Cell Line, Tumor, Programmed Cell Death 1 Receptor antagonists & inhibitors, B7-H1 Antigen antagonists & inhibitors, B7-H1 Antigen metabolism, YY1 Transcription Factor metabolism, YY1 Transcription Factor genetics, Xenograft Model Antitumor Assays, Neoplastic Stem Cells metabolism, Neoplastic Stem Cells immunology, Neoplastic Stem Cells pathology, Neoplastic Stem Cells drug effects, Triple Negative Breast Neoplasms immunology, Triple Negative Breast Neoplasms drug therapy, Triple Negative Breast Neoplasms pathology, Triple Negative Breast Neoplasms metabolism
Abstract

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with limited therapeutic options. IL1 receptor type 2 (IL1R2) promotes breast tumor-initiating cell (BTIC) self-renewal and tumor growth in TNBC, indicating that targeting it could improve patient treatment. In this study, we observed that IL1R2 blockade strongly attenuated macrophage recruitment and the polarization of tumor-associated macrophages (TAM) to inhibit BTIC self-renewal and CD8+ T-cell exhaustion, which resulted in reduced tumor burden and prolonged survival in TNBC mouse models. IL1R2 activation by TAM-derived IL1β increased PD-L1 expression by interacting with the transcription factor Yin Yang 1 (YY1) and inducing YY1 ubiquitination and proteasomal degradation in both TAMs and TNBC cells. Loss of YY1 alleviated the transcriptional repression of c-Fos, which is a transcriptional activator of PDL-1. Combined treatment with an IL1R2-neutralizing antibodies and anti-PD-1 led to enhanced antitumor efficacy and reduced TAMs, BTICs, and exhausted CD8+ T cells. These results suggest that IL1R2 blockade might be a strategy to potentiate immune checkpoint blockade efficacy in TNBC to improve patient outcomes. Significance: IL1R2 in both macrophages and breast cancer cells orchestrates an immunosuppressive tumor microenvironment by upregulating PD-L1 expression and can be targeted to enhance the efficacy of anti-PD-1 in triple-negative breast cancer., (©2024 American Association for Cancer Research.)

Published
2024
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