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732 results on '"Li, Pengyang"'

10. An Analysis of the Impact of Large-scale Performing Arts Events on the Stock Price of Macao Gaming Enterprises: A Case Study of Galaxy Entertainment Group

Author

Li, Pengyang, Wang, Zequan, Chen, Xiaodan, Jin, Jiamin, Striełkowski, Wadim, Editor-in-Chief, Black, Jessica M., Series Editor, Butterfield, Stephen A., Series Editor, Chang, Chi-Cheng, Series Editor, Cheng, Jiuqing, Series Editor, Dumanig, Francisco Perlas, Series Editor, Al-Mabuk, Radhi, Series Editor, Scheper-Hughes, Nancy, Series Editor, Urban, Mathias, Series Editor, Webb, Stephen, Series Editor, Chen, Zhong, editor, Yacob, Shakila, editor, Guan, Guiyun, editor, and Mohd Nor, Nor Fariza, editor

Published
2024
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11. Research on the Thermal Expansion and Contraction Characteristics of UHV AC GIL Expansion Joint

Author

Li, Pengyang, Meng, Peipei, Wu, Xixiu, Hou, Hui, Wang, Rongtai, Zhang, Yiming, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Tan, Kay Chen, Series Editor, Dong, Xuzhu, editor, and Cai, Li, editor

Published
2024
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29. Class-Incremental Few-Shot Object Detection

Author

Li, Pengyang, Li, Yanan, Cui, Han, and Wang, Donghui

Subjects
Computer Science - Computer Vision and Pattern Recognition
Abstract

Conventional detection networks usually need abundant labeled training samples, while humans can learn new concepts incrementally with just a few examples. This paper focuses on a more challenging but realistic class-incremental few-shot object detection problem (iFSD). It aims to incrementally transfer the model for novel objects from only a few annotated samples without catastrophically forgetting the previously learned ones. To tackle this problem, we propose a novel method LEAST, which can transfer with Less forgetting, fEwer training resources, And Stronger Transfer capability. Specifically, we first present the transfer strategy to reduce unnecessary weight adaptation and improve the transfer capability for iFSD. On this basis, we then integrate the knowledge distillation technique using a less resource-consuming approach to alleviate forgetting and propose a novel clustering-based exemplar selection process to preserve more discriminative features previously learned. Being a generic and effective method, LEAST can largely improve the iFSD performance on various benchmarks.

Published
2021

30. Fine-grained Semantic Constraint in Image Synthesis

Author

Li, Pengyang and Wang, Donghui

Subjects
Computer Science - Computer Vision and Pattern Recognition
Abstract

In this paper, we propose a multi-stage and high-resolution model for image synthesis that uses fine-grained attributes and masks as input. With a fine-grained attribute, the proposed model can detailedly constrain the features of the generated image through rich and fine-grained semantic information in the attribute. With mask as prior, the model in this paper is constrained so that the generated images conform to visual senses, which will reduce the unexpected diversity of samples generated from the generative adversarial network. This paper also proposes a scheme to improve the discriminator of the generative adversarial network by simultaneously discriminating the total image and sub-regions of the image. In addition, we propose a method for optimizing the labeled attribute in datasets, which reduces the manual labeling noise. Extensive quantitative results show that our image synthesis model generates more realistic images.

Published
2021

44. Identification of anisomycin, prodigiosin and obatoclax as compounds with broad-spectrum anti-parasitic activity.

Author

Ehrenkaufer, Gretchen, Li, Pengyang, Stebbins, Erin E, Kangussu-Marcolino, Monica M, Debnath, Anjan, White, Corin V, Moser, Matthew S, DeRisi, Joseph, Gisselberg, Jolyn, Yeh, Ellen, Wang, Steven C, Company, Ana Hervella, Monti, Ludovica, Caffrey, Conor R, Huston, Christopher D, Wang, Bo, and Singh, Upinder

Subjects
Cell Line, Fibroblasts, Animals, Humans, Mice, Rats, Parasites, Pyrroles, Prodigiosin, Anisomycin, Antiparasitic Agents, Parasitic Sensitivity Tests, Cell Survival, Drug Repositioning, Biological Sciences, Medical and Health Sciences, Tropical Medicine
Abstract

Parasitic infections are a major source of human suffering, mortality, and economic loss, but drug development for these diseases has been stymied by the significant expense involved in bringing a drug though clinical trials and to market. Identification of single compounds active against multiple parasitic pathogens could improve the economic incentives for drug development as well as simplifying treatment regimens. We recently performed a screen of repurposed compounds against the protozoan parasite Entamoeba histolytica, causative agent of amebic dysentery, and identified four compounds (anisomycin, prodigiosin, obatoclax and nithiamide) with low micromolar potency and drug-like properties. Here, we extend our investigation of these drugs. We assayed the speed of killing of E. histolytica trophozoites and found that all four have more rapid action than the current drug of choice, metronidazole. We further established a multi-institute collaboration to determine whether these compounds may have efficacy against other parasites and opportunistic pathogens. We found that anisomycin, prodigiosin and obatoclax all have broad-spectrum antiparasitic activity in vitro, including activity against schistosomes, T. brucei, and apicomplexan parasites. In several cases, the drugs were found to have significant improvements over existing drugs. For instance, both obatoclax and prodigiosin were more efficacious at inhibiting the juvenile form of Schistosoma than the current standard of care, praziquantel. Additionally, low micromolar potencies were observed against pathogenic free-living amebae (Naegleria fowleri, Balamuthia mandrillaris and Acanthamoeba castellanii), which cause CNS infection and for which there are currently no reliable treatments. These results, combined with the previous human use of three of these drugs (obatoclax, anisomycin and nithiamide), support the idea that these compounds could serve as the basis for the development of broad-spectrum anti-parasitic drugs.

Published
2020

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