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11 results on '"Li, Linqin"'

3. Prompt-Free Few-Shot Learning with ELECTRA for Acceptability Judgment

Author

Li, Linqin, Li, Zicheng, Chen, Ying, Li, Shoushan, Zhou, Guodong, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Liu, Fei, editor, Duan, Nan, editor, Xu, Qingting, editor, and Hong, Yu, editor

Published
2023
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8. Construction of regional integrated transportation networks in Qinghai province under circular economy model

Author

Li Linqin, Xie Jia-an, Cao Guangchao, and Gao Xiaohong

Subjects
Transport engineering, Economic indicator, Circular economy, Transport network, Business, Economic geography, Integrated transportation, Transportation capacity, Positive correlation, Traffic flow, Economic growth model
Abstract

Circular economy is a new concept of development and an economic growth model. This paper studied the relationship between the integrated transport network and circular economy; the characteristics of traffic flow developed by circular economy in Qinghai province, and constructed the regional integrated network mating with circular economy in Qinghai province. Results showed that passenger and cargo transportation capacity has obvious positive correlation with economy development, but the growth rate of passenger and cargo transportation does not match smoothly with that of Qinghai provincial GDP growth in some periods, their significant differences imply that the increase of passenger and cargo transportation is strongly affected by other factors. Traffic flow has positive correlation with road network levels. The development of Qinghai province circular economy mainly relies on the Qaidam areas and the east circular economy area as the core of Xining now. On the above basis, also put forward the suggestions of construction regional integrated network mating with circular economy in Qinghai province to the development of the regional circular economy in the future.

Published
2011

9. Regulatory T cells in the immunotherapy of melanoma.

Author

Ouyang, Zhengxiao, Wu, Hongwei, Li, Linqin, Luo, Yi, Li, Xianan, and Huang, Gang

Abstract

Patients with melanoma are supposed to develop spontaneous immune responses against specific tumor antigens. However, several mechanisms contribute to the failure of tumor antigen-specific T cell responses, inducing immune escape. Importantly, immunosuppression mediated by regulatory T cells (Tregs) in tumor lesions is a dominant mechanism of tumor immune evasion. Based on this information, several therapies targeting Tregs such as cyclophosphamide, IL-2-based therapies, and antibodies against the surface molecular of Tregs have been developed. However, only some of these strategies showed clinical efficacy in patients with melanoma in spite of their success in shifting immune systems to antitumor responses in animal models. In the future, strategies specifically depleting local Tregs, inhibiting Treg migration to the tumor lesion, and Treg depletion in combination with other chemotherapies or immune modulation will hopefully bring benefits to melanoma patients. [ABSTRACT FROM AUTHOR]

Published
2016
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11. Regulatory T cells in the immunotherapy of melanoma.

Author

Ouyang Z, Wu H, Li L, Luo Y, Li X, and Huang G

Subjects
Animals, Antibodies, Monoclonal chemistry, Antigens, Neoplasm immunology, CTLA-4 Antigen metabolism, Cell Movement, Cyclophosphamide therapeutic use, Disease Models, Animal, Humans, Immune System, Immune Tolerance, Immunotherapy methods, Interleukin-2 metabolism, Melanoma immunology, Melanoma pathology, Skin Neoplasms immunology, Melanoma therapy, Skin Neoplasms therapy, T-Lymphocytes, Regulatory immunology
Abstract

Patients with melanoma are supposed to develop spontaneous immune responses against specific tumor antigens. However, several mechanisms contribute to the failure of tumor antigen-specific T cell responses, inducing immune escape. Importantly, immunosuppression mediated by regulatory T cells (Tregs) in tumor lesions is a dominant mechanism of tumor immune evasion. Based on this information, several therapies targeting Tregs such as cyclophosphamide, IL-2-based therapies, and antibodies against the surface molecular of Tregs have been developed. However, only some of these strategies showed clinical efficacy in patients with melanoma in spite of their success in shifting immune systems to antitumor responses in animal models. In the future, strategies specifically depleting local Tregs, inhibiting Treg migration to the tumor lesion, and Treg depletion in combination with other chemotherapies or immune modulation will hopefully bring benefits to melanoma patients.

Published
2016
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