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Aim: To explore the risk factors of prolonged viral shedding time (VST) in critical/non-critical COVID-19 patients during hospitalization. Methods: In this retrospective study, we enrolled 363 patients with SARS-CoV-2 infection admitted in a designated hospital during the COVID-19 outbreak in Nanjing Lukou International Airport. Patients were divided into critical (n = 54) and non-critical (n = 309) groups. We analyzed the relationship between the VST and demographics, clinical characteristics, medications, and vaccination histories, respectively. Results: The median duration of VST was 24 d (IQR, 20–29) of all patients. The VST of critical cases was longer than non-critical cases (27 d, IQR, 22.0–30.0 vs. 23 d, IQR 20–28, P

Objective: To systematically evaluate the clinical efficacy of Wendan Decoction series combined with conventional western medicine in the treatment of coronary heart disease complicated with anxiety and depression. Methods: We searched four Chinese databases including CNKI, WanFang, VIP, SinoMed, and five English databases of PubMed, Cochrane Library, Web of Science, EMBASE, Springer Link for clinical randomized controlled trials of using Wendan Decoction series in the treatment of coronary heart disease complicated with anxiety and depression. Time range for searching was from the establishment of these databases to January 2022. Then we screened the retrieved literature according to the inclusion and exclusion criteria, and conducted data extraction and quality evaluation of the selected literature. Meta analysis was conducted using RevMan 5.3 software. Results: A total of 13 RCT studies and 1 007 patients with coronary heart disease complicated with anxiety and depression were included. Meta-analysis showed that Wendan Decoction series combined with conventional western medicine treatment showed better effects in the improvement rate of clinical anxiety [RR=1.21, 95% CI=(1.12,1.31), P<0.000 01], the improvement rate of depression [RR=1.30, 95% CI=(1.10,1.53), P=0.002], the improvement rate of angina pectoris [RR=1.28, 95% CI=(1.13,1.44), P<0.000 1], increasing the ECG improvement rate [RR=1.29, 95% CI=(1.07, 1.55), P=0.008], increasing the rate of reducing nitroglycerin usage [RR=1.68, 95% CI=(1.25,2.25, P=0.000 6], as well as increasing the improvement rate of TCM symptoms [RR=1.15, 95% CI=(1.04, 1.26), P=0.004]. It also showed better effects in reducing clinical anxiety and depression scores (SAS, SDS, HAMA, HAMD), SAQ scores and TCM symptom scores. The differences were statistically significant. Conclusion: Wendan Decoction series combined with conventional western medicine shows advantages in treating coronary heart disease patients complicated with anxiety and depression in reducing the angina pectoris score, anxiety and depression score, as well as improving the clinical TCM symptoms. [ABSTRACT FROM AUTHOR]

Background: Thyroid hormones (THs) have been found that it is closely associated with the onset and progression of non-alcoholic fatty liver disease (NAFLD). However, the current study could not verify the intrinsic relationship between thyroid hormones and NAFLD, which requires further research., Methods: The searches of studies reported both TH level in serum and NAFLD were performed in PubMed, Web of Science, Cochrane Library, and Embase databases. We combined an overall meta-analysis with a dose-response meta-analysis to assess the correlation and dose-response relationship between thyroid function levels and the risk of NAFLD., Results: Overall, 10 studies were included with a total of 38,425 individuals. We found that the non-linear dose-response model showed that for every 1 ng/dL increase in FT4, the risk of NAFLD was reduced by 10.56% (p=0.003). The odds ratios (ORs) for NAFLD with high free triiodothyronine (FT3) exposure compared to those with low FT3 were 1.580 (95% CI 1.370 to 1.830, I2 = 0.0%, p<0.001) in the overall meta-analysis. The continuous variable meta-analysis indicated that individuals with high levels of TSH (SMD=1.32, 95% CI 0.660 to 1.970, p<0.001) had significantly higher levels of liver fibrosis than those with low levels., Conclusions: Our findings only validate that there is a correlation between the occurrence of NAFLD and abnormal levels of THs, and it is expected that more observational studies will still be conducted in the future to further demonstrate the relationship between thyroid hormones and NAFLD., Trial Registration: Registered number in PROSPERO: CRD42023405052., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Xiang, Cao, Sun, Li, Qi, Zhang, Zhang, Yan and Zhou.)

Aggregation-induced emission (AIE) is an attractive phenomenon in which materials display strong luminescence in the aggregated solid states rather than in the conventional dissolved molecular states. However, highly luminescent inks based on AIE are hard to be obtained because of the difficulty in finely controlling the crystallinity of AIE materials at nanoscale. Herein, we report the preparation of highly luminescent inks via oil-in-water microemulsion induced aggregation of Cu-I hybrid clusters based on the highly soluble copper iodide-tris(3-methylphenyl)phosphine (Cu 4 I 4 (P-(m-Tol) 3 ) 4 ) hybrid. Furthermore, we can synthesize a series of AIE inks with different light-emission colors to cover the whole visible spectrum range via a facile ligand exchange processes. The assemblies of Cu-I hybrid clusters with AIE characteristics will pave the way to fabricate low-cost highly luminescent inks., (© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)