Search

Your search keyword '"Li, Hong-mei"' showing total 1,589 results
Start Over Author "Li, Hong-mei"
1,589 results on '"Li, Hong-mei"'

4. Lipidomics revealed alterations in glycerophospholipid metabolism in skin squamous cell carcinoma

Author

Li-Hong Mei, Hui-Hui Gan, Hong-Feng Wang, Guoxiong Xu, Xuan-Guang Ye, and Gao Yang

Subjects
skin squamous cell carcinoma, lipidomics, glycerophospholipid metabolism, biomarkers, therapeutic targets, Biology (General), QH301-705.5
Abstract

BackgroundSkin squamous cell carcinoma (SCC) is a prevalent malignancy, and dysregulated lipid metabolism has been implicated in its pathogenesis. However, detailed characterization of lipid alterations in SCC remains limited.MethodsWe analyzed lipid metabolic variations in tissue samples from 34 SCC patients and adjacent healthy tissues (located more than 1 cm from the tumor margin) using liquid chromatography-mass spectrometry (LC-MS). Data visualization and discriminatory lipid profiles were identified using principal component analysis (PCA) and sparse partial least squares discriminant analysis (sPLS-DA). Key lipids involved in the SCC metabolism were identified and further validated using an external data set (from a previous study, which similarly explored lipid profiles in oral SCC using lipidomics approaches). Pathway enrichment analysis was conducted to elucidate the metabolic pathways associated with these key lipids.ResultsEight lipids were identified by comparing SCC and healthy tissues including PI(16:0/22:4), PI(18:1/20:4), PE(16:0/20:4), PE(16:0/22:5), PE(16:0/22:6), PE(18:1/20:3), PC(18:1/20:2), and PC(18:2/20:2), as confirmed by independent datasets. All of these lipids were upregulated in SCC tumor tissues. Pathway enrichment analysis revealed significant alterations in glycerophospholipid metabolic pathways, particularly affecting the metabolism of diacylglycerophosphocholines, glycerophosphoethanolamines, and glycerophosphoinositols.ConclusionOur findings reveal that dysregulated glycerophospholipid metabolism plays a pivotal role in the development of SCC.

Published
2024
Full Text
View/download PDF

23. Experience in diagnosis and treatment of spontaneous intracranial hypotension with cerebral venous thrombosis and subdural hematoma: one case report

Author

LI Hong⁃mei, LIU Ling⁃chun, YANG Shun⁃yu, YANG Rui⁃han, LIU Da, and MENG Qiang

Subjects
intracranial hypotension, intracranial thrombosis, cerebral veins, hematoma, subdural, intracranial, mechanical thrombolysis, Neurology. Diseases of the nervous system, RC346-429
Abstract

Objective To report a case of spontaneous intracranial hypotension (SIH) with cerebral venous thrombosis (CVT) and subdural hematoma (SDH), summarize its clinical manifestations and imaging features, and improve clinicians' ability of diagnosis and differential diagnosis, as well as the recognition of the related complications. Methods and Results The patient was a 56⁃year⁃old male with a subacute to chronic disease course, with the onset of orthostatic headache, progressive exacerbation, and developed numbness and weakness in the right limb. Imaging findings revealed diffuse enhancement of dura mater, bilateral chronic SDH and CVT. After rehydration, anticoagulation, mechanical thrombectomy and thrombolytic therapy, the CVT was significantly reduced. Due to the continuous increasion in bleeding tendency and the expansion of SDH, after discontinuation of anticoagulant and craniotomy for hematoma removal, the condition was controlled, and the volume of SDH decreased. Follow⁃up 3 months after discharge, head MRI showed that there was basically no filling defect in the venous sinus, and the visualization was significantly improved; the patient's orthostatic headache disappeared, and no focal neurological dysfunction remained. Conclusions Although SIH with cerebral venous system thrombosis and SDH, treated by fluid replacement, anticoagulation, and endovascular treatment, the symptoms and signs induced by venous thrombosis can be improved, these measures can't prevent the further expansion of the SDH, early detection of leaks and repairs may be more conducive to the recovery.

Published
2022
Full Text
View/download PDF

39. Behavioral responses of Nesidiocoris tenuis(Reuter) to different monochromatic lights and light intensities

Author

Chen, Zhen, Fu, Wen, Zhang, Chun-Fu, Li, Hong-Mei, Zhang, Jun-Jun, Lou, Deng-Ji, and Guo, Kai-Fei

Abstract

Nesidiocoris tenuis(Reuter) is an important omnivorous insect in tobacco fields. It is of practical scientific significance to regulate the population of N. tenuisby employing insect lure strategies with specific light spectra. In this study, the phototactic behavior of N. tenuisadults and nymphs to 15 kinds of monochromatic lights was examined. N. tenuisadults have a higher response rate and a longer displacement to different light spectra and different light intensities compared with nymphs. N. tenuisadults were more attractived by monochromatic lights at 628, 504, 568 and 589 nm among the 15 monochromatic lights. While N. tenuisnymphs were more attractived by monochromatic lights at 628, 549 and 577 nm, and there was no significant difference between the nymphs' response displacements to monochromatic lights except for red light at 628 nm and darkness treatments. The light intensity significantly affected the phototactic behavior of N. tenuisadults but not nymphs. These results suggested that insect traps with a red light at 628 nm, blue-green light at 504 nm, yellow-green light at 568 nm and yellow-green light at 589 nm can be used to monitor and regulate N. tenuispopulation.

Published
2024
Full Text
View/download PDF

40. Ultrasensitive detection of SARS-CoV-2 S protein with aptamers biosensor based on surface-enhanced Raman scattering.

Author

Gu, Man-Man, Guan, Peng-Cheng, Xu, Shan-Shan, Li, Hong-Mei, Kou, Yi-Chuan, Lin, Xiao-Dong, Kathiresan, Murugavel, Song, Yanling, Zhang, Yue-Jiao, Jin, Shang-Zhong, and Li, Jian-Feng

Subjects
SERS spectroscopy, APTAMERS, SARS-CoV-2, DNA, GOLD nanoparticles, BIOSENSORS, SANDWICH construction (Materials)
Abstract

A rapid and accurate diagnostic modality is essential to prevent the spread of SARS-CoV-2. In this study, we proposed a SARS-CoV-2 detection sensor based on surface-enhanced Raman scattering (SERS) to achieve rapid and ultrasensitive detection. The sensor utilized spike protein deoxyribonucleic acid aptamers with strong affinity as the recognition entity to achieve high specificity. The spherical cocktail aptamers-gold nanoparticles (SCAP) SERS substrate was used as the base and Au nanoparticles modified with the Raman reporter molecule that resonates with the excitation light and spike protein aptamers were used as the SERS nanoprobe. The SCAP substrate and SERS nanoprobes were used to target and capture the SARS-CoV-2 S protein to form a sandwich structure on the Au film substrate, which can generate ultra-strong "hot spots" to achieve ultrasensitive detection. Analysis of SARS-CoV-2 S protein was performed by monitoring changes in SERS peak intensity on a SCAP SERS substrate-based detection platform. This assay detects S protein with a LOD of less than 0.7 fg mL−1 and pseudovirus as low as 0.8 TU mL−1 in about 12 min. The results of the simulated oropharyngeal swab system in this study indicated the possibility of it being used for clinical detection, providing a potential option for rapid and accurate diagnosis and more effective control of SARS-CoV-2 transmission. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results