91 results on '"Li, Yu-Tang"'
Search Results
2. Rural-urban Disparities in the Prevalence of Mild Cognitive Impairment and Dementia in Taiwan: A Door-to-door Nationwide Study
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Chih-Ching Liu, Chien-Hui Liu, Yu Sun, Huey-Jane Lee, Li-Yu Tang, and Ming-Jang Chiu
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dementia ,mild cognitive impairment ,prevalence ,risk factors ,urbanization ,Medicine (General) ,R5-920 - Abstract
Background: Screening or diagnosis for the elderly with dementia in rural regions might be delayed and underestimated due to limited utilization of healthcare resources. This study aimed to evaluate the disparities of prevalence and risk factors of mild cognitive impairment (MCI) and dementia between urban and rural residence. Methods: In this nationwide door-to-door survey, 10,432 participants aged 65 years and more were selected through computerized random sampling from all administrative districts in Taiwan and were assessed using an in-person interview. We calculated the prevalence of MCI and dementia, with their risk factors examined using multivariable logistic regression. Results: The prevalence of dementia in rural, suburban, and urban areas among the elderly was 8.69% (95% CI, 8.68–8.69), 6.63% (95% CI, 6.62–6.63), and 4.46% (95% CI, 4.46–4.47), respectively. A similar rural-suburban-urban gradient relationship on the dementia prevalence was observed in any age and sex group. The rural:urban ratio was higher in women than in men for both MCI and dementia. Urbanization remained to be an independent factor for both MCI and dementia after adjustment for age, gender, education, lifestyle, and health status. The beneficial effects of exercise on dementia were more evident in rural areas than in urban ones. Conclusion: Significantly higher prevalence of MCI and dementia were found in rural areas than in urban ones, especially for women. The odds of risk factors for MCI and dementia varied by urbanization status. Focus on the rural-urban inequality and the modification of associated factors specifically for different urbanization levels are needed.
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- 2022
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3. Driving decision-making among older adults with dementia in Taiwan: A longitudinal study
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Mu-Hsing Ho, Hui-Wen Chien, Wei-Chuan Tsai, Ying-Ju Chi, Li-Yu Tang, Victoria Traynor, Megan F. Liu, and Hui-Chen (Rita) Chang
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General Nursing - Published
- 2022
4. [Estimation method of urban green space living vegetation volume based on backpack light detection and ranging]
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Xiao-Xiao, Li, Li-Yu, Tang, Wei, Peng, Jian-Xin, Chen, and Xia, Ma
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Plant Leaves ,Parks, Recreational ,Plants ,Algorithms ,Trees - Abstract
Living vegetation volume (LVV) can objectively and accurately reflect the urban greenery quality, and provide a reliable data foundation for the quantitative study aiming to reveal the mechanisms underlying urban greenery ecological functions. According to the characteristics of dispersion and small scale of unit affiliated green space, we proposed a LVV estimation scheme for such urban green space, which included data acquisition, processing, entity segmentation, classification, single tree canopy extraction, and LVV calculation. First, point cloud data was obtained with a backpack LiDAR system, and the ground point clouds were eliminated by a multi-scale algorithm. Second, the Density Based Spatial Clustering of Application with Noise (DBSCAN) algorithm was used to cluster the non-ground point clouds, and density feature-based competitive algorithm was used to re-segmented for the overlapping area to generate independent objects. Third, the PointNet++ network model was used to extracted plant point clouds. Then, the canopy point clouds were extracted using the similarity of principal direction between neighboring points and distribution density of branch and leaf points. Finally, the LVV of individual tree canopy was calculated by the convex hull method, and then the LVV of the accessory greenland was summed up. Taking a science and technology park as an example, its total LVV was 21034.95 m三维绿量能够客观、准确描述城市绿化水平,可为定量研究城市绿地生态功能的机理提供可靠的数据基础。针对单位附属绿地分布分散、规模较小等特点,本研究提出一种面向该类城市绿地的三维绿量估算方案,该方案包括数据获取、处理、实体分割、分类和单木冠层提取以及三维绿量计算的环节。首先,利用背包式激光雷达测量系统获取三维点云数据,利用变尺度地面点滤波算法剔除地面点云;然后,利用基于密度的聚类算法对非地面点云进行聚类,且基于密度特征的竞争算法对重叠区域进行二次分割,形成独立对象;接着,利用PointNet++模型提取植物点云,根据枝叶点云主方向差异性以及轴向分布密度提取冠层点云;最后,使用凸包法计算单木冠层三维绿量,累计每株木的三维绿量得到区域三维绿量。以某科技园区为例,估算其总三维绿量为21034.95 m
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- 2022
5. iLauncher: an intelligent launcher for mobile apps based on individual usage patterns.
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Li-Yu Tang, Pi-Cheng Hsiu, Jiun-Long Huang, and Ming-Syan Chen
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- 2013
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6. Perceptions of community dementia friendliness: A cross‐sectional study of people with dementia, family caregivers, service providers, and the general public in Taiwan
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Hsin-Yi Lin, Hsin-Yun Liu, Jung Lung Hsu, Yea-Ing Lotus Shyu, I-Ching Su, Yi-Hui Lin, Hsiu-Li Huang, Li-Yu Tang, Suh-Mian Wu, and Yi-Chen Chiu
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Gerontology ,Sociology and Political Science ,Cross-sectional study ,Family caregivers ,Health Policy ,Taiwan ,Public Health, Environmental and Occupational Health ,Reproducibility of Results ,Construct validity ,Service provider ,medicine.disease ,Face-to-face ,Cross-Sectional Studies ,Quality of life (healthcare) ,Caregivers ,Convergent validity ,mental disorders ,Quality of Life ,medicine ,Humans ,Dementia ,Psychology ,Social Sciences (miscellaneous) - Abstract
Promoting dementia-friendly communities is an important strategy for improving quality of life for people with dementia and dementia-family caregivers. The process of building dementia-friendly communities should include all people living in the community. The objective of this study was to compare perceived dementia friendliness in the community among people with dementia, family caregivers, service providers, and the general public. In Taiwan, we surveyed 60 people with dementia, 140 family caregivers, and 200 members of the general public face to face, with 200 service providers surveyed by mail. Participants completed the Perceived Community Dementia Friendliness measure, consisting of seven subscales: care services, community members, community environment, community interactions, transportation, hospitals, and stores and organisations. This measure has acceptable convergent validity, construct validity, and internal consistency reliability for use in Taiwan. Differences in perceived dementia friendliness were examined by chi-square tests/analysis of variance. Among the seven subscales, hospitals were rated with good dementia friendliness by 70% of people with dementia (n = 42); however, care services were rated poor by 23.3% of people with dementia (n = 14). Hospitals were also rated with good dementia friendliness by 39.2% of family caregivers (n = 54). Care services were rated as having good dementia friendliness by 43.5% of service providers (n = 87) and 47% of the general public (n = 86). Furthermore, community interactions were rated as good by small percentages of family caregivers (11.4%, n = 16), service providers (22.2%, n = 44), and the general public (30.9%, n = 58). Family caregivers, service providers, and the general public rated hospitals with the highest mean dementia-friendliness score and community interactions with the lowest. Perceived community-dementia friendliness among participants with dementia differed from that of participants without. People with dementia prioritised improving care services, while people without dementia rated facilitating community interactions as more vital. These differences provide vital insights into understanding the policies and administration of dementia-friendly communities.
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- 2021
7. RETRACTED - Risk factors for mild behavioral impairment in non-demented geriatrics: a population-based survey in Taiwan
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Mao-Hsuan Huang, Li-Yu Tang, Yee-Lam E Chan, Chia-Fen Tsai, Huey-Jane Lee, and Chih-Ming Cheng
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Geriatrics ,medicine.medical_specialty ,business.industry ,medicine.disease ,Logistic regression ,Lower risk ,03 medical and health sciences ,Psychiatry and Mental health ,Clinical Psychology ,0302 clinical medicine ,Internal medicine ,Hyperlipidemia ,medicine ,030212 general & internal medicine ,Geriatrics and Gerontology ,Alzheimer's disease ,Underweight ,medicine.symptom ,business ,Gerontology ,Body mass index ,Population based survey ,030217 neurology & neurosurgery - Abstract
Objectives:To investigate potential risk factors for mild behavioral impairment (MBI) among non-demented geriatrics.Design:Population-based, cross-sectional survey.Setting:Taiwan Alzheimer Disease Association (TADA) Database.Participants:Participants were selected by multistage random sampling of all Taiwan counties. They received in-person interviews between December 2011 and March 2013.Measurements:Demographic data, lifestyle and habits, medical comorbidities, cognitive status measured by the Taiwanese Mini-Mental Status Examination (TMSE) and presence of MCI of the participants were collected. Subjects were distributed to the MBI and non-MBI groups. These factors had been evaluated for their effects on MBI in the univariate and multivariable logistic regression models.Results:In total, 6,196 non-demented participants aged 65 years or older, including 409 MBI and 5,787 non-MBI participants, were recruited. After adjustment for age, sex, education, body mass index, lifestyle and habits, medical comorbidities, and MCI, good sleep was associated with lower risk of MBI (OR 0.09, 95% CI 0.07 – 0.12). Low body weight (OR 2.01, 95% CI 1.21–3.33), low-to-medium education (OR 1.40, 95%CI 1.06–1.85; OR 2.32, 95% CI 1.67–3.21), medical comorbidities of hypertension (OR 1.56, 95% CI 1.25–1.95), hyperlipidemia (OR 1.29, 95% CI 1.00–1.67), cancer (OR 2.05, 95% CI 1.37–3.06) were significantly associated with increased MBI risk. MCI neither increased nor decreased risk of MBI (OR 1.00, 95% CI 0.76–1.32).Conclusions:Good sleep was associated with lower MBI risk. Underweight, lower education, medical comorbidities of cancer, hypertension, hyperlipidemia were predictive of MBI.
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- 2021
8. Comorbidity and dementia: A nationwide survey in Taiwan.
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Ting-Bin Chen, Szu-Yu Yiao, Yu Sun, Huey-Jane Lee, Shu-Chien Yang, Ming-Jang Chiu, Ta-Fu Chen, Ker-Neng Lin, Li-Yu Tang, Chung-Chih Lin, and Pei-Ning Wang
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Medicine ,Science - Abstract
BACKGROUND:Comorbid medical diseases are highly prevalent in the geriatric population, imposing hardship on healthcare services for demented individuals. Dementia also complicates clinical care for other co-existing medical conditions. This study investigated the comorbidities associated with dementia in the elderly population aged 65 years and over in Taiwan. METHODS:We conducted a nationwide, population-based, cross-sectional survey; participants were selected by computerized random sampling from all 19 Taiwan counties between December 2011 and March 2013. After exclusion of incomplete or erroneous data, 8,456 subjects were enrolled. Of them, 6,183 were cognitively normal (control group), 1,576 had mild cognitive impairment (MCI), and 697 had dementia. We collected information about types of comorbidities (i.e., vascular risk factors, lung diseases, liver diseases, gastrointestinal diseases, and cancers), Charlson comorbidity index score, and demographic variables to compare subjects with normal cognition, MCI, and dementia. RESULTS:Regardless of the cognitive condition, over 60% of the individuals in each group had at least one comorbid disease. The proportion of subjects possessing at least three comorbidities was higher in those with cognitive impairment (MCI 20.9%, dementia 27.3%) than in control group (15%). Hypertension and diabetes mellitus were the most common comorbidities. The mean number of comorbidities and Charlson comorbidity index score were greater in MCI and dementia groups than in control group. Logistic regression demonstrated that the comorbidities significantly associated with MCI and dementia were cerebrovascular disease (OR 3.35, CI 2.62-4.28), cirrhosis (OR 3.29, CI 1.29-8.41), asthma (OR 1.56, CI 1.07-2.27), and diabetes mellitus (OR 1.24, CI 1.07-1.44). CONCLUSION:Multiple medical comorbid diseases are common in older adults, especially in those with cognitive impairment. Cerebrovascular disease, cirrhosis, asthma, and diabetes mellitus are important contributors to cognitive deterioration in the elderly. Efforts to lower cumulative medical burden in the geriatric population may benefit cognitive function.
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- 2017
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9. Fluctuating interpretations: Striving to maintain a sense of self in early dementia
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Pen-Chen Kung, Huei-Ling Huang, Yea-Ing Lotus Shyu, Li-Yu Tang, Jung-Lung Hsu, and Wen-Chuin Hsu
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Family caregivers ,Perspective (graphical) ,Psychology of self ,medicine.disease ,Grounded theory ,Developmental psychology ,03 medical and health sciences ,0302 clinical medicine ,Caregivers ,Conceptual framework ,Patient-Centered Care ,Intervention (counseling) ,Grounded Theory ,Early dementia ,medicine ,Humans ,Dementia ,030212 general & internal medicine ,Psychology ,Gerontology ,Qualitative Research ,030217 neurology & neurosurgery - Abstract
This study aimed to develop a conceptual framework of the experience of persons living with the early stages of dementia. A grounded theory approach examined the experience from the perspective of the patient. Data were collected from dyads of persons with mild dementia and their family caregivers (N = 17) using face-to-face interviews at three timepoints over a one-year period. Transcribed interviews were analyzed with constant comparative analysis. The core category was “Fluctuating interpretations: striving to maintain one's sense of self.” Interpretations were comprised of three subcategories: being a stranger to oneself, sense-making, and strategies for coexistence. Different situations influenced the process and affected individuals’ attitudes and behaviors. Interpretations were a protective vehicle and stabilizing force that enabled persons with dementia to coexist with disease changes. Perspectives of persons with dementia during the early stages should be considered when designing intervention strategies for patient-centered care.
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- 2021
10. Corrigendum to “Biodiversity increased both productivity and its spatial stability in temperate forests in northeastern China” [Sci. Total Environ. 780 (2021)/146674]
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Gao, Wen-Qiang, primary, Lei, Xiang-Dong, additional, Liang, Mao-Wei, additional, Larjavaara, Markku, additional, Li, Yu-Tang, additional, Gao, Dong-Li, additional, and Zhang, Hui-Ru, additional
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- 2022
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11. Risk factors for mild behavioral impairment in non-demented geriatrics: a population-based survey in Taiwan - RETRACTION
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Yee-Lam E. Chan, Chih-Ming Cheng, Mao-Hsuan Huang, Huey-Jane Lee, Li-Yu Tang, and Chia-Fen Tsai
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Psychiatry and Mental health ,Clinical Psychology ,Geriatrics and Gerontology ,Gerontology - Published
- 2021
12. Mass‐ratio and complementarity effects simultaneously drive aboveground biomass in temperate Quercus forests through stand structure
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Gao, Wen‐Qiang, primary, Lei, Xiang‐Dong, additional, Gao, Dong‐Li, additional, and Li, Yu‐Tang, additional
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- 2021
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13. Green Photothermal Ink for 0D to 3D Solar‐Driven Devices
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Chen, Honglei, primary, Shen, Ting, additional, Li, Yu‐Tang, additional, Chen, Xiaolan, additional, Yang, Hao‐Cheng, additional, and Li, Weihua, additional
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- 2021
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14. Thirty two cases of type 2 diabetes mellitus of qi and yin deficiency treated with laser acupuncture
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ZHANG, Rong-xian, primary, LI, Hong, additional, XIONG, Jia-wei, additional, JIANG, Yong-qu, additional, LI, Yu-tang, additional, and ZHANG, Jian-bin, additional
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- 2021
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15. [Driving Cessation and Mental Health in Persons With Dementia: A Preliminary Study]
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Shu-Hui, Liu, Chia-Chi, Chang, Chaur-Jong, Hu, Mu-Hsing, Ho, Hui-Chen Rita, Chang, Hui-Wen, Chien, Li-Yu, Tang, Su-Yuan, Chan, Victoria, Traynor, and Megan F, Liu
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Cross-Sectional Studies ,Mental Health ,Caregivers ,Activities of Daily Living ,Quality of Life ,Taiwan ,Humans ,Dementia ,Prospective Studies - Abstract
The driving safety of persons with dementia (PwD) is an important public-health issue worldwide. Driving is closely related to personal autonomy, self-esteem, and independence. When PwD lose their driving privileges, this may lead to negative effects on mental health.The purpose of this study was to evaluate the relationship between driving cessation and mental health in PwD.A cross-sectional design with convenient sampling was used, Data were collected using structured questionnaires. Participants were all PwDs who were recruited from a medical center in northern Taiwan.A total of 78 PwD were recruited. Two-fifths (41%) of the participants were still driving, with motorcycle the most common vehicle used. The participants who had retired from driving were older, and most did not have a spouse, were less socially active, had a lower mean level of functional ability, and perceived a lower association between driving and quality of life. Driving cessation was found to be positively correlated with age and the instrumental activities of daily living. Depression and anxiety levels in former drivers were higher than in current drivers, although the differences were not significant.Among PwD, depression and anxiety is higher in former drivers. It is suggested that a prospective study should be conducted, that driving safety issues for PwD should be addressed in public health education, and that standards of driving safety for PwD should be developed and enacted.失智症病人停止駕駛與其心理健康初探.失智症安全駕駛是全球公共衛生關心的主要議題,駕駛與個人自主性、自尊及獨立性有密切相關,一旦失去駕駛權利,則可能產生心理健康的負面效應。.本研究目的旨在探討停止駕駛與失智症病人心理健康之關係。.研究為橫斷式描述性研究,採方便取樣,使用問卷調查法,研究對象為北部某準醫學中心之失智症個案。.本研究共收案78位失智症病人,研究結果發現有41%之失智症病人仍在駕駛,最常使用交通工具為機車,停止駕駛者通常年齡較大、無配偶者較多、沒參與社交活動居多、日常生活功能較差,以及自覺駕駛對生活品質的重要程度較低。失智症病人停止駕駛之相關因子為年齡及工具性日常生活功能;停止駕駛者之憂鬱及焦慮程度較高,但未達統計差異。.由本研究結果可知停止駕駛之失智症病人的憂鬱與焦慮程度較高,建議未來研究可以進行長期追踪研究,以了解停止駕駛之失智病人的心理健康變化及預測因子;安全駕駛議題應納入公共衛生教育,並制定失智症之安全駕駛規範。.
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- 2021
16. Marital Status, Lifestyle and Dementia: A Nationwide Survey in Taiwan.
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Ling-Yun Fan, Yu Sun, Huey-Jane Lee, Shu-Chien Yang, Ta-Fu Chen, Ker-Neng Lin, Chung-Chi Lin, Pei-Ning Wang, Li-Yu Tang, and Ming-Jang Chiu
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Medicine ,Science - Abstract
Evidence of an association between lifestyle and marital status and risk of dementia is limited in Asia.In this nationwide population-based cross-sectional survey, participants were selected by computerized random sampling from all 19 counties in Taiwan. A total of 10432 residents were assessed by a door-to-door in-person survey, among whom 7035 were normal and 929 were diagnosed with dementia using the criteria recommended by National Institute on Aging-Alzheimer's Association. Premorbid lifestyle habits and demographic data including marital status were compared between normal subjects and participants with dementia.After adjustment for age, gender, education, body mass index, smoking, drinking, marital status, sleep habits, exercise, social engagement and co-morbidities including hypertension, diabetes and cerebrovascular diseases, an increased risk for dementia was found in people with widow or widower status (OR 1.42, 95% CI 1.15-1.77) and people who used to take a nap in the afternoon (OR 1.33, 95% CI 1.02-1.72). Decreased risk was found in people with the habit of regular exercise (OR 0.12, 95% CI 0.09-0.16), adequate night sleep (OR 0.55, 95% CI 0.39-0.76) and regular social engagement (OR 0.53, 95% CI 0.36-0.77).Our results provide preliminary evidence of possible risk-reduction effects for dementia, including regular exercise even in modest amounts, social engagement and adequate night sleep, whereas people with the widow/widower status or who used to take an afternoon nap might have increased risk of dementia.
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- 2015
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17. Rural-urban Disparities in the Prevalence of Mild Cognitive Impairment and Dementia in Taiwan: A Door-to-door Nationwide Study
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Huey-Jane Lee, Li-Yu Tang, Chih Ching Liu, Yu Sun, Chien-Hui Liu, and Ming-Jang Chiu
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Male ,Rural Population ,Epidemiology ,Taiwan ,Logistic regression ,Odds ,Risk Factors ,Urbanization ,mental disorders ,Health care ,Prevalence ,Medicine ,Dementia ,Humans ,Cognitive Dysfunction ,Cognitive impairment ,Aged ,business.industry ,General Medicine ,medicine.disease ,Residence ,Female ,Rural area ,business ,Demography - Abstract
Background Screening or diagnosis for the elderly with dementia in rural regions might be delayed and underestimated due to limited utilization of healthcare resources. This study aimed to evaluate the disparities of prevalence and risk factors of mild cognitive impairment (MCI) and dementia between urban and rural residence. Methods In this nationwide door-to-door survey, 10,432 participants aged 65 years and more were selected by computerized random sampling from all administrative districts in Taiwan and were assessed by an in-person interview. We calculated the prevalence of MCI and dementia with their risk factors examined by multivariable logistic regression. Results The prevalence of dementia in rural, suburban, and urban areas among the elderly was 8.69% (95% CI, 8.68-8.69), 6.63% (95% CI, 6.62-6.63), and 4.46% (95% CI, 4.46-4.47), respectively. A similar rural-suburban-urban gradient relationship on the dementia prevalence was observed in any age and sex group. The rural/urban ratio was higher in women than in men for both MCI and dementia. Urbanization remained to be an independent factor for both MCI and dementia after adjustment for age, gender, education, lifestyle, and health status. The beneficial effects of exercise on dementia were more evident in rural areas than in urban ones. Conclusions Significantly higher prevalence of MCI and dementia were found in rural areas than in urban ones, especially for women. The odds of risk factors for MCI and dementia varied between urbanization statuses. Focus on the rural-urban inequality and the modification of associated factors specifically for different urbanization levels are needed.
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- 2021
18. Suspended Membrane Evaporators Integrating Environmental and Solar Evaporation for Oily Wastewater Purification
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Wu, Shao-Lin, primary, Quan, Lu-Na, additional, Huang, Yan-Ting, additional, Li, Yu-Tang, additional, Yang, Hao-Cheng, additional, and Darling, Seth B., additional
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- 2021
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19. Biodiversity increased both productivity and its spatial stability in temperate forests in northeastern China
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Gao, Wen-Qiang, primary, Lei, Xiang-Dong, additional, Liang, Mao-Wei, additional, Larjavaara, Markku, additional, Li, Yu-Tang, additional, Gao, Dong-Li, additional, and Zhang, Hui-Ru, additional
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- 2021
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20. The lncRNA CASC9 alleviates lipopolysaccharide-induced acute kidney injury by regulating the miR-424-5p/TXNIP pathway
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Fan, Hai-Peng, primary, Zhu, Zhi-Xia, additional, Xu, Jia-Jun, additional, Li, Yu-Tang, additional, Guo, Chun-Wen, additional, and Yan, Hong, additional
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- 2021
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21. Sandwich-Structured Photothermal Wood for Durable Moisture Harvesting and Pumping
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Li, Yu-Tang, primary, Chen, Honglei, additional, Deng, Ran, additional, Wu, Ming-Bang, additional, Yang, Hao-Cheng, additional, and Darling, Seth B., additional
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- 2021
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22. Mild cognitive impairment in combination with comorbid diabetes mellitus and hypertension is negatively associated with health-related quality of life among older persons in Taiwan
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Li-Yu Tang, Wen-Che Tsai, Yea-Ing Lotus Shyu, Ming-Jang Chiu, Hsin-Yun Liu, and Huey-Jane Lee
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Adult ,Male ,medicine.medical_specialty ,Population ,Taiwan ,Comorbidity ,Logistic regression ,behavioral disciplines and activities ,Cognition ,Quality of life ,Negatively associated ,Internal medicine ,Diabetes mellitus ,mental disorders ,Diabetes Mellitus ,medicine ,Humans ,Cognitive Dysfunction ,cardiovascular diseases ,Cognitive impairment ,education ,Aged ,Aged, 80 and over ,education.field_of_study ,business.industry ,Public health ,Public Health, Environmental and Occupational Health ,Odds ratio ,Middle Aged ,medicine.disease ,humanities ,Cross-Sectional Studies ,Chronic Disease ,Hypertension ,Linear Models ,Quality of Life ,Female ,business - Abstract
To fill the gap in knowledge about associations of health-related quality of life (HRQoL) with comorbid diabetes mellitus (DM), hypertension (HTN), and/or mild cognitive impairment (MCI) in the elderly, we explored associations of comorbid DM, HTN, and/or MCI with HRQoL. Data for this study were from a population-based cross-sectional survey of elderly Taiwanese (≥ 65 years old). Participants (N = 4,634; 47.9% male) were categorized into eight chronic-illness groups: DM only (n = 224); HTN only (n = 1226); DM and HTN (n = 365); MCI only (n = 497); DM and MCI (n = 58); HTN and MCI (n = 303); DM, HTN, and MCI (n = 101); and none (healthy; n = 1860). Associations were examined between the eight chronic-illness groups and HRQoL (measured by EQ-5D scores) using binary logistic regression analyses and generalized linear models adjusted for covariates. Index scores were calculated from EQ-5D scores using Taiwan’s general population-preference weights. Compared to the healthy group, after adjusting covariates, MCI alone or with other comorbidities was significantly, negatively associated with HRQoL. Among all chronic-illness groups, comorbid DM, HTN, and MCI exhibited the lowest HRQoL. After adjusting covariates, between-group odds ratios for index scores were significant when comparing comorbid DM and MCI to DM only, comparing comorbid HTN and MCI to HTN only and comorbid DM, comparing HTN and MCI to comorbid DM and HTN, suggesting that MCI additively affects HRQoL. HRQoL of older Taiwanese adults was negatively associated with having MCI. Thus, clinicians managing older persons with chronic illnesses should assess their cognitive function to identify high-risk groups needing HRQoL assistance.
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- 2019
23. A nationwide survey of mild cognitive impairment and dementia, including very mild dementia, in Taiwan.
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Yu Sun, Huey-Jane Lee, Shu-Chien Yang, Ta-Fu Chen, Ker-Neng Lin, Chung-Chih Lin, Pei-Ning Wang, Li-Yu Tang, and Ming-Jang Chiu
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Medicine ,Science - Abstract
An increasing population of dementia patients produces substantial societal impacts. We assessed the prevalence of mild cognitive impairment (MCI) and all-cause dementia, including very mild dementia (VMD), in Taiwan. In a nationwide population-based cross-sectional survey, participants were selected by computerized random sampling from all 19 Taiwan counties and were enrolled between December 2011 and March 2013. Cases were identified through in-person interviews based on the National Institute on Aging-Alzheimer's Association clinical criteria. Demographic data and histories involving mental status and function in daily living were collected. The principal objective assessments were the Taiwanese Mental Status Examination and Clinical Dementia Rating. In all, 10,432 people aged 65 years or older (mean age 76.2 ± 6.7, 52.3% women) were interviewed. The age-adjusted prevalence of all-cause dementia was 8.04% (95% CI 7.47-8.61), including a 3.25% (95% CI 2.89-3.61) prevalence of VMD; that of MCI was 18.76% (95% CI 17.91-19.61). Women had a higher prevalence than men of both all-cause dementia (9.71% vs. 6.36%) and MCI (21.63% vs. 15.57%). MCI affects a considerable portion of the population aged 65 and above in Taiwan. The inclusion of VMD yields dementia prevalence rates higher than those previously reported from Taiwan. Old age, female gender, and a low educational level are significant associated factors.
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- 2014
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24. Mandarin version of dementia and driving decision aid (DDDA): Development and stakeholder evaluation in Taiwan
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Megan F. Liu, Hui-Wen Chien, Mu-Hsing Ho, Victoria Traynor, Jed Montayre, Li-Yu Tang, Su-Yuan Chan, and Hui-Chen Rita Chang
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Medical education ,030504 nursing ,Service delivery framework ,Family caregivers ,Taiwan ,Psychological intervention ,Stakeholder ,Cognition ,medicine.disease ,Focus group ,Decision Support Techniques ,03 medical and health sciences ,0302 clinical medicine ,Caregivers ,Surveys and Questionnaires ,medicine ,Humans ,Dementia ,030212 general & internal medicine ,0305 other medical science ,Psychology ,Gerontology ,Competence (human resources) - Abstract
BACKGROUND Dementia causes cognitive and memory difficulties which can reduce the driving safety of the individuals. The decision-making process for driving retirement is challenging, and yet limited guidance is available. OBJECTIVES This article reports the development of the Taiwanese version of dementia and driving decision aid (DDDA) and the evaluation from stakeholders through a dementia and driving education programme. METHODS A multi-method approach was adopted using a pre-test, post-test survey and focus group interviews. A total of 154 healthcare professionals, family caregivers and people with dementia participated education programme, and 12 experts attended the focus group discussion. The survey included demographics, knowledge, confidence, competence and awareness of using DDDA. Participants completed a survey prior and immediately after the education programme. We translated a 32-page interactive DDDA booklet from the original English version to Mandarin. The education programme consisted of three-hour dementia and driving education module delivered both face-to-face and online. RESULTS The majority of participants described the booklet as balanced (91.7%) with the information presented in a 'good' or 'excellent' manner (93.4%). Most participants (85.3%) felt that DDDA helps them in making decisions about driving. Five themes were extracted from the focus group interview: (1) approach targeted to people with dementia, (2) specific content and additional information, (3) culturally appropriate modification, (4) having the right to drive and (5) booklet dissemination. The knowledge, confidence, competence and awareness of using the DDDA increased significantly (p
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- 2021
25. Decision-Making in People With Dementia or Mild Cognitive Impairment: A Narrative Review of Decision-Making Tools
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Su Yuan Chan, Mu-Hsing Ho, Megan F. Liu, Su Hui Liu, Victoria Traynor, Hui Chen Chang, Hui Wen Chien, Li Yu Tang, and Shibu John
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business.industry ,Health Policy ,Clinical study design ,Health Personnel ,Applied psychology ,General Medicine ,Cochrane Library ,medicine.disease ,Critical appraisal ,Systematic review ,Intervention (counseling) ,Health care ,Decision aids ,Medicine ,Dementia ,Humans ,Cognitive Dysfunction ,Geriatrics and Gerontology ,business ,General Nursing - Abstract
Objectives This review summarized the applicability of various decision-making tools for helping people with dementia or mild cognitive impairment (MCI) and their families make decisions. Design This study was a narrative literature review. The protocol of this review was registered in the International Prospective Register of Systematic Reviews (PROSPERO ID: CRD42020182259). Setting and Participants People with dementia or MCI and their families were included in this study. Methods This review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. We searched the Cochrane Library, PubMed, Embase, Cumulative Index to Nursing and Allied Health Literature, and Chinese Electronic Periodical Services databases from inception to May 2021. The Joanna Briggs Institute Critical Appraisal Checklists for a variety of study designs were used. Results Topics related to decision-making were categorized as everyday activity decisions or medical treatment decisions. Various types of decision-making tools were identified, and we observed that decision aids can be modified and used for both everyday activity decisions and medical treatment decisions. In addition to highlighting decision aids for specific decisional issues and topics, we also elucidated other validated tools that can be used to facilitate the decision-making process. Conclusions and Implications This study highlighted the topics involved in decision-making and using decision-making tools. The current review provides information that can help individuals and health care professionals choose optimal decision-making tools. On the basis of our findings, future studies can determine the most appropriate tools for intervention or outcome measures.
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- 2021
26. Stand structure-dependent mass-ratio and complementarity effects simultaneously drive aboveground biomass in temperate Quercus forests
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Gao, Wen-Qiang, primary, lei, xiangdong, additional, Gao, Dong-Li, additional, and Li, Yu-Tang, additional
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- 2021
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27. Dexamethasone attenuates development of monocrotaline-induced pulmonary arterial hypertension
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Wang, Wei, Wang, Yu-lin, Chen, Xiao-ying, Li, Yu-tang, Hao, Wei, Jin, You-peng, and Han, Bo
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- 2011
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28. Keratin 1 attenuates hypoxic pulmonary artery hypertension by suppressing pulmonary artery media smooth muscle expansion
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Yu-Mei Li, Mo-Jun Lin, Xi-Xi Zeng, Xi Yang, Shaokun Chen, Nan Wang, Li Zhang, and Li‐Yu Tang
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0301 basic medicine ,medicine.medical_specialty ,Vascular smooth muscle ,Physiology ,Hypertension, Pulmonary ,Cell ,Myocytes, Smooth Muscle ,Inflammation ,030204 cardiovascular system & hematology ,Pulmonary Artery ,Muscle hypertrophy ,03 medical and health sciences ,0302 clinical medicine ,Downregulation and upregulation ,Internal medicine ,medicine.artery ,medicine ,Animals ,Hypoxia ,Cells, Cultured ,Cell Proliferation ,integumentary system ,Chemistry ,Muscle, Smooth ,Hypoxia (medical) ,Keratin 1 ,Rats ,030104 developmental biology ,medicine.anatomical_structure ,Endocrinology ,Pulmonary artery ,medicine.symptom ,Keratin-1 - Abstract
Aim Abnormally activated vascular smooth muscle cells are key factors in pulmonary artery remodelling (PAR) and pulmonary artery hypertension (PAH). Keratin 1 is involved in inflammatory diseases; however, its role in PAH is unknown. We speculated that keratin 1 could regulate PASMCs and prevent PAH. Methods Rats were exposed to hypoxia (10% O2 ) or MCT (50 mg/kg, intraperitoneal injection) or treated with AAV6 virus. PAR was measured through HE and Masson staining. PASMC activities were measured using MTS assay, EdU and Western blot analyses after cell knockdown with siRNAs or overexpression with Krt1 vectors. Results 1. Hypoxic PAR was associated with a decrease in keratin 1, especially in PASMCs. 2. Keratin 1 knockdown led to cell proliferation, migration and contraction to synthetic transformation, while keratin 1 overexpression attenuated hypoxia-induced changes in PASMCs. 3. Decreased keratin 1 induced TLR7 upregulation and mediated increases in the inflammatory factors S100a8 and S100a9. 4. Keratin 1 overexpression reduced the inflammatory factor expression induced by TLR7 activation. 5. Further studies demonstrated that keratin 1 expression was negatively correlated with pulmonary vascular pressure following prolonged hypoxia. 6. Pre-treatment with keratin 1 decreased pulmonary artery pressure and the right heart hypertrophy index and alleviated PAR in two model rats. 7. Keratin 1 exhibited a hypermethylation status in hypoxic pulmonary arteries in the sequencing. Hypoxia-induced decrease in keratin 1 expression was associated with Dnmt1 upregulation induced by YY1 downregulation in PASMCs. Conclusion This study suggests that keratin 1 regulates PASMC expansion and has a preventive effect on PAH.
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- 2019
29. Diagnostic accuracy of Instrumental Activities of Daily Living for dementia in community-dwelling older adults
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Wen Ni Wennie Huang, Ta-Fu Chen, Ming-Jang Chiu, Hui-Fen Mao, Yea-Ing Lotus Shyu, Pei Ning Wang, Yu Sun, Li Yu Tang, Huey Jane Lee, Ker Neng Lin, Athena Yi-Jung Tsai, and Ling Hui Chang
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Male ,Gerontology ,Aging ,Activities of daily living ,Population ,Taiwan ,Diagnostic accuracy ,Likelihood ratios in diagnostic testing ,Disability Evaluation ,03 medical and health sciences ,Cognition ,0302 clinical medicine ,Predictive Value of Tests ,Surveys and Questionnaires ,Activities of Daily Living ,mental disorders ,Humans ,Medicine ,Dementia ,030212 general & internal medicine ,education ,Geriatric Assessment ,Cutoff score ,Aged ,Aged, 80 and over ,education.field_of_study ,Receiver operating characteristic ,business.industry ,Age Factors ,Reproducibility of Results ,General Medicine ,Mental Status and Dementia Tests ,medicine.disease ,Cross-Sectional Studies ,Female ,Observational study ,Independent Living ,Geriatrics and Gerontology ,business ,human activities ,030217 neurology & neurosurgery - Abstract
Background many people living with dementia remain underdiagnosed and unrecognised. Screening strategies are important for early detection. Objective to examine whether the Lawton's Instrumental Activities of Daily Living (IADL) scale, compared with other cognitive screening tools-the Mini-Mental State Examination (MMSE), and the Ascertain Dementia 8-item Informant Questionnaire (AD8)-can identify older (≥ 65 years) adults with dementia. Design population-based cross-sectional observational study. Setting all 19 counties in Taiwan. Participants community-dwelling older adults (n = 10,340; mean age 74.87 ± 6.03). Methods all participants underwent a structured in-person interview. Dementia was identified using National Institute on Aging-Alzheimer's Association core clinical criteria for all-cause dementia. Receiver operator characteristic curves were used to determine the discriminant abilities of the IADL scale, MMSE and AD8 to differentiate participants with and without dementia. Results we identified 917 (8.9%) participants with dementia, and 9,423 (91.1%) participants without. The discriminant abilities of the MMSE, AD8 and IADL scale (cutoff score: 6/7; area under curve = 0.925; sensitivity = 89%; specificity = 81%; positive likelihood ratio = 4.75; accuracy = 0.82) were comparable. Combining IADL with AD8 scores significantly improved overall accuracy: specificity = 93%; positive likelihood ratio = 11.74; accuracy = 0.92. Conclusions our findings support using IADL scale to screen older community-dwelling residents for dementia: it has discriminant power comparable to that of the AD8 and MMSE. Combining the IADL and the AD8 improves specificity.
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- 2018
30. Cognitive dysfunction predicts worse health-related quality of life for older stroke survivors: a nationwide population-based survey in Taiwan
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Li Min Kuo, Yea-Ing Lotus Shyu, Li Yu Tang, Huey Jane Lee, Wen-Che Tsai, and Ming-Jang Chiu
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Male ,Gerontology ,Taiwan ,Comorbidity ,03 medical and health sciences ,0302 clinical medicine ,Quality of life (healthcare) ,Surveys and Questionnaires ,Activities of Daily Living ,Humans ,Medicine ,Dementia ,Cognitive status ,Cognitive Dysfunction ,Survivors ,Stroke survivor ,Population based survey ,Stroke ,Aged ,Aged, 80 and over ,Health related quality of life ,030214 geriatrics ,business.industry ,Cognition ,medicine.disease ,humanities ,Psychiatry and Mental health ,Hypertension ,Quality of Life ,Female ,Geriatrics and Gerontology ,Pshychiatric Mental Health ,business ,030217 neurology & neurosurgery - Abstract
This study investigated the associations of cognitive status with specific/overall health-related quality of life (HRQoL) in older stroke survivors in Taiwan.A subsample of 592 older stroke survivors in a nationwide population-based survey of cognitive-dysfunction prevalencewas analyzed. HRQoL was assessed using the EuroQol five-dimension questionnaire (EQ-5D).Stroke survivors with dementia were 5.60 times more likely to have mobility problems, 12.20 times to have self-care problems, 16.61 times to have problems in usual activities, 4.31 times to have pain/discomfort, and 3.28 times to have anxiety/depression than stroke survivors with normal cognitive function. Stroke survivors with mild cognitive dysfunction (MCD) were 2.57 times more likely to have mobility problems, 3.17 times to have self-care problems, 3.31 times to have problems in usual activities, 2.11 times to have pain/discomfort, and 2.35 times to have anxiety/depression than those with normal cognitive function. Both dementia (b = -15.13, p.001) and MCD (b = -6.24, p.001) significantly contributed to lower EQ-5D VAS; both dementia (b = -.15, p.001) and MCD (b = -.10, p.001) significantly contributed to lower EQ-5D index.Dementia and MCD strongly predicted worse overall and specific HRQoL dimensions, especially self-care and usual activities for older stroke survivors.
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- 2017
31. [Untitled]Research and application progress of visual fixation component separation
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Wei, Wei, Shi, Geng-hu, Li, Yu-tang, Zhang, Bing, and Gao, Chuang
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- 2013
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32. [Untitled]Research and application progress of visual fixation component separation
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Wei, Wei, Shi, Geng-hu, Li, Yu-tang, Zhang, Bing, and Gao, Chuang
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- 2013
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33. Relationships Between Cognitive Dysfunction and Health-Related Quality of Life Among Older Persons in Taiwan: A Nationwide Population-Based Survey
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Hsin-Yun Liu, Ming-Jang Chiu, Yea-Ing Lotus Shyu, Wen-Che Tsai, Woan-Shyuan Wang, Huey-Jane Lee, and Li-Yu Tang
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Gerontology ,Male ,media_common.quotation_subject ,Population ,Taiwan ,Severity of Illness Index ,03 medical and health sciences ,0302 clinical medicine ,Secondary analysis ,mental disorders ,medicine ,Dementia ,Humans ,Quality (business) ,Cognitive Dysfunction ,030212 general & internal medicine ,education ,Population based survey ,media_common ,Aged ,Health related quality of life ,Aged, 80 and over ,education.field_of_study ,business.industry ,General Neuroscience ,Cognition ,medicine.disease ,Health Surveys ,Self Care ,Psychiatry and Mental health ,Clinical Psychology ,Cross-Sectional Studies ,Quality of Life ,Female ,Geriatrics and Gerontology ,business ,030217 neurology & neurosurgery - Abstract
Background: To examine the relationships between cognitive dysfunction status and quality of life. Methods: Secondary analysis of a nationwide population-based survey (≥65 years) in Taiwan. The 5-dimension EuroQoL questionnaire (EQ-5D) was completed by 10 013 participants. Results: Participants with mild cognitive impairment (MCI; odds ratio = 4.88), very mild dementia (VMD; 7.96), or dementia (32.85) were more likely than those with normal cognition to report self-care problems. Participants with MCI (3.86), VMD (9.26), or dementia (31.61) were more likely to have usual-activity problems, and those with MCI (3.04), VMD (3.82), or dementia (9.23) were more likely to have mobility problems. Participants with MCI (2.10 and 2.14), VMD (2.77 and 2.18), or dementia (3.04 and 3.02) were more likely to report pain/discomfort and anxiety/depression. Conclusion: Dementia was negatively associated with EQ-5D, especially self-care, usual activities, and mobility. Mild cognitive impairment or VMD was also negatively associated, with VMD more negatively associated. Developing interventions for patients with specific cognitive dysfunctions is critical.
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- 2018
34. Dementia-friendly community indicators from the perspectives of people living with dementia and dementia-family caregivers
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Suh Mian Wu, Chien Liang Liu, Pei-Shan Yang, Hsiu-Li Huang, Jung Lung Hsu, Yi-Chen Chiu, Woan Shyuan Wang, Yea-Ing Lotus Shyu, and Li Yu Tang
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Gerontology ,Adult ,Male ,Patients ,Psychological intervention ,Taiwan ,Day care ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Residence Characteristics ,hemic and lymphatic diseases ,mental disorders ,Adaptation, Psychological ,medicine ,Dementia ,Humans ,Family ,030212 general & internal medicine ,General Nursing ,Qualitative Research ,Aged ,Aged, 80 and over ,Government ,030504 nursing ,Family caregivers ,Dementia friendly ,Middle Aged ,medicine.disease ,Caregivers ,Female ,0305 other medical science ,Psychology ,Developed country ,Qualitative research - Abstract
To identify dementia-friendly communities' indicators and their current conditions in Taiwan from the perspectives of people with dementia and dementia-family caregivers.This qualitative study explored the opinions and experiences of people with dementia and dementia-family caregivers regarding dementia-friendly communities.Participants (16 people with dementia and 20 family caregivers) were recruited from neurological clinics, day care centres for people with dementia and support groups for family caregivers in the Taipei community from July - October, 2016. Data were collected in face-to-face interviews, which were tape recorded and transcribed verbatim. Transcripts were analysed by Miles and Huberman's (1994) guidelines.Similar indicators for dementia-friendly communities were identified in Taiwan as in other countries, including dementia-friendly care services, dementia-friendly hospitals, dementia-friendly community environment, dementia-friendly transportation, dementia-friendly stores and shops, dementia friendly people, integrated dementia-related information and community contribution- and -involvement opportunities for people with dementia. However, Taiwanese people with dementia and family caregivers described no emphasis on the potential of people with dementia to contribute to developing dementia-friendly communities and more top-down expectations for the government's role.These indicators can be a guide for developing and evaluating dementia-friendly communities in Taiwan. Differences between Taiwan and Western developed countries in indicators for dementia-friendly communities can be further explored. Community nursing assessment, interventions, and evaluation based on these dementia-friendly communities indicators can be further developed.This study developed indicators for dementia-friendly communities in an Asian country. These indicators can be used as a guide for developing and evaluating dementia-friendly communities.目的: 根据痴呆患者和痴呆家庭照顾者的意见,制定痴呆友好社区指标以及台湾目前的痴呆友好社区指标。 设计: 此定性研究主要内容是探讨痴呆患者和痴呆家庭照顾者关于痴呆友好社区指标的观点。 方法: 从2016年7月到10月,研究参与者(16位痴呆患者和20 位痴呆家庭照顾者)都是来自台北社区的神经学诊所、痴呆患者日托中心、家庭照顾者的相关专业人士。 结果: 得出的台湾痴呆友好社区指标与其他国家类似,指标包括痴呆友好护理服务、痴呆友好医院、痴呆友好社区环境、痴呆友好交通、痴呆友好商店、痴呆友好人员、完善痴呆信息、社区贡献与痴呆患者参与机会。但是,台湾的痴呆患者和痴呆家庭照顾者表示并不期待痴呆患者和政府会为建设痴呆友好社区做出贡献。 结论: 台湾痴呆友好社区指标与西方发达国家痴呆友好社区指标的不同值得我们进一步研究。根据痴呆友好社区指标发展社区护理评估、干预措施和评估等。 影响: 此研究发现了亚洲国家痴呆友好社区指标。研究得出的指标可用作指南,引导发展和评估痴呆友好社区。.
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- 2018
35. Association of Polypharmacy With Mild Cognitive Impairment and Cognitive Ability: A Nationwide Survey in Taiwan
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Shih-Jen Tsai, Huey Jane Lee, Wen Han Chang, Cheng Hung Yang, Li Yu Tang, Chih Ming Cheng, Chia Fen Tsai, Ming-Jang Chiu, Pei Ning Wang, Yu Chuan Chiu, and Yu Sun
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Gerontology ,Male ,Clinical Dementia Rating ,Cross-sectional study ,Taiwan ,03 medical and health sciences ,0302 clinical medicine ,Cognition ,Risk Factors ,mental disorders ,Medicine ,Dementia ,Humans ,Cognitive Dysfunction ,030212 general & internal medicine ,Aged ,Polypharmacy ,Aged, 80 and over ,Chi-Square Distribution ,business.industry ,Case-control study ,medicine.disease ,Health Surveys ,Psychiatry and Mental health ,Cross-Sectional Studies ,Case-Control Studies ,Linear Models ,Delirium ,Female ,medicine.symptom ,business ,Body mass index ,030217 neurology & neurosurgery - Abstract
BACKGROUND Polypharmacy, defined as the concomitant use of 5 or more medications, has a documented negative association with cognitive impairment such as delirium and is associated, potentially, with a higher risk of dementia. However, whether polypharmacy contributes to increased risk of mild cognitive impairment (MCI) or decreased cognitive capacity requires further investigation. This nationwide population survey investigated the association among polypharmacy, MCI, and dementia. METHODS Through random sampling based on the proportion of all Taiwan counties, subjects were recruited and received in-person interviews between December 2011 and March 2013. Demographic data and clinical information included medical histories, medication use, and mental status measured by the Taiwanese Mini-Mental State Examination (TMSE) and Clinical Dementia Rating (CDR). Data on lifestyle and habits were collected, and subjects were distributed to cognitively normal, MCI, or all-cause dementia groups based on criteria by the National Institute on Aging and the Alzheimer's Association. RESULTS A total of 7,422 people aged 65 years or older were recruited. After adjustment for age, sex, body mass index, education, medical comorbidities, and lifestyle and habits, polypharmacy was associated with a 1.75-fold increased odds of MCI and 2.33-fold increased odds of dementia. Polypharmacy was associated with a 0.51-point decrease in TMSE scores (P = .001) and a 0.10-point increase in CDR score (P < .001). Additionally, for those without specific vascular comorbidities, polypharmacy had a greatly more negative impact on cognitive capacity. CONCLUSIONS Polypharmacy is common in the elderly and is associated with significantly lower cognitive capacity and higher risks of MCI and dementia, especially for persons without diabetes, hypertension, hyperlipidemia, or cerebrovascular diseases.
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- 2017
36. Thirty two cases of type 2 diabetes mellitus of qiand yindeficiency treated with laser acupuncture
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ZHANG, Rong-xian, LI, Hong, XIONG, Jia-wei, JIANG, Yong-qu, LI, Yu-tang, and ZHANG, Jian-bin
- Abstract
To observe the clinical therapeutic effect of laser acupuncture on type 2 diabetes mellitus (T2DM) of qiand yindeficiency type.
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- 2021
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37. Comorbidity and dementia: A nationwide survey in Taiwan
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Shu Chien Yang, Pei Ning Wang, Ker Neng Lin, Li Yu Tang, Chung-Chih Lin, Yu Sun, Ming-Jang Chiu, Szu Yu Yiao, Huey Jane Lee, Ting Bin Chen, and Ta-Fu Chen
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Male ,Pulmonology ,Epidemiology ,Cross-sectional study ,lcsh:Medicine ,Blood Pressure ,Comorbidity ,Logistic regression ,Vascular Medicine ,0302 clinical medicine ,Endocrinology ,Medicine and Health Sciences ,Medicine ,030212 general & internal medicine ,lcsh:Science ,Geriatrics ,Aged, 80 and over ,Cognitive Impairment ,Multidisciplinary ,Cognitive Neurology ,Liver Diseases ,Neurology ,Cirrhosis ,Hypertension ,Regression Analysis ,Female ,Research Article ,medicine.medical_specialty ,Endocrine Disorders ,Cognitive Neuroscience ,Cerebrovascular Diseases ,Taiwan ,Gastroenterology and Hepatology ,03 medical and health sciences ,Internal medicine ,Diabetes mellitus ,mental disorders ,Mental Health and Psychiatry ,Diabetes Mellitus ,Dementia ,Humans ,Asthma ,Aged ,business.industry ,lcsh:R ,Biology and Life Sciences ,medicine.disease ,Health Surveys ,Cross-Sectional Studies ,Metabolic Disorders ,Older people--Health and hygiene ,Physical therapy ,Cognitive Science ,lcsh:Q ,business ,030217 neurology & neurosurgery ,Neuroscience - Abstract
Background Comorbid medical diseases are highly prevalent in the geriatric population, imposing hardship on healthcare services for demented individuals. Dementia also complicates clinical care for other co-existing medical conditions. This study investigated the comorbidities associated with dementia in the elderly population aged 65 years and over in Taiwan. Methods We conducted a nationwide, population-based, cross-sectional survey; participants were selected by computerized random sampling from all 19 Taiwan counties between December 2011 and March 2013. After exclusion of incomplete or erroneous data, 8,456 subjects were enrolled. Of them, 6,183 were cognitively normal (control group), 1,576 had mild cognitive impairment (MCI), and 697 had dementia. We collected information about types of comorbidities (i.e., vascular risk factors, lung diseases, liver diseases, gastrointestinal diseases, and cancers), Charlson comorbidity index score, and demographic variables to compare subjects with normal cognition, MCI, and dementia. Results Regardless of the cognitive condition, over 60% of the individuals in each group had at least one comorbid disease. The proportion of subjects possessing at least three comorbidities was higher in those with cognitive impairment (MCI 20.9%, dementia 27.3%) than in control group (15%). Hypertension and diabetes mellitus were the most common comorbidities. The mean number of comorbidities and Charlson comorbidity index score were greater in MCI and dementia groups than in control group. Logistic regression demonstrated that the comorbidities significantly associated with MCI and dementia were cerebrovascular disease (OR 3.35, CI 2.62–4.28), cirrhosis (OR 3.29, CI 1.29–8.41), asthma (OR 1.56, CI 1.07–2.27), and diabetes mellitus (OR 1.24, CI 1.07–1.44). Conclusion Multiple medical comorbid diseases are common in older adults, especially in those with cognitive impairment. Cerebrovascular disease, cirrhosis, asthma, and diabetes mellitus are important contributors to cognitive deterioration in the elderly. Efforts to lower cumulative medical burden in the geriatric population may benefit cognitive function.
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- 2016
38. The expression of IL-1β can deteriorate the prognosis of nervous system after spinal cord injury
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Li, Tao, primary, Li, Yu-tang, additional, and Song, Di-yu, additional
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- 2018
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39. P4‐142: The sensitivity and specificity of the chinese version of ad8 in a nationwide screening for dementia in taiwan
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Pei Ning Wang, Yu Sun, Ming-Jang Chiu, Huey-Jane Lee, Li-Yu Tang, and Ta-Fu Chen
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Oncology ,medicine.medical_specialty ,Epidemiology ,business.industry ,Health Policy ,medicine.disease ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Chinese version ,Developmental Neuroscience ,Internal medicine ,medicine ,Dementia ,Neurology (clinical) ,Sensitivity (control systems) ,Geriatrics and Gerontology ,business - Published
- 2015
40. Behavioral and Psychologic Symptoms in Different Types of Dementia
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Ming-Jang Chiu, Mau-Sun Hua, Ping-Keung Yip, Ta-Fu Chen, and Li-Yu Tang
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Affective Disorders, Psychotic ,Lewy Body Disease ,Male ,medicine.medical_specialty ,Clinical Dementia Rating ,frontotemporal dementia ,Alzheimer Disease ,mental disorders ,Humans ,Medicine ,Dementia ,Psychiatry ,Vascular dementia ,Aged ,Medicine(all) ,Psychiatric Status Rating Scales ,Psychotropic Drugs ,lcsh:R5-920 ,Mini–Mental State Examination ,Alzheimer's dementia ,medicine.diagnostic_test ,behavior ,business.industry ,Dementia with Lewy bodies ,Dementia, Vascular ,Mental Disorders ,Memory clinic ,vascular dementia ,General Medicine ,Middle Aged ,medicine.disease ,Aggression ,dementia of Lewy bodies ,Female ,Alzheimer's disease ,lcsh:Medicine (General) ,business ,psychologic symptoms ,Frontotemporal dementia - Abstract
Background/Purpose Behavioral and psychologic symptoms of dementia (BPSD) are major sources of a caregiver's burden and also the most important factor when considering the need for institutionalization of dementia patients. BPSD occur in about 90% of patients with dementia. Studies comparing the BPSD in the major types of dementia using unitary behavioral rating scales are limited. We studied BPSD in patients with four major types of dementias from a memory clinic. Methods We recruited patients with dementia from our memory clinic from January 2003 to February 2004. The Behavioral Pathology in Alzheimer's Disease Rating Scale (BEHAVE-AD) was used to measure BPSD severity. Clinical Dementia Rating and Mini Mental State Examination were used to determine dementia severity. Results A total of 137 patients with four major types of dementia were recruited from 155 patients with dementia who attended the clinic during the study period. The main dementia types identified were Alzheimer's dementia (AD) in 54.8%, vascular dementia (VaD) in 20.6%, frontotemporal dementia (FTD) in 8.4%, dementia with Lewy bodies (DLB) in 4.5%, and other dementias in 11.6%. BPSD were found in 92.0% of the patients but only 43.1% received psychotropic treatment. The relative risk of receiving psychotropic treatment for BPSD subscales paralleled the extent of caregivers' burden as assessed by the BEHAVE-AD global rating. Type-specific BPSD, e.g. hallucination was identified for DLB, activity disturbances for FTD, anxiety and phobias for AD and affective disturbance for VaD. Conclusion A strategy of targeting type-specific BPSD may be beneficial, such as environmental stimulus control for DLB patients who are prone to have hallucinations, design of a pacing path for patients with FTD who need support for symptoms of wandering and emotional support for patients with VaD who are susceptible to depression.
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- 2006
41. The development and validation of a dementia behavior disturbance inventory
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En-Chang Wu, Li-Yu Tang, Ping-Keung Yip, and Kai-Kuen Leung
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Adult ,Male ,Gerontology ,Disturbance (geology) ,Activities of daily living ,Psychometrics ,Test validity ,behavioral disciplines and activities ,Nuclear Family ,Cronbach's alpha ,Alzheimer Disease ,Surveys and Questionnaires ,medicine ,Humans ,Dementia ,Interpersonal Relations ,Reliability (statistics) ,Aged ,Aged, 80 and over ,Dementia, Vascular ,Mental Disorders ,Middle Aged ,medicine.disease ,Exploratory factor analysis ,Psychiatry and Mental health ,Clinical Psychology ,Caregivers ,Female ,Geriatrics and Gerontology ,Psychology - Abstract
Objective: To develop an instrument that measures observable problematic behaviors in patients with dementia.Methodology: We used focus group interviews to identify the problematic behaviors of patients with dementia. Eighty-two behaviors grouped into 12 domains were generated from the data collected from five different focus groups. After conducting a content validation process, a 72-item Dementia Behavior Disturbance Inventory (DBDI) rated by a frequency and a disturbance scale was formed. The DBDI was administered to 200 institutionalized elderly patients with dementia by formal caregivers for psychometric evaluation.Results: Inter-item correlation of items in each domain was performed for item reduction. Forty-eight items remained after this procedure. Exploratory factor analysis obtained nine factors that explained 59.2% and 59.6% of the total variance in the frequency and disturbance scales, respectively. Cronbach's α of the entire 48-item frequency and disturbance scales was 0.88 and 0.91, respectively. Most of the factors had acceptable internal consistency reliability. Test–re-test reliability coefficients of the frequency and disturbance scales were 0.78 and 0.64, respectively. The DBDI was weakly but positively related to functions of daily activities and ambulation.Conclusion: The DBDI demonstrates promising psychometrical properties as an instrument to assess problematic behaviors in elderly people with dementia.
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- 2005
42. The use of focus groups in evaluating quality of life components among elderly Chinese people
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Li-Yu Tang, Bee-Horng Lue, Kai-Kuen Leung, and En-Chang Wu
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Male ,Gerontology ,China ,medicine.medical_specialty ,Social connectedness ,Taiwan ,Social Environment ,Vitality ,Residential Facilities ,Asian People ,Quality of life ,Activities of Daily Living ,medicine ,Health Status Indicators ,Humans ,Family ,Interpersonal Relations ,Socioeconomic status ,Aged ,Aged, 80 and over ,Public health ,Public Health, Environmental and Occupational Health ,Social Support ,Focus Groups ,Focus group ,humanities ,Chinese people ,Mood ,Quality of Life ,Female ,Psychology ,Attitude to Health ,Clinical psychology - Abstract
In Taiwan, to measure the quality of life (QOL) of elderly Chinese, one must rely on instruments developed in other Chinese or Western populations and not specifically for the elderly. The purpose of this study is to understand the components of QOL for elderly Chinese from Taiwan living in residential homes or in their communities. Forty-four elderly men and women divided into six focus groups were interviewed on video tape and the resultant recording was analyzed qualitatively by six independent researchers. The study yielded 15 QOL domains grouped into six dimensions: physical health (physical well-being, impact of illness, medical care), psychological health (mood states, life attitude and retrospection, philosophy of living, self-efficacy), social function (connectedness, exercise and leisure activities, social activities and services), living environment (living environment and arrangements, institutional factors), economic status, and religion and death (religion, death). For elderly Chinese in Taiwan, positive and negative life domains are equally important in the perception of life quality; person-environment interaction is a major consideration in the evaluation of QOL; family ties are an important component of QOL; traditional Chinese beliefs exert a positive influence on perceived QOL; and social functioning and vitality have a different meaning in Chinese compared to Western cultures.
- Published
- 2004
43. A nationwide survey of mild cognitive impairment and dementia, including very mild dementia, in Taiwan
- Author
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Li Yu Tang, Pei Ning Wang, Huey Jane Lee, Chung-Chih Lin, Yu Sun, Ta-Fu Chen, Ming-Jang Chiu, Ker Neng Lin, and Shu Chien Yang
- Subjects
Gerontology ,Male ,Activities of daily living ,Cross-sectional study ,Clinical Dementia Rating ,Epidemiology ,Population ,Prevalence ,Taiwan ,lcsh:Medicine ,Severity of Illness Index ,Mental status examination ,Sex Factors ,Alzheimer Disease ,Risk Factors ,Mental Health and Psychiatry ,Activities of Daily Living ,mental disorders ,medicine ,Medicine and Health Sciences ,Dementia ,Humans ,Cognitive Dysfunction ,education ,lcsh:Science ,Aged ,Aged, 80 and over ,education.field_of_study ,Multidisciplinary ,medicine.diagnostic_test ,business.industry ,lcsh:R ,Age Factors ,medicine.disease ,Cross-Sectional Studies ,Neurology ,Educational Status ,Female ,lcsh:Q ,Alzheimer's disease ,business ,Mental Status Schedule ,Research Article - Abstract
An increasing population of dementia patients produces substantial societal impacts. We assessed the prevalence of mild cognitive impairment (MCI) and all-cause dementia, including very mild dementia (VMD), in Taiwan. In a nationwide population-based cross-sectional survey, participants were selected by computerized random sampling from all 19 Taiwan counties and were enrolled between December 2011 and March 2013. Cases were identified through in-person interviews based on the National Institute on Aging-Alzheimer's Association clinical criteria. Demographic data and histories involving mental status and function in daily living were collected. The principal objective assessments were the Taiwanese Mental Status Examination and Clinical Dementia Rating. In all, 10,432 people aged 65 years or older (mean age 76.2 ± 6.7, 52.3% women) were interviewed. The age-adjusted prevalence of all-cause dementia was 8.04% (95% CI 7.47-8.61), including a 3.25% (95% CI 2.89-3.61) prevalence of VMD; that of MCI was 18.76% (95% CI 17.91-19.61). Women had a higher prevalence than men of both all-cause dementia (9.71% vs. 6.36%) and MCI (21.63% vs. 15.57%). MCI affects a considerable portion of the population aged 65 and above in Taiwan. The inclusion of VMD yields dementia prevalence rates higher than those previously reported from Taiwan. Old age, female gender, and a low educational level are significant associated factors.
- Published
- 2014
44. Development of a chinese chronic illness–related stress inventory for primary care
- Author
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Bee-Horng Lue, Li-Yu Tang, En-Chang Wu, and Kai-Kuen Leung
- Subjects
Adult ,Male ,China ,medicine.medical_specialty ,Coping (psychology) ,Psychometrics ,Disease ,Cronbach's alpha ,Surveys and Questionnaires ,medicine ,Health Status Indicators ,Humans ,Psychiatry ,Aged ,Demography ,Primary Health Care ,Discriminant validity ,Reproducibility of Results ,Construct validity ,Middle Aged ,Psychiatry and Mental health ,Clinical Psychology ,Convergent validity ,Chronic Disease ,Female ,Psychology ,Sexual function ,Stress, Psychological ,Clinical psychology - Abstract
This study evaluates the construct validity and internal consistency of a Chronic Illness–Related Stress Inventory (CRSI) for primary care Chinese patients and studies the relationship between chronic illness–related stress and sociodemographic characteristics and indices of disease severity. A total of 301 patients were interviewed using a structured questionnaire. The responses to the CRSI were divided into a frequency scale and a severity scale. Six factors including physical integrity and discomfort, psychosocial function and economic burdens, self-fulfillment and daily life, sexual function, self-esteem, and diet limitations were obtained for each CRSI scale. Except for the last factor, all other factors and the scale as a whole for both scales have a Cronbach α of >0.90. The results of the convergent and discriminant validity analysis were promising. In addition, chronic illness–related stress was related to insurance status and the self-perceived severity of disease.
- Published
- 1999
45. A finger-free wrist-worn pulse oximeter for the monitoring of chronic obstructive pulmonary disease
- Author
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Chu, Chang-Sheng, additional, Chuang, Shuang-Chao, additional, Lee, Yeh Wen, additional, Fan, Chih-Hsun, additional, Chung, Lung Pin, additional, Li, Yu-Tang, additional, and Chen, Jyh-Chern, additional
- Published
- 2016
- Full Text
- View/download PDF
46. iLauncher
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Jiun-Long Huang, Ming-Syan Chen, Pi-Cheng Hsiu, and Li-Yu Tang
- Subjects
Multimedia ,Computer science ,Mobile apps ,Android (operating system) ,computer.software_genre ,computer ,Personalization - Abstract
The next-generation smartphones should provide a signification improvement in terms of personalization. A major challenge in smartphone personalization is how to tackle the diversity in smartphone usage. This paper presents iLauncher, an intelligent quick launch that can adapt to individual usage patterns on the fly to change apps dynamically without user intervention. The rationale behind the development process is that we collected traces of real user activity and conducted statistical analysis to derive some observations that provide useful insights into the design of our algorithm. The results of experiments conducted to evaluate the proposed algorithm are encouraging in terms of prediction accuracy. We have implemented iLauncher based on the algorithm and released it in an Android marketplace for free usage.
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- 2013
47. Diagnostic accuracy of Instrumental Activities of Daily Living for dementia in community-dwelling older adults.
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HUI-FEN MAO, LING-HUI CHANG, ATHENA YI-JUNG TSAI, WEN-NI WENNIE HUANG, LI-YU TANG, HUEY-JANE LEE, YU SUN, TA-FU CHEN, KER-NENG LIN, PEI-NING WANG, YEA-ING LOTUS SHYU, and MING-JANG CHIU
- Subjects
DIAGNOSIS of dementia ,DISCRIMINANT analysis ,INTERVIEWING ,RESEARCH methodology ,MEDICAL screening ,SCIENTIFIC observation ,QUESTIONNAIRES ,ACTIVITIES of daily living ,INDEPENDENT living ,CROSS-sectional method ,RECEIVER operating characteristic curves ,OLD age - Abstract
Background: many people living with dementia remain underdiagnosed and unrecognised. Screening strategies are important for early detection. Objective: to examine whether the Lawton's Instrumental Activities of Daily Living (IADL) scale, compared with other cognitive screening tools--the Mini-Mental State Examination (MMSE), and the Ascertain Dementia 8-item Informant Questionnaire (AD8)--can identify older (≥ 65 years) adults with dementia. Design: population-based cross-sectional observational study. Setting: all 19 counties in Taiwan. Participants: community-dwelling older adults (n = 10,340; mean age 74.87 ± 6.03). Methods: all participants underwent a structured in-person interview. Dementia was identified using National Institute on Aging-Alzheimer's Association core clinical criteria for all-cause dementia. Receiver operator characteristic curves were used to determine the discriminant abilities of the IADL scale, MMSE and AD8 to differentiate participants with and without dementia. Results: we identified 917 (8.9%) participants with dementia, and 9,423 (91.1%) participants without. The discriminant abilities of the MMSE, AD8 and IADL scale (cutoff score: 6/7; area under curve = 0.925; sensitivity = 89%; specificity = 81%; positive likelihood ratio = 4.75; accuracy = 0.82) were comparable. Combining IADL with AD8 scores significantly improved overall accuracy: specificity = 93%; positive likelihood ratio = 11.74; accuracy = 0.92. Conclusions: our findings support using IADL scale to screen older community-dwelling residents for dementia: it has discriminant power comparable to that of the AD8 and MMSE. Combining the IADL and the AD8 improves specificity. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
48. Assessment of behavioral and psychological symptoms of dementia by family caregivers
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Li-Yu Tang, Chin-Ying Chen, Yam-Ting Kwok, Ming-Jang Chiu, and Kai-Kuen Leung
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Male ,Aging ,medicine.medical_specialty ,Health (social science) ,Psychometrics ,Clinical Dementia Rating ,Neuropsychological Tests ,Severity of Illness Index ,Sex Factors ,Rating scale ,Surveys and Questionnaires ,mental disorders ,medicine ,Dementia ,Humans ,Interpersonal Relations ,Psychiatry ,Aged ,Mini–Mental State Examination ,medicine.diagnostic_test ,Family caregivers ,Age Factors ,Construct validity ,Cognition ,Middle Aged ,medicine.disease ,Caregivers ,Multivariate Analysis ,Female ,Family Relations ,Geriatrics and Gerontology ,Psychology ,Gerontology ,Stress, Psychological ,Clinical psychology - Abstract
This study was designed to test the performance and related factors of a self-administered instrument in assessing behavioral and psychological symptoms of dementia (BPSD) by family caregivers. We recruited 173 patients with dementia and major caregivers from two neurological clinics. Information about clinical diagnosis, the Mini Mental State Examination (MMSE), the Clinical Dementia Rating (CDR), the Dementia Behavior Disturbance Inventory (DBDI), and global caregivers’ strain were collected from interview and chart review. We found that DBDI has acceptable construct validity and good internal consistency reliability. BPSD was more frequently found in patients with advanced dementia, poor cognitive function and highly correlated to caregivers’ strain. Multivariate analysis revealed that female patients and caregivers, advanced CDR stages, patient–caregiver relationship, types of dementia and MMSE score were related to the increase of frequency and disturbance index of DBDI. We concluded that BPSD could be evaluated by family caregivers using a self-administered instrument. Further study is indicated to clarify how caregiver characteristics affect the report of behavioral symptoms, and its clinical importance.
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- 2009
49. Institution type-dependent high prevalence of dementia in long-term care units
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Shaw-Ji Chen, Chung-Wei Lin, Tony Hsiu Hsi Chen, Wan-Yu Shih, Rong-Chi Chen, Che-Long Su, Ta-Fu Chen, Ming-Jang Chiu, Yueh-Hsia Chiu, Shu-Feng Chang, and Li-Yu Tang
- Subjects
Community studies ,Gerontology ,Male ,Epidemiology ,MEDLINE ,Taiwan ,Disease ,mental disorders ,medicine ,Prevalence ,Dementia ,Homes for the Aged ,Humans ,Family history ,Vascular dementia ,Aged ,Aged, 80 and over ,business.industry ,Data Collection ,Institutionalization ,medicine.disease ,Long-Term Care ,Nursing Homes ,Long-term care ,Female ,Neurology (clinical) ,Alzheimer's disease ,business - Abstract
Background/Aims: It is estimated that there are 90,000 patients with dementia in the 23 million habitants of Taiwan, with a few institutions specialized in dementia care. To assess the need of institutional care for dementia, we investigated the institution prevalence of dementia. Methods: We performed stratified randomized sampling of elder residents from different types of institutions in different regions of Taiwan. A 2-stage survey with screening and clinical confirmation was carried out in 2004. Results: In total, 1,525 residents aged 65 years and over in 60 institutions participated in the study in which 1,308 elders completed the 2-stage survey. Among these, 631 elders were diagnosed as having dementia. The dementia prevalence was 26.8% in the residential houses, 61.8% in the assisted living facilities and 64.5% in the nursing homes. Vascular dementia was the leading cause of dementia in the institutions. Old age, diabetes mellitus and family history of dementia increased risks for both Alzheimer’s disease and vascular dementia. Conclusion: The investigation showed that the prevalence of dementia in the long-term care units of Taiwan was much higher than those from community studies and the high prevalence in the institutions depended on the type of the long-term care unit.
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- 2007
50. Self-rated health and mortality in Chinese institutional elderly persons
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Bee-Horng Lue, Kai-Kuen Leung, and Li-Yu Tang
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Gerontology ,Male ,Risk ,medicine.medical_specialty ,China ,Visual acuity ,Epidemiology ,Health Status ,Cohort Studies ,Activities of Daily Living ,medicine ,Global health ,Homes for the Aged ,Humans ,Mortality ,Geriatric Assessment ,Self-rated health ,Aged ,Proportional Hazards Models ,Aged, 80 and over ,Analysis of Variance ,Proportional hazards model ,business.industry ,Public health ,Institutionalization ,Prognosis ,Long-Term Care ,Survival Analysis ,Nursing Homes ,Health assessment ,Cohort ,Female ,medicine.symptom ,business ,Attitude to Health ,Demography - Abstract
The relationship between self-rated health (SRH) and subsequent mortality was examined in a cohort of 411 Chinese elderly individuals living in institutions. SRH was assessed by a global health rating, by comparing health with others of the same age, and by perception of recent physical condition. Covariates including age, sex, daily activity function, instrumental daily activity function, cognitive function, self-reported visual acuity, urinary function, number of chronic conditions, number of medications, and history of falls were controlled by the Cox proportional hazard model. Elderly people who rated their global health as “fair or poor” had increased mortality compared to those in the “good” category (RR = 6.00; 95% CI 1.39–25.1) and a borderline significant increase in mortality risk for those who rated themselves in the “average” category (RR = 4.05; 95% CI 0.93–17.70). Elderly people who compared their health with others of the same age as “worse or worst” and “similar” had an RR of 2.75; 95% CI of 0.64–11.83 and RR of 2.40; 95% CI of 0.64–8.96, respectively. Elderly people who rated their physical symptoms as “moderate or severe” and “slight” had an RR of 2.54; 95% CI 0.65–9.80 and RR of 1.05; 95% CI 0.32–3.41, respectively. Age, institutional factors, and history of multiple falls were associated with an increased risk of mortality. We concluded that only the global health rating has direct predictive power for mortality in institutionalized elderly people.
- Published
- 1997
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