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11. MCPIP1 Elicits a Therapeutic Effect on Cervical Cancer by Facilitating XIAP mRNA Decay via Its Endoribonuclease Activity.

Author

Luo, Junyun, He, Ling, Guo, Yanxia, Wang, Junzhi, Liu, Hui, and Li, Zhaoyong

Subjects
MONOCYTE chemotactic factor, GROWTH disorders, CERVICAL cancer, SALMONELLA typhimurium, INHIBITION of cellular proliferation
Abstract

Cervical cancer is the fourth most common malignancy in women globally. Chemotherapies, targeted therapies, and immunotherapies in the treatment of cervical cancer are usually accompanied by effective and adverse effects. Therefore, finding other efficient and accurate molecular targets remains essential to improve the treatment benefits of cervical cancer patients. MCPIP1 (monocyte chemoattractant protein-induced protein 1) is a kind of endonuclease with a CCCH zinc finger domain and a PilT-N-terminal (PIN) domain, and its function in cervical cancer is unknown. We found that MCPIP1 inhibits cell proliferation and promotes cell apoptosis of cervical cancer. Additionally, MCPIP1 suppresses mRNA and protein expression of the apoptotic inhibitor XIAP by decreasing its mRNA stability. Mechanically, MCPIP1 binds to the XIAP mRNA via its CCCH zinc finger domain and degrades the XIAP mRNA via the endonuclease activity coming from its PIN domain. Our study clarifies that MCPIP1 promotes cervical cancer cell apoptosis by suppressing the expression of XIAP, thereby impeding cervical cancer progression. Moreover, targeted delivery of MCPIP1 with engineered Salmonella typhimurium leads to tumor growth retardation in the HeLa xenograft tumor model in mice. Therefore, our study may provide a theoretical basis for formulating clinical treatment strategies for cervical cancer. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Enantioselective Self‐Assembly of a Homochiral Tetrahedral Cage Comprising Only Achiral Precursors.

Author

Chen, Yixin, Cao, Ze, Feng, Tinglong, Zhang, Xiaobo, Li, Zhaoyong, Dong, Xue, Huang, Shaoying, Liu, Yingchun, Cao, Xiaoyu, Sue, Andrew C.‐H., Peng, Chuanhui, Lin, Xufeng, Wang, Linjun, and Li, Hao

Subjects
PLANAR chirality, EXCHANGE reactions, RACEMIZATION, ASYMMETRIC synthesis, TETRAHEDRA
Abstract

How Nature synthesizes enantiomerically pure substances from achiral or racemic resources remains a mystery. In this study, we aimed to emulate this natural phenomenon by constructing chiral tetrahedral cages through self‐assembly, achieved by condensing two achiral compounds–a trisamine and a trisaldehyde. The occurrence of intercomponent CH⋅⋅⋅π interactions among the phenyl building blocks within the cage frameworks results in twisted conformations, imparting planar chirality to the tetrahedrons. In instances where the trisaldehyde precursor features electron‐withdrawing ester side chains, we observed that the intermolecular CH⋅⋅⋅π forces are strong enough to prevent racemization. To attain enantioselective self‐assembly, a chiral amine was introduced during the imine formation process. The addition of three equivalents of chiral amino mediator to one equivalent of the achiral trisaldehyde precursor formed a trisimino intermediate. This chiral compound was subsequently combined with the achiral trisamino precursor, leading to an imine exchange reaction that releasing the chiral amino mediator and formation of the tetrahedral cage with an enantiomeric excess (ee) of up to 75 %, exclusively composed of achiral building blocks. This experimental observation aligns with theoretical calculations based on the free energies of related cage structures. Moreover, since the chiral amine was not consumed during the imine exchange cycle, it enabled the enantioselective self‐assembly of the tetrahedral cage for multiple cycles when new batches of the achiral trisaldehyde and trisamino precursors were successively added. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Data from DIS3L2 Promotes Progression of Hepatocellular Carcinoma via hnRNP U-Mediated Alternative Splicing

Author

Xing, Songge, primary, Li, Zhaoyong, primary, Ma, Wenhao, primary, He, Xiaoping, primary, Shen, Shengqi, primary, Wei, Haoran, primary, Li, Shi-Ting, primary, Shu, Ying, primary, Sun, Linchong, primary, Zhong, Xiuying, primary, Huangfu, Yuhao, primary, Su, Lanhong, primary, Feng, Junru, primary, Zhang, Xiaozhang, primary, Gao, Ping, primary, Jia, Wei-Dong, primary, and Zhang, Huafeng, primary

Published
2023
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27. Supplementary Figure S1-S5, and Tables S1-S8 from DIS3L2 Promotes Progression of Hepatocellular Carcinoma via hnRNP U-Mediated Alternative Splicing

Author

Xing, Songge, primary, Li, Zhaoyong, primary, Ma, Wenhao, primary, He, Xiaoping, primary, Shen, Shengqi, primary, Wei, Haoran, primary, Li, Shi-Ting, primary, Shu, Ying, primary, Sun, Linchong, primary, Zhong, Xiuying, primary, Huangfu, Yuhao, primary, Su, Lanhong, primary, Feng, Junru, primary, Zhang, Xiaozhang, primary, Gao, Ping, primary, Jia, Wei-Dong, primary, and Zhang, Huafeng, primary

Published
2023
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41. Multi-Modal Optical Imaging and Combined Phototherapy of Nasopharyngeal Carcinoma Based on a Nanoplatform

Author

Lin,Yanping, Qiu,Ting, Lan,Yintao, Li,Zhaoyong, Wang,Xin, Zhou,Mengyu, Li,Qiuyu, Li,Yao, Liang,Junsheng, and Zhang,Jian

Subjects
International Journal of Nanomedicine
Abstract

Yanping Lin,1,* Ting Qiu,2,* Yintao Lan,3,* Zhaoyong Li,1 Xin Wang,4 Mengyu Zhou,3 Qiuyu Li,1 Yao Li,1 Junsheng Liang,1 Jian Zhang3,4 1Department of Radiology, DongGuan Tungwah Hospital, DongGuan, Guangdong, 523000, People’s Republic of China; 2Department of Radiology, Zhuhai People’s Hospital (Zhuhai Hospital Affiliated with Jinan University), Zhuhai, Guangdong, 519000, People’s Republic of China; 3Department of Biomedical Engineering, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, Guangdong, 511436, People’s Republic of China; 4Department of Oncology, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People’s Hospital, Qingyuan, Guangdong, 511500, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jian Zhang; Junsheng Liang, Email jianzhang@gzhmu.edu.cn; 2581892622@qq.comAbstract: Nasopharyngeal carcinoma (NPC) is a common malignant tumor of the head and neck with a high incidence rate worldwide, especially in southern China. Phototheranostics in combination with nanoparticles is an integrated strategy for enabling simultaneous diagnosis, real-time monitoring, and administration of precision therapy for nasopharyngeal carcinoma (NPC). It has shown great potential in the field of cancer diagnosis and treatment owing to its unique noninvasive advantages. Many Chinese and international research teams have applied nano-targeted drugs to optical diagnosis and treatment technology to conduct multimodal imaging and collaborative treatment of NPC, which has become a hot research topic. In this review, we aimed to introduce the recent developments in phototheranostics of NPC based on a nanoplatform. This study aimed to elaborate on the applications of nanoplatform-based optical imaging strategies and treatment modalities, including fluorescence imaging, photoacoustic imaging, Raman spectroscopy imaging, photodynamic therapy, and photothermal therapy. This study is expected to provide a scientific basis for further research and development of NPC diagnosis and treatment.Keywords: nasopharyngeal carcinoma, optical imaging, phototherapy, nanoparticle

Published
2022

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