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Background: The emergence of multidrug resistance among enterococci makes effective treatment of enterococcalinfections more challenging. Giant pandas (Ailuropoda melanoleuca) are vulnerable to oral trauma and lesions as they feast on bamboo. Enterococcimay contaminate such oral lesions and cause infection necessitating treatment with antibiotics. However, few studies have focused on the virulence and drug resistance of oral-derived enterococci, including Enterococcus faecium, in giant pandas. In this study, we analyzed the prevalence of 8 virulence genes and 14 drug resistance genes in E. faeciumisolates isolated from saliva samples of giant pandas held in captivity in China and examined the antimicrobial drug susceptibility patterns of the E. faeciumisolates. Results: Twenty-eight isolates of E. faeciumwere successfully isolated from the saliva samples. Four virulence genes were detected, with the acmgene showing the highest prevalence (89%). The cylA, cpd, esp, and hylgenes were not detected. The isolated E. faeciumisolates possessed strong resistance to a variety of drugs; however, they were sensitive to high concentrations of aminoglycosides. The resistance rates to vancomycin, linezolid, and nitrofurantoin were higher than those previously revealed by similar studies in China and other countries. Conclusions: The findings of the present study indicate the drugs of choice for treatment of oral E. faeciuminfection in the giant panda.