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Picture fuzzy set is an extension of intuitionistic fuzzy set, which can deal with inconsistent and uncertain information more accurately. Similarity measure, as an important mathematical tool to evaluate the degree of similarity between picture fuzzy sets, has been widely used to deal with multi-attribute decision-making problems. But there are unreasonable and counter-intuitive cases due to a few undesirable properties. In order to handle these unreasonable cases, this paper proposes a parametric similarity measure based on three parameters m1, m2 and m3, in which decision makers with different decision styles can obtain the appropriate similarity measure by adjusting parameters m1, m2 and m3. Moreover, we analyze some existing similarity measures from the perspective of mathematics and show that the proposed similarity measure is effective by numerical examples. In the end, we use the proposed similarity measure to solve the problems of multi-attribute decision-making. Through the comparison and analysis, we find that the proposed similarity measure is more effective than some existing similarity measures between picture fuzzy sets. [ABSTRACT FROM AUTHOR]

OBJECTIVE: In this study, the regulatory mechanism of miR-22-3p/AKT3 in the development of Wilms' tumor (WT) was investigated. PATIENTS AND METHODS: Twenty-seven pairs of surgical tumor specimens and adjacent normal tissues were obtained from Jining No. 1 People's Hospital. The expression level of miR-22-3p in WT tissues and cell lines was measured by quantitative RT-PCR. MTT and transwell assays were performed to analyze cell proliferation and invasion in WT. The relationship between miR-22-3p and AKT3 was verified by a Dual-Luciferase assay. The protein expression of AKT3 was evaluated by Western blotting analysis. RESULTS: MiR-22-3p was downregulated and AKT3 was upregulated in WT. Functionally, overexpression of miR-22-3p inhibited cell proliferation and invasion in WT. Moreover, miR-22-3p directly targets AKT3. The knockdown of AKT3 suppressed cell proliferation and invasion in WT. In addition, upregulation of AKT3 restored the tumor suppressive effect of miR-22-3p in WT. CONCLUSIONS: MiR-22-3p inhibits the proliferation and invasion of WT cells by downregulating AKT3, indicating that miR-22-3p may be developed as a new biomarker for the diagnosis of WT. [ABSTRACT FROM AUTHOR]

The present paper studies fuzzy matroids in view of degree. First we generalize the notion of (L,M)-fuzzy independent structure by introducing the degree of M-fuzzy family of independent L-fuzzy sets with respect to a mapping from LX to M. Such kind of degrees is proved to satisfy some axioms similar to those satisfied by (L,M)-fuzzy independent structure. Then we define and study some special degrees (e.g. quotient degrees and isomorphism degrees) with respect to mappings between two (L,M)-fuzzy matroid-like spaces in details. Finally we give characterizations of these degrees and investigate relationships between them. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To investigate the role and regulate the target of miRNA-411 on spinal cord injury. MATERIALS AND METHODS: The microglia cultured in vitro was activated by lipopolysaccharide (LPS) to express the inflammatory phenotype. The inflammatory response through miRNA-411 transfection in microglia was measured to certain whether increased miRNA-411 suppressed interleukin-18 (IL-18) level to attenuate the inflammation amplification via downregulating JNK pathway. Furthermore, we established spinal cord injury (SCI) model in SD rats and further explored the glial inflammatory degree and neurological recovery following miRNA-411 treatment. Lastly, we estimated the hindlimbs function of SCI rats with miRNA-411 administration or not within four weeks at post-SCI. RESULTS: In vitro, miRNA-411 inhibited IL-18 expression and downregulated JNK pathway, along with that inflammatory microglia were declined. In SCI rats, we detected the decreased amounts of inflammatory microglia and reduction of the inflammatory factors after miRNA-411 treatment. IL-18 and JNK pathway was also restrained resulted from increased miRNA-411. In addition, apoptosis degree in injury site reduced and survived axons were relatively multiple in the miRNA-411 group compared with the SCI group. The Basso-Beattie-Bresnahan (BBB) locomotor scores of miRNA-411 treated rats were superior to those in rats with no treatment. CONCLUSIONS: MiRNA-411 increase ameliorates the inflammatory microglia-induced neurological lesion and promotes neural recovery by JNK pathway inhibition via negative targeting IL-18 in SCI. [ABSTRACT FROM AUTHOR]

In the wake of the stronger and stronger development of carbon market, the carbon price fluctuation has drawn the attention of researchers, encouraging numerous researchers involved in the carbon price study. Owing to the strongly nonstationary and nonlinear characteristics of carbon price, most of existing approaches failed to forecast the carbon price perfectly. In our study, a novel hybrid forecasting model is presented to forecast the carbon price. Variational mode decomposition (VMD) and independent component analysis (ICA) are utilized to preprocess the chosen data for getting the independent components. Then the independent components are trained by radial basis function neural network (RBFNN) to predict them respectively. Finally, the forecasting result is obtained by linear combination. In addition, the numerical results show that the VMD-ICA-RBFNN model outperforms wavelet-based NN, VMD-RBFNN, EMD-ICA-RBFNN, RBFNN, ARIMA-GARCH and ARIMA models. [ABSTRACT FROM AUTHOR]