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• Quantifying the impact of peer pressure on environmental improvements among local governments in China. • Investigating cities ' reaction to declining air quality rankings through regression discontinuity design. • Demonstrating the efficacy of political incentives in combating pollution and the catalytic effect of rankings on policy action. • Assessing the benefits resulting from air pollution reductions using an exposure response function. This paper estimates the impact of peer governmental pressure on air quality using a regression discontinuity design inherent in China's air quality ranking system. Because air quality rankings are important for political evaluations, local officials who witnessed a decline in air quality ranking are motivated to enforce more stringent environmental standards compared to their counterparts with increased rankings. By exploiting this regulatory discontinuity with monthly air quality ranking data from 2012 to 2020 of 169 cities, we find that cities experiencing a lower air quality ranking in the current month compared to the previous month exhibit a subsequent improvement in air quality during the following month, as evidenced by decreased pollutant concentrations. Furthermore, our analysis reveals that in cities where pollutant rankings decline more sharply, officials are less likely to encounter fewer promotion opportunities. Importantly, we observe that the discontinuity in individual pollutant concentrations is not solely influenced by their respective rankings but is also impacted by the overall A ir Q uality I ndex (AQI) ranking. Linking the reduction in air pollutants concentration with the economic benefits, a back-of-the-envelope calculation indicates the decrease in premature deaths due to cardiovascular and respiratory diseases amounts to approximately 200 thousand, resulting in an associated economic saving of more than 600 billion Chinese yuan. [ABSTRACT FROM AUTHOR]

Rabies is a lethal zoonotic disease that is mainly caused by the rabies virus (RABV). Although effective vaccines have long existed, current vaccines take both time and cost to produce. Messenger RNA (mRNA) technology is an emergent vaccine platform that supports rapid vaccine development on a large scale. Here, an optimized mRNA vaccine construct (LVRNA001) expressing rabies virus glycoprotein (RABV-G) was developed in vitro and then evaluated in vivo for its immunogenicity and protective capacity in mice and dogs. LVRNA001 induced neutralizing antibody production and a strong Th1 cellular immune response in mice. In both mice and dogs, LVRNA001 provided protection against challenge with 50-fold lethal dose 50 (LD50) of RABV. With regards to protective efficiency, an extended dosing interval (14 days) induced greater antibody production than 3- or 7-day intervals in mice. Finally, post-exposure immunization against RABV was performed to evaluate the survival rates of dogs receiving two 25 μg doses of LVRNA001 vs. five doses of inactivated vaccine over the course of three months. Survival rate in the LVRNA001 group was 100%, whereas survival rate in the inactivated vaccine control group was only 33.33%. In conclusion, these results demonstrated that LVRNA001 induced strong protective immune responses in mice and dogs, which provides a new and promising prophylactic strategy for rabies. [ABSTRACT FROM AUTHOR]

• Investigating how pension coverage reduces energy poverty in rural China. • Exploiting age-based eligibility for pension coverage to address endogeneity. • Anticipatory response is explored to validate the estimates. • Liquidity constraint might restrict anticipatory responses. • Competing interpretations on living arrangements and lifestyle are excluded. This paper estimates the causal effect of income change on reducing energy poverty by exploiting age-based eligibility for China's New Rural Pension Scheme (NRPS) through a regression discontinuity (RD) design. More than one billion people worldwide live in energy poverty, and the situation is even more difficult in developing world. It is an important development challenge to reduce energy poverty, which could be further associated with health outcome, labor productivity, and educational achievements. While public policies that increase income for poor households are the most direct ways to reduce energy poverty, the reverse causality makes establishing a convincing causal link between income and energy poverty challenging. Using the quasi-experimental variation in income induced by NRPS, this paper addresses the endogeneity of income and examines the impact of exogenous sharp changes in income on energy consumption behaviors. The findings indicate substantial increases in modern energy consumption and sizable reductions in solid fuels (e.g., straw and fuelwood), suggesting that "windfall income" by pension coverage alleviates energy poverty. Although individuals could anticipate the income shocks by pension coverage, the evidence suggests that they do not engage in anticipatory responses to smooth their consumption. Further evidence shows that liquidity constraints may be the underlying mechanism for the lack of anticipatory responses in household energy consumption. Besides reducing energy poverty, the results demonstrate that pension coverage leads to a decrease in elderly labor supply, an increase in subjective health and life satisfaction, and an increase in non-energy consumption, all of which are positively associated with the well-beings of senior citizens. We anticipate that the findings of this paper in the context of China may be extended to developing world which has been expected to set up targeted measures to tackle energy poverty in upcoming decades. [ABSTRACT FROM AUTHOR]

• CSFV E2-Fc subunit vaccine mediated the efficiency of mucosal vaccination against CSFV. • The CSFV E2-Fc recombinant fusion protein was demonstrated to bind to FcγRI on antigen-presenting cells. • The CSFV E2-Fc recombinant fusion protein could provide protective immunity against CSFV in swine. Classical swine fever (CSF) remains one of the most important highly contagious and fatal viral disease of swine with high morbidity and mortality. CSF is caused by classical swine fever virus (CSFV), a small, enveloped RNA virus of the genus Pestivirus. The aim of this study was to construct the a novel CSFV Fc-fusion recombinant protein and evaluate the efficacy as a vaccine against CSFV. Here, we obtained a novel subunit vaccine expressing CSFV E2 recombinant fusion protein in CHO-S cells. Functional analysis revealed that CSFV Fc-fusion recombinant protein (CSFV-E2-Fc) could bind to FcγRI on antigen-presenting cells (APCs) and significantly increase IgA levels in serum and feces, inducing stronger mucosal immune response in swine. Additionally, CSFV-E2-Fc immunization enhanced CSFV-specific T cell immune response with a Th1-like pattern of cytokine secretion, remarkably stimulated the Th1-biased cellular immune response and humoral immune response. Further, the protective effects of CSFV-E2-Fc subunit vaccines were confirmed. The data suggest that CSFV E2-Fc recombinant fusion protein may be a promising candidate subunit vaccine to elicit immune response and protect against CSFV. [ABSTRACT FROM AUTHOR]

Molecular adjuvants are vaccine delivery vehicle to increase specific antigens effectiveness. Herein, we concentrated on IgG Fc, an effective molecular adjuvant, to develop novel pseudorabies virus (PRV) subunit vaccines. Two major protective antigen genes of PRV were constructed and linked into the mouse IgG Fc fragment. The gD, gD-IgG2aFc, gB and gB-IgG2aFc proteins were expressed using a baculovirus system. Mice intranasally immunized with gD-IgG2aFc or gB-IgG2aFc subunit vaccine exhibited significantly higher PRV-specific antibodies, neutralizing antibodies and intracellular cytokines than the mice intranasally immunized with gD or gB subunit vaccine. Moreover, no histopathological lesions were observed in mice immunized with gB-IgG2aFc subunit vaccine via histopathology examination. Further, the gB-IgG2aFc subunit vaccine was efficient for PRV infection compared with live attenuated vaccine. Overall, these results suggest that IgG2a Fc fragment, as a potential molecular adjuvant, fused with PRV antigen might be a promising and efficient PRV vaccine candidate. [ABSTRACT FROM AUTHOR]

The electricity system faces load-matching pressure due to imbalances during peak times or extreme weather, making it costly to phase out coal-fired electricity and reduce carbon emissions. The electricity spot market pilot (ESMP) policy provides reserve capacities for grids, but its effectiveness on green economic development is still unknown. Therefore, using panel data from 286 cities in China from 2006 to 2019, this study analyzes the impact of the ESMP policy on green economic performance. The results indicate a significantly positive effect of the ESMP policy on green economic performance. In addition, the policy could help to phase out 6.3% of coal-fired capacity, on average, reduce coal-fired equipment utilization hours by 0.9%, and increase renewable equipment utilization hours by 4% in pilot regions. These findings provide new insights into ESMP policy and green economic development. [ABSTRACT FROM AUTHOR]

Recent evidence suggests that exposure to air pollution adversely impacts health outcomes, cognitive function, and labor productivity, however, less is known about the effect of air pollution exposure on social conflicts. Using daily air pollution, we study the effect of exposure to air pollution on social conflicts. For identification strategies, we estimate models with high-dimensional fixed effects and two instrumental variables using atmospheric inversions and wind patterns as exogenous shocks to local pollution. Our findings suggest a positive impact of air pollution on social conflicts, and the magnitude is larger with more severe pollution exposure. Moreover, the significant differences exist between social conflicts occurring in different workplaces, and those occurring at development levels, both of which are related to the extent of pollution exposure. Finally, taking lottery sales as a proxy for risk preference to investigate the potential mechanisms, we show that the increased social conflicts alone with pollution exposure may be attributed to the rising risk preference. This provides indirect support for a plausible channel through which air pollution results in behavioral and social outcomes. The results are robust to alternative specifications and placebos. The findings suggest that reducing air pollution gains the unintended consequence of preventing social conflicts. [ABSTRACT FROM AUTHOR]

Energy resource depletion and environmental degradation have become big challenges for China's sustainable development. Energy efficiency improvement is usually regarded as an major pathway for reducing the pressure on energy and the environment. However, this would be undermined by the rebound effect, because the rebound effect would partially or even totally offset the anticipated of efficiency improvement. Evidence of the rebound effect has important implications for the economic, resource and environmental consequences of improving energy efficiency, as well as enables policy makers to take informed decisions on energy and environmental issues. In this paper, we incorporate the endogenous energy efficiency into the model specification of rebound effect, and build a unified comprehensive framework for analyzing rebound effect and related issues. We applied this framework to conduct empirical analysis and comparison of heavy and light industries, considering heterogeneity across sub-industries. Furthermore, this paper goes beyond simple estimation of rebound effect, and takes additional effort to highlight the policy application via combining energy subsidies and technological progress with rebound effect. [ABSTRACT FROM AUTHOR]

Is it the heavy industry or light industry that performs better in energy efficiency incorporating undesirable outputs? Energy efficiency is the gap between actual and target energy inputs, thus the more energy intensive heavy industry is not necessarily the less energy efficient one. The purpose of this paper is to evaluate and compare the ecological total-factor energy efficiency (ETFEE) of the heavy and light industries as well as to assess their technology gaps. Considering the slack-bias of conventional DEA models and technological heterogeneity between heavy and light industries, the slack-based DEA model (SBM) and meta-frontier technology have been combined. The empirical results show that: (1) China's industries did not perform efficiently. Among them, heavy industry, albeit has more advanced technology, demonstrates lower energy efficiency than light industry. Thus, China needs to stimulate heavy industry to achieve its potential in efficiency improvement. (2) Compared with light industry, governmental stimulus induced expansion has promoted technological advancement in heavy industry, but it still has had no effect on the utilization of existing technologies by, for example, improving the managerial efficiency. Greater pressure on environmental standards is needed to motivate factories in heavy industry to utilize existing technologies more sufficiently. (3) Technological gap among industries has enlarged, thus more attention should be paid on encouraging technology spillover from heavy industry to light industry. [ABSTRACT FROM AUTHOR]

When talking about energy conservation, "Rebound Effect" (RE) is always concerned, which defined as the increasing energy consumption relative to the counterfactual predicted by technological progress because of efficiency induced decrease in the real price of energy services. In this paper, we try to find a way to figure out the RE through calculating the substitution relations accord with the definition. Based on the trans-log cost function and considering the asymmetric impact on energy-cost share equation, the paper applies Allen-Uzawa substitution elasticity to establish the price-oriented analysis diagram of fossil-energy consumption RE. Using time series data, applying the joint method of the dynamic OLS (DOLS) and the seemingly unrelated regressions (SUR), the RE in China's electricity generation sector is estimated. The results showed that the RE is 11.6% in China's electricity generation sector if allowing for asymmetric price effects, which indicates that China's power generation sector generally displays a feature of energy saving. [ABSTRACT FROM AUTHOR]

This paper empirically investigates both price and volatility spillover effects in a comprehensive VEC–MGARCH framework. The hedging strategy is further discussed using the spillover effects. Crude oil and natural gas markets of US, Europe and Japan are examined for regional segmentation and different pricing mechanisms of natural gas. Our results show that the European and Japanese gas prices are cointegrated with Brent oil prices, but US gas price is decoupled from oil due to natural gas market liberalization and shale gas expansion. In all cases, the results support the presence of price spillover from crude oil markets to natural gas markets, but a reverse relationship does not exist. The asymmetric price spillover effects might be explained by the relative size of each market. It was also found that the volatility in oil market seems to spillover to the natural gas market, and vice versa, in both US and Europe. On the contrary, volatility seems to be independent in natural gas and oil markets in Japan. The difference in the results of the volatility spillover effects could be explained by the pricing mechanism of natural gas, especially the risk avoidance mechanism in gas pricing in Japan. The risk management performance of hedging strategy is remarkable considering volatility spillover. [ABSTRACT FROM AUTHOR]

Renewable energy is believed to be the central issue in sustainable development. Literatures on renewables׳ costs are rather sparse, especially on costs of integration and system balancing. The objective of this paper is to fill the research gap by providing an assessment for the cost of China׳s grid-connected renewable energy development and analyze its sharing between different stakeholders. Due to China׳s pricing mechanism of renewable energy and their cost decreasing potential, the pricing model of feed-in tariff and dynamic technological learning processes are employed. In the estimation of purchasing cost, the positive bias is overcome by considering China׳s energy-saving dispatching policy. The results suggest that purchasing cost would be 32.57–40.80 billion Yuan over 2012–2020, and peak in 2017. Grid integration costs which further involve costs of grid infrastructure and system balancing are also investigated. We find that grid infrastructure will cost 27.88 billion Yuan by 2015 and soar to 45.32 billion by 2020, while system balancing will cost 31.49 billion Yuan in 2015 and 63.97 billion Yuan in 2020 among which a substantial part (over 60%) comes from electricity loss in energy transfer. The different parts of these costs are underwritten by disparate participants due to China׳s renewable energy policies and its institutional arrangement. Purchasing cost is shared by power consumers through RES; the cost of grid infrastructure is mainly covered by grid enterprises; and there is no mechanism to specify how to share the cost electricity loss during system balancing which might become a major obstacle for system balancing. [ABSTRACT FROM AUTHOR]

China's economic growth has been progressively moving towards reducing carbon intensity. In parallel, Japan has long been regarded as the pioneer of energy efficiency worldwide. Why have these two economic giants had such different experiences of carbon intensity in the past decades? A closer examination in both countries may hold vital clues, which are still very unclear. This paper compares the patterns of carbon intensity between China and Japan, in which we propose a bilateral-country decomposition framework by combining production-theoretical decomposition analysis and index decomposition analysis. The decomposition highlights the effects of emission factor, energy structure, sectoral structure, substitution among labor-energy and capital-energy, and technological progress. The results show that the energy structure, sectoral structure, and capital-energy substitution are the main drivers behind that China is much higher carbon intensity than Japan, accounting for 26%, 25%, and 38%, respectively. Yet, these effects also narrowed the carbon intensity gap between China and Japan over the years. Furthermore, the labor-energy substitution effect has generally decreased the carbon intensity gap. The technological effect has a minor impact on the carbon intensity gap per year, while it plays a dominant role in enlarging the carbon intensity gap over time. • An improved approach is proposed to decompose driving forces of carbon intensity. • The approach is applied to carbon intensity gap between China and Japan. • Potential energy intensity of each sector is uncovered by input substitution. • Enabling policymakers in developing countries to reduce carbon intensity. [ABSTRACT FROM AUTHOR]

China, with a heavy dependence on coal power, has announced a clear goal of carbon neutrality by 2060. Electrification of final energy use and high penetration of renewable energy are essential to achieve this. The resulting growth of intermittent renewables and changes in demand curve profiles require greater flexibility in the power system for real-time balancing – greater ability of generators and consumers to ramp up and down. However, the plan and market system with regulated prices makes this challenging. We discuss the options to improve flexibility, including 1) increasing supply-side flexibility, through retrofitting existing power plants to boost their responsiveness; 2) promoting flexibility from power grids, through building an efficient power grid with inter-provincial and inter-regional transmission capacity to balance spatial mismatch, given that China has a vast territory; 3) encouraging demand flexibility, through demand-response measures to enable demand shifting over time and space to address fluctuations in renewable energy generation; and 4) providing flexibility from energy storage. We consider policies to achieve this, in particular, power market reforms to unlock the flexibility potential of these sources. Regulated electricity prices and lack of auxiliary services markets are major obstacles and we discuss how markets in other countries provide lessons in providing incentives for a more flexible system. • Carbon neutrality requires electrification and intermittent renewables. • Discuss options to improve flexibility in power system with high renewables. • Attention to technology and market policies in system with regulated prices and quotas. • Exploring how markets in other countries may provide lessons for China. [ABSTRACT FROM AUTHOR]

China, with a heavy dependence on coal power, has announced a clear goal of carbon neutrality by 2060. Electrification of final energy use and high penetration of renewable energy are essential to achieve this. The resulting growth of intermittent renewables and changes in demand curve profiles require greater flexibility in the power system for real-time balancing – greater ability of generators and consumers to ramp up and down. However, the plan and market system with regulated prices makes this challenging. We discuss the options to improve flexibility, including 1) increasing supply-side flexibility, through retrofitting existing power plants to boost their responsiveness; 2) promoting flexibility from power grids, through building an efficient power grid with inter-provincial and inter-regional transmission capacity to balance spatial mismatch, given that China has a vast territory; 3) encouraging demand flexibility, through demand-response measures to enable demand shifting over time and space to address fluctuations in renewable energy generation; and 4) providing flexibility from energy storage. We consider policies to achieve this, in particular, power market reforms to unlock the flexibility potential of these sources. Regulated electricity prices and lack of auxiliary services markets are major obstacles and we discuss how markets in other countries provide lessons in providing incentives for a more flexible system. • Carbon neutrality requires electrification and intermittent renewables. • Discuss options to improve flexibility in power system with high renewables. • Attention to technology and market policies in system with regulated prices and quotas. • Exploring how markets in other countries may provide lessons for China. [ABSTRACT FROM AUTHOR]

Given that China is committed to peak its carbon dioxide emissions in or before 2030 under the Paris Agreement, promoting renewable energy to substitute coal is one critical solution to facilitate China to meet this commitment. Among various types of renewable energy, solar energy is an attractive choice that will significantly influence the future of energy supply and energy usage. We first provide an overview of the most recent development of solar energy in China, in which the changing pattern from stationary to distributive forms is highlighted. We show that the diversified prices and subsidies across regions may play an important role in the changing pattern. Furthermore, we find major challenges that might impede the future expansion of solar energy. To address these challenges, governments need to propose policies to develop technologies and meditate the benefits of stakeholders, especially grid companies and electricity end-users. Market-based policies are also expected to accelerate the learning-by-doing process through R&D investment, which will help reduce and ultimately eliminate solar subsidies. • An overview of the most recent development of solar energy in China. • A new pattern from stationary to distributive forms of solar energy is highlighted. • Reasons for the changing pattern: Diversified prices and subsidies. • Challenges and policy options for the expansion of China's solar energy. [ABSTRACT FROM AUTHOR]

Pseudorabies (PR), caused by pseudorabies virus (PRV), is an acute and febrile infectious disease in swine. To eradicate PR, a more efficacious vaccine needs to be developed. Here, the gE/gI- and TK/gE/gI-gene-deleted recombinant PRV (rGXΔgE/gI and rGXΔTK/gE/gI) are constructed through CRISPR/Cas9 and Cre/Lox systems. We found that the rGXΔTK/gE/gI was safer than rGXΔgE/gI in mice. Additionally, the effects of rGXΔgE/gI and rGXΔTK/gE/gI were further evaluated in swine. The rGXΔgE/gI and rGXΔTK/gE/gI significantly increased numbers of IFN-γ-producing CD4+ and CD8+ T-cells in swine, whereas there was no difference between rGXΔgE/gI and rGXΔTK/gE/gI. Moreover, rGXΔgE/gI and rGXΔTK/gE/gI promoted a PRV-specific humoral immune response. The PRV-specific humoral immune response induced by rGXΔgE/gI was consistent with that caused by rGXΔTK/gE/gI. After the challenge, swine vaccinated with rGXΔgE/gI and rGXΔTK/gE/gI showed no clinical signs and viral shedding. However, histopathological detection revealed that rGXΔgE/gI, not rGXΔTK/gE/gI, caused pathological lesions in brain and lung tissues. In summary, these results demonstrate that the TK/gE/gI-gene-deleted recombinant PRV was safer compared with rGXΔgE/gI in swine. The data imply that the TK/gE/gI-gene-deleted recombinant PRV may be a more efficacious vaccine candidate for the prevention of PR. [ABSTRACT FROM AUTHOR]

• rAAV-G could induce the production of high levels of anti-RABV neutralizing antibodies. • rAAV-G could induce the Th1 and Th2 cellular immune response in mice. • High levels of neutralizing antibodies could remain for long periods of time in mice. • rAAV-G could provide strongly effective protection in mice infected with RABV. Rabies is a highly lethal infectious zoonosis caused by rabies virus (RABV), and the mortality rate is almost 100 % once clinical symptoms appear, which poses a huge threat to public health security across the many parts of the word. Vaccination is reported to be the most effective approach to prevent the disease. G protein is the only protein present on the surface of RABV, it also could induce humoral immunity to produce virus neutralizing antibodies (VNA) and stimulate T cells to produce cellular immunity. Adeno-associated viruses (AAVs) have been used as vectors for gene therapy of different human diseases for its low immunogenicity, high safety and long-term stable expression. To develop a safe and effective vaccine, recombinant AAVs containing different kind of G gene were constructed. After intramuscular (i.m.) immunization in mice, all of these rAAV-G vaccines could induce the production of high levels of VNA and effective cellular immune response. Consistently, all of the rAAV-G vaccines could provide protection against lethal RABV challenge. Our results shown that the rAAV-G vaccines could be potential candidates used in the control of RABV infection. In addition, rAAV-G as a vaccine has many advantages of low preparation cost, simple storage and transportation conditions (4 °C storage and transportation), simple immunization program (only one immunization) and so on. Thence, the rAAV-G vaccines could be potential candidates used in the control of RABV infection. [ABSTRACT FROM AUTHOR]

Cervical perivascular sympathectomy (CPVS) can improve communication disorders in children with cerebral palsy (CP); however, there are no research reports on the factors affecting surgical efficacy. This study aimed to establish a nomogram for poor prognosis after CPVS. We collected data from 313 CP patients who underwent CPVS at the Neurosurgery Cerebral Palsy Center of the Second Affiliated Hospital of Xinjiang Medical University from January 2019 to January 2023. Among them, 70% (n = 216) formed the training cohort and 30% (n = 97) the validation cohort. The general data and laboratory examination data of both groups were analyzed. In training cohort, 82 (37.96%) showed improved postoperative communication function. Logistic analysis identified motor function, serum alkaline phosphatase, serum albumin, and prothrombin activity as the prognostic factors. Using these four factors, a prediction model was constructed with an area under the curve (AUC) of 0.807 (95% confidence interval [CI], 0.743–0.870), indicating its ability to predict adverse outcomes after CPVS. The validation cohort results showed an AUC of 0.76 (95% CI, 0.650–0.869). The consistency curve and Hosmer–Lemeshow test (χ2 = 10.988 and p = 0.202, respectively) demonstrated good consistency between the model-predicted incidence and the actual incidence of poor prognosis. Motor function, serum alkaline phosphatase, serum albumin, and prothrombin activity are independent risk factors associated with the prognosis of communication disorders after CPVS. The combined prediction model has a good clinical prediction effect and has promising potential to be used for early prediction of prognosis of CPVS. [ABSTRACT FROM AUTHOR]

In recent years, the task of maritime emergency rescue has increased, while the cost of time for traditional methods of search and rescue is pretty long with poor effect subject to the constraints of the complex circumstances around the sea, the effective conditions, and the support capability. This paper applies deep learning and proposes a YOLOv5s‐SwinDS algorithm for target detection in distress at sea. Firstly, the backbone network of the YOLOv5s algorithm is replaced by swin transformer, and a multi‐level feature fusion module is introduced to enhance the feature expression ability for maritime targets. Secondly, deformable convolutional networks v2 (DCNv2) is used instead of traditional convolution to improve the recognition capability for irregular targets when the neck network features are output. Finally, the CIoU loss function is replaced with SIoU to reduce the redundant box effectively while accelerating the convergence and regression of the predicted box. Experimenting on the publicly dataset SeaDronesSee, the Precision$Precision$, Recall$Recall$, mAP0.5$mAP_{0.5}$ and mAP0.5−0.95$mAP_{0.5-0.95}$ of YOLOv5s‐SwinDS model are 87.9%, 75.8%, 79.1% and 42.9%, respectively, which get higher results than the original YOLOv5s model, the YOLOv7 series of models, and the YOLOv8 series of models. The experiments verifies that the algorithm has good performance in detecting maritime distress targets. [ABSTRACT FROM AUTHOR]

Background: There is a lack of research to determine the efficacy of cervical perivascular sympathectomy (CPVS) in children with cerebral palsy (CP). Objective: This study aimed to evaluate the efficacy of CPVS in children with CP and analyze the associated influential factors. Methods: Using the method of retrospective cohort studies, children who underwent CPVS were included in the CPVS group, whereas those who underwent selective posterior rhizotomy (SPR) were included in the SPR group. The Communication Function Classification System (CFCS) and Teacher Drooling Scale (TDS) were used to evaluate the communication function and salivation in the two groups before and 12 months after surgery and compare the surgical efficiency between the two groups, and the factors affecting the efficacy were screened by binary logistic regression. Results: The study included 406 patients, 202 in the CPVS group and 204 in the SPR group. No significant differences were observed in the baseline characteristics (p > 0.05). The surgical efficacy of the CPVS group (47.01%) was significantly higher than that in the SPR group (9.81%) (χ2 = 71.08, p < 0.001). Binary logic regression analysis showed that preterm birth and Gross Motor Function Classification System (GMFCS) grade were influencing factors of surgical efficacy. Eighteen patients developed postoperative complications. Conclusion: CPVS is a safe and effective surgery for cerebral palsy. Preterm birth and GMFCS grade are independent factors affecting the efficacy of surgery. [ABSTRACT FROM AUTHOR]

Porcine reproductive and respiratory syndrome (PRRS) has caused huge economic losses in the swine industry worldwide. Live and inactivated vaccines have only been partially successful in generating protective immune responses. The PRRS virus (PRRSV) glycoprotein 5 (GP5) is a major viral antigenic target and is thus suitable for development of genetically engineered PRRSV vaccines. Here, a modified GP5 and ferritin were fused and expressed using a baculovirus system to generate a GP5m-ferritin nanoparticle vaccine. We demonstrated that the GP5m-ferritin vaccine elicited higher serum antibody titers in pigs than inactivated PRRSV. Moreover, immunization with GP5m-Ft promoted a Th1-dominant cellular immune response and enhanced specific T-lymphocyte immune responses. GP5m-ferritin-vaccinated pigs had significantly lower mean rectal temperatures, respiratory scores, viremia, and macroscopic and microscopic lung lesion scores post-challenge compared with unvaccinated pigs. These results indicated that GP5m-ferritin subunit vaccines can elicit specific protective immune responses and represent promising vaccine candidates. • GP5m-ferritin vaccine elicited higher neutralizing antibody titers in pigs than inactivated PRRSV. • Immunization with GP5m- ferritin promoted a Th1-dominant cellular immune response and enhanced specific T-lymphocyte immune responses. • The clinical symptoms and tissue lesions of pigs inoculated with GP5m-ferritin were significantly reduced after challenge. [ABSTRACT FROM AUTHOR]

As a financial instrument and a crucial component of the environmental governance system, the comprehensive impacts of green credit on both the economy and the environment remain unclear. This study examines Chinese provincial data from 2001 to 2018 and employs multiple models to assess the dynamic effects of green credit on carbon productivity. The findings indicate a significant positive influence of green credit on carbon productivity within local and surrounding areas. Furthermore, the promotion effect of green credit on carbon productivity is mainly through energy structure transformation, upgrading of industrial structure and green technology innovation. Interestingly, when considering the spatiotemporal aspect, we observe an initial marginal negative impact of green credit on carbon productivity, which subsequently transitions to a positive effect. The regions demonstrating the highest positive impacts of green credit are primarily concentrated in the southwestern region rich in renewable energy and the economically developed eastern coastal region. [ABSTRACT FROM AUTHOR]

Emissions from heavy urban traffic have been the most abundant components of urban air pollution in China. Compared to the fast increasing consumption of automobile, the growth rate of urban traffic infrastructure investment (UTII) is relative low. It is a controversial issue for the policymaker whether promoting the UTII could make a positive impact on reducing air pollution or not. This study is designed to test the relations between the UTII and air quality, using the data of 83 cities from 2000 to 2012. Based on the empirical results from the fixed effect model and dynamic panel data model, increasing the UTII could generally mitigate the air pollution, but the long-run and short-run effects are significantly different. In the short run, the UTII effect on air quality is −0.02, since the urban traffic infrastructure construction might cause more detours and road blockages, which would enhance the fine-particle emissions of the low-speed traffic. In contrast, the UTII could widen the roads and make the traffic system more accessible in the long run, so the estimated positive effect is about 0.05. The robustness tests about different regions and scales of cities are conducted. Policy suggestions are further recommended to reduce air pollution. [ABSTRACT FROM AUTHOR]

Subseasonal predictions of the regional summer rainfall over several tropical Asian ocean and land domains are examined using hindcasts by the NCEP CFSv2. Higher actual and potential forecast skill are found over oceans than over land. The forecast for Arabian Sea (AS) rainfall is most skillful, while that for Indo-China (ICP) rainfall is most unskillful. The rainfall-surface temperature (ST) relationship over AS is characterized by strong and fast ST forcing but a weak and slow ST response, while the relationships over the Bay of Bengal, the South China Sea (SCS), and the India subcontinent (IP) show weak and slow ST forcing, but apparently strong and rapid ST response. Land-air interactions are often less noticeable over ICP and southern China (SC) than over IP. The CFSv2 forecasts reasonably reproduce these observed features, but the local rainfall-ST relationships often suffer from different degrees of unrealistic estimation. Also, the observed local rainfall is often related to the circulation over limited regions, which gradually become more extensive in forecasts as lead time increases. The prominent interannual differences in forecast skill of regional rainfall are sometimes associated with apparent disparities in forecasts of local rainfall-ST relationships. Besides, interannual variations of boreal summer intraseasonal oscillation, featured by obvious changes in frequency and amplitude of certain phases, significantly modulate the forecasts of rainfall over certain regions, especially the SCS and SC. It is further discussed that the regional characteristics of rainfall and model's deficiencies in capturing the influences of local and large-scale features are responsible for the regional discrepancies of actual predictability of rainfall. [ABSTRACT FROM AUTHOR]

China receives great global attention for its energy consumption. To implement effective and fair policies to save energy, it is critical to understand what drives China's energy consumption and regional disparities. Most of previous studies failed to include indirect factors embodied in the inter-sectoral and regional input-output flows. Therefore, a hybrid structural decomposition analysis is conducted to explore drivers of energy consumption and regional disparities. The results present: (1) energy, directly or indirectly, is flowing from coastal regions to Northwest, Southwest and Central China. (2) The growth of residents' income to contribution of energy consumption is by 106.7% and 169.8% during 2002–2007 and 2007–2012, respectively. Meanwhile, the positive impact of income on energy consumption is larger in urban than rural areas, and the structure effect has a significantly negative impact on energy consumption in Northwest and Southwest regions. (3) By factors, the substitution effect non-energy to energy inputs in industry sector might bring more energy consumption. By sectors, the technological advancement of the non-industry sectors decreases energy consumption by 31.7% and 174.6% during 2002–2007 and 2007–2012, respectively. Technological advancement of industry sectors plays the most important role in increasing energy consumption across China. [Display omitted] • Developing a hybrid structural decomposition analysis to capture drivers of energy consumption and regional disparities. • Income effect is more important than structure effect to explain increase of energy consumption. • The impacts of technical progress on energy consumption vary by regions, factors and sectors. • The industry and income effect contribute most to the increase in the energy consumption. [ABSTRACT FROM AUTHOR]

BCC-CSM2-HR is a high-resolution version of the Beijing Climate Center (BCC) Climate System Model (T266 in the atmosphere and 1/4 ∘ latitude × 1/4 ∘ longitude in the ocean). Its development is on the basis of the medium-resolution version BCC-CSM2-MR (T106 in the atmosphere and 1 ∘ latitude × 1 ∘ longitude in the ocean) which is the baseline for BCC participation in the Coupled Model Intercomparison Project Phase 6 (CMIP6). This study documents the high-resolution model, highlights major improvements in the representation of atmospheric dynamical core and physical processes. BCC-CSM2-HR is evaluated for historical climate simulations from 1950 to 2014, performed under CMIP6-prescribed historical forcing, in comparison with its previous medium-resolution version BCC-CSM2-MR. Observed global warming trends of surface air temperature from 1950 to 2014 are well captured by both BCC-CSM2-MR and BCC-CSM2-HR. Present-day basic atmospheric mean states during the period from 1995 to 2014 are then evaluated at global scale, followed by an assessment on climate variabilities in the tropics including the tropical cyclones (TCs), the El Niño–Southern Oscillation (ENSO), the Madden–Julian Oscillation (MJO), and the quasi-biennial oscillation (QBO) in the stratosphere. It is shown that BCC-CSM2-HR represents the global energy balance well and can realistically reproduce the main patterns of atmospheric temperature and wind, precipitation, land surface air temperature, and sea surface temperature (SST). It also improves the spatial patterns of sea ice and associated seasonal variations in both hemispheres. The bias of the double intertropical convergence zone (ITCZ), obvious in BCC-CSM2-MR, almost disappears in BCC-CSM2-HR. TC activity in the tropics is increased with resolution enhanced. The cycle of ENSO, the eastward propagative feature and convection intensity of MJO, and the downward propagation of QBO in BCC-CSM2-HR are all in a better agreement with observations than their counterparts in BCC-CSM2-MR. Some imperfections are, however, noted in BCC-CSM2-HR, such as the excessive cloudiness in the eastern basin of the tropical Pacific with cold SST biases and the insufficient number of tropical cyclones in the North Atlantic. [ABSTRACT FROM AUTHOR]

Understanding how urbanisation and industrialisation interact with carbon emissions (CEs) among different regions informs the approaches for achieving emissions reduction targets and promoting regional economic development. However, this topic has not been adequately addressed in previous studies. Therefore, it is of great significance to conduct an empirical investigation of the interactions between urbanisation, industrialisation and CEs. Aided by the gravity model, the barycentre trajectories of urbanisation, industrialisation and CEs are analysed. Additionally, the total transfer amounts of industry and CEs are quantitatively examined by using an improved shift-share analysis method, and the spatial aggregation features of urbanisation, industrialisation and CEs are elucidated by constructing a three-dimensional (3D) contribution matrix model. The key conclusions are as follows: (1) The barycentre of industrialisation and urbanisation migrated to the southwest, while that of CE migrated to the northwest and the speed of this movement was faster than that of urbanisation and industrialisation. (2) Industrial transfer mainly occurred in 2005–2012, while the turning point of industrial upgrading appeared in 2013. Furthermore, midwestern regions mainly underwent industrial transfer, while northwest regions always showed CEs transfer from 2005 to 2016. (3) To achieve coordination among urbanisation, industrialisation and emission reductions, 30 provinces are grouped into 8 types according to the 3D contribution matrix model, and optimisation strategies are proposed to highlight regional disparities. These findings have significant implications for making informed decisions regarding urbanisation and industrialisation development as well as emissions-reduction policies. Unlabelled Image • The barycenter of the gravity model is used to map the transfer trajectories. • The transfer amount of industry and carbon emissions are measured by the improved shift share analysis. • Spatial agglomeration characteristics of carbon emission are classified. • Proposing the differentiated strategies for promoting low carbon transition in China. [ABSTRACT FROM AUTHOR]

• A framework to assess the effects of time-dependent regulations was established. • Special period regulation (SPR) effectively reduced the air pollution level. • There are heterogeneous impacts of the SPR across cities. • The effects of SPR are negative across 24 h and weak from 12 pm to 2–3 pm. • SPR achieves a "win-win" status about environmental protection and economic growth. This study examines the impacts of time-dependent environmental regulations on air pollution during the autumn and winter. This was done by exploiting a quasi-experimental setting where a special period regulation was implemented in the Changsha-Zhuzhou-Xiangtan region (CZT, located within Hunan Province in southern China), but not in cities surrounding CZT over the same period. Using hourly level data from October 1, 2014, to September 30, 2017, and by employing a difference-in-differences model, we found that the special period regulation significantly reduced PM 2.5 concentrations, the Air Quality Index, and the probability of the occurrence of severely polluted days in CZT. Furthermore, we found that while this regulation had significant negative impacts on air pollution in Changsha, the impacts were not robust in Zhuzhou and Xiangtan. Our results further revealed that the regulatory effects were significantly negative over a 24-hour time period, but the effects temporarily weakened from 12 pm to 2–3 pm. We also confirmed that such regulations can be used to achieve a "win-win" situation in terms of environmental protection and economic growth. Thus, the results suggest that time-dependent environmental regulations will be valuable in combination with existing policies to improve air quality during specific periods. [ABSTRACT FROM AUTHOR]

BCC-ESM1 is the first version of the Beijing Climate Center's Earth System Model, and is participating in phase 6 of the Coupled Model Intercomparison Project (CMIP6). The Aerosol Chemistry Model Intercomparison Project (AerChemMIP) is the only CMIP6-endorsed MIP in which BCC-ESM1 is involved. All AerChemMIP experiments in priority 1 and seven experiments in priorities 2 and 3 have been conducted. The DECK (Diagnostic, Evaluation and Characterization of Klima) and CMIP historical simulations have also been run as the entry card of CMIP6. The AerChemMIP outputs from BCC-ESM1 have been widely used in recent atmospheric chemistry studies. To facilitate the use of the BCC-ESM1 datasets, this study describes the experiment settings and summarizes the model outputs in detail. Preliminary evaluations of BCC-ESM1 are also presented, revealing that: the climate sensitivities of BCC-ESM1 are well within the likely ranges suggested by IPCC AR5; the spatial structures of annual mean surface air temperature and precipitation can be reasonably captured, despite some common precipitation biases as in CMIP5 and CMIP6 models; a spurious cooling bias from the 1960s to 1990s is evident in BCC-ESM1, as in most other ESMs; and the mean states of surface sulfate concentrations can also be reasonably reproduced, as well as their temporal evolution at regional scales. These datasets have been archived on the Earth System Grid Federation (ESGF) node for atmospheric chemistry studies. [ABSTRACT FROM AUTHOR]

BCC-CSM2-HR is a high-resolution version of the Beijing Climate Center (BCC) Climate System Model. Its development is on the basis of the medium-resolution version BCC-CSM2-MR which is the baseline for BCC participation to the Coupled Model Intercomparison Project Phase 6 (CMIP6). This study documents the high-resolution model, highlights major improvements in the representation of atmospheric dynamic core and physical processes. BCC-CSM2-HR is evaluated for present-day climate simulations from 1971 to 2000, which are performed under CMIP6-prescribed historical forcing, in comparison with its previous medium-resolution version BCC-CSM2-MR. We focus on basic atmospheric mean states over the globe and variabilities in the tropics including the tropic cyclones (TCs), the El Niño–Southern Oscillation (ENSO), the Madden-Julian Oscillation (MJO), and the quasi-biennial oscillation (QBO) in the stratosphere. It is shown that BCC-CSM2-HR keeps well the global energy balance and can realistically reproduce main patterns of atmosphere temperature and wind, precipitation, land surface air temperature and sea surface temperature. It also improves in the spatial patterns of sea ice and associated seasonal variations in both hemispheres. The bias of double intertropical convergence zone (ITCZ), obvious in BCC-CSM2-MR, is almost disappeared in BCC-CSM2-HR. TC activity in the tropics is increased with resolution enhanced. The cycle of ENSO, the eastward propagative feature and convection intensity of MJO, the downward propagation of QBO in BCC-CSM2-HR are all in a better agreement with observation than their counterparts in BCC-CSM2-MR. We also note some weakness in BCC-CSM2-HR, such as the excessive cloudiness in the eastern basin of the tropical Pacific with cold Sea Surface Temperature (SST) biases and the insufficient number of tropical cyclones in the North Atlantic. [ABSTRACT FROM AUTHOR]

• The variation of strength with loading rate under various loading modes were revealed for cement-stabilized macadam. • The fatigue properties of cement stabilized macadam under different loading modes were uniformly characterized. • The new strength structure coefficient associated with the loading rate was proposed for cement-stabilized macadam. Cement-stabilized macadam is widely employed as a base-layer of pavement in China, because of its high strength and stiffness. However, fatigue cracking of the cement-stabilized macadam based pavement is prone to occur under multiple traffic loads, which affects the service life of the pavement. The main objective of this work is to reveal the fatigue characteristics of cement-stabilized macadam under various loading modes by developing a unified fatigue characteristics model. To this end, an unconfined compressive strength test, indirect tensile strength test, and four-point bending strength test were conducted for the cement-stabilized macadam samples under various loading rates. A power function was employed to the pattern of variation of strength with loading rates. The stress ratio of the fatigue test associated with the loading rate was obtained and defined as the rate-dependent stress ratio. Also, the fatigue tests under various loading modes were implemented based on the rate-dependent stress ratio and nominal stress ratio. The preliminary laboratory experimental results showed that it is challenging to compare fatigue performance under different loading modes based on nominal stress ratio. However, the problems of uncertainty and non-uniqueness of fatigue characteristics under various loading modes were resolved by employing the idea of rate-dependent stress ratio in the correlation analyses. Based on that, the new strength structure coefficient associated with the loading rate was proposed in this study. Therefore, the proposed research results provided the fundamental understanding of the fatigue resistance design of pavement with semi-rigid base-layer. [ABSTRACT FROM AUTHOR]

• Study fatigue based on modulus decay considering variance of compressive-tensile. • A synchronous test method of modulus was used to monitor modulus during fatigue test. • The modulus decay mode of tensile and compressive were established and compared. The cement stabilized macadam base experiences tensile and compressive stresses simultaneously in the actual pavement structures, resulting in the influence of stress states on fatigue performance. In this paper, the fatigue performance of cement stabilized macadam was analyzed based on modulus decay considering the difference between compressive and tensile modulus. A synchronous measurement method of tensile and compressive modulus, which based on convention four-point bending test, was utilized to measure modulus of cement stabilized macadam during a fatigue test. The four-point bending fatigue test was conducted upon four different stress levels of 0.25 MPa, 0.5 MPa, 1.0 MPa, and 1.5 MPa. The average of 10 closest modulus values nearby the first 1% of fatigue life was adopted to determine the initial modulus. The last 5 cycles before the failure of the specimen in the fatigue test was determined as the critical modulus value. It was observed from the tests results that the critical value of compressive fatigue modulus was 8 times higher than that of tensile fatigue modulus. The initial and critical values of both tensile and compression decreased with the increase of stress levels. Under different stress levels, the modulus decay mode of tensile and compressive modulus was similar, but the decay rates of tensile modulus were higher than that of compressive modulus. Based on the modulus decay mode, the concept of critical failure point was put forward to characterize the fatigue behavior of cement stabilized macadam. During the fatigue process, both tensile and compressive modulus decay presented three stages, i.e. preliminary stage, stable stage, and rapid attenuation stage. The stable stage of tensile modulus was shorter than that of compressive modulus, which means that the primary fatigue damage occurred in the tensile zone. [ABSTRACT FROM AUTHOR]

The main advancements of the Beijing Climate Center (BCC) climate system model from phase 5 of the Coupled Model Intercomparison Project (CMIP5) to phase 6 (CMIP6) are presented, in terms of physical parameterizations and model performance. BCC-CSM1.1 and BCC-CSM1.1m are the two models involved in CMIP5, whereas BCC-CSM2-MR, BCC-CSM2-HR, and BCC-ESM1.0 are the three models configured for CMIP6. Historical simulations from 1851 to 2014 from BCC-CSM2-MR (CMIP6) and from 1851 to 2005 from BCC-CSM1.1m (CMIP5) are used for models assessment. The evaluation matrices include the following: (a) the energy budget at top-of-atmosphere; (b) surface air temperature, precipitation, and atmospheric circulation for the global and East Asia regions; (c) the sea surface temperature (SST) in the tropical Pacific; (d) sea-ice extent and thickness and Atlantic Meridional Overturning Circulation (AMOC); and (e) climate variations at different timescales, such as the global warming trend in the 20th century, the stratospheric quasi-biennial oscillation (QBO), the Madden–Julian Oscillation (MJO), and the diurnal cycle of precipitation. Compared with BCC-CSM1.1m, BCC-CSM2-MR shows significant improvements in many aspects including the tropospheric air temperature and circulation at global and regional scales in East Asia and climate variability at different timescales, such as the QBO, the MJO, the diurnal cycle of precipitation, interannual variations of SST in the equatorial Pacific, and the long-term trend of surface air temperature. [ABSTRACT FROM AUTHOR]

Abstract With the shale gas revolution and the maturity of new energy technologies, the global oil-based energy pattern began to be remodeled worldwide. From the perspective of China, coal has played a dominant leading role in the energy structure. Therefore, it is becoming increasingly irrational to replace fossil fuels with oil. This paper considers the impact of fluctuations of three fossil energy (oil, coal and natural gas) prices on new energy companies stock prices to meet the needs of policy makers and investors in this rapidly developing field. Due to the incomplete substitution among fossil fuels, this paper uses the Divisia price synthesis method to synthesize these three prices into a composite price index. Furthermore, we use a variable vector autoregressive model to explore dynamic relationships among stock prices of new energy companies and technology companies, fossil energy prices and carbon futures prices. The results reveal that previous stock prices of new energy companies had the most significant impact on the current level. However, fossil energy prices account for only a small part of stock price fluctuations of new energy companies. Highlights • Synthesizing prices of coal, oil and natural gas into a Divisia price index. • Exploring impacts of fossil energy price changes on new energy stock prices. • Historical stock prices of new energy company have the most significant impact on the current level. • Technology stock prices have a greater impact on new energy stock prices than fossil energy prices. [ABSTRACT FROM AUTHOR]

High sensitivity magnetic sensing is proposed using a sandwich structure with polydimethylsiloxane (PDMS) flexible resonator as the core. The directional sensing feature is provided by the sandwich structure's preset magnetic field. The small Young's modulus of flexible material corresponds to larger variation, resulting in a highly sensitive magnetic response. In the unshielded environment, the experimental results demonstrate redshift sensitivity of 1.08 nm / mT and blueshift sensitivity of 1.12 nm / mT, which are attributed to a slight variation in the PDMS's Young's modulus. The directivity curve's concave point has a depth of 34.6 dB. The minimum detectable magnetic field of 0.96 nT · Hz − 1/2 is achieved at 1.4 kHz. [ABSTRACT FROM AUTHOR]

• A FEM of UHPC grouted RC column-footing socket joints was established. • Influencing parameters of joints performance were analyzed. • An estimation method of moment capacity was proposed. Socket connection is an effective connection method for assembling precast columns and adjacent components in accelerate bridge construction(ABC). In order to further enhance the efficiency of this connection type, an extensive numerical study of reinforced concrete(RC) column-footing socket joints was conducted by experimental data. The force transmission mechanism, the influence of parameters on the strength and failure state of the socket joints are revealed. It was found that the socket depth, longitudinal rebar ratio and axial load ratio have notable effect on the mechanical performance of the socket joints compared with other parameters. Base on the numerical simulation and experimental results, a calculation method for the moment capacity of socket joints was developed, which can accurately predict the moment capacity and failure mode of RC column-footing joints with socket connections. A design method of RC column-footing socket joints was also given for practical engineering. [ABSTRACT FROM AUTHOR]

MicroRNA (miR)-125a-5p represses tafazzin phospholipid-lysophospholipid transacylases (TAFAZZIN) expression and inhibits the epithelial-mesenchymal transition (EMT) of ovarian cancer cells. EMT was found to have a crucial role in the acquisition of chemoresistance. Thus, the present study aimed to determine whether miR-125a-5p reverses EMT and restores drug sensitivity by negatively regulating TAFAZZIN in breast cancer. The expression of miR-125a-5p/TAFAZZIN and its association with chemotherapy response were determined in tissue samples from patients with breast cancer. Furthermore, the effects of miR-125a-5p on breast cancer cells were elucidated using cell proliferation and cell apoptosis assays. Then, the regulatory mechanism of miR-125a-5p in breast cancer was investigated by reverse transcription-quantitative PCR, western blotting, dual-luciferase reporter and RNA immunoprecipitation assays. The results demonstrated that miR-125a-5p inhibited the EMT of MCF-7/adriamycin (Adr) breast cancer cells, as well as decreased the proliferation and increased the apoptosis of breast cancer cells treated with Adr/docetaxel. In addition, miR-125a-5p downregulated the expression levels of TAFAZZIN, Transglutaminase 2, phosphorylated-AKT, N-cadherin, vimentin and proliferating cell nuclear antigen, and significantly increased those of E-cadherin, cleaved caspase-3 and Bax in MCF7/Adr cells. Similar results were obtained with small interfering RNA-TAFAZZIN. Moreover, TAFAZZIN was identified as a direct target of miR-125a-5p in MCF7/Adr breast cancer cells. In addition, increased miR-125a-5p expression was observed in breast tumors from patients exhibiting a chemotherapy response, and TAFAZZIN mRNA expression was elevated in patients with no chemotherapy response. Hence, miR-125a-5p expression was negatively correlated with TAFAZZIN mRNA expression in breast cancer tissues. All these data suggested that miR-125a-5p reverses EMT and restores drug sensitivity by negatively regulating TAFAZZIN in breast cancer and, therefore, has potential as a novel therapeutic target for this disease. [ABSTRACT FROM AUTHOR]

Traffic-related air pollution has become an urgent problem in many developing countries with rapid industrialization and urbanization. Traffic infrastructure construction, especially road reconstruction, is a prominent instrument of improving the road capacity and then affecting air quality. We employ the road area as the proxy variable of road infrastructure construction and further divide the road reconstruction pattern into lengthening pattern and widening pattern, respectively to evaluate the impact on urban air quality. The empirical result shows that the coefficient of road infrastructure construction represented by the road area is between −0.0818 and −0.0905, which means increasing road area has an emission-alleviating effect on air pollution. Moreover, we also find that the effect of road lengthening on air quality is better than road widening in the eastern China, but the improvement of road widening in the Central and Western China is better than the road lengthening. The result provides a valuable reference for policy recommendations on urban road infrastructure planning to improve air quality. • An empirical study is conducted to explore the effect of road construction. • Air pollution index is selected as the dependent variable to measure urban air quality. • An increase in road area can improve air quality. • Two road construction methods both have air pollution-reducing effect. • In the eastern cities, road lengthening is more effective in improving air quality. [ABSTRACT FROM AUTHOR]

• The Ayyagari model was applied to semi-rigid layers materials. • The unified fatigue model was obtained based on yield criterion. • A new design index of structural resistance was proposed. As the primary high-grade pavement structure, asphalt pavement with semi-rigid layers has been extensively applied in China. Among the semi-rigid layers materials, cement-treated aggregates (CTA) are an essential pavement element, and its fatigue life significantly affects the durability of the asphalt pavement structure. Various fatigue tests have been adopted to evaluate the fatigue properties of CTA. However, the fatigue resistance of the CTA measured under various methods is different, which seriously affects the accuracy of the structural design of the semi-rigid layers. Hence, this work aims to establish a design criterion for CTA to characterize the structural resistance of semi-rigid layers. The uniaxial compression (UC), four-point bending (4 PB), and indirect tensile (IDT) strength and fatigue tests for CTA were carried out. According to the traditional S - N fatigue model, the curves of fatigue performance and stress ratio of CTA under various stress states are quite different. To intuitively compare the structural resistance of CTA under various test types, the mean stress and effective stress of CTA under different loading rates were obtained. The yield surface was then established based on the Ayyagari model, considering the multiaxial yield criterion of CTA. The effective stress ratio was defined, and its relationship with the fatigue life of CTA was established. Based on the Ayyagari model and the normalized equation, the fatigue resistance criterion of semi-rigid layers under the three-dimensional stress state was proposed. [ABSTRACT FROM AUTHOR]

• The strength variation rules of different loading modes under two mixing methods and different loading rates were revealed. • Under two mixing conditions, the strength of different loading modes was uniformed characterized. • The validity and completeness of strength parameters of semi-rigid base asphalt pavement structure design were improved. Cement stabilized macadam base is the primary stress diffusion and bearing layer of semi-rigid asphalt pavement, therefore its mechanical behavior directly affects pavement performance. The indirect tensile strength, unconfined compressive strength, and bending strength are the essential parameters for evaluating the bearing capacity of cement stabilized macadam. In the design of a pavement structure, the conventional mixing strength values of a test sample are analyzed and calculated at a fixed loading rate. By using this procedure, the influence of the mixing method and the different loading rates on the strength values are ignored. Besides, the strength obtained by using the fixed loading rate with different loading modes has significant differences. As a result, the artificial randomness of the strength parameter in the design of a semi-rigid asphalt pavement structure increases. In an attempt, to improve the effectiveness and completeness of the strength parameters of cement stabilized macadam under different loading modes, mechanical tests were conducted on samples prepared with both vibration mixing and conventional mixing methods. This procedure included, indirect tensile strength test, unconfined compressive strength test, and four-point bending strength test under different loading rates. The results of these strength tests each group of samples (vibration and conventional mixing method) were compared. Besides, all samples were subjected to 6 different loading rates when conducting each loading mode. These experimental values were analyzed. The loading rate and the strength value have a power function relationship and the correlation of strength rates was revealed. The results demonstrated that the vibration mixing method increases the indirect tensile strength, unconfined compressive strength, and four-point bending strength by 13%, 14%, and 10%, respectively. A unified strength model (S / S 0 = 0.9841 + 0.16856ln (0.01019 + v / v 0) under two mixing methods and various loading modes were established by using the variation between loading rate ratio and strength ratio. In the unified model, the strength under vibration mixing and conventional mixing methods, and the strength among different loading rates can be converted, which improved the test efficiency. The established unified model solves the problem of uncertainty and uniqueness of strength parameters under different loading modes. The accuracy of the semi-rigid asphalt pavement structure resistance design was effectively improved, thereby providing theoretical guidance for the construction of semi-rigid base asphalt pavement engineering. [ABSTRACT FROM AUTHOR]

Bei Qi Wu Jia (BQWJ), a modern preparation of a traditional Chinese medicinal formula, is a combination of Radix Astragali and Acanthopanacis Senticosi. Although BQWJ has been used to treat insomnia, fatigue, and loss of appetite, toxicological safety studies are rare in the literature. Aim of the study : To evaluate the acute and subacute toxicity of BQWJ extract after oral administration in mice and rats, respectively. In the acute toxicity study, mice underwent oral administration of 67.5 g extract/kg/day. In the subacute toxicity study, rats underwent a single oral administration of 1.25, 2.5, 5.0, or 10.0 g/kg/day of BQWJ extract for 28 days. The animals' general behavior, body weight, food intake, biochemical and hematologic parameters, organ coefficients, and pathological morphology were analyzed. No evidence of toxicity was observed in the mice after acute exposure to BQWJ extract. The subacute results included no deaths and no changes in general behavior. Although BQWJ extract resulted in some significant changes in other parameters, these alterations cannot be considered treatment-related because they remained within normal ranges throughout the 28 days. In conclusion, the oral administration of BQWJ extract at doses of less than 67.5 g/kg/day for 1 day or 10.0 g/kg/day for 28 consecutive days can be considered safe and showed no distinct toxicity or side effects in this study. The mixture of Radix Astragali and Acanthopanacis Senticosi (ratio 1:1.12) was powdered and extracted in boiling water two times under reflux condition for 3 h each time. The two decoctions were mixed and filtered and then concentrated under reduced pressure, yielding Bei Qi Wu Jia extract, and stored at room temperature. Strict quality control was established by high-performance liquid chromatography (HPLC) analysis using two methods.In the acute toxicity study, mice underwent oral administration of 67.5 g/kg/day of Bei Qi Wu Jia extract. In the subacute toxicity study, rats underwent a single oral administration of 1.25, 2.5, 5.0, or 10.0 g/kg/day of Bei Qi Wu Jia extract for 28 days. The animals' general behavior, body weight, food intake, biochemical and hematologic parameters, organ coefficients, and pathological morphology were analyzed. Image 1 [ABSTRACT FROM AUTHOR]