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The traditional clustering algorithm passively depends on the number of Access Points(AP) deployed on indoor positioning environment，which leads to low efficiency and high positioning error. The layout of AP is a key factor which affects the positioning accuracy of indoor location fingerprint positioning. So a sensor network is built in this paper, which consists of the Intel chips embedded micro-system and the SA44B measuring receivers produced by Signal Hound US. Firstly, the objective function of indoor positioning is established on the basis of the wave path loss theory. Next, the simulated annealing algorithm and the simplex fusion algorithm are used to optimize the objective function, and then the most reasonable layout of AP indoor location is achieved. Finally, the optimized AP position coordinates as the initial cluster centers that are modified by the K-means clustering algorithm，to improve the positioning efficiency and the precision of the system. The traditional K-means algorithm is used as the comparison object in the paper. The experimental results show that the precision of the clustering localization algorithm after the AP location optimization is improved by 13.8%.

Objective: The purpose of the study was to evaluate the effect of family-centered nursing based on Timing It Right Framework (TIR) on self-management and quality of life in patients with acute cerebral infarction., Methods: According to the rules of randomized control, 100 patients with acute cerebral infarction were divided into two groups, including the control group (n=50) received treatment of routine nursing and follow-up, and the research group (n=50) implemented with a family-centered nursing based on TIR. The changes in self-management ability, mental function, social function, psychological resilience, quality of life, and family nursing ability at discharge and 6 months after discharge were compared between the two groups, and the data of patients' adherence to medication and nursing satisfaction were collected., Results: The overall excellent rate of medication adherence and nursing satisfaction in the research group (96.00%, 98.00%) were significantly higher than those in the control group (80.00%, 78.00%) ( P <0.05). The scores of ESCA, CD-RISC, and GQOL-74 in the research group were significantly higher than those in the control group after discharge, while the scores of SDSS, FCTI and NIHSS in the research group were significantly lower than those in the control group ( P <0.05)., Conclusion: The implementation of the family-centered nursing based on TIR can promote the self-management ability and quality of life, improve psychological resilience, enhance social function and family nursing ability, and improve medication adherence and the nurse-patient relationship in patients with acute cerebral infarction., Competing Interests: None., (AJTR Copyright © 2021.)