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41 results on '"Li, Tingsheng"'

1. First and Second Generation γ-Secretase Modulators (GSMs) Modulate Amyloid-β (Aβ) Peptide Production through Different Mechanisms

Author

Borgegard, Tomas, Juréus, Anders, Olsson, Fredrik, Rosqvist, Susanne, Sabirsh, Alan, Rotticci, Didier, Paulsen, Kim, Klintenberg, Rebecka, Yan, Hongmei, Waldman, Magnus, Stromberg, Kia, Nord, Johan, Johansson, Jonas, Regner, Anna, Parpal, Santiago, Malinowsky, David, Radesater, Ann-Cathrin, Li, Tingsheng, Singh, Rajeshwar, Eriksson, Hakan, and Lundkvist, Johan

Published
2012
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23. Highly sensitive fluorescence and SERS detection of azide through a simple click reaction of 8-chloroquinoline and phenylacetylene.

Author

Zeng, Qing, Ye, Lingling, Ma, Lu, Yin, Wenqing, Li, Tingsheng, Liang, Aihui, and Jiang, Zhiliang

Abstract

In 0.19 mol/L acetic acid (HAc), a click reaction of 8-chloroquinoline/azide/phenylacetylene take places in aqueous solution without Cu(I) as a catalyst. 8-Chloroquinoline (CQN) exhibited a strong fluorescence peak at 430 nm that was quenched linearly as the concentration of azide increased from 20 to 1000 ng/mL. This quenching was due to consumption of CQN in the click reaction and a decrease in the number of efficiently excited photons due to the presence of triazole-quinoline ramification molecules with strong hydrophobicity. Using blue nanosilver sol as the substrate, CQN absorbed onto the surface of nanosilver particles, showing a strong surface-enhanced Raman scattering (SERS) peak at 1585 cm-1 that decreased linearly as the azide concentration increased from 8 to 500 ng/mL; the detection limit was 4 ng/mL. Thus, two new, simple and sensitive fluorescence and SERS methods have been developed for the determination of azide via the click reaction. Copyright © 2014 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Published
2015
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24. Ketopiperazine-based renin inhibitors: Optimization of the “C” ring

Author

Holsworth, Daniel D., primary, Cai, Cuiman, additional, Cheng, Xue-Min, additional, Cody, Wayne L., additional, Downing, Dennis M., additional, Erasga, Noe, additional, Lee, Chitase, additional, Powell, Noel A., additional, Edmunds, Jeremy J., additional, Stier, Michael, additional, Jalaie, Mehran, additional, Zhang, Erli, additional, McConnell, Pat, additional, Ryan, Michael J., additional, Bryant, John, additional, Li, Tingsheng, additional, Kasani, Aparna, additional, Hall, Eric, additional, Subedi, Rajendra, additional, Rahim, Mohammad, additional, and Maiti, Samarendra, additional

Published
2006
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34. A Label-Free Nanogold DNAzyme-Cleaved Surface-Enhanced Resonance Raman Scattering Method for Trace UO Using Rhodamine 6G as Probe.

Author

Jiang, Zhiliang, Yao, Dongmei, Wen, Guiqing, Li, Tingsheng, Chen, Bin, and Liang, Aihui

Subjects
SURFACE enhanced Raman effect, RHODAMINES, DNA, BUFFER solutions, SUBSTRATES (Materials science)
Abstract

In pH 5.5 2-( N-morpholino)-ethanosulfonic acid buffer solution containing 0.25 M NaCl at 80 °C, the single-stranded substrate DNA hybridizes with the enzyme DNA to form double-stranded DNA (dsDNA). The substrate chain of dsDNA could be cracked catalytically by UO to produce a short single-stranded DNA (ssDNA) that adsorbed on the nanogold (NG) surface to form a stable nanogold-ssDNA conjugate and then further combine with rhodamine 6G (RhG) to form a NG-ssDNA-RhG conjugate that can be monitored by the surface-enhanced resonance Raman scattering (SERRS) spectral technique at 1,360 cm. Under the selected conditions, the increased SERRS intensity Δ I was linear to UO concentration in the range of 5-125 nmol/L, with a detection limit of 1.6 nmol/L. Using a 0.5-μmol/L Hg as enhancer, a 2.5-100-nmol/L UO can be determined. [ABSTRACT FROM AUTHOR]

Published
2013
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37. A Highly Sensitive Resonance Scattering Spectral Assay for Hg2+ Based on the Aptamer-Modified AuRu Nanoparticle-NaClO3-NaI-Cationic Surfactant Catalytic Reaction.

Author

Liang, Aihui, Zhang, Jing, Cai, Wei, Jiang, Zhiliang, Li, Tingsheng, Yao, Junen, and Shang, Guangyi

Subjects
GOLD alloys, NANOPARTICLES, SCATTERING (Physics), SPECTRUM analysis, MERCURY, SURFACE active agents, CATIONS, CATALYSIS, CHEMICAL reactions, SODIUM compounds
Abstract

Gold ruthenium (AuRu) nanoparticles were modified by single strand DNA (ssDNA) to prepare an aptamer AuRu nanoprobe (AuRussDNA) for Hg2+. The nanoprobe reacted with Hg2+ to form double-stranded T-Hg2+-T mismatches, and the released AuRu nanoparticles aggregated to big particles, which induced an increase in the resonance scattering (RS) signal at 592 nm. The RS signal was linear to the concentration of Hg2+ in the range of 0.0067-3.3 nmol L-1. Using the AuRussDNA in filtration solution as a catalyst, a new catalytic RS assay was proposed for detection of trace Hg2+. This method was applied for the determination of Hg2+ in real samples. [ABSTRACT FROM AUTHOR]

Published
2011
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38. Synergistic oxidation of cyclohexane and hydrogen sulfide under Gif conditions

Author

H. R. Barton, Derek, Li, Tingsheng, and MacKinnon, John

Abstract

Saturated hydrocarbons and hydrogen sulfide can be synergistically oxidised by oxygen (or air) to give efficiently ketones (and the corresponding alcohols) and sulfur in the presence of a Gif catalyst based on FeII, picolinic acid and 4-tert-butylpyridine with acetonitrile as solvent at room temperature and nearly neutral pH.

Published
1997
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41. Highly sensitive fluorescence and SERS detection of azide through a simple click reaction of 8-chloroquinoline and phenylacetylene.

Author

Zeng Q, Ye L, Ma L, Yin W, Li T, Liang A, and Jiang Z

Subjects
Acetylene chemistry, Azides chemistry, Catalysis, Click Chemistry, Copper chemistry, Fluorescence, Lasers, Limit of Detection, Sensitivity and Specificity, Silver chemistry, Spectrometry, Fluorescence, Acetylene analogs & derivatives, Azides analysis, Quinolines chemistry, Spectrum Analysis, Raman methods
Abstract

In 0.19 mol/L acetic acid (HAc), a click reaction of 8-chloroquinoline/azide/phenylacetylene take places in aqueous solution without Cu(I) as a catalyst. 8-Chloroquinoline (CQN) exhibited a strong fluorescence peak at 430 nm that was quenched linearly as the concentration of azide increased from 20 to 1000 ng/mL. This quenching was due to consumption of CQN in the click reaction and a decrease in the number of efficiently excited photons due to the presence of triazole-quinoline ramification molecules with strong hydrophobicity. Using blue nanosilver sol as the substrate, CQN absorbed onto the surface of nanosilver particles, showing a strong surface-enhanced Raman scattering (SERS) peak at 1585 cm(-1) that decreased linearly as the azide concentration increased from 8 to 500 ng/mL; the detection limit was 4 ng/mL. Thus, two new, simple and sensitive fluorescence and SERS methods have been developed for the determination of azide via the click reaction., (Copyright © 2014 John Wiley & Sons, Ltd.)

Published
2015
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