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Previous studies have established the use of various blue pigments, including both local and imported varieties, in the decoration of architecture in ancient China. However, the application of these pigments in local religious architecture has been understudied. In this study, the chemical analysis of ultramarine blue pigments was conducted on a mural painting retrieved from Yongle Taoist Temple in ancient China. The results showed that both imported and local pigments were used individually in the initial drawing period of the Yuan Dynasty (AD 1271–1368), whereas they were mixed in a later restoration in the Qing Dynasty (AD 1636–1912). Of particular significance, the analysis revealed the presence of lapis lazuli in a local religious relic of the Yuan Dynasty for the first time. Further analysis of the elemental proportions and associated minerals led to speculation about the origin of the lapis lazuli, which is believed to have come from Badakhshan, the northeastern region of Afghanistan, and been transported to Central China through the Silk Road. This finding shed light on the trade routes and usage of these pigments in the construction of religious architecture from the Yuan to the Qing dynasties. [ABSTRACT FROM AUTHOR]

Buddhist Utopian vision shaped the art of Pure Land; so did many other factors, including the actual locale. Taking Mogao Cave 172 as the main case study, this article deciphers a visual paradigm of a Pure Land painting and cave in Dunhuang (Gansu, China) from the high Tang period (710–780 CE). By analyzing the visual contents and compositions, the painting medium, the cave spaces, and the cliff site, this study investigates the ways in which the architectural images and spaces in Cave 172 helped to convey the invitation to Pure Land. A close reading of the Western Pure Land painting in Cave 172 reveals the spatial construct of the Buddhist paradise that encouraged a transformative viewing experience. A situated visual analysis of Cave 172 with its auxiliary cave and neighboring caves illustrates the historical procedure in which Pure Land imageries were further integrated with the architectural spaces of caves and cave suites. As this study demonstrates, strategies of spatial layering, self-symmetry and scaling, and plastic and multimedia practices of cave-making enhanced the situatedness of the utopian vision. [ABSTRACT FROM AUTHOR]

Identifying therapy-related AML (t-AML) of newly diagnosed acute leukemias is of great interest. Development of t-AML can occur after cytotoxic chemotherapy and/or radiation. We report a case of t-AML with CBFB::MYH11 fusion in a patient with a distant history of treated stage IIIB nodular sclerosing Hodgkin's lymphoma. We present the clinical course of the patient and the methods used to detect and monitor the rearrangement. Core binding factor AML (CBF-AML) after exposure to treatment is considered to be a good prognostic marker. The identification of these favorable AML subtypes such as CBF-AML highlights the importance of identifying genetic alterations, especially with increasing incidences of t-AML due to changes in choice of treatment and prognosis. [ABSTRACT FROM AUTHOR]

In the past two years, several horizontal wells with ultra-long horizontal intervals were completed in Changqing oil and gas field. The longest horizon interval reached 4466 m, which set a record of the longest onshore horizontal well in Asia. There were a lot of difficulties such as high friction, mudstone collapse, and sand carrying that puzzled the drilling of wells with ultra-long horizontal intervals. To solve these problems, some key treatment agents were screened to form a novel water-based drilling fluid system (CQSP-RH). The yield point and extreme pressure lubrication coefficient of the novel system were 18 Pa and 0.058, respectively. The filtrate volume of the novel system was only 1.9 mL at room temperature and was 12 mL at 120 °C. When the cuttings were rolled for 16 h at 120 °C, the primary recovery of them could reach 98.64%. Subsequently, the novel system was applied to wells with ultra-long horizontal intervals. The friction resistance between drilling tools and sidewall was controlled within 500 KN; the solid contents of drilling fluid was controlled within 10%. The results proved that the novel system have superb properties and tremendous potential to drill deeper horizontal wells. [ABSTRACT FROM AUTHOR]

Babesiosis is a tick-borne intraerythrocytic protozoal infection, which causes illness in humans and lyses infected erythrocytes. Babesiosis infections are most common in the northeast US, where Babesia microti is endemic.1 Symptoms are nonspecific which may lead to a missed or delayed diagnosis. We present a case of severe Babesiosis requiring exchange transfusion in an immunocompetent patient with alcohol abuse and high-risk sexual behavior. [ABSTRACT FROM AUTHOR]

Biophysical and bioanalytical methods were used to characterize the fully oxidized Fc and understand the effect of methionine oxidation on the structure and stability of the human IgG1 Fc expressed in Escherichia coli. The results revealed the need to monitor and control methionine oxidation during manufacturing and storage of protein therapeutics to minimize its impact on the Fc's physical and covalent stability and potentially its biological functions.

The article describes the case of a 16-year-old male immigrated from Honduras, the health implications of detainment in the subject, and the steps taken to ensure proper medical screening and care. He immigrated with his 15-year-old brother to avoid gang recruitment. It is noted that clinicians in the U.S. should be aware of the complex medical needs of newly-arrived immigrant children. Pediatricians have the opportunity to support the health and well-being of the population.

The hematopoietic stem cell line, Myl-D7, is maintained by a self-renewing stem cell population that spontaneously generates myeloid, lymphoid, and erythroid progeny. MS-5 stromal cells are necessary for the growth of Myl-D7 cells. One component of the Myl-D7 cells proliferation activity released by MS-5 stromal cells was enriched by Q sepharose fractionation and shown to be colony stimulating factor-1 (CSF-1) by Western blotting, BAC1.2F5 cell bioassay and inhibition of Myl-D7 proliferation by CSF-1 antibody. The requirement of Myl-D7 cells for CSF-1 was also demonstrated independently by selecting for rare, stroma-independent Myl-D7 mutant clones able to grow without stroma and additional factors. Eighty-nine stroma-independent mutant clones were obtained and belonged to two classes. The majority of mutants did not secrete any growth promoting activity. The second, rarer class of mutants releases a factor that stimulates proliferation/survival for up to several months and approximately half of the secretors express high levels of CSF-1 mRNA. Wild type Myl-D7 grown with supernatants from the secretor cells retained the stem cell phenotype. These data suggest that CSF-1 may act as a key factor in stroma-regulated hematopoiesis and cell–cell interaction. J. Cell. Physiol. 206: 556–562, 2006. © 2005 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]

Here we report the NMR resonance assignments for the Fc region of human IgG1 expressed in E. coli, a 51.4 kDa dimer in solution (residues 221–447). The assignments have been deposited in the BioMagResBank with a BMRB accession number of 15514. [ABSTRACT FROM AUTHOR]

Dercum's disease (DD), also described as adiposis dolorosa, is a poorly understood and rare adipose tissue disorder involving obesity and painful adipose tissue masses. Patients may have associated bruising and constitutional symptoms such as fatigue, difficulty concentrating, and sleep disturbance. DD was initially described in 1888 by Francis Xavier Dercum, and was classified into four subtypes, including generalized diffuse, generalized nodular, localized nodular, and juxta-articular subtypes. While this disease has been described for more than 130 years, its etiology and treatment remain elusive. We describe a case of a patient with DD who presented to Ochsner Medical Center, New Orleans, LA, for evaluation of treatment options. We review current knowledge on this rare disease and data on modern treatment methods., (Copyright ©2021, Yale Journal of Biology and Medicine.)

gammadelta T cells uniquely contribute to host immune defense, but how this is accomplished remains unclear. Here, we analyzed the nonclassical major histocompatibility complex class I T10 and T22-specific gammadelta T cells in mice and found that encountering antigen in the thymus was neither required nor inhibitory for their development. But when triggered through the T cell receptor, ligand-naive lymphoid-gammadelta T cells produced IL-17, whereas ligand-experienced cells made IFN-gamma. Immediately after immunization, a large fraction of IL-17(+) gammadelta T cells were found in the draining lymph nodes days before the appearance of antigen-specific IL-17(+) *beta T cells. Thus, thymic selection determines the effector fate of gammadelta T cells rather than constrains their antigen specificities. The swift IL-17 response mounted by antigen-naive gammadelta T cells suggests a critical role for these cells at the onset of an acute inflammatory response to novel antigens.