153 results on '"Li, Qing-Li"'
Search Results
2. Kinetic analysis on the hydrogen cyanide formation in the premixed methane/ammonia flame
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Wang, Du, Tian, Zhen-Yu, Li, Qing-Li, Kuang, Jiu-Jie, and Yu, Xu-Peng
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- 2025
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3. Improvement of astrocytic gap junction involves the anti-depressive effect of celecoxib through inhibition of NF-κB
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Xiao-xi Zheng, Cheng-feng Zhang, Li-qing Li, Jun-rui Ye, Si-yu Ren, Zhao Zhang, Xin He, Shi-feng Chu, and Nai-hong Chen
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Major depression disorder ,Inflammation ,Astrocyte ,Gap junction ,COX-2 ,NF-κB ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Context: Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, has been shown to exhibit anti-depressive effects in clinical trials. However, the direct mechanism underlying its effect on neuroinflammation remains unclear. Neuroinflammatory reaction from astrocytes leads to depression, and our previous study found that gap junction disorder between astrocytes aggravated neuroinflammatory reaction in depressed mice. Objective: To investigate the potential mechanism of celecoxib's effects on astrocytic gap junctions during the central nervous inflammation-induced depression. Materials & methods: Stereotaxic injection of lipopolysaccharide (LPS) into the prefrontal cortex (PFC) to establish a model of major depressive disorder (MDD). Celecoxib was administrated into PFC 15 min after LPS injection. The depressive performance was tested by tail suspension test and forced swimming test, and the levels of proinflammation cytokines were determined at mRNA and protein levels. Resting-state functional connection (rsFC) was employed to assess changes in the default mode network (DMN). Additionally, astrocytic gap junctions were also determined by lucifer yellow (LY) diffusion and transmission electron microscope (TEM), and the expression of connexin 43 (Cx43) was measured by western blotting, quantitative polymerase chain reaction, and immunofluorescence. Results: LPS injection induced significant depressive performance, which was ameliorated by celecoxib treatment. Celecoxib also improved rsFC in the DMN. Furthermore, celecoxib improved astrocytic gap junctions as evidenced by increased LY diffusion, shortened gap junction width, and normalized levels of phosphorylated Cx43. Celecoxib also blocked the phosphorylation of p65, and inhibition of p65 abolished the improvement of Cx43. Discussion & conclusion: Anti-depressive effects of celecoxib are mediated, at least in part, by the inhibition of nuclear factor- kappa B (NF-κB) and the subsequent improvement of astrocytic gap junction function
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- 2024
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4. Myocardial microvascular function assessed by CMR first-pass perfusion in patients treated with chemotherapy for gynecologic malignancies
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Yang, Meng-Xi, Li, Qing-Li, Wang, Dan-Qing, Ye, Lu, Li, Ke-Min, Lin, Xiao-Juan, Li, Xue-Sheng, Fu, Chuan, Ma, Xin-Mao, Guo, Ying-Kun, Yin, Ru-Tie, and Yang, Zhi-Gang
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- 2022
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5. Efficacy and safety of radiotherapy plus anti-PD1 versus transcatheter arterial chemoembolization plus sorafenib for advanced hepatocellular carcinoma: a real-world study
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Jian-Xu Li, Wen-Xiang Deng, Shi-Ting Huang, Xiao-Feng Lin, Mei-Ying Long, Jie Zhang, Ting-Shi Su, Li-Qing Li, Ya-Dan Pang, Chun-Feng Liang, Hong-Mei Zhou, Hai-Yan Lu, Shi-Xiong Liang, and Bang-De Xiang
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Hepatocellular carcinoma ,Anti-PD1 ,Radiotherapy ,Overall survival ,Transcatheter arterial chemoembolization ,Sorafenib ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background The combination of transcatheter arterial chemoembolization (TACE) plus sorafenib prolonged progression-free survival (PFS) and overall survival (OS) than sorafenib or TACE monotherapy for patients with hepatocellular carcinoma (HCC). This study assessed the efficacy and safety of radiotherapy (RT) plus monoclonal antibody against programmed cell death 1 (anti-PD1) versus TACE plus sorafenib for patients with advanced HCC. Methods Patients with advanced HCC who treated with RT plus anti-PD1 and TACE plus sorafenib were enrolled. Objective response rate (ORR), PFS, disease control rate (DCR) and OS were calculated to assess the antitumor response and the treatment-related adverse events to the safety. Results Between January 2018 to March 2021, 37 patients underwent RT plus anti-PD1 and 41 patients underwent TACE plus sorafenib. The baseline characteristics between the two groups were comparable. The ORR and DCR were significantly higher in the RT + PD1 group than the TACE plus sorafenib group according to RECIST 1.1 (54.05% vs. 12.20%, P
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- 2022
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6. Research progress of fibroblast growth factor homologous factor 1 in the pathogenesis of arrhythmia
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QIN Tao, LI Qing, LI Ju-xiang
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fibroblast growth factor homologous factor ,arrhythmia ,sodium channel ,phosphorylation ,Medicine - Abstract
Fibroblast growth factor homologous factor 1 (FHF1) is an intracellular signaling protein, a non-specific fibroblast growth factor that does not bind to fibroblast growth factor receptors. FHF1 combines with the C-terminus of cardiac voltage-gated sodium ion channels to regulate Na+current, which in turn affects the action potential of myocardial cells and results in arrhythmias with a higher frequence.
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- 2020
7. Chemoradiotherapy Versus Chemotherapy Alone for Advanced Esophageal Squamous Cell Carcinoma: The Role of Definitive Radiotherapy for Primary Tumor in the Metastatic Setting
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Li-Qing Li, Qing-Guo Fu, Wei-Dong Zhao, Yu-Dan Wang, Wan-Wan Meng, and Ting-Shi Su
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esophageal squamous cell carcinoma ,advanced ,metastatic ,chemoradiotherapy ,definitive radiotherapy ,survival ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
IntroductionThe role of definitive radiotherapy in advanced esophageal squamous cell carcinoma (ESCC), especially in the metastatic setting, remains unclear. Therefore, we aimed to investigate the efficacy of chemoradiotherapy (CRT) versus chemotherapy (CT) alone in these selected patients.MethodsWe retrospectively evaluated 194 newly diagnosed advanced ESCC who underwent definitive CRT or CT alone, including 97 patients with locally advanced and 97 patients with distant metastatic disease. Cumulative overall survival (OS) and progression-free survival (PFS) were evaluated with a log-rank test. Propensity score matching was used to simulate random allocation. In addition, we performed subgroup analysis in the locally advanced and metastatic disease.ResultsAfter matching, 63 well-paired patients were selected. The adjusted median OS (12.5 vs. 7.6 months, p = 0.002) and PFS (9.0 vs. 4.8 months, p = 0.0025) in the CRT group were superior to that in the CT-alone group. Further subgroup analysis revealed that CRT conferred survival benefits to both locally advanced and metastatic cohorts. For patients with distant metastasis, median OS (12.9 vs. 9.3 months, p = 0.029) and PFS (9.9 vs. 4.0 months, p =0.0032) in the CRT group were superior to that in the CT-alone group. In a multivariate Cox regression analysis of the entire cohort, additional definitive radiotherapy was independently associated with better OS (p = 0.041) and PFS (p = 0.007).ConclusionsIn both locally advanced and metastatic ESCC, additional definitive-dose radiotherapy was associated with improved clinical outcomes. Therefore, more consideration should be given to its application in the metastatic setting.
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- 2022
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8. Cognition of the warning symptoms and risk factors for cancer among Chinese college students: a cross-sectional study based on a summer social practice activity
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Feng, Lin-sen, primary, Li, Qing-li, additional, Yang, Qing, additional, Zhu, Yu-lu, additional, Yin, Fu-lin, additional, Wang, Qi-yao, additional, Zhong, Wen-jue, additional, Wu, Xiao-qian, additional, Yan, Ruo-yu, additional, and Dong, Zheng-jiao, additional
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- 2023
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9. Pingchuan formula attenuates airway mucus hypersecretion via regulation of the PNEC-GABA-IL13-Muc5ac axis in asthmatic mice
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Xiang Piao, Shen-hua Jiang, Jia-ni Wang, Jie Wu, Wan-chao Xu, Li-qing Li, Zheng Xue, and Jian-er Yu
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Asthma ,Pingchuan formula ,PNEC ,GABA ,TCM ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Background/aims: Asthma is a common chronic respiratory disease. It has been reported that Pingchuan formula (PCF) can control asthma attacks by reducing airway inflammation, muscle spasm and mucus secretion. However, PCF’s mechanism for reducing airway mucus hypersecretion remains unclear. This study aimed to investigate the effect of PCF on airway mucus secretion in asthmatic mice and to explore changes in the PNEC-GABA-IL13-Muc5ac axis. Methods: Male Babl/c mice were used to establish the asthma model via sensitisation with OVA. Mice were randomly divided into Normal, OVA, DEX, and PCF groups. After treatment, lung histopathology was observed with H&E and PAS staining. BALF levels of IL-5 and IL-13 were detected using ELISA. The levels of mRNA and protein expression for GAD1, GABAARβ1, GABAARα1 and Muc5ac in the lung tissue were measured by RT-PCR and Western blot assays. PNECs were observed with AgNOR staining. Results: PCF treatment effectively reduced goblet cell (P
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- 2021
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10. A Prospective Study of Liver Regeneration After Radiotherapy Based on a New (Su’S) Target Area Delineation
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Ting-Shi Su, Li-Qing Li, Shi-Xiong Liang, Bang-De Xiang, Jian-Xu Li, Jia-Zhou Ye, and Le-Qun Li
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radiotherapy ,liver regeneration ,model ,nomogram ,hepatocellular carcinoma ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
BackgroundIn this study, we designed a new (Su’S) target area delineation to protect the normal liver during liver regeneration and prospectively evaluate liver regeneration after radiotherapy, as well as to explore the clinical factors of liver regeneration and established a model and nomogram.MethodsThirty patients treated with preoperative downstaging radiotherapy were prospectively included in the training cohort, and 21 patients treated with postoperative adjuvant radiotherapy were included in the validation cohort. The cut-off points of each optimal predictor were obtained using receiver-operating characteristic analysis. A model and nomogram for liver regeneration after radiotherapy were developed and validated.ResultsAfter radiotherapy, 12 (40%) and 13 (61.9%) patients in the training and validation cohorts experienced liver regeneration, respectively. The risk stratification model based on the cutoffs of standard residual liver volume spared from at least 20 Gy (SVs20 = 303.4 mL/m2) and alanine aminotransferase (ALT=43 u/L) was able to effectively discriminate the probability of liver regeneration. The model and nomogram of liver regeneration based on SVs20 and ALT showed good prediction performance (AUC=0.759) in the training cohort and performed well (AUC=0.808) in the validation cohort.ConclusionsSVs20 and ALT were optimal predictors of liver regeneration. This model may be beneficial to the constraints of the normal liver outside the radiotherapy-targeted areas.
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- 2021
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11. Chemotherapy effect on myocardial fibrosis markers in patients with gynecologic cancer and low cardiovascular risk
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Ye, Lu, primary, Wang, Dan-qing, additional, Yang, Meng-xi, additional, Li, Qing-li, additional, Luo, Hong, additional, Lin, Xiao-juan, additional, Li, Ke-min, additional, Song, Liang, additional, Ma, Yu, additional, Huang, Hui-qiong, additional, Zhong, Lan, additional, Yang, Lu, additional, Zhang, Jian-jun, additional, Gong, Feng-ming, additional, Xu, Hua-yan, additional, Xie, Lin-jun, additional, Yin, Ru-tie, additional, and Guo, Ying-kun, additional
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- 2023
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12. Improved synaptic and cognitive function in aged 3 × Tg-AD mice with reduced amyloid-β after immunotherapy with a novel recombinant 6Aβ15-TF chimeric vaccine
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Yu, Yun-Zhou, Li, Qing-Li, Wang, Hai-Chao, Liu, Si, Pang, Xiao-Bin, Xu, Qing, Zhou, Xiao-Wei, and Huang, Pei-Tang
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- 2018
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13. Long-Term Survival Analysis of Transarterial Chemoembolization Plus Radiotherapy vs. Radiotherapy for Hepatocellular Carcinoma With Macroscopic Vascular Invasion
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Ting-Shi Su, Li-Qing Li, Wan-Wan Meng, Yu-Dan Wang, Yi-Tian Chen, Jian-Xu Li, You-Qin Du, Song Qu, Chang Zhao, De-Jia Huang, Shi-Xiong Liang, and Le-Qun Li
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hepatocellular carcinoma ,major vessel invasion ,TACE ,radiotherapy ,overall survival ,radiation-induced liver disease ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background: Macroscopic vascular invasion (MVI) is a terminal manifestation of hepatocellular carcinoma (HCC) and carries an extremely poor prognosis. In Chinese and Korean HCC guidelines, transarterial chemoembolization (TACE), or/and radiotherapy (RT) is adopted for treatment of MVI. In the current study, we aimed to compare the long-term outcome of TACE + RT to that of RT alone in patients with local advanced HCC with MVI.Methods: In this retrospective study, 148 treatment-naive patients of HCC with MVI were enrolled. Of the patients enrolled, 49 received TACE + RT treatment, whereas 99 patients received RT alone as a monotherapy. Overall survival (OS), progression-free survival (PFS), and intrahepatic control were evaluated using univariable and propensity score–matched analyses.Results: During follow-up, 126 patients (85.1%) died. The median follow-up time was 55.0 months in the RT group and 57.0 months in the TACE + RT group. The TACE + RT group showed better OS and PFS than the RT group, but intrahepatic control was comparable in these two groups. Of 41 cases well-pairs after propensity score matching, the associations between TACE + RT and better OS and PFS remained (15.0 vs. 8.0 months, and 8.0 vs. 4.0 months, all P < 0.05). The 1-, 2-, 3-, and 5-years OS rates in the TACE + RT group were 56.1, 28.6, 20.8, and 15.7 vs. 31.5%, 13.1%, 9.8%, and 6.7% in the RT group, respectively (P = 0.017). The 6-, 12-, and 24-months rates in the TACE + RT group were 51.2, 39.0, and 23.1% vs. 36.6%, 13.9%, and 11.1% in the RT group, respectively (P = 0.04). Two patients (4.1%) experienced radiation-induced liver disease (RILD), and one (2.0%) experienced RT-related gastrointestinal (GI) bleed in the TACE + RT groups. Nine patients (9.1%) experienced RILD, and two (2.0%) experienced RT-related GI bleed in the RT groups.Conclusion: Transarterial chemoembolization + RT had well-complementarity with no more complications than RT alone, providing a better PFS and OS compared with RT-alone treatment for HCC with MVI.
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- 2020
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14. Sensitive and Label-Free Colorimetric Detection of Glyphosate Based on the Suppression Peroxidase-Mimicking Activity of Cu(II) Ions
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Li, Qing Li, Yumeng Guo, Xiangyi He, and Guangli
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label-free ,colorimetric analysis ,copper ions ,peroxidase-mimicking activity ,glyphosate - Abstract
The sensitive and accurate determination of glyphosate (Glyp) is urgently demanded because it is closely correlated with human health and environmental safety. In this work, we proposed a sensitive and convenient colorimetric assay by employing copper ion peroxidases for the detection of Glyp in the environment. Free Cu(II) ions displayed high peroxidase activity and can catalytically oxidize the colorless 3,3′,5,5′-tetramethylbenzidine (TMB) into blue oxTMB, resulting in an obviously visible discoloration reaction. Once the Glyp is added, the ability of copper ions to mimic peroxidase can be largely suppressed because of the generation of Glyp–Cu2+ chelate. The favorable selectivity and sensitivity were demonstrated in the colorimetric analysis of Glyp. Furthermore, this rapid and sensitive method was successfully applied in the accurate and reliable determination of glyphosate in the real sample, holding promising applications in pesticide determination in the environment.
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- 2023
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15. A lightweight algorithm for woven fabric defect detection
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Yun Yi Yin and Li Qing Li
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- 2022
16. Myocardial edema during chemotherapy for gynecologic malignancies: A cardiac magnetic resonance T2 mapping study
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Yang, Meng-Xi, primary, Li, Qing-Li, additional, Wang, Dan-Qing, additional, Ye, Lu, additional, Li, Ke-Min, additional, Lin, Xiao-Juan, additional, Li, Xue-Sheng, additional, Fu, Chuan, additional, Ma, Xin-Mao, additional, Liu, Xi, additional, Yin, Ru-Tie, additional, Yang, Zhi-Gang, additional, and Guo, Ying-Kun, additional
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- 2022
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17. Development and reliability and validity test of the Fear of Cancer Scale (FOCS)
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Feng, Lin-sen, primary, Wu, Xiao-qian, additional, Li, Qing-li, additional, Yang, Qing, additional, Yin, Fu-lin, additional, Wang, Qi-yao, additional, Zhu, Yu-lu, additional, Yan, Ruo-yu, additional, Tu, Chang-ling, additional, Yang, Li-ying, additional, Zhong, Wen-jue, additional, and Dong, Zheng-jiao, additional
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- 2022
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18. Combining stereotactic body radiotherapy with camrelizumab for unresectable hepatocellular carcinoma: a single-arm trial
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Jian-Xu Li, Ting-Shi Su, Wen-Feng Gong, Jian-Hong Zhong, Liu-Ying Yan, Jie Zhang, Li-Qing Li, Mei-Ling He, Rui-Jun Zhang, You-Qin Du, Xiao-Ting Wang, Shi-Xiong Liang, and Bang-De Xiang
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Carcinoma, Hepatocellular ,Hepatology ,Liver Neoplasms ,Humans ,Antibodies, Monoclonal, Humanized ,Radiosurgery ,Immune Checkpoint Inhibitors - Abstract
Purpose Stereotactic body radiotherapy (SBRT) may have significant immunomodulatory effects that enhance tumor response to immune checkpoint inhibitors. This phase 2 clinical trial was conducted to evaluate the safety and efficacy of combining palliative SBRT with camrelizumab (an anti-PD1 monoclonal antibody) in patients with unresectable hepatocellular carcinoma (uHCC). Methods Patients with uHCC, Child–Pugh A/B liver function, and at least one measurable lesion were enrolled between April 2020 and August 2022. Patients were administered 200 mg camrelizumab intravenously from the first day of palliative SBRT and then every 3 weeks. Palliative SBRT was delivered daily over five fractions per week, with a dose range of 30–50 Gy. The primary endpoints were objective response rate (ORR) and safety. This trial was registered at ClinicalTrials.gov (NCT04193696). Results Twenty-one patients were enrolled; the median radiation dose was 40 Gy, and the median number of cycles of camrelizumab was five. The ORR was 52.4%. After a median follow-up of 19.7 months, the median progression-free and overall survival were 5.8 and 14.2 months, respectively. The overall survival probability was 85.7% at 6 months, 76.2% at 9 months, and 59.9% at 12 months. All grade 3 treatment-related adverse events (TRAEs) occurred in five patients (23.8%) and were manageable. No grade 4/5 TRAEs were observed. Conclusion Palliative SBRT plus camrelizumab showed promising antitumor activity against uHCC. Toxicities were manageable with no unexpected safety issues. This study provides evidence of a new therapeutic method for the treatment of uHCC.
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- 2022
19. Effect of Body Composition on Outcomes in Patients with Hepatocellular Carcinoma Undergoing Radiotherapy: A Retrospective Study
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Li-Qing Li, Wei-Dong Zhao, Ting-Shi Su, Yu-Dan Wang, Wan-Wan Meng, and Shi-Xiong Liang
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Cancer Research ,Nutrition and Dietetics ,Carcinoma, Hepatocellular ,Oncology ,Liver Neoplasms ,Body Composition ,Medicine (miscellaneous) ,Humans ,Muscle, Skeletal ,Prognosis ,Retrospective Studies - Abstract
Computed tomography (CT)-assessed body composition is considered a novel prognostic factor for cancer patients. Owing to the need for new prognostic markers for hepatocellular carcinoma (HCC) patients undergoing radiotherapy, we investigated the impact of body composition on outcomes in this patient population. We retrospectively evaluated 109 HCC patients receiving radiotherapy. The skeletal muscle index, subcutaneous adipose tissue index (SATI), and visceral adipose tissue index within 1 mo, before radiotherapy were assessed based on a single CT image slice at the level of the third lumbar (L3) vertebra. The impact of body composition parameters on progression-free survival (PFS) and overall survival (OS) was assessed. Overall, 62 (56.9%) patients died, and 47 (43.1%) patients experienced recurrence during a median follow-up period of 20.5 mo. Multivariate analysis revealed that SATI was an independent prognostic factor for both PFS (hazard ratio [HR] 0.542
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- 2022
20. [Pollution Characteristics and Risk Assessment of Nutrients and Heavy Metals in Sediments of the Fuhe River Influenced Area, Baiyangdian Lake]
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Xing-Hong, Chen, Li-Qing, Li, Mei-Yi, Zhang, Wei-Jun, Zhang, Dong-Sheng, Wang, and Hong-Jie, Wang
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China ,Geologic Sediments ,Lakes ,Metals, Heavy ,Nutrients ,Risk Assessment ,Water Pollutants, Chemical ,Environmental Monitoring - Abstract
Based on the flow direction of the Fuhe River into Baiyangdian Lake, the impacted area of the Fuhe River was divided into 6 subareas, and sediments from 48 sites were collected in November 2020. The characteristics and risks of sediment nutrients and heavy metal pollution in these six subareas were investigated. The results showed that the average
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- 2022
21. Efficacy and Safety of Radiotherapy Plus Anti-PD1 Versus Transcatheter Arterial Chemoembolization Plus Sorafenib For Advanced Hepatocellular Carcinoma: a Real-World Study
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Jian-Xu Li, Wen-Xiang Deng, Shi-Ting Huang, Xiao-Feng Lin, Mei-Ying Long, Jie Zhang, Ting-Shi Su, Li-Qing Li, Ya-Dan Pang, Chun-Feng Liang, Hong-Mei Zhou, Hai-Yan Lu, Shi-Xiong Liang, and Bang-De Xiang
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Background: The combination of transcatheter arterial chemoembolization (TACE) plus sorafenib prolonged progression-free survival (PFS) and overall survival (OS) than sorafenib or TACE monotherapy for patients with hepatocellular carcinoma (HCC). This study assessed the efficacy and safety of radiotherapy (RT) plus monoclonal antibody against programmed cell death 1 (anti-PD1) versus TACE plus sorafenib for patients with advanced HCC.Methods: Patients with advanced HCC who treated with RT plus anti-PD1 and TACE plus sorafenib were enrolled. Objective response rate (ORR), PFS, disease control rate (DCR) and OS were calculated to assess the antitumor response and the treatment-related adverse events to the safety.Results: Between January 2018 to March 2021, 37 patients underwent RT plus anti-PD1 and 41 patients underwent TACE plus sorafenib. The baseline characteristics between the two groups were comparable. The ORR and DCR were significantly higher in the RT+PD1 group than the TACE plus sorafenib group according to RECIST 1.1 (54.05% vs 12.20%, P < 0.001; 70.27% vs 46.37%, P = 0.041; respectively) and according to mRECIST (56.76% vs 31.71%, P = 0.039; 70.27% vs 46.37%, P = 0.041; respectively). RT plus anti-PD1 provided significantly better PFS (HR, 0.51; 95% CI 0.30-0.86; p=0.017) than TACE plus sorafenib. Moreover, patients with RT plus anti-PD1 had significantly higher 3-, 6-, and 9-month OS rates than those with TACE plus sorafenib(97.3% vs 92.30%, P < 0.001; 91.89% vs 68.60%, P < 0.001; 75.5% vs 60.60%, P < 0.001; respectively). The median OS was more favorable 17.4 months for the RT+PD1 group and 11.9 months for the TACE plus sorafenib group. No treatment-related death was observed. Grade 3 or more treatment-related adverse events (TRAEs) occurred significantly less in patients in the RT+PD1 group than the TACE plus sorafenib group (29.7% vs 75.6%, p < 0.001), and all TRAEs were manageable.Conclusions: In this real-world study, RT plus anti-PD1 showed significantly promising efficacy and manageable safety than TACE plus sorafenib in patients with advanced HCC. Toxicities were manageable, with no unexpected safety signals. The study provides evidence on a new therapeutic method in the treatment of advanced HCC.
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- 2021
22. Pingchuan formula improves allergic asthma in mice through inhibiting nuclear factor-kappa B / mitogen-activated protein kinase signaling pathway
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Ming-Yun, Wu, Jian-Er, Yu, Li, Bai, Zheng, Xue, Shen-Hua, Jiang, Li-Qing, Li, Xiang, Piao, Wan-Chao, Xu, Jia-Ni, Wang, and Qian, Shen
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Disease Models, Animal ,Mice ,MAP Kinase Signaling System ,Tumor Necrosis Factor-alpha ,NF-kappa B ,Animals ,Mitogen-Activated Protein Kinases ,p38 Mitogen-Activated Protein Kinases ,Asthma ,Drugs, Chinese Herbal - Abstract
To examine the role and decipher the mechanism of Pingchuan formula (PCF) in treating allergic asthma.The mice were treated with saline, dexamethasone (DXM) and PCF for 1 week after the asthma model was established and their respiratory function including respiratory resistance (RI), pulmonary dynamic compliance (Cdyn) and maximum voluntary ventilation (MVV) were measured. In addition, cellular changes in bronchoalveolar lavage fluid (BALF) and pathological changes in lung biopsy as well as the expression level of -smooth muscle actin (α-SMA), transforming growth factor-beta1 (TGF-α1) in BALF and interleukin-5 (IL-5), interleukin-13 (IL-13), tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), nuclear factor-kappa B-p65 (NF-κBp65), inhibitor-α of nuclear transcription factor κB (IκBα), p38 mitogen-activated protein kinase (p38MAPK), c-jun n-terminal kinase (JNK) and its phosphorylated proteins in lung tissue were also examined and compared among different groups.Our data suggested that the respiratory functions were significantly improved and the pathological changes ameliorated in the DXM group and the PCF group compared to the model group. Both DXM and PCF effectively decreased the number of eosinophils, lymphocytes, and neutrophils in BAL as well as the secretion of α-SMA and TGF-α1, IL-5, IL-13, while increased the expression of TNF-α and IFN-γ. Furthermore, our study indicated that the NF-κBp65, IκBα, p38MAPK and JNK pathways were inhibited under the treatment of PCF.Our data indicated that PCF can attenuate the inflammatory response in asthma through inhibiting the NF-κB/MAPK signaling pathway. This study not only supported the use of PCF in allergic asthma in clinic but also shed light upon afurther understanding of thediseasepathogenesis.
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- 2021
23. [Distribution Characteristics and Risk Assessment of Antibiotics and Polycyclic Aromatic Hydrocarbons in the Sediments of Desilting Demonstration Area in Baiyangdian Lake]
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Tong-Fei, Wang, Wei-Jun, Zhang, Li-Qing, Li, Mei-Yi, Zhang, Gui-Ying, Liao, and Dong-Sheng, Wang
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Geologic Sediments ,Lakes ,Tandem Mass Spectrometry ,Animals ,Polycyclic Aromatic Hydrocarbons ,Risk Assessment ,Gas Chromatography-Mass Spectrometry ,Water Pollutants, Chemical ,Anti-Bacterial Agents ,Environmental Monitoring - Abstract
A total of 22 antibiotics and 16 polycyclic aromatic hydrocarbons(PAHs) in sediments before and after desilting in typical areas(fish ponds and open water) of Baiyangdian Lake were analyzed using HPLC-MS/MS and GC/MS(high performance liquid chromatography and gas chromatography coupled with mass spectrometry), to evaluate their potentially risks to the ecological environment. The results showed that the contents of 22 antibiotics in Baiyangdian Lake sediments ranged from 0 to 52.89 ng·g
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- 2021
24. [Identification of Dredging Depths Based on Sediment Vertical Distribution Profiles of Total Nitrogen and Total Phosphorus and Their Adsorption-desorption Equilibria]
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Ya-Ting, Zhou, Xing-Hong, Chen, Li-Qing, Li, Wei-Jun, Zhang, Mei-Yi, Zhang, Dong-Sheng, Wang, and Hong-Jie, Wang
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China ,Geologic Sediments ,Lakes ,Nitrogen ,Phosphorus ,Adsorption ,Water Pollutants, Chemical - Abstract
A dredging demonstration project in the Baiyangdian Lake included open waters and fishing ponds to reduce the internal release of nitrogen and phosphorus from bottom sediments. The dredging depth design was determined by both the sediment vertical distribution profile of total nitrogen and phosphorus, and the sediment adsorption-desorption equilibrium method. The determined dredging depths were very similar and coincident. The dredging depth for the demonstration area of open waters in Nanliuzhuang was identified as(50±10) cm; and the dredging depths for fishing ponds were(30±10) cm in both the Nanliuzhuang and Caiputai demonstration areas. The equilibrium nitrogen(NH
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- 2021
25. Cr(VI) reduction in chromium-contaminated soil by indigenous microorganisms under aerobic condition
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Liyuan Chai, Li-qing Li, Zhihui Yang, Jia-wei Li, Qi Liao, Yan Shi, and Chang-qing Su
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010302 applied physics ,biology ,Chemistry ,Environmental remediation ,Metals and Alloys ,chemistry.chemical_element ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Geotechnical Engineering and Engineering Geology ,Condensed Matter Physics ,biology.organism_classification ,01 natural sciences ,Soil contamination ,Chromium ,Bioremediation ,Environmental chemistry ,0103 physical sciences ,Materials Chemistry ,Bioreactor ,0210 nano-technology ,Indigenous microorganisms ,Incubation ,Bacteria - Abstract
Bioremediation plays an increasingly important role in the remediation of chromium-contaminated soil because it is an environmentally friendly technology. To investigate the Cr(VI) reduction process by indigenous microorganisms in soil, a batch of incubation experiments were carried out in a bioreactor under aerobic conditions. The results showed that in the presence of indigenous microorganisms, the Cr(VI) concentration in the chromium-contaminated soil decreased from 1521.9 to 199.2 mg/kg within 66 h with culture medium addition, while a slight decrease in the Cr(VI) concentration was found in the sterilized soil, implying that the indigenous microorganisms contributed to the Cr(VI) reduction. In the microbial remediation process, Cr(VI) microbial reduction occurred after the reduction of, Mn 4+ and Fe 3+ and, before reduction. The reduction process of Cr(VI) can be divided into two phases, characterized by the exponential equation model of microbial reduction and the linear equation model of the combined effect of the major ions. It can be concluded that indigenous Cr(VI)-reducing bacteria have a potential application for in-situ remediation of Cr(VI)-contaminated soil.
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- 2019
26. New Staging Model for Radiation-based Hepatocellular Carcinoma Treatment: A National Multicenter Study
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Ting-Shi Su, Shi-Xiong Liang, Li-Qing Li, Qiu-Hua Liu, Xue-Zhang Duan, Jing Sun, Hai Zeng, Hai-Sheng Zhu, Jian-Xu Li, Xiao-Fei Zhu, Hong-Qing Zhuang, Ping Liang, and Yong Huang
- Subjects
Hepatology - Published
- 2022
27. Stereotactic body radiotherapy versus intensity-modulated radiotherapy for hepatocellular carcinoma with portal vein tumor thrombosis
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Ying Zhou, Ting-Shi Su, Shi-Xiong Liang, Li-Qing Li, Yong Huang, and Ping Liang
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medicine.medical_specialty ,Carcinoma, Hepatocellular ,medicine.medical_treatment ,Portal vein ,Radiosurgery ,Effective dose (radiation) ,03 medical and health sciences ,0302 clinical medicine ,Text mining ,Internal medicine ,medicine ,Humans ,Retrospective Studies ,Venous Thrombosis ,Hepatology ,business.industry ,Portal Vein ,Liver Neoplasms ,medicine.disease ,Thrombosis ,Colorectal surgery ,Radiation therapy ,030220 oncology & carcinogenesis ,Hepatocellular carcinoma ,030211 gastroenterology & hepatology ,Radiology ,Radiotherapy, Intensity-Modulated ,business - Abstract
Background: It is unclear whether robotic stereotactic body radiotherapy (SBRT) is superior to intensity-modulated radiotherapy (IMRT) in advanced hepatocellular carcinoma (HCC). This study aimed to compare the long-term outcomes of SBRT with those of IMRT in HCCs with portal vein tumor thrombosis (PVTT). Methods: We retrospectively evaluated 287 HCC patients with PVTT who underwent radiotherapy between January 2000 and January 2017. Of them, 154 and 133 patients were treated with IMRT and SBRT, respectively. Overall survival (OS), progression-free survival (PFS), intrahepatic control (IC), and local control (LC) were evaluated in univariable and propensity-score matched analyses. Results: After matching, 102 well-paired patients were selected. There was no significant difference in the 6-, 12-, 24-, and 60-month cumulative OS (73.5, 42.9, 23.6, 7.6% vs. 72.4, 45.1, 29.8, 13.2%, P=0.151), PFS (53.9, 29.3, 21.8, 7.5% vs. 54.5, 19.3, 12.0, 9.6%, P=0.744) , IC (61.4, 45.7, 39.0, 26.8% vs. 75.1, 45.8, 35.9, 28.7%, P=0.144), and LC (85.2, 56.5, 52.1, 47.4% vs. 87.4, 65.2, 62.1, 62.1%, P=0.191) between the IMRT and SBRT groups. A biologically effective dose assumed at an a/b ratio of 10 (BED10) of ≥100 Gy was the optimal cutoff for predicting the OS, PFS, IC, and LC in the patients who received SBRT. Conclusions: When high-precision tracking technology is available, SBRT appears to be a safe and more time-efficient treatment, achieving comparable OS, PFS, IC and LC to IMRT for local advanced HCC with PVTT. A BED10≥100 Gy is recommended if tolerated by normal tissue.
- Published
- 2020
28. Radio-immunotherapy for advanced HCC: A pilot study of irradiation dose
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Ting-Shi Su, Jian-Xu Li, Li-Qing Li, Bang-De Xiang, and Shi-Xiong Liang
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Cancer Research ,Oncology - Abstract
426 Background: Preclinically, radiation therapy for tumors was well known to reverse the immunosuppressive state by reprograming the tumor microenvironment. The combination of radiotherapy and immune checkpoint inhibitors (radio-immunotherapy) has renewed interest in clinical practice, and different irradiation dose may contribute diversely to immune response and abscopal effect. This pilot study aimed to assess the antitumour activity of the anti-PD-1 inhibitor Camrelizumab combined with different irradiation dose in patients with advanced hepatocellular carcinoma (HCC). Methods: Between April 2020 and January 2021, 20 patients with advanced HCC were prospectively enrolled in this pilot study. Five patients were treatment-naive and 15 patients were diagnosis as progressive diseases after previous treatment. For each patient, one to 3 intrahepatic and/or extrahepatic lesions were selected to irradiate. Camrelizumab was concurrently administered with 200mg on the first day of radiation and then every 3 weeks until disease progression, or unacceptable toxicity. Eligible patients were randomly assigned to receive 3 irradiation doses: low-dose group of 30Gy/10 fractions(3Gy/fx), intermediate-dose group of 40Gy/10 fractions (4Gy/fx), and high-dose group of 50Gy/10 fractions (5Gy/fx). Results: Nine patients had intrahepatic lesions (8 of macrovascular invasion) and 11 had extrahepatic metastases. The median number of treatment lines receiving immunotherapy of Camrelizumab was 2 (range 1-5). Enrolment to the 30Gy group was halted after 2 patients due to the poor clinical response. Finally, 2, 11, and 7 patients received the irradiation dose of 30, 40, and 50Gy, respectively. Twenty-eight selected lesions were irradiated (partial lesions in 12 patients and all lesions in 8 patients). Grade 3 treatment-related adverse events were observed in 4 patients, including 2 thrombocytopenia and 1 anaemia in the 40Gy group, and 1 anaemia in the 50Gy group. The median follow-up time was 12 months (range 7.0–18.0 months). There was a significant difference in PFS, but no difference in OS between the three groups. The median, 6- and 12-months PFS for the 30, 40, and 50 Gy groups were 1.7 months, 0% and 0% vs. 4.0 months (95%CI 1.7-6.3 months), 27.3% and 18.2% vs. 7.8 months (95%CI 4.1-11.5 months), 57.1% and 38.1%, respectively (P = 0.027). The median, 12-months OS were 11.4 months and 50% vs. 11.8 months and 34.6% vs. not reached and 66.7%, respectively (P = 0.229). The disease control rates were statistically different between the 30, 40, and 50Gy groups (50% vs. 54.5% vs. 100%, P = 0.039), whereas objective response rates were not significant different (0% vs. 45.5% vs. 71.4%, P = 0.123). Conclusions: Higher irradiation dose with 50 Gy in 10 fractions plus Camrelizumab may augment the radio-immunotherapy activity in advanced HCC with favorable PFS. The present study offers guidance for the dose selection of subsequent clinical trials. Clinical trial information: ChiCTR2000032375.
- Published
- 2022
29. Unconventional microbial mechanisms for the key factors influencing inorganic nitrogen removal in stormwater bioretention columns
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Jian Yang, Liuqin Huang, Allen P. Davis, Li-Qing Li, Weiyu She, Wen Liu, Xiaoxi Sun, Linxin Li, Junyue Luo, and Hongchen Jiang
- Subjects
inorganic chemicals ,Pollutant ,Environmental Engineering ,Denitrification ,organic chemicals ,Ecological Modeling ,Stormwater ,Heterotroph ,food and beverages ,Pollution ,chemistry.chemical_compound ,Bioretention ,chemistry ,Environmental chemistry ,Environmental science ,Sulfate ,Surface runoff ,Saturation (chemistry) ,Waste Management and Disposal ,Water Science and Technology ,Civil and Structural Engineering - Abstract
Bioretention systems are environmentally friendly measures to control the amount of water and pollutants in urban stormwater runoff, and their treatment performance for inorganic N strongly depends on various microbial processes. However, microbial responses to variations of N mass reduction in bioretention systems are complex and poorly understood, which is not conducive to management designs. In the present study, a series of bioretention columns were established to monitor their fate performance for inorganic N (NH4+ and NO3−) by using different configurations and by dosing with simulated stormwater events. The results showed that NH4+ was efficiently oxidized to NO3−, mainly by ammonia- and nitrite-oxidizing bacteria in the oxic media, regardless of the configurations of the bioretention systems or stormwater conditions. In contrast, NO3− removal pathways varied greatly in different columns. The presence of vegetation efficiently improved NO3− mass reduction through root assimilation and enhancement of microbial NO3− reduction in the rhizosphere. The construction of an organic-rich saturation zone can make the redox potential so low that heterotrophic denitrification cannot occur, so as to ensure high NO3− mass reduction mainly via stimulating chemolithotrophic NO3− reduction coupled with oxidation of reductive sulfur compounds derived from the bio-reduction of sulfate. In contrast, in the organic-poor saturation zone, multiple oligotrophic NO3− reduction pathways may be responsible for the high NO3− mass reduction. These findings highlight the necessity of considering the variation of N bio-transformation pathways for inorganic N removal in the configuration of bioretention systems.
- Published
- 2022
30. Long-Term Survival Analysis of Transarterial Chemoembolization Plus Radiotherapy vs. Radiotherapy for Hepatocellular Carcinoma With Macroscopic Vascular Invasion
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Shi-Xiong Liang, Wan-Wan Meng, Yu-Dan Wang, Jian-Xu Li, Chang Zhao, Li-Qing Li, You-Qin Du, Song Qu, Le-Qun Li, Yi-Tian Chen, De-Jia Huang, and Ting-Shi Su
- Subjects
0301 basic medicine ,Cancer Research ,medicine.medical_specialty ,medicine.medical_treatment ,overall survival ,lcsh:RC254-282 ,Gastroenterology ,Vascular invasion ,03 medical and health sciences ,Liver disease ,0302 clinical medicine ,Internal medicine ,major vessel invasion ,medicine ,Overall survival ,radiotherapy ,Original Research ,TACE ,business.industry ,Retrospective cohort study ,hepatocellular carcinoma ,Bleed ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,medicine.disease ,Radiation therapy ,030104 developmental biology ,Oncology ,030220 oncology & carcinogenesis ,Hepatocellular carcinoma ,radiation-induced liver disease ,Propensity score matching ,business - Abstract
Background: Macroscopic vascular invasion (MVI) is a terminal manifestation of hepatocellular carcinoma (HCC) and carries an extremely poor prognosis. In Chinese and Korean HCC guidelines, transarterial chemoembolization (TACE), or/and radiotherapy (RT) is adopted for treatment of MVI. In the current study, we aimed to compare the long-term outcome of TACE + RT to that of RT alone in patients with local advanced HCC with MVI.Methods: In this retrospective study, 148 treatment-naive patients of HCC with MVI were enrolled. Of the patients enrolled, 49 received TACE + RT treatment, whereas 99 patients received RT alone as a monotherapy. Overall survival (OS), progression-free survival (PFS), and intrahepatic control were evaluated using univariable and propensity score–matched analyses.Results: During follow-up, 126 patients (85.1%) died. The median follow-up time was 55.0 months in the RT group and 57.0 months in the TACE + RT group. The TACE + RT group showed better OS and PFS than the RT group, but intrahepatic control was comparable in these two groups. Of 41 cases well-pairs after propensity score matching, the associations between TACE + RT and better OS and PFS remained (15.0 vs. 8.0 months, and 8.0 vs. 4.0 months, all P < 0.05). The 1-, 2-, 3-, and 5-years OS rates in the TACE + RT group were 56.1, 28.6, 20.8, and 15.7 vs. 31.5%, 13.1%, 9.8%, and 6.7% in the RT group, respectively (P = 0.017). The 6-, 12-, and 24-months rates in the TACE + RT group were 51.2, 39.0, and 23.1% vs. 36.6%, 13.9%, and 11.1% in the RT group, respectively (P = 0.04). Two patients (4.1%) experienced radiation-induced liver disease (RILD), and one (2.0%) experienced RT-related gastrointestinal (GI) bleed in the TACE + RT groups. Nine patients (9.1%) experienced RILD, and two (2.0%) experienced RT-related GI bleed in the RT groups.Conclusion: Transarterial chemoembolization + RT had well-complementarity with no more complications than RT alone, providing a better PFS and OS compared with RT-alone treatment for HCC with MVI.
- Published
- 2020
31. Functional CYP3A variants affecting tacrolimus trough blood concentrations in Chinese renal transplant recipients
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Li-qing Li, Siyao Yang, Jiejing Chen, Wen Xue, Danxin Wang, De-mei Ye, Jian Xu, Di-na Chen, Chuan-jiang Li, Wolfgang Sadee, Huijie Lu, Liusheng Lai, Liang Li, Wanying Qian, Tengfei Yang, Qing-ping Li, Weiguo Sui, Que Zheng, Yan Chen, and Ping Zheng
- Subjects
0301 basic medicine ,Adult ,Male ,medicine.medical_specialty ,Aging ,CYP3A ,chemical and pharmacologic phenomena ,Single-nucleotide polymorphism ,Hematocrit ,030226 pharmacology & pharmacy ,Gastroenterology ,Polymorphism, Single Nucleotide ,Tacrolimus ,Cohort Studies ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Asian People ,Internal medicine ,Genetics ,Medicine ,Cytochrome P-450 CYP3A ,Humans ,Allele ,CYP3A5 ,CYP3A7 ,Pharmacology ,Creatinine ,medicine.diagnostic_test ,business.industry ,Genetic Variation ,Middle Aged ,Kidney Transplantation ,Transplant Recipients ,surgical procedures, operative ,030104 developmental biology ,chemistry ,Molecular Medicine ,Female ,business ,Immunosuppressive Agents - Abstract
The aim of this study was to identify novel genetic variants affecting tacrolimus trough blood concentrations. We analyzed the association between 58 single nucleotide polymorphisms (SNPs) across the CYP3A gene cluster and the log-transformed tacrolimus concentration/dose ratio (log (C0/D)) in 819 renal transplant recipients (Discovery cohort). Multivariate linear regression was used to test for associations between tacrolimus log (C0/D) and clinical factors. Luciferase reporter gene assays were used to evaluate the functions of select SNPs. Associations of putative functional SNPs with log (C0/D) were further tested in 631 renal transplant recipients (Replication cohort). Nine SNPs were significantly associated with tacrolimus log (C0/D) after adjustment for CYP3A5*3 and clinical factors. Dual luciferase reporter assays indicated that the rs4646450 G allele and rs3823812 T allele were significantly associated with increased normalized luciferase activity ratios (p
- Published
- 2020
32. Automated tongue segmentation in hyperspectral images for medicine
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Liu, Zhi, Yan, Jing-qi, Zhang, David, and Li, Qing-Li
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Astronomy ,Physics - Abstract
Automatic tongue area segmentation is crucial for computer aided tongue diagnosis, but traditional intensity-based segmentation methods that make use of monochromatic images cannot provide accurate and robust results. We propose a novel tongue segmentation method that uses hyperspectral images and the support vector machine. This method combines spatial and spectral information to analyze the medical tongue image and can provide much better tongue segmentation results. The promising experimental results and quantitative evaluations demonstrate that our method can provide much better performance than the traditional method. OCIS codes: 100.5010, 100.2960, 170.4580, 170.6510.
- Published
- 2007
33. Dissolved Inorganic Nitrogen Behavior and Fate in Bioretention Systems: Role of Vegetation and Saturated Zones
- Author
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Allen P. Davis, Li-Qing Li, Yu-Qing Liu, and Jia-Min Yang
- Subjects
Environmental Engineering ,0208 environmental biotechnology ,Stormwater ,Dissolved inorganic nitrogen ,02 engineering and technology ,020801 environmental engineering ,Bioretention ,Environmental chemistry ,medicine ,Environmental Chemistry ,Environmental science ,medicine.symptom ,Dissolved nitrogen ,Vegetation (pathology) ,General Environmental Science ,Civil and Structural Engineering - Abstract
Management of inorganic dissolved nitrogen (NH4-N and NO3-N) in urban stormwater is challenging. This study investigated the role of bioretention plants and a saturated zone (SZ) on nitroge...
- Published
- 2019
34. Classification of hyperspectral medical tongue images for tongue diagnosis
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Zhi, Liu, Zhang, David, Yan, Jing-qi, Li, Qing-Li, and Tang, Qun-lin
- Published
- 2007
- Full Text
- View/download PDF
35. Description of mechanism function about dehydration of cobalt oxalate dihydrate by multiple rates isotemperature method
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Li-qing, Li and Dong-hua, Chen
- Published
- 2004
- Full Text
- View/download PDF
36. A new staging system for radiotherapy-based treatment of hepatocellular carcinoma: A multicenter cohort study
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Shi-Xiong Liang, Ting-Shi Su, Li-Qing Li, Xiao-Fei Zhu, Qiu-Hua Liu, and Ping Liang
- Subjects
Radical treatment ,Cancer Research ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,External beam radiation ,medicine.disease ,Radiation therapy ,Tumor Status ,Oncology ,Hepatocellular carcinoma ,medicine ,Liver function ,Radiology ,business ,Staging system ,Cohort study - Abstract
e16155 Background: External beam radiation therapy has been used as a palliative to radical treatment of hepatocellular carcinoma (HCC) depending on different tumor status, liver function and patient's general state of health. The existing models of HCC staging cannot perfectly predict the prognosis of radiotherapy. In this study, we aimed to set up a new staging system for radiotherapy-based treatment by incorporating bilirubin-albumin (ALBI) grade and tumor status for the prognostic classifications of HCC. Methods: This multicenter cohort study included 878 HCC patients who received radiotherapy-based treatment. A new staging system was established: stage I, solitary nodule without macrovascular invasion or 2-3 nodules with no more than 3.0 cm each other and PS 0-2 (Ia: ALBI-1 grade; Ib: ALBI-2 or 3 grade); stage II: 2-3 nodules with anyone more than 3.0 cm or ≥4 nodules and PS 0-2 (IIa: ALBI-1 grade; IIb: ALBI-2 grade); stage III: macrovascular invasion or regional lymph node metastasis or distant metastasis and PS 0-2 (IIIa: ALBI-1 grade; IIIb:ALBI-2 grade); stage IV: ALBI-3 grade without stage I patient or/and PS score 3-4. The new modified staging system and the existing staging systems, such as the BCLC, TNM, CNLC staging systems were used for prognostic analysis. All patients were separated into different stages and substages. The long-term overall survival outcomes and time-dependent receiver operating characteristic (ROC) were analyzed. Results: A training cohort of 595 patients underwent stereotactic body radiotherapy (SBRT) from 2011 to 2017 and an external validation cohort of 283 patients underwent intensity-modulated radiotherapy (IMRT) from 2000 to 2013 were included into establishing and validating the new staging system. In the training cohort, the median follow-up time was 55 months (range, 6–100 months), and the new staging system had a good discriminatory ability to separate patients into different stages with 4 notably different curves and substages with 7 notably different curves. BCLC staging could not differentiate stage 0 to A, and stage C to D in these selected patients. TNM staging could not completely distinguish stage IIIb to IV, but also stage Ia to Ib. CNLC staging could not differentiate among stage IIIa, IIIb, and IV. In the external validation, the median follow-up time was 95 months (range, 9–120 months), and the new staging system also had a good discriminatory ability to separate patients into different stages with 4 notably different curves and substages with 7 notably different curves. The new staging system had a better area under curve of time-dependent ROC than BCLC, TNM and CNLC staging in both SBRT and IMRT cohorts. Conclusions: The new modified (Su’s) staging system could provide a good discriminatory ability to separate patients into different stages and substages after radiotherapy treatment. It may be used to supplement the other HCC staging systems.
- Published
- 2021
37. Liver regeneration after radiotherapy in patients with hepatocellular carcinoma: A simple-to-use model and nomogram
- Author
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Shi-Xiong Liang, Ting-Shi Su, and Li-Qing Li
- Subjects
Liver injury ,Cancer Research ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Nomogram ,medicine.disease ,Liver regeneration ,Clinical Practice ,Radiation therapy ,Oncology ,Hepatocellular carcinoma ,Medicine ,In patient ,Radiology ,business ,Liver cancer - Abstract
e16115 Background: In the past clinical practice of radiotherapy for liver cancer, liver regeneration (LR) which is beneficial to the prevention or recovery of radiation-induced liver injury, has not received enough attention. In current study, we aimed to build and validate multivariate model for liver regeneration after radiation therapy for hepatocellular carcinoma (HCC) based on data from 2 prospective studies. Methods: Thirty patients treated with preoperative downstaging radiotherapy were prospectively included in the training cohort, and 21 patients treated with postoperative adjuvant radiotherapy were included in the validation cohort. Liver regeneration was defined as an increase of more than 10% of normal liver volume in the areas of the protected hepatic segment or lobe, without Child-Pugh class decreased and tumor progression compared to pre-radiotherapy. Model and nomogram of liver regeneration after radiotherapy were developed and validated. The cut-off points of each optimal predictors were obtained using receiver-operating characteristic analysis. Risk stratification based on the cut-off point was conducted to compare the proportion of patients with liver regeneration between subgroups. Results: After radiotherapy, 12 (40%) cases in the training cohort and 13 (61.9%) cases in the validation cohort experienced liver regeneration. The model and nomogram of liver regeneration based on SVs20 (standard residual liver volume spared from at least 20 Gy) and alanine aminotransferase (ALT) showed good prediction performance (AUC = 0.759) in training cohort and performed well (AUC = 0.808) in the validation cohort. The risk stratification according to the cutoffs of SVs20 with 303.4 mL and ALT with 43 U/L demonstrated clear differentiation in risk of liver regeneration between the training(P = 0.049) and entire cohort (P = 0.032). The proportion of patients with liver regeneration decrease progressively with 88.9% in high-probability group (ALT<43 U/L and SVs20<303.4 mL), 60% in high-intermediate probability group (ALT ≥43 U/L and SVs20<303.4 mL), 43.75% in low-intermediate probability group (ALT<43 U/L and SVs20≥303.4 mL) and 33% in low- probability group (ALT≥43 U/L and SVs20≥303.4 mL). Conclusions: SVs20 and ALT are optimal predictors for liver regeneration. This simple-to-use nomogram is beneficial to the constraints of normal liver outside the radiotherapy target area and make prognosis-based decision without complex calculations. Clinical trial information: ChiCTR1800015350. [Table: see text]
- Published
- 2021
38. Superior efficacy of a Cremophor-free albumin-bound paclitaxel compared with solvent-based paclitaxel in Chinese patients with metastatic breast cancer
- Author
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GUAN, Zhong-Zhen, LI, Qing Li, FENG, Fengyi, JIANG, Zefei, SHEN, Zhenzhou, YU, Shiying, FEN, Jifeng, HUANG, Jianjin, YAO, Zhiwen, and BHAR, Paul
- Published
- 2009
- Full Text
- View/download PDF
39. Effect of treatment with geraniol on ovalbumin-induced allergic asthma in mice
- Author
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Zhang Xinguang, Zheng Xue, Jianer Yu, Fei Liu, Li-qing Li, Jie Wu, and Wan-chao Xu
- Subjects
CD4-Positive T-Lymphocytes ,0301 basic medicine ,Eotaxin ,medicine.medical_treatment ,Immunoglobulin E ,Leukocyte Count ,chemistry.chemical_compound ,0302 clinical medicine ,Malondialdehyde ,Immunology and Allergy ,Anti-Asthmatic Agents ,Lung ,Glutathione Transferase ,Mice, Inbred BALB C ,biology ,medicine.diagnostic_test ,respiratory system ,Glutathione ,Cytokine ,030220 oncology & carcinogenesis ,Cytokines ,Female ,Bronchoalveolar Lavage Fluid ,Pulmonary and Respiratory Medicine ,NF-E2-Related Factor 2 ,Ovalbumin ,Acyclic Monoterpenes ,Glutamate-Cysteine Ligase ,Immunology ,GATA3 Transcription Factor ,Superoxide dismutase ,03 medical and health sciences ,medicine ,Animals ,RNA, Messenger ,Superoxide Dismutase ,Terpenes ,business.industry ,Allergens ,Asthma ,030104 developmental biology ,Bronchoalveolar lavage ,chemistry ,biology.protein ,T-Box Domain Proteins ,business ,Geraniol - Abstract
Background Asthma, a complex highly prevalent airway disease, is a major public health problem for which current treatment options are inadequate. Objective To evaluate the antiasthma activity of geraniol and investigate its underlying molecular mechanisms. Methods In a standard experimental asthma model, Balb/c mice were sensitized with ovalbumin, treated with geraniol (100 or 200 mg/kg) or a vehicle control, during ovalbumin challenge. Results Treatment of ovalbumin-sensitized/challenged mice with geraniol significantly decreased airway hyperresponsiveness to inhaled methacholine. Geraniol treatment reduced eotaxin levels in bronchoalveolar lavage fluid and attenuated infiltration of eosinophils induced by ovalbumin. Geraniol treatment reduced T H 2 cytokines (including interleukins 4, 5, and 13), increased T H 1 cytokine interferon γ in bronchoalveolar lavage fluid, and reduced ovalbumin-specific IgE in serum. In addition, treatment of ovalbumin-sensitized/challenged mice with geraniol enhanced T-bet (T H 1 response) messenger RNA expression and reduced GATA-3 (T H 2 response) messenger RNA expression in lungs. Furthermore, treatment of ovalbumin -sensitized/challenged mice with geraniol further enhanced Nrf2 protein expression and activated Nrf2-directed antioxidant pathways, such as glutamate-cysteine ligase, superoxide dismutase, and glutathione S-transferase, and enhanced formation of reduced glutathione and reduced formation of malondialdehyde in lungs. Conclusion Geraniol attenuated important features of allergic asthma in mice, possibly through the modulation of T H 1/T H 2 balance and activation the of Nrf2/antioxidant response element pathway.
- Published
- 2016
40. Quantum path control in the presence of a half-cycle pulse to generate isolated attosecond pulse
- Author
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Li-Qing Li, Xiang-Yang Miao, and Chang-Long Xia
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Physics ,Femtosecond pulse shaping ,Wave packet ,Electron ,Dihydrogen cation ,01 natural sciences ,Atomic and Molecular Physics, and Optics ,010305 fluids & plasmas ,Analytical Chemistry ,Pulse (physics) ,Harmonics ,0103 physical sciences ,Atomic physics ,010306 general physics ,Quantum ,Ultrashort pulse ,Spectroscopy - Abstract
Quantum path control on the harmonic emission from hydrogen molecular ion is investigated via combining an intense few-cycle laser and a half-cycle pulse (HCP). The results show that the quantum paths of returning electrons can be effectively modified due to the introduction of the HCP which extremely dominates the acceleration process of ionized electron. With the favorable conditions, the long quantum path is completely eliminated and an isolated 61 as pulse can be obtained by superposing proper harmonics. Moreover, the electron wave packet distributions and the double-well model are presented to explore the underlying physical mechanism.
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- 2016
41. Study on Woven Fabric Texture Based on Fourier Transform and Gabor Transform
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Chen Xia, Jun Wang, Ting Ting Shan, Li Qing Li, and Le Xue
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Image fusion ,Texture compression ,Materials science ,business.industry ,Mechanical Engineering ,ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION ,Gabor transform ,Texture (geology) ,symbols.namesake ,Fourier transform ,Gabor filter ,Mechanics of Materials ,Texture filtering ,Woven fabric ,symbols ,General Materials Science ,Computer vision ,Artificial intelligence ,business ,ComputingMethodologies_COMPUTERGRAPHICS - Abstract
Woven fabric texture was periodic and complex, the woven fabric texture analysis method was based on Fourier transform and Gabor transform. Firstly the frequency range of woven fabric texture was obtained by using the Fourier Transform method, and the influence on fabric frequency of image resolution and fabric density was analyzed. Then the main parameters of Gabor filter was confirmed by the woven fabric texture frequency, and the sub-images which contain different texture information were obtained after the woven fabric images were decomposed and fused in different scales and directions using the Gabor filters. Finally the main texture enhancement method, the main texture elimination method, the direntional texture analysis method and extraessential texture enhancement method were discussed. The experiment proved that this method would be a powerful tool in the application of texture analysis.
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- 2015
42. Impact of UGT2B7 and ABCC2 genetic polymorphisms on mycophenolic acid metabolism in Chinese renal transplant recipients
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Ping Fang, Huijie Lu, Ping Zheng, Chuan-jiang Li, Di-na Chen, Hao-yang Wan, De-mei Ye, Qing-ping Li, Yan Chen, Liang Li, Jie Li, and Li-qing Li
- Subjects
0301 basic medicine ,Adult ,Male ,medicine.medical_specialty ,Genotype ,Single-nucleotide polymorphism ,Kidney ,030226 pharmacology & pharmacy ,Gastroenterology ,Polymorphism, Single Nucleotide ,Mycophenolic acid ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Pharmacokinetics ,Asian People ,Internal medicine ,Bayesian multivariate linear regression ,Genetic model ,Genetics ,medicine ,Humans ,Glucuronosyltransferase ,Pharmacology ,Creatinine ,business.industry ,Albumin ,Mycophenolic Acid ,Kidney Transplantation ,Multidrug Resistance-Associated Protein 2 ,Transplant Recipients ,UGT2B7 ,030104 developmental biology ,chemistry ,Molecular Medicine ,Female ,Multidrug Resistance-Associated Proteins ,business ,medicine.drug - Abstract
Aim: To evaluate genetic variants affecting mycophenolic acid (MPA) metabolism in Chinese renal transplant recipients. Methods: Total 11 SNPs of UGT1A9, UGT1A8, UGT2B7, ABCC2, ABCG2 and SLCO1B3 were genotyped in 408 Chinese renal transplant recipients. Associations between SNPs and MPA concentration/dose ratio (C0/D) were analyzed using different genetic models. Multivariate linear regression was used to analyze associations between log (C0/D) and clinical factors. Results: After adjustment by clinical factors, UGT2B7 rs7662029 was associated with log (C0/D) using a dominant (p = 0.041) and an additive (p = 0.038) model, ABCC2 rs717620 was associated with log (C0/D) using a recessive model (p = 0.019). Using additive model, SNP–SNP interactions were identified (p = 0.002) between ABCC2 rs717620 and UGT1A9 rs2741049, with interactions (p = 0.002) between ABCC2 rs717620 and UGT1A8 rs1042597. Age, albumin and serum creatinine were associated with log (C0/D). Conclusion: rs7662029 and rs717620 may affect MPA pharmacokinetics. SNP–SNP interactions and clinical factors may have significant effects on MPA metabolism.
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- 2018
43. [Effects of Three Bioretention Configurations on Dissolved Nitrogen Removal from Urban Stormwater]
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Li-Qing, Li, Nan, Hu, Yu-Qing, Liu, Sheng-Liang, Tu, and Hua-Chao, Chen
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Pennisetum ,Biodegradation, Environmental ,Nitrates ,Nitrogen ,Rain ,Denitrification ,Water Purification - Abstract
Multiple chemical forms of nitrogen in urban storm water make its management challenging. Three types of bioretention systems were constructed in 2015 with loamy sand as filter media, including a conventional freely drained bioretention (CB), a modified bioretetion incorporated a submerged zone (MB1), and a modified bioretention incorporating a submerged zone with woodchips addition (MB2). This study investigated the role of vegetation, the use of submerged zone and carbon addition in achieving co-optimized dissolved nitrogen removal in bioretention systems. Twelve bioretention columns were monitored over a 12-month period of dosing with synthetic storm water under varying hydrology and nitrogen loading rates. All the studied bioretention systems could achieve very good ammonia removal (more than 95%) at an average inflow ammonia concentration of (5.45±2.21) mg·L
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- 2018
44. [Urban Runoff Phosphorus Removal Pathways in Bioretention Systems]
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Li-Qing, Li, Yu-Qing, Liu, Jia-Min, Yang, and Juan, Wang
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Pennisetum ,Soil ,Biodegradation, Environmental ,Rain ,Phosphorus ,Silicon Dioxide ,Water Pollutants, Chemical - Abstract
The role of vegetation and saturated zones in stormwater-dissolved phosphorus (PO
- Published
- 2018
45. Nerve growth factor and substance P may be involved in moist exposed burn ointment‑mediated chronic refractory wound healing
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Bin Ge, Hong‑Meng Zeng, Huang‑De Fu, Yang Zhou, Qing‑Feng Shu, Shu Wang, and Li‑Qing Li
- Subjects
Cancer Research ,substance P ,Basic fibroblast growth factor ,moist exposed burn ointment ,wound healing ,Substance P ,Tropomyosin receptor kinase A ,nerve growth factor ,Andrology ,03 medical and health sciences ,chemistry.chemical_compound ,tyrosine kinase A receptor ,0302 clinical medicine ,Immunology and Microbiology (miscellaneous) ,Western blot ,medicine ,medicine.diagnostic_test ,business.industry ,nerve repair ,Granulation tissue ,Articles ,General Medicine ,medicine.anatomical_structure ,Nerve growth factor ,chemistry ,Apoptosis ,030220 oncology & carcinogenesis ,business ,Wound healing ,030217 neurology & neurosurgery - Abstract
Moist exposed burn ointment (MEBO) is becoming increasingly popular in China as it shortens wound-healing time and reduces scar formation. However, its exact mechanism in mediating the wound-healing process is not yet clear. In the present study a total of 90 healthy adult male Wistar rats of specific-pathogen-free grade were divided equally into a control group, wound group, MEBO group, recombinant bovine basic fibroblast growth factor (rb-bFGF) group and sham operation group. Wound healing was observed from the extracted granulation tissues and recorded at three time points on 3, 7 and 14 days. Different levels of tumor necrosis factor α (TNF-α) and interleukin-6 (IL-6) in tissue homogenate were detected using ELISA. Western blot analysis and quantitative PCR were used to detect the expression of nerve growth factor (NGF), substance P (SP) as well as tyrosine kinase A (TrkA) receptor protein and the corresponding mRNA levels in granulation tissue. It was observed that the wound healing progressed faster in the MEBO and rb-bFGF groups compared with the wound group (P
- Published
- 2018
46. Therapeutic effects of liver soothing�pingchuan�formula decoction on experimental asthma in BALB/c mice via regulation of nerve growth factor-tyrosine kinase A pathway
- Author
-
Li‑Qing Li, Yi‑Tao Zhao, Jian‑Er Yu, Zheng Xue, Li Bai, Jing‑Dong Zhou, Zhang Xinguang, Jie Wu, and Fei Liu
- Subjects
tyrosine kinase A ,Male ,0301 basic medicine ,nerve growth factor-tyrosine kinase A pathway ,Cancer Research ,medicine.medical_specialty ,medicine.medical_treatment ,Intraperitoneal injection ,Inflammation ,Tropomyosin receptor kinase A ,Biochemistry ,nerve growth factor ,BALB/c ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Genetics ,medicine ,Animals ,Anti-Asthmatic Agents ,Lung ,Molecular Biology ,Sensitization ,Mice, Inbred BALB C ,medicine.diagnostic_test ,biology ,Chemistry ,Articles ,Protein-Tyrosine Kinases ,biology.organism_classification ,Asthma ,Disease Models, Animal ,Ovalbumin ,030104 developmental biology ,Endocrinology ,Bronchoalveolar lavage ,medicine.anatomical_structure ,Nerve growth factor ,Liver ,nervous system ,Oncology ,030220 oncology & carcinogenesis ,liver soothing pingchuan formula decoction ,biology.protein ,Molecular Medicine ,medicine.symptom ,Drugs, Chinese Herbal ,Signal Transduction - Abstract
The present study was designed to investigate the effects of liver soothing pingchuan formula decoction (LSPF) on experimental asthma in BALB/c mice and explore its potential molecular mechanisms. An animal model of asthma was established in BALB/c mice through sensitization and activation with intraperitoneal injection of 10% ovalbumin (OVA)/Al(OH)3 solution in addition to inhalation of a 5% OVA solution. LSPF (300 and 600 mg/kg/day) was initially administered orally prior to activation. Following this, bronchoalveolar lavage fluid (BALF) and lung tissues were collected for histopathalogical examination. Levels of inflammatory cells and cytokines were determined in the BALF, and levels of nerve growth factor (NGF) and tyrosine kinase A (TrkA) in the lung tissues were determined. The results of the present study indicated that increased inflammatory reactions were observed following OVA sensitization (P
- Published
- 2018
47. Comprehensive ecological risk assessment for heavy metal pollutions in three phases in rivers
- Author
-
Jun Zhou, Biao Ma, Li-qing Li, Bao-jie Zhang, Ying Zhang, and Feng-jie Gao
- Subjects
Pollutant ,Environmental chemistry ,Pollution index ,Materials Chemistry ,Metals and Alloys ,Environmental engineering ,Environmental science ,Ecological risk ,Metal toxicity ,Heavy metals ,Metal pollution ,Geotechnical Engineering and Engineering Geology ,Condensed Matter Physics - Abstract
Literature lacked in providing a comprehensive research on heavy metal detection in aquatic, biological and sedimentary states of rivers. The present study was imparted with all these three components of the river. Heavy metal toxicity or pollution index was used as a tool for ecological risk assessment by considering the single state studies conducted by many researchers. An intensive ecological risk assessment model was constructed and heavy metals were indicated as a serious threat to the environment. The model was applied to determining five toxic heavy metals in three states of the Songhua River. According to the ecological risk index, heavy metal pollution in three phases was categorized as aquatic>biological>sedimentary, while the overall descending order of heavy metal ecological risk index was as Cd>Hg>As>Pb>Cr. Cd and Hg were selected as the priority pollutants of Songhua River.
- Published
- 2015
48. Using Lix984 to Recover Cu2+ from Plating Wastewater Containing Chloride
- Author
-
Yun Peng Tan, Li Qin Yang, and Li Qing Li
- Subjects
Pollution ,Waste management ,media_common.quotation_subject ,General Engineering ,chemistry.chemical_element ,Hydrochloric acid ,Chloride ,Copper ,chemistry.chemical_compound ,chemistry ,Wastewater ,medicine ,Leaching (metallurgy) ,medicine.drug ,media_common ,Nuclear chemistry - Abstract
There is abundant Cu2+in plating wastewater containing chloride. Lix984, which is mainly applied in sulphate medium to extract Cu2+, was chosen as the extractant due to it has good performance. The influence parameters for extraction efficiency have been investigated. The results showed that Lix984 can successfully separate Cu2+from simulating plating wastewater in chloride medium. And more, the maximal extraction efficiency is up to 93.3% for Cu2+by single-stage extraction, and recover Cu2+in hydrochloric acid medium by stripping, it can be obtained that stripping of copper >95.2%. These results can greatly broaden an application field of Lix984, especially in the field of acidic wastewater containing chloride and leaching solution with hydrochloric acid of mining process, in addition, it can provide help for the decreasing of environment pollution and recycling Cu2+.
- Published
- 2014
49. Periodicity Estimation of Regular Textile Fabrics Based on Energy Function
- Author
-
Fei Qi, Li-Qing Li, and Jun Wang
- Subjects
Textile ,business.industry ,Computer science ,Applied mathematics ,Function (mathematics) ,business ,Energy (signal processing) - Published
- 2016
50. The Study on Software Fault Tolerance
- Author
-
XuDong Li, Hai Lu, and Li Qing Li
- Subjects
Command pattern ,Java ,business.industry ,Computer science ,Design pattern ,Real-time computing ,General Medicine ,Software ,Software fault tolerance ,Strategy pattern ,Embedded system ,Fault coverage ,Redundancy (engineering) ,business ,computer ,Rollback ,computer.programming_language - Abstract
Software Fault -tolerance is an effective and reliable design technique and Recovery Block Scheme is an important Software Fault-tolerant measure. Here is the brief introduction of the implementation of Software Fault-tolerant technique and the design pattern by employing software redundancy and then proposes the implementation of Recovery Block Scheme. Firstly, based on the program block’s fault captured by exception-progressing mechanism, it applies the Command Pattern and Active Objective Pattern to manage and schedule arithmetic unit to achieve rollback, clears the data generated by fault operation block and restores to the state before the operation. The design pattern provides a widely available recovery block schemes design pattern, simplifies the implementation of arithmetic unit and gives the core algorithm through Java.
- Published
- 2012
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