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24. STUDY ON BEND-TWIST COUPLING CHARACTERISTICS OF WEB OFFSET FOR LARGE WIND TURBINE BLADES (MT)

Author

WANG HaiSheng, MIAO WeiPao, LI Chun, ZHANG Li, YAN YangTian, LI Zhi Hao, and YUE Min Nan

Subjects
Wind turbine blade, Bend-twist coupling, Composite material, Structure coupling, Node displacement method, Mechanical engineering and machinery, TJ1-1570, Materials of engineering and construction. Mechanics of materials, TA401-492
Abstract

In order to research the influence of the web deflection on the bend-twist coupling characteristics of large wind turbine blades, the CAD model of NREL 5 MW blade is established based on NX secondary development, the aerodynamic loads of the blade are obtained by CFD method, the blade bendind angle and twisting angle are solved by the node displacement method to analyze the influence of web deflection for bend-twist coupling blade. The results show that the offset web helps to achieve the bend-twist coupling of blades. Under the action of aerodynamic load, the bending and twisting angle both increase along spanwise direction of blade gradually, and reach the magnitude at the tip of the blade; in forward bias, negative correlation between twist angle and offset, reverse bias is the opposite; positive bias blades bend-twist coupling coefficient is decreasing trend with the increase of deflection angle, reverse bias blade are greater than the conventional blade.

Published
2023
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34. Causal Association between Circulating Metabolites and Dementia: A Mendelian Randomization Study.

Author

Li, Hong-Min, Qiu, Cheng-Shen, Du, Li-Ying, Tang, Xu-Lian, Liao, Dan-Qing, Xiong, Zhi-Yuan, Lai, Shu-Min, Huang, Hong-Xuan, Kuang, Ling, Zhang, Bing-Yun, and Li, Zhi-Hao

Abstract

The causal association of circulating metabolites with dementia remains uncertain. We assessed the causal association of circulating metabolites with dementia utilizing Mendelian randomization (MR) methods. We performed univariable MR analysis to evaluate the associations of 486 metabolites with dementia, Alzheimer's disease (AD), and vascular dementia (VaD) risk. For secondary validation, we replicated the analyses using an additional dataset with 123 metabolites. We observed 118 metabolites relevant to the risk of dementia, 59 of which were lipids, supporting the crucial role of lipids in dementia pathogenesis. After Bonferroni adjustment, we identified nine traits of HDL particles as potential causal mediators of dementia. Regarding dementia subtypes, protective effects were observed for epiandrosterone sulfate on AD (OR = 0.60, 95% CI: 0.48–0.75) and glycoproteins on VaD (OR = 0.89, 95% CI: 0.83–0.95). Bayesian model averaging MR (MR-BMA) analysis was further conducted to prioritize the predominant metabolites for dementia risk, which highlighted the mean diameter of HDL particles and the concentration of very large HDL particles as the predominant protective factors against dementia. Moreover, pathway analysis identified 17 significant and 2 shared metabolic pathways. These findings provide support for the identification of promising predictive biomarkers and therapeutic targets for dementia. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Analysis of changes in social isolation, loneliness, or both, and subsequent cognitive function among older adults: Findings from a nationwide cohort study.

Author

Huang, Qing‐Mei, Zhang, Pei‐Dong, Shen, Dong, Gao, Jian, Li, Zhi‐Hao, Lv, Yue‐Bin, Shi, Xiao‐Ming, and Mao, Chen

Abstract

INTRODUCTION: The study aimed to investigate the associations of changes in social isolation, loneliness, or both, with cognitive function. METHODS: Data were from 7299 older adults in the Chinese Longitudinal Healthy Longevity Survey. We defined four change patterns (no, incident, transient, and persistent) for social isolation and loneliness, and created nine‐category variable to represent the joint changes. Tobit regression models and Cox models were performed. RESULTS: Incident, transient, and persistent social isolation or loneliness may accelerate cognitive decline (p < 0.05). Incident, transient, and persistent social isolation were associated with higher cognitive impairment risk, while only persistent loneliness was associated with higher cognitive impairment risk (p < 0.001). Notably, short‐term or persistent social isolation was associated with accelerated cognitive decline and incident cognitive impairment, regardless of different loneliness change status (p < 0.05). DISCUSSION: Short‐term or persistent social isolation and persistent loneliness may be a salient risk factor for cognitive decline and cognitive impairment. Highlights: Incident, transient, and persistent social isolation were associated with accelerated cognitive decline and higher cognitive impairment risk.Persistent loneliness was associated with accelerated cognitive decline and higher cognitive impairment risk.Short‐term or persistent social isolation with concurrent different loneliness change status accelerated cognitive decline and higher cognitive impairment risk. [ABSTRACT FROM AUTHOR]

Published
2024
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40. Association between atherogenic index of plasma and all-cause mortality and specific-mortality: a nationwide population‑based cohort study.

Author

You, Fang-Fei, Gao, Jian, Gao, Yi-Ning, Li, Zhi-Hao, Shen, Dong, Zhong, Wen-Fang, Yang, Jin, Wang, Xiao-Meng, Song, Wei-Qi, Yan, Hao, Yan, Hao-Yu, Xie, Jia-Hao, Chen, Huan, and Mao, Chen

Subjects
MORTALITY, COHORT analysis, CANCER-related mortality, OLDER women, DEATH rate
Abstract

Background: Atherogenic index of plasma (AIP), a marker of atherosclerosis and cardiovascular disease (CVD). However, few studies have investigated association between AIP and all-cause mortality and specific-mortality in the general population. Methods: This study included data from 14,063 American adults. The exposure variable was the AIP, which was defined as log10 (triglycerides/high-density lipoprotein cholesterol). The outcome variables included all-cause mortality and specific-mortality. Survey-weighted cox regressions were performed to evaluate the relation between AIP and all-cause mortality and specific-mortality. Weighted restricted cubic spline was conducted to examin the non-linear relationship. Results: During 10 years of follow-up, we documented 2,077, 262, 854, and 476 cases of all-cause mortality, diabetes mortality, CVD mortality and cancer mortality, respectively. After adjustment for potential confounders, we found that atherogenic index of plasma (AIP) was significantly associated with an increased risk of diabetes mortality when comparing the highest to the lowest quantile of AIP in female (p for trend = 0.001) or participants older than 65 years (p for trend = 0.002). AIP was not significantly associated with all-cause mortality, CVD mortality and cancer mortality (p > 0.05). Moreover, a non-linear association was observed between AIP and all-cause mortality in a U-shape (p for non-linear = 0.0011), while a linear relationship was observed with diabetes mortality and non-diabetes mortality (p for linear < 0.0001). Conclusions: In this study, there is a no significant association between high AIP levels and a high risk of all-cause and cardiovascular mortality. Besides, a higher AIP was significantly associated with an increased risk of diabetes mortality, which only found in women older than 65 years. AIP was associated with all-cause mortality in a U-shape. This association could be explained by the finding that higher AIP predicted a higher risk of death from diabetes, and that lower AIP predicted a higher risk of death from non-diabetes causes. Highlight: We used a large national database and a prospective cohort study with a long follow-up period. Higher AIP was significantly associated with an increased risk of diabetes mortality, only in women older than 65 years. There is a no significant association between high AIP levels and a high risk of all-cause and cardiovascular mortality. AIP was associated with all-cause mortality in a U-shape. This finding suggest that controlling AIP levels may have a positive effect on reducing diabetes mortality. [ABSTRACT FROM AUTHOR]

Published
2024
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48. Dietary Diversity Changes and Cognitive Frailty in Chinese Older Adults: A Prospective Community-Based Cohort Study

Author

Zhong, Wen-Fang, primary, Song, Wei-Qi, additional, Wang, Xiao-Meng, additional, Li, Zhi-Hao, additional, Shen, Dong, additional, Liu, Dan, additional, Zhang, Pei-Dong, additional, Shen, Qiao-Qiao, additional, Liang, Fen, additional, Nan, Ying, additional, Xiang, Jia-Xuan, additional, Chen, Zi-Ting, additional, Li, Chuan, additional, Li, Shi-Tian, additional, Lv, Xiao-Gang, additional, Lin, Xiu-Rong, additional, Lv, Yue-Bin, additional, Gao, Xiang, additional, Kraus, Virginia Byers, additional, Shi, Xiao-Ming, additional, and Mao, Chen, additional

Published
2023
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