Search

Your search keyword '"Li, Zhongwei"' showing total 1,193 results
Start Over Author "Li, Zhongwei"
1,193 results on '"Li, Zhongwei"'

12. Long-term expandable mouse and human-induced nephron progenitor cells enable kidney organoid maturation and modeling of plasticity and disease

Author

Huang, Biao, Zeng, Zipeng, Kim, Sunghyun, Fausto, Connor C., Koppitch, Kari, Li, Hui, Li, Zexu, Chen, Xi, Guo, Jinjin, Zhang, Chennan C., Ma, Tianyi, Medina, Pedro, Schreiber, Megan E., Xia, Mateo W., Vonk, Ariel C., Xiang, Tianyuan, Patel, Tadrushi, Li, Yidan, Parvez, Riana K., Der, Balint, Chen, Jyun Hao, Liu, Zhenqing, Thornton, Matthew E., Grubbs, Brendan H., Diao, Yarui, Dou, Yali, Gnedeva, Ksenia, Ying, Qilong, Pastor-Soler, Nuria M., Fei, Teng, Hallows, Kenneth R., Lindström, Nils O., McMahon, Andrew P., and Li, Zhongwei

Published
2024
Full Text
View/download PDF

21. Wiskott-Aldrich syndrome protein forms nuclear condensates and regulates alternative splicing

Author

Yuan, Baolei, Zhou, Xuan, Suzuki, Keiichiro, Ramos-Mandujano, Gerardo, Wang, Mengge, Tehseen, Muhammad, Cortés-Medina, Lorena V, Moresco, James J, Dunn, Sarah, Hernandez-Benitez, Reyna, Hishida, Tomoaki, Kim, Na Young, Andijani, Manal M, Bi, Chongwei, Ku, Manching, Takahashi, Yuta, Xu, Jinna, Qiu, Jinsong, Huang, Ling, Benner, Christopher, Aizawa, Emi, Qu, Jing, Liu, Guang-Hui, Li, Zhongwei, Yi, Fei, Ghosheh, Yanal, Shao, Changwei, Shokhirev, Maxim, Comoli, Patrizia, Frassoni, Francesco, Yates, John R, Fu, Xiang-Dong, Esteban, Concepcion Rodriguez, Hamdan, Samir, Izpisua Belmonte, Juan Carlos, and Li, Mo

Subjects
Rare Diseases, Human Genome, Genetics, Generic health relevance, Alternative Splicing, Cell Nucleus, Humans, RNA Polymerase II, RNA Splicing Factors, RNA-Binding Proteins, Wiskott-Aldrich Syndrome, Wiskott-Aldrich Syndrome Protein
Abstract

The diverse functions of WASP, the deficiency of which causes Wiskott-Aldrich syndrome (WAS), remain poorly defined. We generated three isogenic WAS models using patient induced pluripotent stem cells and genome editing. These models recapitulated WAS phenotypes and revealed that WASP deficiency causes an upregulation of numerous RNA splicing factors and widespread altered splicing. Loss of WASP binding to splicing factor gene promoters frequently leads to aberrant epigenetic activation. WASP interacts with dozens of nuclear speckle constituents and constrains SRSF2 mobility. Using an optogenetic system, we showed that WASP forms phase-separated condensates that encompasses SRSF2, nascent RNA and active Pol II. The role of WASP in gene body condensates is corroborated by ChIPseq and RIPseq. Together our data reveal that WASP is a nexus regulator of RNA splicing that controls the transcription of splicing factors epigenetically and the dynamics of the splicing machinery through liquid-liquid phase separation.

Published
2022

40. Cut-out : music, profanity, and subcultural politics in 1990s China

Author

Li, Zhongwei

Subjects
306, H Social Sciences (General), JA Political science (General), M Music
Abstract

This thesis examines the subcultural politics of the "cut-out generation" in 1990s China. It is driven by a double aspiration, and aims to bridge gaps in two main fields of literature. The first aspiration is a historical one: I offer a fine historical account of the "cut-out generation" as a slice of 1990s Chinese society, which remained overlooked in Chinese studies. The second aspiration is a theoretical one: I interrogate existing theories and concepts in the larger field of cultural studies, including music and materiality, subculture and profanity, regime of value and structure of feeling, with evidence found in this Chinese case, and point toward a comprehensive framework for the analysis of subcultural politics. The methodological approach consists of 72 in-depth life history interview and archival analysis of a "cut-out archive", both conducted through an "ethnographic imagination" lens. The thesis unpacks subcultural politics by looking into the materiality of subcultural objects, the sensuous interactions between people and things, and the dialectical interplay between a subculture and its historical, structural settings. It has three main empirical foci corresponding to each empirical chapter and organized under three theoretical themes: politics of value, dialectics of profanity, and structure of feeling. The first empirical chapter (politics of value) investigates three contested materialities of the cut-outs as plastic scrap, defective records, and "music info", demonstrating in this way the different regimes of value which the cut-outs travelled through. The second one (dialectics of profanity) reveals how the cut-outs became a music object whose profanity was realized in various sensuous and creative relationships formed with Chinese consumers. The last empirical chapter (structure of feeling) provides a historicized analysis of the structure of feeling of the "cut-out generation", which functioned as an affective infrastructure which both "emerged" from and "penetrated" the historical context of 1990s China.

Published
2019

48. Author Correction: Wiskott-Aldrich syndrome protein forms nuclear condensates and regulates alternative splicing

Author

Yuan, Baolei, Zhou, Xuan, Suzuki, Keiichiro, Ramos-Mandujano, Gerardo, Wang, Mengge, Tehseen, Muhammad, Cortés-Medina, Lorena V., Moresco, James J., Dunn, Sarah, Hernandez-Benitez, Reyna, Hishida, Tomoaki, Kim, Na Young, Andijani, Manal M., Bi, Chongwei, Ku, Manching, Takahashi, Yuta, Xu, Jinna, Qiu, Jinsong, Huang, Ling, Benner, Christopher, Aizawa, Emi, Qu, Jing, Liu, Guang-Hui, Li, Zhongwei, Yi, Fei, Ghosheh, Yanal, Shao, Changwei, Shokhirev, Maxim, Comoli, Patrizia, Frassoni, Francesco, Yates, III, John R., Fu, Xiang-Dong, Esteban, Concepcion Rodriguez, Hamdan, Samir, Izpisua Belmonte, Juan Carlos, and Li, Mo

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results