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141 results on '"Li, Yi-Wen"'

14. Comparison of the prophylactic antithrombotic effect of indobufen and warfarin in patients with nephrotic syndrome: a randomized controlled trial.

Author

Gao, Xin-Yi, Liu, Yue-Ming, Zheng, Dan-Na, Li, Yi-Wen, Li, Hua, Xiong, Xiao-Ling, Chen, Hong-Yu, Wang, Hua, Yu, Xiao-Yong, Qu, Kai, Jin, Juan, Lin, Bo, and He, Qiang

Subjects
NEPHROTIC syndrome, RANDOMIZED controlled trials, WARFARIN, THROMBOTIC thrombocytopenic purpura, CEREBRAL embolism & thrombosis, THROMBOEMBOLISM
Abstract

The risk of thromboembolic events is elevated in patients with nephrotic syndrome, and warfarin use has been associated with an increased risk of bleeding. Indobufen, a selective cyclooxygenase-1 inhibitor, is currently being evaluated for the prevention of thromboembolic events in nephrotic syndrome. This study aimed to compare the efficacy and safety of indobufen with that of warfarin in patients with nephrotic syndrome. This multicenter, randomized, three-arm, open-label, parallel controlled trial involved a total of 180 adult patients with nephrotic syndrome from four centers in China. Patients were randomly assigned to receive 100 mg indobufen (bid), 200 mg indobufen (bid), and 3 mg warfarin (qd) daily for 12 weeks. The primary endpoints included thromboembolic and bleeding events, while laboratory results and adverse events constituted secondary endpoints. No thromboembolic events occurred in the high-/low-dose indobufen and warfarin groups. Moreover, the use of a low dose of indobufen significantly reduced the risk of minor bleeding events compared with warfarin use (2% versus 18%, p <.05). Finally, adverse events were more frequent in warfarin-treated patients. This study found that indobufen therapy provided equivalent effects in preventing thromboembolic events compared with warfarin therapy, while low dose of indobufen was associated with a reduced risk of bleeding events, thus it should be recommended for the prevention of thromboembolic events in clinical practice in patients with nephrotic syndrome. ChiCTR-IPR-17013428. [ABSTRACT FROM AUTHOR]

Published
2023
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17. A Social Recommendation Mechanism for Crowdfunding

Author

Li, Yung-Ming, Liou, Jyh-Hwa, Li, Yi-Wen, van der Aalst, Wil M.P., Series editor, Mylopoulos, John, Series editor, Rosemann, Michael, Series editor, Shaw, Michael J., Series editor, Szyperski, Clemens, Series editor, and Abramowicz, Witold, editor

Published
2017
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22. The crystal structure of 2-bromoisophthalic acid, C8H5BrO4

Author

Li Shu-Jing, Li Ke, and Li Yi-Wen

Subjects
1941305, Physics, QC1-999, Crystallography, QD901-999
Abstract

C8H5BrO4, triclinic, P1̄ (no. 2), a = 4.8161(3) Å, b = 7.3727(5) Å, c = 12.1230(7) Å, α = 81.004(3)°, β = 78.897(3)°, γ = 72.829(3)°, V = 401.30(4) Å3, Z = 2, Rgt(F) = 0.0201, wRref(F2) = 0.0479, T = 150(2) K.

Published
2019
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29. Photocatalytic dicarboxylation of strained CC bonds with CO2viaconsecutive visible-light-induced electron transfer

Author

Liu, Yi, Wang, Zhe-Hao, Xue, Guan-Hua, Chen, Lin, Yuan, Li-Hua, Li, Yi-Wen, Yu, Da-Gang, and Ye, Jian-Heng

Abstract

Dicarboxylic acids have a wide range of applications in the polymer industry to construct valuable materials. Photocatalysis has recently emerged as an efficient and sustainable strategy to generate dicarboxylic acids. However, photocatalytic dicarboxylation with CO2is mainly limited to unsaturated bonds, and the dicarboxylation of CC single bonds still remains a challenge. Herein, we report a photocatalytic dicarboxylation of CC single bonds in strained rings with CO2units viaconsecutive photo-induced electron transfer (ConPET). It is also the first photocatalytic reductive ring-opening reaction of cyclobutanes. Notably, this transition-metal-free protocol exhibits good functional group tolerance, broad substrate scope, facile scalability, and easy product derivatizations. Moreover, diacids can easily be derivatized to main-chain liquid crystalline polyesters.

Published
2024
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