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This study introduces a novel approach for synthesizing Benzoxazine‐centered Polychiral Polyheterocycles (BPCPHCs) via an innovative asymmetric carbene‐alkyne metathesis‐triggered cascade. Overcoming challenges associated with intricate stereochemistry and multiple chiral centers, the catalytic asymmetric Carbene Alkyne Metathesis‐mediated Cascade (CAMC) is employed using dirhodium catalyst/Brønsted acid co‐catalysis, ensuring precise stereo control as validated by X‐ray crystallography. Systematic substrate scope evaluation establishes exceptional diastereo‐ and enantioselectivities, creating a unique library of BPCPHCs. Pharmacological exploration identifies twelve BPCPHCs as potent Nav ion channel blockers, notably compound 8 g. In vivo studies demonstrate that intrathecal injection of 8 g effectively reverses mechanical hyperalgesia associated with chemotherapy‐induced peripheral neuropathy (CIPN), suggesting a promising therapeutic avenue. Electrophysiological investigations unveil the inhibitory effects of 8 g on Nav1.7 currents. Molecular docking, dynamics simulations and surface plasmon resonance (SPR) assay provide insights into the stable complex formation and favorable binding free energy of 8 g with C5aR1. This research represents a significant advancement in asymmetric CAMC for BPCPHCs and unveils BPCPHC 8 g as a promising, uniquely acting pain blocker, establishing a C5aR1‐Nav1.7 connection in the context of CIPN. [ABSTRACT FROM AUTHOR]

High penetration of uncertain wind power generation brings challenges to power system operational security and economy. Here, an adjustable box uncertainty set is first presented to characterize the spatiotemporal correlation of multiple wind power generations. Afterward, a two‐stage risk‐adjusted robust energy dispatching model is established as a min‐max‐min optimization problem for active distribution networks operating with high penetration wind power generation. Then a three‐layer Nest Column and Constraint Generation (NCCG) decomposition approach is designed to efficiently solve the proposed model. Finally, the proposed two‐stage adaptive robust optimization model and NCCG approach are validated by a distribution network with uncertain wind power generations, and the simulation results indicate the distribution network operation economy could be compromised with robustness by adjusting the conservative regulation parameter. [ABSTRACT FROM AUTHOR]

The problem of source number estimation was a key issue in blind source separation (BSS), because the number of sources directly affected the effect of BSS. To solve this problem, this study proposed a single-channel blind source number estimation algorithm that took the information entropy as the statistical evaluation index, and used the information entropy to measure the information quantity of the source signal to determine the source number. To calculate the information entropy of the estimated source signals, firstly, the Gaussian mixture model (GMM) was used to fit their distributions. Secondly, samples obeying the target distribution were sampled and the entropy was calculated based on the Markov chain Monte Carlo (MCMC) algorithm. Finally, the source number was obtained by minimizing the average information entropy of the source signal. A series of experiments based on simulation data and real communication data showed that the proposed algorithm had strong robustness and could estimate the number of sources with 94% accuracy, thus verifying the effectiveness of the algorithm. [ABSTRACT FROM AUTHOR]

The stator structure is one of the main factors affecting the electromagnetic performance of permanent magnet (PM) motors. In this paper, an in-depth study and analysis of how to reduce the cogging torque is carried out from the perspective of the stator structure. According to the theory of cogging torque synthesis, this paper presents a unified calculation formula for different PM motor skewed notch designs. This theory is verified with a 20-pole, 60-slot motor and a 20-pole, 24-slot motor, respectively. The formula worked out proved to be highly applicable. The formula is intended to address how to quickly obtain key data (skew angle, notch depth) in a skewed notch study. [ABSTRACT FROM AUTHOR]