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206 results on '"Li, Gaocan"'

1. Virus-like structures for combination antigen protein mRNA vaccination

Author

Zhang, Jingjing, Li, Yanmei, Zeng, Fengyuan, Mu, Changyong, Liu, Change, Wang, Lichun, Peng, Xiaowu, He, Liping, Su, Yanrui, Li, Hongbing, Wang, An, Feng, Lin, Gao, Dongxiu, Zhang, Zhixiao, Xu, Gang, Wang, Yixuan, Yue, Rong, Si, Junbo, Zheng, Lichun, Zhang, Xiong, He, Fuyun, Yi, Hongkun, Tang, Zhongshu, Li, Gaocan, Ma, Kaili, and Li, Qihan

Published
2024
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16. A new vaccine strategy based on VLSs for use against SARS-CoV-2 variants: Evaluation of their immune effectiveness and investigation of the mechanism

Author

Li, Qihan, primary, Zhang, Jingjing, additional, Li, Yanmei, additional, Mu, Changyong, additional, Liu, Change, additional, Wang, Lichun, additional, Peng, Xiaowu, additional, He, Liping, additional, Su, Yanrui, additional, Li, Hongbing, additional, Wang, An, additional, Feng, Lin, additional, Gao, Dongxiu, additional, Zhang, Zhixiao, additional, Xu, Gang, additional, Wang, Yixuan, additional, Zeng, Fengyuan, additional, Yue, Rong, additional, Si, Junbo, additional, Zheng, Lichun, additional, Zhang, Xiong, additional, He, Fuyun, additional, Yi, Hongkun, additional, Tang, Zhongshu, additional, Li, Gaocan, additional, Li, Yuhua, additional, and Ma, Kaili, additional

Published
2023
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17. Biomimetic Targeting Nanoplatform for Atherosclerosis Theranostics Via Photoacoustic Diagnosis and "Hand‐In‐Hand" Immunoregulation.

Author

Ma, Boxuan, Chen, Zhezhe, Xu, Hong, Sun, Shuo, Huang, Chengchen, Li, Gaocan, Zhang, Wenbin, Shang, Min, Wang, Yunbing, and Fu, Guosheng

Subjects
TRANSFORMING growth factors-beta, IMMUNOREGULATION, T cell differentiation, DIAGNOSIS, COMPANION diagnostics
Abstract

Atherosclerosis can cause severe cardiovascular disease, which is usually diagnosed in late stages with life‐threatening complications. The lack of obvious symptoms limits its early diagnosis and timely treatment. In this work, a theranostic nanoplatform PGA@PMP is constructed for targeting photoacoustic diagnosis and a "hand‐in‐hand" immunoregulation of early‐stage atherosclerosis. Coated with biomimetic platelet membrane, PGA@PMP can actively target to the pathological endothelium and respond to the reactive oxygen species (ROS) in lesions for further disassembly and releasing photoacoustic probe along with immune‐regulate complex GWAS. The photoacoustic probe performs a noninvasive imaging with distinct recognition of plaques. In company, triggered by local cathepsin B, GWAS can be degraded for respective regulation on inducing M2 macrophages and stimulating regulatory T (Treg) cells. The transforming growth factor beta (TGF‐β) expressed by up‐regulated M2 macrophages also intensifies the Treg cell differentiation, which synergistically inhibits the foam cell formation and rebuilds a well‐balanced immune microenvironment. The in vivo evaluations suggest that the "hand‐in‐hand" strategy on regulating macrophages polarization and T cell differentiation indicates the restraint on atherosclerotic progression and the reversal of formed lesions even under high‐fat diet. Together, PGA@PMP provides an integrated solution for targeting theranostics of early‐stage atherosclerosis and delivers an exciting outcome of reversing the formed lesions. [ABSTRACT FROM AUTHOR]

Published
2024
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43. Integrated prodrug micelles with two-photon bioimaging and pH-triggered drug delivery for cancer theranostics.

Author

Xu, Hong, Ma, Boxuan, Jiang, Jizhou, Xiao, Sutong, Peng, Rongrong, Zhuang, Weihua, Li, Gaocan, and Wang, Yunbing

Subjects
PRODRUGS, DRUG delivery systems, CANCER treatment, PH standards, BIO-imaging sensors
Abstract

Nanodrug carriers with fluorescence radiation are widely used in cancer diagnosis and therapy due to their real-time imaging, less side effect, better drug utilization as well as the good bioimaging ability. However, traditional nanocarriers still suffer from unexpectable drug leakage, unsatisfactory tumor-targeted drug delivery and shallow imaging depth, which limit their further application in cancer theranostics. In this study, an integrated nanoplatform is constructed by polymeric prodrug micelles with two-photon and aggregation-induced emission bioimaging, charge reversal and drug delivery triggered by acidic pH. The prodrug micelles can be self-assembled by the TP-PEI (DA/DOX)-PEG prodrug polymer, which consists of the two-photon fluorophore (TP), dimethylmaleic anhydride (DA) grafted polyethyleneimine (PEI) and polyethylene glycol (PEG). The PEG segment, DOX and DA are bridged to polymer by acid cleavable bonds, which provides the micelles a 'stealth' property and a satisfactory stability during blood circulation, while the outside PEG segment is abandoned along with the DA protection in the tumor acidic microenvironment, thus leading to charge reversal-mediated accelerated endocytosis and tumor-targeted drug delivery. The great antitumor efficacy and reduced side effect of these pH-sensitive prodrug micelles are confirmed by antitumor assays in vitro and in vivo. Meanwhile, these micelles exhibited great deep-tissue two-photon bioimaging ability up to 150 μm in depth. The great antitumor efficacy, reduced side effect and deep two-photon tissue imaging make the TP-PEI (DA/DOX)-PEG prodrug micelles would be an efficient strategy for theranostic nanoplatform in cancer treatment. [ABSTRACT FROM AUTHOR]

Published
2020
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50. Discovery of dual-emissive probe for mitochondria

Author

Wang Yunbing, Zhang Weihua, and Li Gaocan

Subjects
Histology, Chemistry, Biomedical Engineering, Biophysics, Bioengineering, DUAL (cognitive architecture), Mitochondrion, Biotechnology
Published
2016

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