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Your search keyword '"Li, Jian-ang"' showing total 24 results
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24 results on '"Li, Jian-ang"'

2. Construction of S100 family members prognosis prediction model and analysis of immune microenvironment landscape at single-cell level in pancreatic adenocarcinoma: a tumor marker prognostic study

Author

Xu, Zi-jin, primary, Li, Jian-ang, additional, Cao, Ze-yuan, additional, Xu, Hua-xiang, additional, Ying, Ying, additional, Xu, Zhi-hang, additional, Liu, Run-jie, additional, Guo, Yuquan, additional, Zhang, Zi-xin, additional, Wang, Wen-quan, additional, and Liu, Liang, additional

Published
2024
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14. Cell-intrinsic PD-1 promotes proliferation in pancreatic cancer by targeting CYR61/CTGF via the hippo pathway

Author

Pu, Ning, primary, Gao, Shanshan, additional, Yin, Hanlin, additional, Li, Jian-ang, additional, Wu, Wenchuan, additional, Fang, Yuan, additional, Zhang, Lei, additional, Rong, Yefei, additional, Xu, Xuefeng, additional, Wang, Dansong, additional, Kuang, Tiantao, additional, Jin, Dayong, additional, Yu, Jun, additional, and Lou, Wenhui, additional

Published
2019
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15. DIAPH3 promotes pancreatic cancer progression by activating selenoprotein TrxR1‐mediated antioxidant effects.

Author

Rong, Yefei, Gao, Jie, Kuang, Tiantao, Chen, Jianlin, Li, Jian‐ang, Huang, Yufeng, Xin, Haiguang, Fang, Yuan, Han, Xu, Sun, Lun‐Quan, Deng, Yue‐Zhen, Li, Zhi, and Lou, Wenhui

Subjects
PANCREATIC cancer, CANCER invasiveness, SELENIUM compounds, METABOLIC regulation, ALIMENTARY canal, ENDOPLASMIC reticulum, RIBOSOMES
Abstract

Pancreatic cancer is a highly malignant tumour of the digestive tract which is difficult to diagnose and treat. Approximately 90% of cases arise from ductal adenocarcinoma of the glandular epithelium. The morbidity and mortality of the disease have increased significantly in recent years. Its 5‐year survival rate is <1% and has one of the worst prognoses amongst malignant tumours. Pancreatic cancer has a low rate of early‐stage diagnosis, high surgical mortality and low cure rate. Selenium compounds produced by selenoamino acid metabolism may promote a large amount of oxidative stress and subsequent unfolded reactions and endoplasmic reticulum stress by consuming the NADPH in cells, and eventually lead to apoptosis, necrosis or necrotic cell death. In this study, we first identified DIAPH3 as a highly expressed protein in the tissues of patients with pancreatic cancer, and confirmed that DIAPH3 promoted the proliferation, anchorage‐independent growth and invasion of pancreatic cancer cells using overexpression and interference experiments. Secondly, bioinformatics data mining showed that the potential proteins interacted with DIAPH3 were involved in selenoamino acid metabolism regulation. Selenium may be incorporated into selenoprotein synthesis such as TrxR1 and GPX4, which direct reduction of hydroperoxides or resist ferroptosis, respectively. Our following validation confirmed that DIAPH3 promoted selenium content and interacted with the selenoprotein RPL6, a ribosome protein subunit involved in selenoamino acid metabolism. In addition, we verified that DIAPH3 could down‐regulate cellular ROS level via up‐regulating TrxR1 expression. Finally, nude mice xenograft model experimental results demonstrate DIAPH3 knock down could decrease tumour growth and TrxR1 expression and ROS levels in vivo. Collectively, our observations indicate DIAPH3 could promote pancreatic cancer progression by activating selenoprotein TrxR1‐mediated antioxidant effects. [ABSTRACT FROM AUTHOR]

Published
2021
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16. AB069. P041. A nomogram based on postoperative neutrophil-to-lymphocyte rate and TNM stage to predict the prognostic value in pancreatic ductal adenocarcinoma with open distal pancreatosplenectomy

Author

Pu, Ning, primary, Yin, Hanlin, additional, Li, Jian-ang, additional, Zhao, Guochao, additional, Xu, Yadong, additional, Nuerxiati, Abulimiti, additional, Wang, Dansong, additional, Xu, Xuefeng, additional, Kuang, Tiantao, additional, Jin, Dayong, additional, Lou, Wenhui, additional, and Wu, Wenchuan, additional

Published
2018
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19. Alkaline Phosphatase-To-Albumin Ratio as a Prognostic Indicator in Pancreatic Ductal Adenocarcinoma after Curative Resection

Author

Pu, Ning, primary, Gao, Shanshan, additional, Xu, Yadong, additional, Zhao, Guochao, additional, Lv, Yang, additional, Nuerxiati, Abulimiti, additional, Li, Jian-ang, additional, Wang, Dansong, additional, Xu, Xuefeng, additional, Kuang, Tiantao, additional, Wang, Xiaolin, additional, Lou, Wenhui, additional, Liu, Lingxiao, additional, and Wu, Wenchuan, additional

Published
2017
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21. Successful treatment of a case with pancreatic neuroendocrine carcinoma with focal hepatoid differentiation: a case report and literature review

Author

Xin, Bao-Bao, Li, Jian-Ang, Han, Xu, Zhao, Jing, Ji, Yuan, Lou, Wen-Hui, and Xu, Xue-Feng

Subjects
Case Report
Abstract

A 33-year-old Chinese woman was admitted to our hospital because of an elevated serum alpha-fetoprotein (AFP) level (300 ng/mL) found in a regular medical checkup. Computed tomography imaging of the abdomen revealed a 1.6 × 2.2 cm low-attenuation mass in the head of the pancreas, with no enlarged lymph nodes and no metastatic liver nodules, and a pancreaticoduodenectomy was performed and the tumor was completely removed. The tumor was solid, unencapsulated and poorly demarcated, measuring 2 × 1.4 × 1.8 cm, and the cut surface was grey-yellowish. Histologically, most of the areas of the tumor were composed of small monotonous and round shaped neuroendocrine cells, and approximately 20% of the areas were cells with indistinct cytoplasmic borders, large oval nuclei, prominent nucleoli and abundant eosinophilic cytoplasm, resembling the appearance of HCC. Immunohistochemical stains revealed that the neuroendocrine areas were diffusely positive for chromogranin, and the hepatoid areas showed diffuse and strong positive reaction to AFP. After surgery the AFP level reduced to normal. She received six cycles of postoperative chemotherapy and three years after the surgery was found to have an elevated serum AFP level again which gave rise to the suspicion of tumor recurrence, and a positron emission tomography-computed tomography confirmed the speculation by showing a hypermetabolic lymph node behind the body of the pancreas. She then underwent radiotherapy and the AFP level reduced to normal. Up till now she has survived 46 months since the initial diagnosis. This case and previous cases suggest that the serum AFP could be a useful marker for early detection of the disease, but careful differential diagnosis should be performed, and AFP could also be a marker for evaluation of therapeutic response and recurrence of the AFP-producing hepatoid carcinomas of pancreas.

Published
2014

23. The Impact of Internal Stenting of Pancreatojejunostomy on the Pancreatic Fistula Rate after Pancreaticoduodenectomy.

Author

Xu Xue-Feng, Li Jian-Ang, and Lou Wen-Hui

Subjects
*SURGICAL stents, *PANCREATIC surgery, *JEJUNOSTOMY, *PANCREATIC fistula, *SURGICAL anastomosis, *PREVENTION
Abstract

The article focuses on a prospective controlled study that examine the impact of internal stenting of pancreaticojejunostomy on the prevention of postoperative pancreatic fistula (POPF). One end of a plastic stent was placed into the pancreatic duct and anchored by absorbable sutures, while the other end was put into the jejunum with a 10-centimeter distance from the choledochojejunal anastomosis. More patients in the nonstented group developed pancreatic fistula than in the stented group.

Published
2014
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24. Successful treatment of a case with pancreatic neuroendocrine carcinoma with focal hepatoid differentiation: a case report and literature review.

Author

Xin BB, Li JA, Han X, Zhao J, Ji Y, Lou WH, and Xu XF

Abstract

A 33-year-old Chinese woman was admitted to our hospital because of an elevated serum alpha-fetoprotein (AFP) level (300 ng/mL) found in a regular medical checkup. Computed tomography imaging of the abdomen revealed a 1.6 × 2.2 cm low-attenuation mass in the head of the pancreas, with no enlarged lymph nodes and no metastatic liver nodules, and a pancreaticoduodenectomy was performed and the tumor was completely removed. The tumor was solid, unencapsulated and poorly demarcated, measuring 2 × 1.4 × 1.8 cm, and the cut surface was grey-yellowish. Histologically, most of the areas of the tumor were composed of small monotonous and round shaped neuroendocrine cells, and approximately 20% of the areas were cells with indistinct cytoplasmic borders, large oval nuclei, prominent nucleoli and abundant eosinophilic cytoplasm, resembling the appearance of HCC. Immunohistochemical stains revealed that the neuroendocrine areas were diffusely positive for chromogranin, and the hepatoid areas showed diffuse and strong positive reaction to AFP. After surgery the AFP level reduced to normal. She received six cycles of postoperative chemotherapy and three years after the surgery was found to have an elevated serum AFP level again which gave rise to the suspicion of tumor recurrence, and a positron emission tomography-computed tomography confirmed the speculation by showing a hypermetabolic lymph node behind the body of the pancreas. She then underwent radiotherapy and the AFP level reduced to normal. Up till now she has survived 46 months since the initial diagnosis. This case and previous cases suggest that the serum AFP could be a useful marker for early detection of the disease, but careful differential diagnosis should be performed, and AFP could also be a marker for evaluation of therapeutic response and recurrence of the AFP-producing hepatoid carcinomas of pancreas.

Published
2014

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