Search

Your search keyword '"Li, Zhenmei"' showing total 129 results
Start Over Author "Li, Zhenmei"
129 results on '"Li, Zhenmei"'

1. Interpretation of Consensus on Diagnosis and Management of Cushing's Disease: a Guideline Update of the International Pituitary Society——Diagnosis

Author

Huiwen TAN, Yu TANG, Yerong YU, Jianwei LI, Jiaqi LI, Zhenmei AN, Chun WANG, Yi WEI

Subjects
cushing syndrome, cushing disease, diagnostic and treatment guideline, pituitary adenoma, diagnostic techniques and procedures, therapy, Medicine
Abstract

Cushing disease, the most common cause of endogenous Cushing's syndrome characterized by hypercortisolemia, is a clinical syndrome caused by adrenocorticotropic hormone (ACTH) ——secreting pituitary adenomas. The excessive secretion of ACTH in Cushing's disease stimulates bilateral adrenal hyperplasia and causes hypercortisolemia, which can lead to a series of severe clinical syndromes such as electrolyte imbalance, glucose and lipid metabolism disorders, involving multiple organs and systems in the body. The clinical symptoms of Cushing's disease are complex and diverse, and its diagnosis and treatment are extremely challenging. In December 2021, the International Pituitary Society released the Consensus on Diagnosis and Management of Cushing's Disease: a Guideline Update, which focuses on the complications and comorbidities of Cushing's disease, such as hypercoagulability, cardiovascular disease, metabolic bone disease, growth hormone deficiency and infection, etc.; discusses the application of the latest evidence in clinical practice, with a particular focus on new treatment and screening options, diagnostic algorithms, and best practices for preventing disease recurrence. Based on the latest evidence-based medical evidence, this article focuses on the interpretation of Cushing's disease——related laboratory examinations, imaging examinations, diagnosis and treatment management procedures, and recurrence monitoring discussed in the Consensus on Diagnosis and Management of Cushing's Disease: a Guideline Update, in order to improve the general practitioners and specialists'understanding of this syndrome and improve the prognosis of patients with Cushing's disease.

Published
2022
Full Text
View/download PDF

3. Targeting Histone Demethylases in MYC-Driven Neuroblastomas with Ciclopirox

Author

Yang, Jun, Milasta, Sandra, Hu, Dongli, AlTahan, Alaa M, Interiano, Rodrigo B, Zhou, Junfang, Davidson, Jesse, Low, Jonathan, Lin, Wenwei, Bao, Ju, Goh, Pollyanna, Nathwani, Amit C, Wang, Ruoning, Wang, Yingdi, Ong, Su Sien, Boyd, Vincent A, Young, Brandon, Das, Sourav, Shelat, Anang, Wu, Yinan, Li, Zhenmei, Zheng, Jie J, Mishra, Ashutosh, Cheng, Yong, Qu, Chunxu, Peng, Junmin, Green, Douglas R, White, Stephen, Guy, R Kiplin, Chen, Taosheng, and Davidoff, Andrew M

Subjects
Rare Diseases, Cancer, Neuroblastoma, Pediatric, Genetics, Neurosciences, Pediatric Cancer, Animals, Antifungal Agents, Cell Differentiation, Cell Proliferation, Ciclopirox, Epigenesis, Genetic, Gene Expression Regulation, Enzymologic, Histone Demethylases, Histones, Humans, Mice, Mice, SCID, Oxidative Phosphorylation, Proto-Oncogene Proteins c-myc, Pyridones, RNA, Small Interfering, Transcription, Genetic, Tumor Cells, Cultured, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

Histone lysine demethylases facilitate the activity of oncogenic transcription factors, including possibly MYC. Here we show that multiple histone demethylases influence the viability and poor prognosis of neuroblastoma cells, where MYC is often overexpressed. We also identified the approved small-molecule antifungal agent ciclopirox as a novel pan-histone demethylase inhibitor. Ciclopirox targeted several histone demethylases, including KDM4B implicated in MYC function. Accordingly, ciclopirox inhibited Myc signaling in parallel with mitochondrial oxidative phosphorylation, resulting in suppression of neuroblastoma cell viability and inhibition of tumor growth associated with an induction of differentiation. Our findings provide new insights into epigenetic regulation of MYC function and suggest a novel pharmacologic basis to target histone demethylases as an indirect MYC-targeting approach for cancer therapy. Cancer Res; 77(17); 4626-38. ©2017 AACR.

Published
2017

4. 17-DMAG dually inhibits Hsp90 and histone lysine demethylases in alveolar rhabdomyosarcoma

Author

Singh, Shivendra, Abu-Zaid, Ahmed, Lin, Wenwei, Low, Jonathan, Abdolvahabi, Alireza, Jin, Hongjian, Wu, Qiong, Cooke, Bailey, Fang, Jie, Bowling, John, Vaithiyalingam, Sivaraja, Currier, Duane, Yun, Mi-Kyung, Fernando, Dinesh M., Maier, Julie, Tillman, Heather, Bulsara, Purva, Lu, Zhaohua, Das, Sourav, Shelat, Anang, Li, Zhenmei, Young, Brandon, Lee, Richard, Rankovic, Zoran, Murphy, Andrew J., White, Stephen W., Davidoff, Andrew M., Chen, Taosheng, and Yang, Jun

Published
2021
Full Text
View/download PDF

14. Myrcene exerts anti-tumor effects on oral cancer cells in vitro via induction of apoptosis

Author

Wu, Zexiu, Li, Zhenmei, and Liang, Yuan

Subjects
Pharmaceutical Science, Pharmacology (medical), Monoterpene, Oral cancer, Proliferation, Myrcene, Apoptosis, Anticancer
Abstract

Purpose: To investigate the anticancer potential of myrcene against oral cancer cells.Methods: The effect of myrcene on oral cancer cell growth were studied using CCK-8 proliferation andclonogenic assays, while Annexin V-FITC/PI and DAPI staining methods were used for the determination of its effect on cell apoptosis. Protein expression levels were assayed by western blotting technique. Wound healing and Transwell chamber assays were used to determine the effect of myrcene on oral cancer cell migration and invasion, respectively.Results: Myrcene significantly and dose-dependently inhibited oral cancer cell growth (p < 0.05). The anti-proliferative effect of myrcene was comparatively lower on Hs27 human fibroblast cells than on SCC9 oral cancer cells. Myrcene stimulated apoptosis in human oral cancer cells via enhancement of Bax expression and repression of Bcl-2 expression. The percentage of early and late apoptotic cells increased from 4.03 in untreated control to 27.77 when treated with 20 μM myrcene. Moreover, myrcene in vitro significantly suppressed the migration and invasion of oral cancer cells (p < 0.05).Conclusion: These results indicate that myrcene exerts potent anticancer effects on oral cancer cells via induction of apoptosis, and should be further investigated in vivo for this purpose.

Published
2022

15. Data from Targeting Histone Demethylases in MYC-Driven Neuroblastomas with Ciclopirox

Author

Yang, Jun, primary, Milasta, Sandra, primary, Hu, Dongli, primary, AlTahan, Alaa M., primary, Interiano, Rodrigo B., primary, Zhou, Junfang, primary, Davidson, Jesse, primary, Low, Jonathan, primary, Lin, Wenwei, primary, Bao, Ju, primary, Goh, Pollyanna, primary, Nathwani, Amit C., primary, Wang, Ruoning, primary, Wang, Yingdi, primary, Ong, Su Sien, primary, Boyd, Vincent A., primary, Young, Brandon, primary, Das, Sourav, primary, Shelat, Anang, primary, Wu, Yinan, primary, Li, Zhenmei, primary, Zheng, Jie J., primary, Mishra, Ashutosh, primary, Cheng, Yong, primary, Qu, Chunxu, primary, Peng, Junmin, primary, Green, Douglas R., primary, White, Stephen, primary, Guy, R. Kiplin, primary, Chen, Taosheng, primary, and Davidoff, Andrew M., primary

Published
2023
Full Text
View/download PDF

16. Data from Bromodomain-Selective BET Inhibitors Are Potent Antitumor Agents against MYC-Driven Pediatric Cancer

Author

Slavish, P. Jake, primary, Chi, Liying, primary, Yun, Mi-Kyung, primary, Tsurkan, Lyudmila, primary, Martinez, Nancy E., primary, Jonchere, Barbara, primary, Chai, Sergio C., primary, Connelly, Michele, primary, Waddell, M. Brett, primary, Das, Sourav, primary, Neale, Geoffrey, primary, Li, Zhenmei, primary, Shadrick, William R., primary, Olsen, Rachelle R., primary, Freeman, Kevin W., primary, Low, Jonathan A., primary, Price, Jeanine E., primary, Young, Brandon M., primary, Bharatham, Nagakumar, primary, Boyd, Vincent A., primary, Yang, Jun, primary, Lee, Richard E., primary, Morfouace, Marie, primary, Roussel, Martine F., primary, Chen, Taosheng, primary, Savic, Daniel, primary, Guy, R. Kiplin, primary, White, Stephen W., primary, Shelat, Anang A., primary, and Potter, Philip M., primary

Published
2023
Full Text
View/download PDF

17. Supplementary Data from Bromodomain-Selective BET Inhibitors Are Potent Antitumor Agents against MYC-Driven Pediatric Cancer

Author

Slavish, P. Jake, primary, Chi, Liying, primary, Yun, Mi-Kyung, primary, Tsurkan, Lyudmila, primary, Martinez, Nancy E., primary, Jonchere, Barbara, primary, Chai, Sergio C., primary, Connelly, Michele, primary, Waddell, M. Brett, primary, Das, Sourav, primary, Neale, Geoffrey, primary, Li, Zhenmei, primary, Shadrick, William R., primary, Olsen, Rachelle R., primary, Freeman, Kevin W., primary, Low, Jonathan A., primary, Price, Jeanine E., primary, Young, Brandon M., primary, Bharatham, Nagakumar, primary, Boyd, Vincent A., primary, Yang, Jun, primary, Lee, Richard E., primary, Morfouace, Marie, primary, Roussel, Martine F., primary, Chen, Taosheng, primary, Savic, Daniel, primary, Guy, R. Kiplin, primary, White, Stephen W., primary, Shelat, Anang A., primary, and Potter, Philip M., primary

Published
2023
Full Text
View/download PDF

18. Figure S1-S6, Table S1-S2 from Targeting Histone Demethylases in MYC-Driven Neuroblastomas with Ciclopirox

Author

Yang, Jun, primary, Milasta, Sandra, primary, Hu, Dongli, primary, AlTahan, Alaa M., primary, Interiano, Rodrigo B., primary, Zhou, Junfang, primary, Davidson, Jesse, primary, Low, Jonathan, primary, Lin, Wenwei, primary, Bao, Ju, primary, Goh, Pollyanna, primary, Nathwani, Amit C., primary, Wang, Ruoning, primary, Wang, Yingdi, primary, Ong, Su Sien, primary, Boyd, Vincent A., primary, Young, Brandon, primary, Das, Sourav, primary, Shelat, Anang, primary, Wu, Yinan, primary, Li, Zhenmei, primary, Zheng, Jie J., primary, Mishra, Ashutosh, primary, Cheng, Yong, primary, Qu, Chunxu, primary, Peng, Junmin, primary, Green, Douglas R., primary, White, Stephen, primary, Guy, R. Kiplin, primary, Chen, Taosheng, primary, and Davidoff, Andrew M., primary

Published
2023
Full Text
View/download PDF

26. Phenyl‐Glutarimides: Alternative Cereblon Binders for the Design of PROTACs

Author

Min, Jaeki, primary, Mayasundari, Anand, additional, Keramatnia, Fatemeh, additional, Jonchere, Barbara, additional, Yang, Seung Wook, additional, Jarusiewicz, Jamie, additional, Actis, Marisa, additional, Das, Sourav, additional, Young, Brandon, additional, Slavish, Jake, additional, Yang, Lei, additional, Li, Yong, additional, Fu, Xiang, additional, Garrett, Shalandus H., additional, Yun, Mi‐Kyung, additional, Li, Zhenmei, additional, Nithianantham, Stanley, additional, Chai, Sergio, additional, Chen, Taosheng, additional, Shelat, Anang, additional, Lee, Richard E., additional, Nishiguchi, Gisele, additional, White, Stephen W., additional, Roussel, Martine F., additional, Potts, Patrick Ryan, additional, Fischer, Marcus, additional, and Rankovic, Zoran, additional

Published
2021
Full Text
View/download PDF

29. Pharmacological and non-pharmacological treatments for insomnia

Author

Li Jia, Li Zhenmei, Zhu Dongliang, Han Qi, Wang Chun, and Deng Chao

Subjects
Complementary Therapies, medicine.medical_specialty, insomnia, Histamine Antagonists, MEDLINE, law.invention, Benzodiazepines, Pharmacotherapy, Meta-Analysis as Topic, systematic review, Randomized controlled trial, law, Sleep Initiation and Maintenance Disorders, Study Protocol Systematic Review, medicine, Insomnia, Humans, Intensive care medicine, network meta-analysis, Non pharmacological, Melatonin, Protocol (science), Sleep disorder, Cognitive Behavioral Therapy, business.industry, Central Nervous System Depressants, General Medicine, medicine.disease, Antidepressive Agents, meta-analysis, Research Design, Meta-analysis, medicine.symptom, business, Drugs, Chinese Herbal, Systematic Reviews as Topic, Research Article
Abstract

Background: Although nonpharmacological therapies are recommended as first-line treatments for insomnia, they do not widely implement in practice owing to costly or time-consuming. As a result, pharmacotherapy remains to be commonly prescribed for patients with the sleep disorder. Pharmacotherapy for insomnia consists of different types of drugs. Few studies focused on comprehensively evaluating all available drugs for insomnia. Our review aims to compare efficacy and safety of pharmacological and nonpharmacological treatments by synthesizing direct evidence and indirect evidence to help clinicians and patients make informed decisions for insomnia. Methods: We will search the MEDLINE, EMBASE, and Cochrane Register of Controlled Trials between January 2000 and June 12, 2021. Randomized controlled trials of pharmacological and nonpharmacological interventions for insomnia will be included. Study quality will be assessed on the basis of the methodology and categories described in the Cochrane Collaboration Handbook. Eight network meta-analyses were conducted. A Bayesian network meta-analysis would be performed, and relative ranking of agents would be assessed. A node splitting method will be used to examine the inconsistency between direct and indirect comparisons when a loop connecting 3 arms exists. Results: The results of this paper will be submitted to a peer-reviewed journal for publication. Conclusion: The conclusion of our study will provide updated evidence to rank the effectiveness and safety of pharmacological and nonpharmacological interventions for insomnia. Ethics and dissemination: Ethical approval is not applicable, as this study is a network meta-analysis based on published trials. INPLASY registration number: INPLASY202160031

Published
2021

34. Bromodomain-Selective BET Inhibitors Are Potent Antitumor Agents against MYC-Driven Pediatric Cancer

Author

Slavish, P. Jake, primary, Chi, Liying, additional, Yun, Mi-Kyung, additional, Tsurkan, Lyudmila, additional, Martinez, Nancy E., additional, Jonchere, Barbara, additional, Chai, Sergio C., additional, Connelly, Michele, additional, Waddell, M. Brett, additional, Das, Sourav, additional, Neale, Geoffrey, additional, Li, Zhenmei, additional, Shadrick, William R., additional, Olsen, Rachelle R., additional, Freeman, Kevin W., additional, Low, Jonathan A., additional, Price, Jeanine E., additional, Young, Brandon M., additional, Bharatham, Nagakumar, additional, Boyd, Vincent A., additional, Yang, Jun, additional, Lee, Richard E., additional, Morfouace, Marie, additional, Roussel, Martine F., additional, Chen, Taosheng, additional, Savic, Daniel, additional, Guy, R. Kiplin, additional, White, Stephen W., additional, Shelat, Anang A., additional, and Potter, Philip M., additional

Published
2020
Full Text
View/download PDF

36. Geldanamycin inhibits Jumonji histone lysine demethylase KDM4 and targets chimeric transcription factor PAX3-FOXO1

Author

Abu-Zaid, Ahmed, primary, Singh, Shivendra, additional, Lin, Wenwei, additional, Low, Jonathan, additional, Abdolvahabi, Alireza, additional, Cooke, Bailey, additional, Bowling, John, additional, Vaithiyalingam, Sivaraja, additional, Fang, Jie, additional, Currier, Duane, additional, Yun, Mi-Kyung, additional, AlTahan, Alaa, additional, Fernando, Dinesh M., additional, Maier, Julie, additional, Tillman, Heather, additional, Bulsara, Purva, additional, Lu, Zhaohua, additional, Das, Sourav, additional, Li, Zhenmei, additional, Young, Brandon, additional, Lee, Richard, additional, Rankovic, Zoran, additional, White, Stephen, additional, Davidoff, Andrew M., additional, Chen, Taosheng, additional, and Yang, Jun, additional

Published
2019
Full Text
View/download PDF

49. The Research of On-line Real-time Automatic Detector on Communication Fiber-Optic Diameter

Author

Li Tianze, Li Zhenmei, Sheng Cui-xia, and Wang Shuyun

Subjects
Printed circuit board, Optical fiber, Computer science, law, Detector, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, Electronic engineering, Charge-coupled device, Optical filter, Line (electrical engineering), Beam (structure), Power (physics), law.invention
Abstract

This article expounds linear array Charge Coupled Device (CCD) 's characteristics, working theory, driving time sequence and the design of the linear array CCD driving board for binarization. A kind of on-line real-time automatic detector with high precision was developed on this base. The device mainly includes: beam collimational system; linear array CCD driving board for binarization; constant current source power supply; the main circuit board system and so on.. The article analyses the choice of light source and illumination's matching, the design of beam collimational system; the detailed TCD 1206 driving sequence and a series of questions such as linear array CCD binarization, the main circuit board system's design and so on. Furthermore, discusses and prospects the device's application.

Published
2008

50. Harmonic Analysis System of Power Network Based on Wavelet Transform

Author

Li Zhenmei, Shen Jin, Yang Shu-lian, and Li Tianze

Subjects
Discrete wavelet transform, Wavelet, Frequency band, Computer science, Stationary wavelet transform, Second-generation wavelet transform, Harmonics, Electronic engineering, Wavelet transform, Wavelet packet decomposition
Abstract

The harmonic analysis system of power network was developed based on wavelet transform by using the virtual instrument. The system consists of sensors, signal conditioning circuits, data acquisition and computers. Within the system, the wavelet packet was adopted to analyse harmonics and locate the distortion point by means of the MATLAB script node in LabVIEW, in which the signals were divided into multi -frequency band according to the power signal character, and the frequency band was selected adaptively so as to promote the time-frequency resolution of signals.

Published
2007

Catalog

Books, media, physical & digital resources
See catalog results