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8 results on '"Li, Po-Chen"'

2. Repurposing pitavastatin and atorvastatin to overcome chemoresistance of metastatic colorectal cancer under high glucose conditions

Author

Cheng, Wei-Ming, primary, Li, Po-Chen, additional, Nguyen, Minh Tran-Binh, additional, Lin, Yu-Teng, additional, Huang, Yu-Tang, additional, Cheng, Tai-Shan, additional, Nguyen, Thi-Huong, additional, Tran, Thu-Ha, additional, Huang, Tzu-Yi, additional, Hoang, Thu-Huyen, additional, Chen, Sin-Yu, additional, Chu, Yu-Chieh, additional, Wu, Chih-Wei, additional, Lee, Ming-Fen, additional, Chiou, Yi-Shiou, additional, Liu, Hsiao-Sheng, additional, Hong, Yi-Ren, additional, Chang, Peter Mu-Hsin, additional, Hu, Yu‑Feng, additional, Chang, Ying-Chih, additional, Lai, Jin-Mei, additional, and Huang, Chi-Ying F., additional

Published
2024
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7. Using Non-Destructive Analysis Techniques to Examine the Artworks of Taiwanese Artist Cheng-Po Chen (1895-1947)

Author

Li-Po Chen, Han-Chung Wu, Ping-Chih Huang, Chun-Hsiung Kuei, and Ioseba I. Soraluze

Subjects
endocrine system, biology, Chemistry, viruses, Art history, General Chemistry, biology.organism_classification, Conservation, Oil paint, Chen, visual_art, Non destructive, visual_art.visual_art_medium, Fluorescence spectrometer
Abstract

This study employed the non-destructive techniques to analyze and examine the artworks of the Taiwanese artist Cheng-Po Chen (1895-1947) for disclosing the damage to Chen's artworks and determine his creation habits. Ten pieces of artworks that required restoration were examined using ultraviolet examination techniques. Based on the differences in their fluorescence characteristics, various parts of these works were shown to have been retouched, thus, original and retouched regions were distinguished. Examining these works using Infrared instrument revealed that Chen did not use charcoal to prepare drafts, and he directly applied oil paint to the canvases. Subsequently, these two examination techniques were adopted to examine sketches. The results showed that residues imprinted on them cause of storage methods were organic materials from charcoal and not carbon granules. The X-ray examination identified numerous creations beneath the surface of several artworks. The X-ray fluorescence spectrometer was used for elemental analysis of the pigments. The results corresponded with the pigments listed in Chen's purchase form, thus, we summarized the composition of palettes used by Chen. In general, this study acquired a considerable amount of information from the pigment examinations and established a database of the pigments that Chen commonly employed in his artworks.

Published
2013

8. Forkhead box M1 mediates metabolic reprogramming in human colorectal cancer cells.

Author

Li PC, Dai SY, Lin YS, Chang YT, Liu CC, Wang IC, and Lee MF

Subjects
Humans, HT29 Cells, HCT116 Cells, Glycolysis, Gene Expression Regulation, Neoplastic, Warburg Effect, Oncologic, Signal Transduction, Cell Proliferation, Cellular Reprogramming physiology, TOR Serine-Threonine Kinases metabolism, TOR Serine-Threonine Kinases genetics, Proto-Oncogene Proteins c-akt metabolism, Metabolic Reprogramming, Forkhead Box Protein M1 metabolism, Forkhead Box Protein M1 genetics, Colorectal Neoplasms metabolism, Colorectal Neoplasms genetics, Colorectal Neoplasms pathology
Abstract

Metabolic reprogramming is recognized as a hallmark of cancer, enabling cancer cells to acquire essential biomolecules for cell growth, often characterized by upregulated glycolysis and/or fatty acid synthesis-related genes. The transcription factor forkhead box M1 (FOXM1) has been implicated in various cancers, contributing significantly to their development, including colorectal cancer (CRC), a major global health concern. Despite FOXM1's established role in cancer, its specific involvement in the Warburg effect and fatty acid biosynthesis in CRC remains unclear. We analyzed The Cancer Genome Atlas (TCGA) Colonic Adenocarcinoma and Rectal Adenocarcinoma (COADREAD) datasets to derive the correlation of the expression levels between FOXM1 and multiple genes and the survival prognosis based on FOXM1 expression. Using two human CRC cell lines, HT29 and HCT116, we conducted RNAi or plasmid transfection procedures, followed by a series of assays, including RNA extraction, quantitative real-time polymerase chain reaction, Western blot analysis, cell metabolic assay, glucose uptake assay, Oil Red O staining, cell viability assay, and immunofluorescence analysis. Higher expression levels of FOXM1 correlated with a poorer survival prognosis, and the expression of FOXM1 was positively correlated with glycolysis-related genes SLC2A1 and LDHA , de novo lipogenesis-related genes ACACA and FASN , and MYC . FOXM1 appeared to modulate AKT/mammalian target of rapamycin (mTOR) signaling, the expression of c-Myc, proteins related to glycolysis and fatty acid biosynthesis, and glucose uptake, as well as extracellular acidification rate in HT29 and HCT116 cells. In summary, FOXM1 plays a regulatory role in glycolysis, fatty acid biosynthesis, and cellular energy consumption, thereby influencing CRC cell growth and patient prognosis. NEW & NOTEWORTHY Transcription factor forkhead box M1 (FOXM1) regulates glycolysis, fatty acid biosynthesis, and cellular energy consumption, which, together, controls cell growth and patient prognosis in colorectal cancer (CRC).

Published
2024
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