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1,249 results on '"Li, Xiao-Jun"'

3. Trimodal single-cell profiling reveals a novel pediatric CD8αα+ T cell subset and broad age-related molecular reprogramming across the T cell compartment

Author

Thomson, Zachary, He, Ziyuan, Swanson, Elliott, Henderson, Katherine, Phalen, Cole, Zaim, Samir Rachid, Pebworth, Mark-Phillip, Okada, Lauren Y., Heubeck, Alexander T., Roll, Charles R., Hernandez, Veronica, Weiss, Morgan, Genge, Palak C., Reading, Julian, Giles, Josephine R., Manne, Sasikanth, Dougherty, Jeanette, Jasen, C. J., Greenplate, Allison R., Becker, Lynne A., Graybuck, Lucas T., Vasaikar, Suhas V., Szeto, Gregory L., Savage, Adam K., Speake, Cate, Buckner, Jane H., Li, Xiao-jun, Bumol, Thomas F., Wherry, E.John, Torgerson, Troy R., Vella, Laura A., Henrickson, Sarah E., Skene, Peter J., and Gustafson, Claire E.

Published
2023
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6. Author Correction: Trimodal single-cell profiling reveals a novel pediatric CD8αα+ T cell subset and broad age-related molecular reprogramming across the T cell compartment

Author

Thomson, Zachary, He, Ziyuan, Swanson, Elliott, Henderson, Katherine, Phalen, Cole, Zaim, Samir Rachid, Pebworth, Mark-Phillip, Okada, Lauren Y., Heubeck, Alexander T., Roll, Charles R., Hernandez, Veronica, Weiss, Morgan, Genge, Palak C., Reading, Julian, Giles, Josephine R., Manne, Sasikanth, Dougherty, Jeanette, Jasen, C. J., Greenplate, Allison R., Becker, Lynne A., Graybuck, Lucas T., Vasaikar, Suhas V., Szeto, Gregory L., Savage, Adam K., Speake, Cate, Buckner, Jane H., Li, Xiao-jun, Bumol, Thomas F., Wherry, E.John, Torgerson, Troy R., Vella, Laura A., Henrickson, Sarah E., Skene, Peter J., and Gustafson, Claire E.

Published
2024
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25. Validation of Serum Test for Advanced Liver Fibrosis in Patients With Nonalcoholic Steatohepatitis

Author

Loomba, Rohit, Jain, Anjali, Diehl, Anna Mae, Guy, Cynthia D, Portenier, Dana, Sudan, Ranjan, Singh, Seema, Faulkner, Claire, Richards, Lisa, Hester, Kelly D, Okada, Lauren, Li, Xiao-Jun, Mimms, Larry, and Abdelmalek, Manal F

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Hepatitis, Chronic Liver Disease and Cirrhosis, Digestive Diseases, Liver Disease, Detection, screening and diagnosis, 4.1 Discovery and preclinical testing of markers and technologies, Good Health and Well Being, Adult, Algorithms, Area Under Curve, Biopsy, Female, Humans, Hyaluronic Acid, Liver Cirrhosis, Male, Middle Aged, Non-alcoholic Fatty Liver Disease, ROC Curve, Reproducibility of Results, Retrospective Studies, Severity of Illness Index, Tissue Inhibitor of Metalloproteinase-1, alpha-Macroglobulins, Patient Stratification, NPV, Steatohepatitis, NASH, Gastroenterology & Hepatology, Clinical sciences
Abstract

Background & aimsWe analyzed markers of fibrosis in serum samples from patients with nonalcoholic fatty liver disease (NAFLD), assessed by liver biopsy. We used serum levels of markers to develop an algorithm to discriminate patients with advanced fibrosis from those with mild or moderate fibrosis and validated its performance in 2 independent cohorts of patients with NAFLD.MethodsWe performed a retrospective analysis of serum samples from 396 patients with NAFLD and different stages of fibrosis (F0-F4), collected from 2007 through 2017 on the day of liver biopsy (training cohort 1). We measured serum concentrations of alpha-2 macroglobulin (A2M), hyaluronic acid (HA), and TIMP metallopeptidase inhibitor 1 (TIMP1), and used measurements to develop an algorithm that could discriminate patients with NAFLD with advanced fibrosis (F3-F4; 24.1% of cohort) from those with mild or moderate fibrosis (F0-F2; 79.5% of cohort). We validated the algorithm using serum samples collected from a separate 396 patients from the same time period and location (validation cohort 1), as well as 244 patients with NAFLD evaluated at a separate location, from 2011 through 2017, within a median of 11 days of liver biopsy (cohort 2).ResultsThe algorithm identified patients with advanced fibrosis vs mild or moderate fibrosis in training cohort 1 with an area under the receiver operating characteristic (AUROC) curve of 0.867 (95% CI, 0.827-0.907), 84.8% sensitivity (95% CI, 75.5%-91.0%), and 72.3% specificity (95% CI, 66.9%-77.3%), at a cutoff score of 17. The AUROC for the combined validation cohorts 1 and 2 (n=640) was 0.856 (95% CI, 0.820-0.892), identifying patients with 79.7% sensitivity (95% CI, 71.9%-86.2%) and 75.7% specificity (95% CI, 71.8%-79.4%) at the predetermined cutoff score of 17. The algorithm had negative predictive values that ranged from 92.5% to 94.7% in the validation cohorts; it correctly classified 90.0% of F0 samples, 75.0% of F1 samples, 77.4% of F3 samples, and 94.4% of F4 samples.ConclusionWe developed an algorithm that identifies patients with advanced fibrosis from those with mild to moderate fibrosis in patients with NAFLD with an AUROC value of approximately 0.86, based on levels of serum biomarkers. We validated the findings in 2 separate sets of patients with biopsy-proven NAFLD. The algorithm can be used non-invasively to determine risk of advanced fibrosis in patients with NAFLD.

Published
2019

30. Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus

Author

Duy, Phan Q., Weise, Stefan C., Marini, Claudia, Li, Xiao-Jun, Liang, Dan, Dahl, Peter J., Ma, Shaojie, Spajic, Ana, Dong, Weilai, Juusola, Jane, Kiziltug, Emre, Kundishora, Adam J., Koundal, Sunil, Pedram, Maysam Z., Torres-Fernández, Lucia A., Händler, Kristian, De Domenico, Elena, Becker, Matthias, Ulas, Thomas, Juranek, Stefan A., Cuevas, Elisa, Hao, Le Thi, Jux, Bettina, Sousa, André M. M., Liu, Fuchen, Kim, Suel-Kee, Li, Mingfeng, Yang, Yiying, Takeo, Yutaka, Duque, Alvaro, Nelson-Williams, Carol, Ha, Yonghyun, Selvaganesan, Kartiga, Robert, Stephanie M., Singh, Amrita K., Allington, Garrett, Furey, Charuta G., Timberlake, Andrew T., Reeves, Benjamin C., Smith, Hannah, Dunbar, Ashley, DeSpenza, Jr., Tyrone, Goto, June, Marlier, Arnaud, Moreno-De-Luca, Andres, Yu, Xin, Butler, William E., Carter, Bob S., Lake, Evelyn M. R., Constable, R. Todd, Rakic, Pasko, Lin, Haifan, Deniz, Engin, Benveniste, Helene, Malvankar, Nikhil S., Estrada-Veras, Juvianee I., Walsh, Christopher A., Alper, Seth L., Schultze, Joachim L., Paeschke, Katrin, Doetzlhofer, Angelika, Wulczyn, F. Gregory, Jin, Sheng Chih, Lifton, Richard P., Sestan, Nenad, Kolanus, Waldemar, and Kahle, Kristopher T.

Published
2022
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32. Two new species of Ganoderma (Ganodermataceae, Basidiomycota) from Southwest China.

Author

He, Jun, Li, Xiao-Jun, Tan, Wan-Zhong, Wu, Xiao-Qu, Wu, Dan, Luo, Zong-Long, Zhou, Qi Wu, Li, E-Xian, and Li, Shu-Hong

Abstract

Ganoderma is a large and diverse genus containing fungi that cause white rot to infect a number of plant families. This study describes G. phyllanthicola and G. suae as new species from Southwest China, based on morphological and molecular evidence. Ganoderma phyllanthicola is characterized by dark brown to purplish black pileus surface with dense concentric furrows, pale yellow margin, irregular pileipellis cells, small pores (5–7 per mm) and ellipsoid to sub-globose basidiospores (8.5–10.0 × 6.0–7.5 µm). Ganoderma suae is characterized by reddish brown to oxblood red pileus surface and lead gray to greyish-white pore surface, heterogeneous context, wavy margin and almond-shaped to narrow ellipsoid basidiospores (8.0–10.5 × 5.0–7.0 μm). The phylogeny of Ganoderma is reconstructed with multi-gene sequences: the internal transcribed spacer region (ITS), the large subunit (nrLSU), translation elongation factor 1-α gene (TEF-1α) and the second subunit of RNA polymerase II (RPB2). The results show that G. suae and G. phyllanthicola formed two distinct line-ages within Ganoderma. Descriptions, illustrations and phylogenetic analyses results of the two new species are presented. [ABSTRACT FROM AUTHOR]

Published
2024
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34. High temperature resistant aging stability of lead-free solder joints by TLP bonding

Author

LI Zheng-bing, WANG De, HU De-an, CHEN Yi-ping, CHENG Dong-hai, GUO Yi-le, HE Kai, HUANG Shuo, and LI Xiao-jun

Subjects
snagcu composite solder, reflow welding, transient liquid phase bonding, ag particle, Materials of engineering and construction. Mechanics of materials, TA401-492
Abstract

The Sn4.7Ag1.7Cu+Ag composite solder/Cu joint was prepared with Sn4.7Ag1.7Cu+Ag composite solder by transient liquid phase (TLP) bonding process.The microstructure of the joints under constant temperature aging was observed by SEM, combined with EDS, the microstructure and properties of the joints under different processes were compared and analyzed. The results show that the service performance of Sn4.7Ag1.7Cu+Ag/Cu joint at high temperature (300℃) is improved with the increase of Ag particle content. When the content of Ag is 25% (mass fraction), the joint does not break after 15 days of service at 83℃ higher than the melting point (217℃) of the base solder, and the tensile strength is 25.74 MPa, which achieves the purpose of low-temperature welding and high-temperature service. Comparing with Sn4.7Ag1.7Cu/Cu joints under reflow welding, with the aging process, the residual Ag particles in Sn4.7Ag1.7Cu+Ag composite solder/Cu joint are dissolved and a large number of Ag3Sn compounds are produced near the interface of the joint. A large number of bulk Ag3Sn compounds can effectively inhibit the diffusion of Sn into the Cu substrate and achieve the purpose of inhibiting the growth of the Cu3Sn layer.Under the condition of service temperature of 200℃, with the aging process, the mechanical properties of the Sn4.7Ag1.7Cu+Ag composite solder/Cu joint first decrease and then increase, then decrease to a stable state, and its mechanical properties are better than that of the Sn4.7Ag1.7Cu/Cu joint.

Published
2021
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39. A constitutive model considering post-liquefaction deformation based on the logarithmic skeleton curve

Author

DONG Qing, ZHOU Zheng-hua, SU Jie, LI Xiao-jun, and HAO Bing

Subjects
logarithmic skeleton curve, effective stress, liquefaction of saturated sand, loading-unloading rules, large deformation constitutive model, Engineering geology. Rock mechanics. Soil mechanics. Underground construction, TA703-712
Abstract

Most of the constitutive model for liquefaction analysis cannot simulate the large post-liquefaction deformation of saturated sand, and there is little research on the nonlinear time-domain large deformation constitutive relationships suitable for seismic response analysis of saturated sand sites. In this paper, a feasible, simple and applicable large deformation constitutive model for time domain analysis is proposed through experimental analysis and theoretical research. The post-liquefaction stress-strain relationships of liquefied sand are obtained based on the undrained cyclic triaxial test data, then loading-reloading rules of large post-liquefaction deformation are proposed. Combined with the effective stress constitutive model based on logarithmic skeleton curve, a constitutive model that can quantitatively describe the large deformation of saturated sand liquefaction is proposed. According to the test results, the constitutive model can simulate small to large deformations from the pre-to post-liquefaction regime of sand. This constitutive model is also implemented to the program Soilresp1D for the dynamic response analysis of liquefiable soil sites. The results show that the time domain nonlinear large deformation unified constitutive model based on the logarithmic dynamic skeleton curve, effective stress-modified logarithmic dynamic skeleton constitutive model and liquefaction large deformation constitutive model can be directly applied to the dynamic response analysis of saturated sand.

Published
2021
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42. Multimodal analysis for human ex vivo studies shows extensive molecular changes from delays in blood processing

Author

Savage, Adam K., Gutschow, Miriam V., Chiang, Tony, Henderson, Kathy, Green, Richard, Chaudhari, Monica, Swanson, Elliott, Heubeck, Alexander T., Kondza, Nina, Burley, Kelli C., Genge, Palak C., Lord, Cara, Smith, Tanja, Thomson, Zachary, Beaubien, Aldan, Johnson, Ed, Goldy, Jeff, Bolouri, Hamid, Buckner, Jane H., Meijer, Paul, Coffey, Ernest M., Skene, Peter J., Torgerson, Troy R., Li, Xiao-jun, and Bumol, Thomas F.

Published
2021
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43. Four paradoxes about the special theory of relativity

Author

Li, Xiao-Jun, Chen, Kai, Li, Xiao-Niu, and Li, Yong-An

Subjects
Physics - Popular Physics
Abstract

Various paradoxes about the relativity theory have been developed since the birth of this theory. Each paradox somewhat shows people's query about the relativity theory, and solving of each paradox demonstrates the correctness of relativity theory once again. In this paper, four paradoxes about the special theory of relativity are brought forward: displacement paradox, electromagnetic transformation paradox, Doppler paradox and magnetic force paradox. We hope some researchers can reasonably explain these paradoxes, and then knowledge of the relativity theory will become more abundant., Comment: 12 pages, 7 figures

Published
2016

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