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1. Regulatory Molecules of Synaptic Plasticity in Anxiety Disorder

Author

Sha Z, Xu J, Li N, and Li O

Subjects
synaptic plasticity, anxiety, mglurs, bdnf, hcn, psd95, Medicine (General), R5-920
Abstract

Zhongwei Sha, Jian Xu, Nana Li, Ou Li Department of Mental Diseases, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of ChinaCorrespondence: Zhongwei Sha, Department of Mental Diseases, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 274 Middle Zhijiang Road, Zhabei, Shanghai, 200071, People’s Republic of China, Tel/Fax +86 21-56639828, Email shazhongwei1989@163.comAbstract: Synaptic plasticity is the capacity of synaptic transmission between neurons to be strengthened or weakened. There are many signal molecules accumulated in the presynaptic and postsynaptic membranes that can lead to the regulation of synaptic plasticity and involvement in numerous of neurological and psychiatric diseases, including anxiety disorder. However, the regulatory mechanisms of synaptic plasticity in the development of anxiety disorder have not been well summarized. This review mainly aims to discuss the biological functions and mechanisms of synaptic plasticity-related molecules in anxiety disorder, with a particular focus on the metabotropic glutamate receptors, brain-derived neurotrophic factor, hyperpolarization-activated cyclic nucleotide–gated channels, and postsynaptic density 95. The summarized functions and mechanisms of synaptic plasticity-related molecules in anxiety will provide insight into novel neuroplasticity modifications for targeted therapy for anxiety.Keywords: synaptic plasticity, anxiety, mGluRs, BDNF, HCN, PSD95

Published
2023

2. Effectiveness and Safety of Bu Shen Kai Qiao Fang in the Treatment of Alzheimer’s Disease: Study Protocol for a Multicenter, Prospective, Real-World Clinical Trial

Author

Xu Z, Li O, Liang Y, Wu Z, Xu J, Wang L, Li L, and Sun Y

Subjects
alzheimer's disease, bu shen kai qiao fang, real-world ctrial, mmse, moca, aβ42, tau, Medicine (General), R5-920
Abstract

ZeYu Xu,1,* Ou Li,1,* YaTing Liang,1,* ZhiBing Wu,2 Jiamei Xu,2 Ling Wang,3 Ling Li,3 YongNing Sun1 1Department of Brain and Mental Disease, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, ShangHai, 200040, People’s Republic of China; 2Department of Encephalopathy, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, People’s Republic of China; 3Department of Geriatrics, Shaanxi Provincial Hospital of Traditional Chinese Medicine, Xi’an, 710003, People’s Republic of China*These authors contributed equally to this workCorrespondence: YongNing Sun, Shanghai University of Traditional Chinese Medicine, Shanghai, 200040, People’s Republic of China, Tel +8618930177579, Email ynsun2002@126.comBackground: Alzheimer’s disease (AD) is a common degenerative disease of the nervous system with serious impact on quality of life of patients and their families. With an aging population, AD has become a major public health problem in China and worldwide. However, the physiological and pathological mechanisms of AD have not been fully elucidated, and there is a lack of effective prevention and clinical treatment methods. Many studies have found that traditional Chinese medicine (TCM) has a good therapeutic effect on cognitive function in AD patients. Bu Shen Kai Qiao Fang (BSKQF) is one such Chinese herbal preparation used in the treatment of AD. We designed a protocol for a real-world clinical study of BSKQF combined with Donepezil hydrochloride (DH) to evaluate the efficacy and safety of this approach in the treatment of AD patients.Methods: This is a protocol for a real-world, multicenter, prospective, observational cohort study. The study will recruit 860 AD patients from four hospitals across China. Equal numbers of patients will be treated with BSKQF and DH or with DH only. The criteria for grouping are based primarily on patient preference. Outcome measures include scores on the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment Scale (MOCA) and will be recorded at baseline, and at one, two and three months after enrollment. The plasma Aβ 42 and plasma Tau levels of participating patients will also be measured by ELISA at baseline and after 3 months of treatment. Safety metrics and adverse events (AEs) of participating patients will be monitored and recorded.Discussion: This study will evaluate the clinical efficacy and safety of BSKQF in the treatment of AD. The results will provide reliable evidence for the clinical application of BSKQF in the treatment of AD.Study Registration: Trial registration: Chinese Clinical Trial Registry, NO. ChiCTR2000039670, Registered 5 November 2020 https://www.chictr.org.cn/showprojEN.html?proj=63800.Keywords: Alzheimer’s disease, Bu Shen Kai Qiao Fang, real-world trial, MMSE, MOCA, Aβ 42, tau

Published
2023

5. Simulations of the measurement results of differential cross sections of n-p and n-d elastic scattering at CSNS Back-n WNS

Author

Cui Zengqi, Bai Huaiyong, Jiang Haoyu, Hu Yiwei, Zhang Guohui, Fan Ruirui, Jiang Wei, Yi Han, Tang Jingyu, An Qi, Bao Jie, Bao Yu, Cao Ping, Chen Haolei, Chen Qiping, Chen Yonghao, Chen Yukai, Chen Zhen, Feng Changqing, Gao Keqing, Gu Minhao, Han Changcai, Han Zijie, He Guozhu, He Yongcheng, Hong Yang, Huang Hanxiong, Huang Weiling, Huang Xiru, Ji Xiaolu, Ji Xuyang, Jiang Zhijie, Jing Hantao, Kang Ling, Kang Mingtao, Li O, Li Chao, Li Jiawen, Li Lun, Li Qiang, Li Xiao, Li Yang, Liu Rong, Liu Shubin, Liu Xingyan, Luan Guangyuan, Mu Qili, Ning Changjun, Qi Binbin, Ren Jie, Ren Zhizhou, Ruan XiChao, Song Zhaohui, Song Yingpeng, Sun Hong, Sun Kang, Sun Xiaoyang, Sun Zhijia, Tan Zhixin, Tang Hongqing, Tang Xinyi, Tian Binbin, Wang Lijiao, Wang Pengcheng, Wang Qi, Wang Taofeng, Wang Zhaohui, Wen Jie, Wen Zhongwei, Wu Qingbiao, Wu Xiaoguang, Wu Xuan, Xie Likun, Yang Yiwei, Yu Li, Yu Tao, Yu Yongji, Zhang Linhao, Zhang Qiwei, Zhang Xianpeng, Zhang Yuliang, Zhang Zhiyong, Zhao Yubin, Zhou Luping, Zhou Zuying, Zhu Danyang, Zhu Kejun, and Zhu Peng

Subjects
Physics, QC1-999
Abstract

Differential cross-section data for the n-p and n-d elastic scattering (1H(n, el), 2H(n, el)) are collected and analyzed from EXFOR library. For En > 20 MeV, the experimental results for both reactions are scarce with large uncertainties and discrepancies in general. For En ≤ 20 MeV, the experimental results lack systematicness, most of which were measured around En = 14 MeV even though the differential cross sections of n-p scattering in 1 keV ≤ En ≤ 20 MeV region are recommended as standard. Taking these facts into account, more accurate and systematic measurements are planned. The experiments will be conducted using ΔE-E detectors of the Light-charged Particle Detector Array (LPDA) system at China Spallation Neutron Source (CSNS) Back-n White Neutron Source (WNS), and simulations are carried out. Using polyethylene and deuterated polyethylene as samples, both n-p and n-d scattering reactions are simulated along with the neutron-induced 12C background reactions, and the 2-D spectra and the counting rates of the ΔE-E detectors are obtained. According to the simulations, the applicable neutron energy range and positions of the detectors are recommended, and the beam time for the event and background measurements is suggested.

Published
2020
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9. Multimodal and multicontrast image fusion via deep generative models

Author

Dimitri, Giovanna Maria, Spasov, Simeon, Duggento, Andrea, Passamonti, Luca, Li`o, Pietro, and Toschi, Nicola

Subjects
Computer Science - Machine Learning
Abstract

Recently, it has become progressively more evident that classic diagnostic labels are unable to reliably describe the complexity and variability of several clinical phenotypes. This is particularly true for a broad range of neuropsychiatric illnesses (e.g., depression, anxiety disorders, behavioral phenotypes). Patient heterogeneity can be better described by grouping individuals into novel categories based on empirically derived sections of intersecting continua that span across and beyond traditional categorical borders. In this context, neuroimaging data carry a wealth of spatiotemporally resolved information about each patient's brain. However, they are usually heavily collapsed a priori through procedures which are not learned as part of model training, and consequently not optimized for the downstream prediction task. This is because every individual participant usually comes with multiple whole-brain 3D imaging modalities often accompanied by a deep genotypic and phenotypic characterization, hence posing formidable computational challenges. In this paper we design a deep learning architecture based on generative models rooted in a modular approach and separable convolutional blocks to a) fuse multiple 3D neuroimaging modalities on a voxel-wise level, b) convert them into informative latent embeddings through heavy dimensionality reduction, c) maintain good generalizability and minimal information loss. As proof of concept, we test our architecture on the well characterized Human Connectome Project database demonstrating that our latent embeddings can be clustered into easily separable subject strata which, in turn, map to different phenotypical information which was not included in the embedding creation process. This may be of aid in predicting disease evolution as well as drug response, hence supporting mechanistic disease understanding and empowering clinical trials.

Published
2023
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12. The SNO+ Experiment

Author

Collaboration, SNO, Albanese, V., Alves, R., Anderson, M. R., Andringa, S., Anselmo, L., Arushanova, E., Asahi, S., Askins, M., Auty, D. J., Back, A. R., Back, S., Barão, F., Barnard, Z., Barr, A., Barros, N., Bartlett, D., Bayes, R., Beaudoin, C., Beier, E. W., Berardi, G., Bialek, A., Biller, S. D., Blucher, E., Bonventre, R., Boulay, M., Braid, D., Caden, E., Callaghan, E. J., Caravaca, J., Carvalho, J., Cavalli, L., Chauhan, D., Chen, M., Chkvorets, O., Clark, K. J., Cleveland, B., Connors, C., Cookman, D., Coulter, I. T., Cox, M. A., Cressy, D., Dai, X., Darrach, C., Davis-Purcell, B., Deluce, C., Depatie, M. M., Descamps, F., Di Lodovico, F., Dittmer, J., Doxtator, A., Duhaime, N., Duncan, F., Dunger, J., Earle, A. D., Fabris, D., Falk, E., Farrugia, A., Fatemighomi, N., Felber, C., Fischer, V., Fletcher, E., Ford, R., Frankiewicz, K., Gagnon, N., Gaur, A., Gauthier, J., Gibson-Foster, A., Gilje, K., González-Reina, O. I., Gooding, D., Gorel, P., Graham, K., Grant, C., Grove, J., Grullon, S., Guillian, E., Hall, S., Hallin, A. L., Hallman, D., Hans, S., Hartnell, J., Harvey, P., Hedayatipour, M., Heintzelman, W. J., Heise, J., Helmer, R. L., Hodak, B., Hodak, M., Hood, M., Horne, D., Hreljac, B., Hu, J., Hussain, S. M. A., Iida, T., Inácio, A. S., Jackson, C. M., Jelley, N. A., Jillings, C. J., Jones, C., Jones, P. G., Kamdin, K., Kaptanoglu, T., Kaspar, J., Keeter, K., Kefelian, C., Khaghani, P., Kippenbrock, L., Klein, J. R., Knapik, R., Kofron, J., Kormos, L. L., Korte, S., Krar, B., Kraus, C., Krauss, C. B., Kroupová, T., Labe, K., Lafleur, F., Lam, I., Lan, C., Land, B. J., Lane, R., Langrock, S., Larochelle, P., Larose, S., LaTorre, A., Lawson, I., Lebanowski, L., Lefeuvre, G. M., Leming, E. J., Li, A., Li, O., Lidgard, J., Liggins, B., Liimatainen, P., Lin, Y. H., Liu, X., Liu, Y., Lozza, V., Luo, M., Maguire, S., Maio, A., Majumdar, K., Manecki, S., Maneira, J., Martin, R. D., Marzec, E., Mastbaum, A., Mathewson, A., McCauley, N., McDonald, A. B., McFarlane, K., Mekarski, P., Meyer, M., Miller, C., Mills, C., Mlejnek, M., Mony, E., Morissette, B., Morton-Blake, I., Mottram, M. J., Nae, S., Nirkko, M., Nolan, L. J., Novikov, V. M., O'Keeffe, H. M., O'Sullivan, E., Gann, G. D. Orebi, Parnell, M. J., Paton, J., Peeters, S. J. M., Pershing, T., Petriw, Z., Petzoldt, J., Pickard, L., Pracsovics, D., Prior, G., Prouty, J. C., Quirk, S., Read, S., Reichold, A., Riccetto, S., Richardson, R., Rigan, M., Ritchie, I., Robertson, A., Robertson, B. C., Rose, J., Rosero, R., Rost, P. M., Rumleskie, J., Schumaker, M. A., Schwendener, M. H., Scislowski, D., Secrest, J., Seddighin, M., Segui, L., Seibert, S., Semenec, I., Shaker, F., Shantz, T., Sharma, M. K., Shokair, T. M., Sibley, L., Sinclair, J. R., Singh, K., Skensved, P., Smiley, M., Sonley, T., Sörensen, A., St-Amant, M., Stainforth, R., Stankiewicz, S., Strait, M., Stringer, M. I., Stripay, A., Svoboda, R., Tacchino, S., Tam, B., Tanguay, C., Tatar, J., Tian, L., Tolich, N., Tseng, J., Tseung, H. W. C., Turner, E., Van Berg, R., Vázquez-Jáuregui, E., Veinot, J. G. C., Virtue, C. J., von Krosigk, B., Walker, J. M. G., Walker, M., Wallig, J., Walton, S. C., Wang, J., Ward, M., Wasalski, O., Waterfield, J., Weigand, J. J., White, R. F., Wilson, J. R., Winchester, T. J., Woosaree, P., Wright, A., Yanez, J. P., Yeh, M., Zhang, T., Zhang, Y., Zhao, T., Zuber, K., and Zummo, A.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment, Nuclear Experiment
Abstract

The SNO+ experiment is located 2 km underground at SNOLAB in Sudbury, Canada. A low background search for neutrinoless double beta ($0\nu\beta\beta$) decay will be conducted using 780 tonnes of liquid scintillator loaded with 3.9 tonnes of natural tellurium, corresponding to 1.3 tonnes of $^{130}$Te. This paper provides a general overview of the SNO+ experiment, including detector design, construction of process plants, commissioning efforts, electronics upgrades, data acquisition systems, and calibration techniques. The SNO+ collaboration is reusing the acrylic vessel, PMT array, and electronics of the SNO detector, having made a number of experimental upgrades and essential adaptations for use with the liquid scintillator. With low backgrounds and a low energy threshold, the SNO+ collaboration will also pursue a rich physics program beyond the search for $0\nu\beta\beta$ decay, including studies of geo- and reactor antineutrinos, supernova and solar neutrinos, and exotic physics such as the search for invisible nucleon decay. The SNO+ approach to the search for $0\nu\beta\beta$ decay is scalable: a future phase with high $^{130}$Te-loading is envisioned to probe an effective Majorana mass in the inverted mass ordering region., Comment: 61 pages, 23 figures, 4 tables

Published
2021
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14. α-PD-1 therapy elevates Treg/Th balance and increases tumor cell pSmad3 that are both targeted by α-TGFβ antibody to promote durable rejection and immunity in squamous cell carcinomas

Author

Dodagatta-Marri, E, Meyer, DS, Reeves, MQ, Paniagua, R, To, MD, Binnewies, M, Broz, ML, Mori, H, Wu, D, Adoumie, M, Del Rosario, R, Li, O, Buchmann, T, Liang, B, Malato, J, Arce Vargus, F, Sheppard, D, Hann, BC, Mirza, A, Quezada, SA, Rosenblum, MD, Krummel, MF, Balmain, A, and Akhurst, RJ

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Vaccine Related, Cancer, Orphan Drug, Clinical Research, Immunization, Immunotherapy, Rare Diseases, Aetiology, 2.1 Biological and endogenous factors, Antineoplastic Agents, Immunological, Biomarkers, CD4 Lymphocyte Count, Carcinoma, Squamous Cell, Cell Line, Tumor, Drug Synergism, Epithelial-Mesenchymal Transition, Humans, Immunohistochemistry, Lymphocyte Count, Lymphocytes, Tumor-Infiltrating, Programmed Cell Death 1 Receptor, Signal Transduction, Smad3 Protein, T-Lymphocytes, Helper-Inducer, T-Lymphocytes, Regulatory, Transforming Growth Factor beta, Checkpoint blockade, Squamous cell carcinoma, Tumor mutation load, -TGF, -PD-1 combinatorial immunotherapy, Tregs, pSmad signaling, Epithelial mesenchymal transition, α-TGFβ /α-PD-1 combinatorial immunotherapy, Oncology and carcinogenesis
Abstract

BackgroundCheckpoint blockade immunotherapy has improved metastatic cancer patient survival, but response rates remain low. There is an unmet need to identify mechanisms and tools to circumvent resistance. In human patients, responses to checkpoint blockade therapy correlate with tumor mutation load, and intrinsic resistance associates with pre-treatment signatures of epithelial mesenchymal transition (EMT), immunosuppression, macrophage chemotaxis and TGFβ signaling.MethodsTo facilitate studies on mechanisms of squamous cell carcinoma (SCC) evasion of checkpoint blockade immunotherapy, we sought to develop a novel panel of murine syngeneic SCC lines reflecting the heterogeneity of human cancer and its responses to immunotherapy. We characterized six Kras-driven cutaneous SCC lines with a range of mutation loads. Following implantation into syngeneic FVB mice, we examined multiple tumor responses to α-PD-1, α-TGFβ or combinatorial therapy, including tumor growth rate and regression, tumor immune cell composition, acquired tumor immunity, and the role of cytotoxic T cells and Tregs in immunotherapy responses.ResultsWe show that α-PD-1 therapy is ineffective in establishing complete regression (CR) of tumors in all six SCC lines, but causes partial tumor growth inhibition of two lines with the highest mutations loads, CCK168 and CCK169. α-TGFβ monotherapy results in 20% CR and 10% CR of established CCK168 and CCK169 tumors respectively, together with acquisition of long-term anti-tumor immunity. α-PD-1 synergizes with α-TGFβ, increasing CR rates to 60% (CCK168) and 20% (CCK169). α-PD-1 therapy enhances CD4 + Treg/CD4 + Th ratios and increases tumor cell pSmad3 expression in CCK168 SCCs, whereas α-TGFβ antibody administration attenuates these effects. We show that α-TGFβ acts in part through suppressing immunosuppressive Tregs induced by α-PD-1, that limit the anti-tumor activity of α-PD-1 monotherapy. Additionally, in vitro and in vivo, α-TGFβ acts directly on the tumor cell to attenuate EMT, to activate a program of gene expression that stimulates immuno-surveillance, including up regulation of genes encoding the tumor cell antigen presentation machinery.ConclusionsWe show that α-PD-1 not only initiates a tumor rejection program, but can induce a competing TGFβ-driven immuno-suppressive program. We identify new opportunities for α-PD-1/α-TGFβ combinatorial treatment of SCCs especially those with a high mutation load, high CD4+ T cell content and pSmad3 signaling. Our data form the basis for clinical trial of α-TGFβ/α-PD-1 combination therapy (NCT02947165).

Published
2019

16. Design and Construction of the DEAP-3600 Dark Matter Detector

Author

Amaudruz, P. -A., Baldwin, M., Batygov, M., Beltran, B., Bina, C. E., Bishop, D., Bonatt, J., Boorman, G., Boulay, M. G., Broerman, B., Bromwich, T., Bueno, J. F., Burghardt, P. M., Butcher, A., Cai, B., Chan, S., Chen, M., Chouinard, R., Churchwell, S., Cleveland, B. T., Cranshaw, D., Dering, K., DiGioseffo, J., Dittmeier, S., Duncan, F. A., Dunford, M., Erlandson, A., Fatemighomi, N., Florian, S., Flower, A., Ford, R. J., Gagnon, R., Giampa, P., Golovko, V. V., Gorel, P., Gornea, R., Grace, E., Graham, K., Grant, D. R., Gulyev, E., Hall, A., Hallin, A. L., Hamstra, M., Harvey, P. J., Hearns, C., Jillings, C. J., Kamaev, O., Kemp, A., Kuźniak, M., Langrock, S., La Zia, F., Lehnert, B., Li, O., Lidgard, J. J., Liimatainen, P., Lim, C., Lindner, T., Linn, Y., Liu, S., Majewski, P., Mathew, R., McDonald, A. B., McElroy, T., McFarlane, K., McGinn, T., McLaughlin, J. B., Mead, S., Mehdiyev, R., Mielnichuk, C., Monroe, J., Muir, A., Nadeau, P., Nantais, C., Ng, C., Noble, A. J., O'Dwyer, E., Ohlmann, C., Olchanski, K., Olsen, K. S., Ouellet, C., Pasuthip, P., Peeters, S. J. M., Pollmann, T. R., Rand, E. T., Rau, W., Rethmeier, C., Retière, F., Seeburn, N., Shaw, B., Singhrao, K., Skensved, P., Smith, B., Smith, N. J. T., Sonley, T., Soukup, J., Stainforth, R., Stone, C., Strickland, V., Sur, B., Tang, J., Taylor, J., Veloce, L., Vázquez-Jáuregui, E., Walding, J., Ward, M., Westerdale, S., White, R., Woolsey, E., and Zielinski, J.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment
Abstract

The Dark matter Experiment using Argon Pulse-shape discrimination (DEAP) has been designed for a direct detection search for particle dark matter using a single-phase liquid argon target. The projected cross section sensitivity for DEAP-3600 to the spin-independent scattering of Weakly Interacting Massive Particles (WIMPs) on nucleons is $10^{-46}~\rm{cm}^{2}$ for a 100 GeV/$c^2$ WIMP mass with a fiducial exposure of 3 tonne-years. This paper describes the physical properties and construction of the DEAP-3600 detector., Comment: minor corrections in version 2. 70 pages, 24 figures, to be submitted to Astroparticle Physics Journal

Published
2017
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17. In-situ characterization of the Hamamatsu R5912-HQE photomultiplier tubes used in the DEAP-3600 experiment

Author

Amaudruz, P-A, Batygov, M, Beltran, B, Bina, CE, Bishop, D, Bonatt, J, Boorman, G, Boulay, MG, Broerman, B, Bromwich, T, Bueno, JF, Butcher, A, Cai, B, Chan, S, Chen, M, Chouinard, R, Churchwell, S, Cleveland, BT, Cranshaw, D, Dering, K, Dittmeier, S, Duncan, FA, Dunford, M, Erlandson, A, Fatemighomi, N, Ford, RJ, Gagnon, R, Giampa, P, Golovko, VV, Gorel, P, Gornea, R, Grace, E, Graham, K, Grant, DR, Gulyev, E, Hall, A, Hallin, AL, Hamstra, M, Harvey, PJ, Hearns, C, Jillings, CJ, Kamaev, O, Kemp, A, Kuźniak, M, Langrock, S, La Zia, F, Lehnert, B, Li, O, Lidgard, JJ, Liimatainen, P, Lim, C, Lindner, T, Linn, Y, Liu, S, Mathew, R, McDonald, AB, McElroy, T, McFarlane, K, McLaughlin, J, Mead, S, Mehdiyev, R, Mielnichuk, C, Monroe, J, Muir, A, Nadeau, P, Nantais, C, Ng, C, Noble, AJ, O’Dwyer, E, Ohlmann, C, Olchanski, K, Olsen, KS, Ouellet, C, Pasuthip, P, Peeters, SJM, Pollmann, TR, Rand, ET, Rau, W, Rethmeier, C, Retière, F, Seeburn, N, Shaw, B, Singhrao, K, Skensved, P, Smith, B, Smith, NJT, Sonley, T, Stainforth, R, Stone, C, Strickland, V, Sur, B, Tang, J, Taylor, J, Veloce, L, Vázquez-Jáuregui, E, Walding, J, Ward, M, Westerdale, S, White, R, and Woolsey, E

Subjects
Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, PMT, Hamamatsu R5912-HQE, Single photoelectron charge distribution, Afterpulsing, Late and double pulsing, Dark noise, Dark matter detection, physics.ins-det, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Other Physical Sciences, Nuclear & Particles Physics, Nuclear and plasma physics
Abstract

The Hamamatsu R5912-HQE photomultiplier-tube (PMT) is a novel high-quantum efficiency PMT. It is currently used in the DEAP-3600 dark matter detector and is of significant interest for future dark matter and neutrino experiments where high signal yields are needed. We report on the methods developed for in-situ characterization and monitoring of DEAP's 255 R5912-HQE PMTs. This includes a detailed discussion of typical measured single-photoelectron charge distributions, correlated noise (afterpulsing), dark noise, double, and late pulsing characteristics. The characterization is performed during the detector commissioning phase using laser light injected through a light diffusing sphere and during normal detector operation using LED light injected through optical fibres.

Published
2019

18. In-situ characterization of the Hamamatsu R5912-HQE photomultiplier tubes used in the DEAP-3600 experiment

Author

Amaudruz, PA, Batygov, M, Beltran, B, Bina, CE, Bishop, D, Bonatt, J, Boorman, G, Boulay, MG, Broerman, B, Bromwich, T, Bueno, JF, Butcher, A, Cai, B, Chan, S, Chen, M, Chouinard, R, Churchwell, S, Cleveland, BT, Cranshaw, D, Dering, K, Dittmeier, S, Duncan, FA, Dunford, M, Erlandson, A, Fatemighomi, N, Ford, RJ, Gagnon, R, Giampa, P, Golovko, VV, Gorel, P, Gornea, R, Grace, E, Graham, K, Grant, DR, Gulyev, E, Hall, A, Hallin, AL, Hamstra, M, Harvey, PJ, Hearns, C, Jillings, CJ, Kamaev, O, Kemp, A, Kuźniak, M, Langrock, S, La Zia, F, Lehnert, B, Li, O, Lidgard, JJ, Liimatainen, P, Lim, C, Lindner, T, Linn, Y, Liu, S, Mathew, R, McDonald, AB, McElroy, T, McFarlane, K, McLaughlin, J, Mead, S, Mehdiyev, R, Mielnichuk, C, Monroe, J, Muir, A, Nadeau, P, Nantais, C, Ng, C, Noble, AJ, O'Dwyer, E, Ohlmann, C, Olchanski, K, Olsen, KS, Ouellet, C, Pasuthip, P, Peeters, SJM, Pollmann, TR, Rand, ET, Rau, W, Rethmeier, C, Retière, F, Seeburn, N, Shaw, B, Singhrao, K, Skensved, P, Smith, B, Smith, NJT, Sonley, T, Stainforth, R, Stone, C, Strickland, V, Sur, B, Tang, J, Taylor, J, Veloce, L, Vázquez-Jáuregui, E, Walding, J, Ward, M, Westerdale, S, White, R, and Woolsey, E

Subjects
PMT, Hamamatsu R5912-HQE, Single photoelectron charge distribution, Afterpulsing, Late and double pulsing, Dark noise, Dark matter detection, physics.ins-det, Nuclear & Particles Physics, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Other Physical Sciences
Abstract

The Hamamatsu R5912-HQE photomultiplier-tube (PMT) is a novel high-quantum efficiency PMT. It is currently used in the DEAP-3600 dark matter detector and is of significant interest for future dark matter and neutrino experiments where high signal yields are needed. We report on the methods developed for in-situ characterization and monitoring of DEAP's 255 R5912-HQE PMTs. This includes a detailed discussion of typical measured single-photoelectron charge distributions, correlated noise (afterpulsing), dark noise, double, and late pulsing characteristics. The characterization is performed during the detector commissioning phase using laser light injected through a light diffusing sphere and during normal detector operation using LED light injected through optical fibres.

Published
2019

19. Design and construction of the DEAP-3600 dark matter detector

Author

Amaudruz, P-A, Baldwin, M, Batygov, M, Beltran, B, Bina, CE, Bishop, D, Bonatt, J, Boorman, G, Boulay, MG, Broerman, B, Bromwich, T, Bueno, JF, Burghardt, PM, Butcher, A, Cai, B, Chan, S, Chen, M, Chouinard, R, Churchwell, S, Cleveland, BT, Cranshaw, D, Dering, K, DiGioseffo, J, Dittmeier, S, Duncan, FA, Dunford, M, Erlandson, A, Fatemighomi, N, Florian, S, Flower, A, Ford, RJ, Gagnon, R, Giampa, P, Golovko, VV, Gorel, P, Gornea, R, Grace, E, Graham, K, Grant, DR, Gulyev, E, Hall, A, Hallin, AL, Hamstra, M, Harvey, PJ, Hearns, C, Jillings, CJ, Kamaev, O, Kemp, A, Kuźniak, M, Langrock, S, La Zia, F, Lehnert, B, Li, O, Lidgard, JJ, Liimatainen, P, Lim, C, Lindner, T, Linn, Y, Liu, S, Majewski, P, Mathew, R, McDonald, AB, McElroy, T, McFarlane, K, McGinn, T, McLaughlin, JB, Mead, S, Mehdiyev, R, Mielnichuk, C, Monroe, J, Muir, A, Nadeau, P, Nantais, C, Ng, C, Noble, AJ, O’Dwyer, E, Ohlmann, C, Olchanski, K, Olsen, KS, Ouellet, C, Pasuthip, P, Peeters, SJM, Pollmann, TR, Rand, ET, Rau, W, Rethmeier, C, Retière, F, Seeburn, N, Shaw, B, Singhrao, K, Skensved, P, Smith, B, Smith, NJT, Sonley, T, Soukup, J, Stainforth, R, Stone, C, Strickland, V, Sur, B, and Tang, J

Subjects
Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, Dark matter, WIMP, Liquid Argon, DEAP, SNOLAB, Low background, astro-ph.IM, hep-ex, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Nuclear & Particles Physics, Astronomical sciences, Particle and high energy physics
Abstract

The Dark matter Experiment using Argon Pulse-shape discrimination (DEAP) has been designed for a direct detection search for particle dark matter using a single-phase liquid argon target. The projected cross section sensitivity for DEAP-3600 to the spin-independent scattering of Weakly Interacting Massive Particles (WIMPs) on nucleons is 10−46cm2 for a 100 GeV/c2 WIMP mass with a fiducial exposure of 3 tonne-years. This paper describes the physical properties and construction of the DEAP-3600 detector.

Published
2019

20. Design and construction of the DEAP-3600 dark matter detector

Author

Amaudruz, PA, Baldwin, M, Batygov, M, Beltran, B, Bina, CE, Bishop, D, Bonatt, J, Boorman, G, Boulay, MG, Broerman, B, Bromwich, T, Bueno, JF, Burghardt, PM, Butcher, A, Cai, B, Chan, S, Chen, M, Chouinard, R, Churchwell, S, Cleveland, BT, Cranshaw, D, Dering, K, DiGioseffo, J, Dittmeier, S, Duncan, FA, Dunford, M, Erlandson, A, Fatemighomi, N, Florian, S, Flower, A, Ford, RJ, Gagnon, R, Giampa, P, Golovko, VV, Gorel, P, Gornea, R, Grace, E, Graham, K, Grant, DR, Gulyev, E, Hall, A, Hallin, AL, Hamstra, M, Harvey, PJ, Hearns, C, Jillings, CJ, Kamaev, O, Kemp, A, Kuźniak, M, Langrock, S, La Zia, F, Lehnert, B, Li, O, Lidgard, JJ, Liimatainen, P, Lim, C, Lindner, T, Linn, Y, Liu, S, Majewski, P, Mathew, R, McDonald, AB, McElroy, T, McFarlane, K, McGinn, T, McLaughlin, JB, Mead, S, Mehdiyev, R, Mielnichuk, C, Monroe, J, Muir, A, Nadeau, P, Nantais, C, Ng, C, Noble, AJ, O'Dwyer, E, Ohlmann, C, Olchanski, K, Olsen, KS, Ouellet, C, Pasuthip, P, Peeters, SJM, Pollmann, TR, Rand, ET, Rau, W, Rethmeier, C, Retière, F, Seeburn, N, Shaw, B, Singhrao, K, Skensved, P, Smith, B, Smith, NJT, Sonley, T, Soukup, J, Stainforth, R, Stone, C, Strickland, V, Sur, B, and Tang, J

Subjects
Dark matter, WIMP, Liquid Argon, DEAP, SNOLAB, Low background, astro-ph.IM, hep-ex, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Nuclear & Particles Physics
Abstract

The Dark matter Experiment using Argon Pulse-shape discrimination (DEAP) has been designed for a direct detection search for particle dark matter using a single-phase liquid argon target. The projected cross section sensitivity for DEAP-3600 to the spin-independent scattering of Weakly Interacting Massive Particles (WIMPs) on nucleons is 10−46cm2 for a 100 GeV/c2 WIMP mass with a fiducial exposure of 3 tonne-years. This paper describes the physical properties and construction of the DEAP-3600 detector.

Published
2019

21. In-situ characterization of the Hamamatsu R5912-HQE photomultiplier tubes used in the DEAP-3600 experiment

Author

DEAP Collaboration, Amaudruz, P. -A., Batygov, M., Beltran, B., Bina, C. E., Bishop, D., Bonatt, J., Boorman, G., Boulay, M. G., Broerman, B., Bromwich, T., Bueno, J. F., Butcher, A., Cai, B., Chan, S., Chen, M., Chouinard, R., Churchwell, S., Cleveland, B. T., Cranshaw, D., Dering, K., Dittmeier, S., Duncan, F. A., Dunford, M., Erlandson, A., Fatemighomi, N., Ford, R. J., Gagnon, R., Giampa, P., Golovko, V. V., Gorel, P., Gornea, R., Grace, E., Graham, K., Grant, D. R., Gulyev, E., Hall, A., Hallin, A. L., Hamstra, M., Harvey, P. J., Hearns, C., Jillings, C. J., Kamaev, O., Kemp, A., Kuźniak, M., Langrock, S., La Zia, F., Lehnert, B., Li, O., Lidgard, J. J., Liimatainen, P., Lim, C., Lindner, T., Linn, Y., Liu, S., Mathew, R., McDonald, A. B., McElroy, T., McFarlane, K., McLaughlin, J., Mead, S., Mehdiyev, R., Mielnichuk, C., Monroe, J., Muir, A., Nadeau, P., Nantais, C., Ng, C., Noble, A. J., O'Dwyer, E., Ohlmann, C., Olchanski, K., Olsen, K. S., Ouellet, C., Pasuthip, P., Peeters, S. J. M., Pollmann, T. R., Rand, E. T., Rau, W., Rethmeier, C., Retiére, F., Seeburn, N., Shaw, B., Singhrao, K., Skensved, P., Smith, B., Smith, N. J. T., Sonley, T., Stainforth, R., Stone, C., Strickland, V., Sur, B., Tang, J., Taylor, J., Veloce, L., Vázquez-Jáuregui, E., Walding, J., Ward, M., Westerdale, S., White, R., Woolsey, E., and Zielinski, J.

Subjects
Physics - Instrumentation and Detectors
Abstract

The Hamamatsu R5912-HQE photomultiplier-tube (PMT) is a novel high-quantum efficiency PMT. It is currently used in the DEAP-3600 dark matter detector and is of significant interest for future dark matter and neutrino experiments where high signal yields are needed. We report on the methods developed for in-situ characterization and monitoring of DEAP's 255 R5912-HQE PMTs. This includes a detailed discussion of typical measured single-photoelectron charge distributions, correlated noise (afterpulsing), dark noise, double, and late pulsing characteristics. The characterization is performed during the detector commissioning phase using laser light injected through a light diffusing sphere and during normal detector operation using LED light injected through optical fibres.

Published
2017
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22. DEAP-3600 Dark Matter Search

Author

DEAP Collaboration, Amaudruz, P. -A., Batygov, M., Beltran, B., Bonatt, J., Boulay, M. G., Broerman, B., Bueno, J. F., Butcher, A., Cai, B., Chen, M., Chouinard, R., Cleveland, B. T., Dering, K., DiGioseffo, J., Duncan, F., Flower, T., Ford, R., Giampa, P., Gorel, P., Graham, K., Grant, D. R., Guliyev, E., Hallin, A. L., Hamstra, M., Harvey, P., Jillings, C. J., Kuźniak, M., Lawson, I., Li, O., Liimatainen, P., Majewski, P., McDonald, A. B., McElroy, T., McFarlane, K., Monroe, J., Muir, A., Nantais, C., Ng, C., Noble, A. J., Ouellet, C., Palladino, K., Pasuthip, P., Peeters, S. J. M., Pollmann, T., Rau, W., Retière, F., Seeburn, N., Singhrao, K., Skensved, P., Smith, B., Sonley, T., Tang, J., Vázquez-Jáuregui, E., Veloce, L., Walding, J., and Ward, M.

Subjects
Physics - Instrumentation and Detectors, Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment
Abstract

The DEAP-3600 experiment is located 2 km underground at SNOLAB, in Sudbury, Ontario. It is a single-phase detector that searches for dark matter particle interactions within a 1000-kg fiducial mass target of liquid argon. A first generation prototype detector (DEAP-1) with a 7-kg liquid argon target mass demonstrated a high level of pulse-shape discrimination (PSD) for reducing $\beta$/$\gamma$ backgrounds and helped to develop low radioactivity techniques to mitigate surface-related $\alpha$ backgrounds. Construction of the DEAP-3600 detector is nearly complete and commissioning is starting in 2014. The target sensitivity to spin-independent scattering of Weakly Interacting Massive Particles (WIMPs) on nucleons of 10$^{-46}$ cm$^2$ will allow one order of magnitude improvement in sensitivity over current searches at 100 GeV WIMP mass. This paper presents an overview and status of the DEAP-3600 project and discusses plans for a future multi-tonne experiment, DEAP-50T., Comment: International Conference on High Energy Physics (ICHEP 2014), Valencia, 2014

Published
2014
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23. Improving Photoelectron Counting and Particle Identification in Scintillation Detectors with Bayesian Techniques

Author

Akashi-Ronquest, M., Amaudruz, P. -A., Batygov, M., Beltran, B., Bodmer, M., Boulay, M. G., Broerman, B., Buck, B., Butcher, A., Cai, B., Caldwell, T., Chen, M., Chen, Y., Cleveland, B., Coakley, K., Dering, K., Duncan, F. A., Formaggio, J. A., Gagnon, R., Gastler, D., Giuliani, F., Gold, M., Golovko, V. V., Gorel, P., Graham, K., Grace, E., Guerrero, N., Guiseppe, V., Hallin, A. L., Harvey, P., Hearns, C., Henning, R., Hime, A., Hofgartner, J., Jaditz, S., Jillings, C. J., Kachulis, C., Kearns, E., Kelsey, J., Klein, J. R., Kuzniak, M., LaTorre, A., Lawson, I., Li, O., Lidgard, J. J., Liimatainen, P., Linden, S., McFarlane, K., McKinsey, D. N., MacMullin, S., Mastbaum, A., Mathew, R., McDonald, A. B., Mei, D. -M., Monroe, J., Muir, A., Nantais, C., Nicolics, K., Nikkel, J. A., Noble, T., O'Dwyer, E., Olsen, K., Gann, G. D. Orebi, Ouellet, C., Palladino, K., Pasuthip, P., Perumpilly, G., Pollmann, T., Rau, P., Retiere, F., Rielage, K., Schnee, R., Seibert, S., Skensved, P., Sonley, T., Vazquez-Jauregui, E., Veloce, L., Walding, J., Wang, B., Wang, J., Ward, M., and Zhang, C.

Subjects
Physics - Instrumentation and Detectors, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment, Nuclear Experiment
Abstract

Many current and future dark matter and neutrino detectors are designed to measure scintillation light with a large array of photomultiplier tubes (PMTs). The energy resolution and particle identification capabilities of these detectors depend in part on the ability to accurately identify individual photoelectrons in PMT waveforms despite large variability in pulse amplitudes and pulse pileup. We describe a Bayesian technique that can identify the times of individual photoelectrons in a sampled PMT waveform without deconvolution, even when pileup is present. To demonstrate the technique, we apply it to the general problem of particle identification in single-phase liquid argon dark matter detectors. Using the output of the Bayesian photoelectron counting algorithm described in this paper, we construct several test statistics for rejection of backgrounds for dark matter searches in argon. Compared to simpler methods based on either observed charge or peak finding, the photoelectron counting technique improves both energy resolution and particle identification of low energy events in calibration data from the DEAP-1 detector and simulation of the larger MiniCLEAN dark matter detector., Comment: 16 pages, 16 figures

Published
2014
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24. Weaning from mechanical ventilation in intensive care units across 50 countries (WEAN SAFE): a multicentre, prospective, observational cohort study

Author

Pham, T, Heunks, L, Bellani, G, Madotto, F, Aragao, I, Beduneau, G, Goligher, E, Grasselli, G, Laake, J, Mancebo, J, Penuelas, O, Piquilloud, L, Pesenti, A, Wunsch, H, van Haren, F, Brochard, L, Laffey, J, Abrough, F, Acharya, S, Amin, P, Arabi, Y, Bauer, P, Beitler, J, Berkius, J, Bugedo, G, Camporota, L, Cerny, V, Cho, Y, Clarkson, K, Estenssoro, E, Gritsan, A, Hashemian, S, Hermans, G, Jovanovic, B, Kurahashi, K, Matamis, D, Moerer, O, Molnar, Z, Ozyilmaz, E, Panka, B, Papali, A, Perbet, S, Qiu, H, Razek, A, Rittayamai, N, Roldan, R, Serpa Neto, A, Szuldrzynski, K, Talmor, D, Tomescu, D, Villagomez, A, Zeggwagh, A, Abe, T, Aboshady, A, Acampo-de Jong, M, Adderley, J, Adiguzel, N, Agrawal, V, Aguilar, G, Aguirre, G, Aguirre-Bermeo, H, Ahlstrom, B, Akbas, T, Akker, M, Al Sadeh, G, Alamri, S, Algaba, A, Ali, M, Aliberti, A, Allegue, J, Alvarez, D, Amador, J, Andersen, F, Ansari, S, Apichatbutr, Y, Apostolopoulou, O, Arellano, D, Arica, M, Arikan, H, Arinaga, K, Arnal, J, Asano, K, Asin-Corrochano, M, Avalos Cabrera, J, Avila Fuentes, S, Aydemir, S, Aygencel, G, Azevedo, L, Bacakoglu, F, Badie, J, Baedorf Kassis, E, Bai, G, Balaraj, G, Ballico, B, Banner-Goodspeed, V, Banwarie, P, Barbieri, R, Baronia, A, Barrett, J, Barrot, L, Barrueco-Francioni, J, Barry, J, Bawangade, H, Beavis, S, Beck, E, Beehre, N, Belenguer Muncharaz, A, Belliato, M, Bellissima, A, Beltramelli, R, Ben Souissi, A, Benitez-Cano, A, Benlamin, M, Benslama, A, Bento, L, Benvenuti, D, Bernabe, L, Bersten, A, Berta, G, Bertini, P, Bertram-Ralph, E, Besbes, M, Bettini, L, Beuret, P, Bewley, J, Bezzi, M, Bhakhtiani, L, Bhandary, R, Bhowmick, K, Bihari, S, Bissett, B, Blythe, D, Bocher, S, Boedjawan, N, Bojanowski, C, Boni, E, Boraso, S, Borelli, M, Borello, S, Borislavova, M, Bosma, K, Bottiroli, M, Boyd, O, Bozbay, S, Briva, A, Bruel, C, Bruni, A, Buehner, U, Bulpa, P, Burt, K, Buscot, M, Buttera, S, Cabrera, J, Caccese, R, Caironi, P, Canchos Gutierrez, I, Canedo, N, Cani, A, Cappellini, I, Carazo, J, Cardonnet, L, Carpio, D, Carriedo, D, Carrillo, R, Carvalho, J, Caser, E, Castelli, A, Castillo Quintero, M, Castro, H, Catorze, N, Cengiz, M, Cereijo, E, Ceunen, H, Chaintoutis, C, Chang, Y, Chaparro, G, Chapman, C, Chau, S, Chavez, C, Chelazzi, C, Chelly, J, Chemouni, F, Chen, K, Chena, A, Chiarandini, P, Chilton, P, Chiumello, D, Chou-Lie, Y, Chudeau, N, Cinel, I, Cinnella, G, Clark, M, Clark, T, Clementi, S, Coaguila, L, Codecido, A, Collins, A, Colombo, R, Conde, J, Consales, G, Cook, T, Coppadoro, A, Cornejo, R, Cortegiani, A, Coxo, C, Cracchiolo, A, Crespo Ramirez, M, Crova, P, Cruz, J, Cubattoli, L, Cukurova, Z, Curto, F, Czempik, P, D'Andrea, R, da Silva Ramos, F, Dangers, L, Danguy des Deserts, M, Danin, P, Dantas, F, Daubin, C, Dawei, W, de Haro, C, de Jesus Montelongo, F, De Mendoza, D, de Pablo, R, De Pascale, G, De Rosa, S, Decavele, M, Declercq, P, Deicas, A, del Carmen Campos Moreno, M, Dellamonica, J, Delmas, B, Demirkiran, O, Demirkiran, H, Dendane, T, di Mussi, R, Diakaki, C, Diaz, A, Diaz, W, Dikmen, Y, Dimoula, A, Doble, P, Doha, N, Domingos, G, Dres, M, Dries, D, Duggal, A, Duke, G, Dunts, P, Dybwik, K, Dykyy, M, Eckert, P, Efe, S, Elatrous, S, Elay, G, Elmaryul, A, Elsaadany, M, Elsayed, H, Elsayed, S, Emery, M, Ena, S, Eng, K, Englert, J, Erdogan, E, Ergin Ozcan, P, Eroglu, E, Escobar, M, Esen, F, Esen Tekeli, A, Esquivel, A, Esquivel Gallegos, H, Ezzouine, H, Facchini, A, Faheem, M, Fanelli, V, Farina, M, Fartoukh, M, Fehrle, L, Feng, F, Feng, Y, Fernandez, I, Fernandez, B, Fernandez-Rodriguez, M, Ferrando, C, Ferreira da Silva, M, Ferreruela, M, Ferrier, J, Flamm Zamorano, M, Flood, L, Floris, L, Fluckiger, M, Forteza, C, Fortunato, A, Frans, E, Frattari, A, Fredes, S, Frenzel, T, Fumagalli, R, Furche, M, Fusari, M, Fysh, E, Galeas-Lopez, J, Galerneau, L, Garcia, A, Garcia, M, Garcia, E, Garcia Olivares, P, Garlicki, J, Garnero, A, Garofalo, E, Gautam, P, Gazenkampf, A, Gelinotte, S, Gelormini, D, Ghrenassia, E, Giacomucci, A, Giannoni, R, Gigante, A, Glober, N, Gnesin, P, Gollo, Y, Gomaa, D, Gomero Paredes, R, Gomes, R, Gomez, R, Gomez, O, Gomez, A, Gondim, L, Gonzalez, M, Gonzalez, I, Gonzalez-Castro, A, Gordillo Romero, O, Gordo, F, Gouin, P, Graf Santos, J, Grainne, R, Grando, M, Granov Grabovica, S, Grasso, S, Grasso, R, Grimmer, L, Grissom, C, Gu, Q, Guan, X, Guarracino, F, Guasch, N, Guatteri, L, Gueret, R, Guerin, C, Guerot, E, Guitard, P, Gul, F, Gumus, A, Gurjar, M, Gutierrez, P, Hachimi, A, Hadzibegovic, A, Hagan, S, Hammel, C, Han Song, J, Hanlon, G, Heines, S, Henriksson, J, Herbrecht, J, Heredia Orbegoso, G, Hermon, A, Hernandez, R, Hernandez, C, Herrera, L, Herrera-Gutierrez, M, Hidalgo, J, Hill, D, Holmquist, D, Homez, M, Hongtao, X, Hormis, A, Horner, D, Hornos, M, Hou, M, House, S, Housni, B, Hugill, K, Humphreys, S, Humbert, L, Hunter, S, Hwa Young, L, Iezzi, N, Ilutovich, S, Inal, V, Innes, R, Ioannides, P, Iotti, G, Ippolito, M, Irie, H, Iriyama, H, Itagaki, T, Izura, J, Izza, S, Jabeen, R, Jamaati, H, Jamadarkhana, S, Jamoussi, A, Jankowski, M, Jaramillo, L, Jeon, K, Jeong Lee, S, Jeswani, D, Jha, S, Jiang, L, Jing, C, Jochmans, S, Johnstad, B, Jongmin, L, Joret, A, Junhasavasdikul, D, Jurado, M, Kam, E, Kamohara, H, Kane, C, Kara, I, Karakurt, S, Karnjanarachata, C, Kataoka, J, Katayama, S, Kaushik, S, Kelebek Girgin, N, Kerr, K, Kerslake, I, Khairnar, P, Khalid, A, Khan, A, Khanna, A, Khorasanee, R, Kienhorst, D, Kirakli, C, Knafelj, R, Kol, M, Kongpolprom, N, Kopitko, C, Korkmaz Ekren, P, Kubisz-Pudelko, A, Kulcsar, Z, Kumasawa, J, Kuriyama, A, Kutchak, F, Labarca, E, Labat, F, Laborda, C, Laca Barrera, M, Lagache, L, Landaverde Lopez, A, Lanspa, M, Lascari, V, Le Meur, M, Lee, S, Lee, Y, Lee, J, Lee, W, Legernaes, T, Leiner, T, Lemiale, V, Leonor, T, Lepper, P, Li, D, Li, H, Li, O, Lima, A, Lind, D, Litton, E, Liu, N, Liu, L, Liu, J, Llitjos, J, Llorente, B, Lopez, R, Lopez, C, Lopez Nava, C, Lovazzano, P, Lu, M, Lucchese, F, Lugano, M, Lugo Goytia, G, Luo, H, Lynch, C, Macheda, S, Madrigal Robles, V, Maggiore, S, Magret Iglesias, M, Malaga, P, Mallapura Maheswarappa, H, Malpartida, G, Malyarchikov, A, Mansson, H, Manzano, A, Marey, I, Marin, N, Marin, M, Markman, E, Martin, F, Martin, A, Martin Dal Gesso, C, Martinez, F, Martinez-Fidalgo, C, Martin-Loeches, I, Mas, A, Masaaki, S, Maseda, E, Massa, E, Mattsson, A, Maugeri, J, Mccredie, V, Mccullough, J, Mcguinness, S, Mckown, A, Medve, L, Mei, C, Mellado Artigas, R, Mendes, V, Mervat, M, Michaux, I, Mikhaeil, M, Milagros, O, Milet, I, Millan, M, Minwei, Z, Mirabella, L, Mishra, S, Mistraletti, G, Mochizuki, K, Moghal, A, Mojoli, F, Molin, A, Montiel, R, Montini, L, Monza, G, Mora Aznar, M, Morakul, S, Morales, M, Moreno Torres, D, Morocho Tutillo, D, Motherway, C, Mouhssine, D, Mouloudi, E, Munoz, T, Munoz de Cabo, C, Mustafa, M, Muthuchellappan, R, Muthukrishnan, M, Muttini, S, Nagata, I, Nahar, D, Nakanishi, M, Nakayama, I, Namendys-Silva, S, Nanchal, R, Nandakumar, S, Nasi, A, Nasir, K, 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E., Lopez Nava C., Lovazzano P., Lu M., Lucchese F., Lugano M., Lugo Goytia G., Luo H., Lynch C., Macheda S., Madrigal Robles V. H., Maggiore S. M., Magret Iglesias M., Malaga P., Mallapura Maheswarappa H., Malpartida G., Malyarchikov A., Mansson H., Manzano A., Marey I., Marin N., Marin M. D. C., Markman E., Martin F., Martin A., Martin Dal Gesso C., Martinez F., Martinez-Fidalgo C., Martin-Loeches I., Mas A., Masaaki S., Maseda E., Massa E., Mattsson A., Maugeri J., McCredie V., McCullough J., McGuinness S., McKown A., Medve L., Mei C., Mellado Artigas R., Mendes V., Mervat M. K. E., Michaux I., Mikhaeil M., Milagros O., Milet I., Millan M. T., Minwei Z., Mirabella L., Mishra S., Mistraletti G., Mochizuki K., Moghal A., Mojoli F., Molin A., Montiel R., Montini L., Monza G., Mora Aznar M., Morakul S., Morales M., Moreno Torres D., Morocho Tutillo D. R., Motherway C., Mouhssine D., Mouloudi E., Munoz T., Munoz de Cabo C., Mustafa M., Muthuchellappan R., Muthukrishnan M., Muttini S., Nagata I., Nahar D., Nakanishi M., Nakayama I., Namendys-Silva S. A., Nanchal R., Nandakumar S., Nasi A., Nasir K., Navalesi P., Naz Aslam T., Nga Phan T., Nichol A., Niiyama S., Nikolakopoulou S., Nikolic E., Nitta K., Noc M., Nonas S., Nseir S., Nur Soyturk A., Obata Y., Oeckler R., Oguchi M., Ohshimo S., Oikonomou M., Ojados A., Oliveira M. T., Oliveira Filho W., Oliveri C., Olmos A., Omura K., Orlandi M. C., Orsenigo F., Ortiz-Ruiz De Gordoa L., Ota K., Ovalle Olmos R., Oveges N., Oziemski P., Ozkan Kuscu O., Pachas Alvarado F., Pagella G., Palaniswamy V., Palazon Sanchez E. L., Palmese S., Pan G., Pan W., Papanikolaou M., Papavasilopoulou T., Parekh A., Parke R., Parrilla F. J., Parrilla D., Pasha T., Pasin L., Patao L., Patel M., Patel G., Pati B. K., Patil J., Pattnaik S., Paul D., Pavesi M., Pavlotsky V. A., Paz G., Paz E., Pecci E., Pellegrini C., Pena Padilla A. G., Perchiazzi G., Pereira T., Pereira V., Perez M., Perez Calvo C., Perez Cheng M., Perez Maita R., Perez-Araos R., Perez-Teran P., Perez-Torres D., Perkins G., Persona P., Petnak T., Petrova M., Philippart F., Picetti E., Pierucci E., Piervincenzi E., Pinciroli R., Pintado M. -C., Piraino T., Piras S., Piras C., Pirompanich P., Pisani L., Platas E., Plotnikow G., Porras W., Porta V., Portilla M., Portugal J., Povoa P., Prat G., Pratto R., Preda G., Prieto I., Prol-Silva E., Pugh R., Qi Y., Qian C., Qin T., Qu H., Quintana T., Quispe Sierra R., Quispe Soto R., Rabbani R., Rabee M., Rabie A., Rahe Pereira M. A., Rai A., Raj Ashok S., Rajab M., Ramdhani N., Ramey E., Ranieri M., Rathod D., Ray B., Redwanul Huq S. M., Regli A., Reina R., Resano Sarmiento N., Reynaud F., Rialp G., Ricart P., Rice T., Richardson A., Rieder M., Rinket M., Rios F., Risso Vazquez A., Riva I., Rivette M., Roca O., Roche-Campo F., Rodriguez C., Rodriguez G., Rodriguez Gonzalez D., Rodriguez Tucto X. Y., Rogers A., Romano M. E., Rortveit L., Rose A., Roux D., Rouze A., Rubatto Birri P. N., Ruilan W., Ruiz Robledo A., Ruiz-Aguilar A. L., Sadahiro T., Saez I., Sagardia J., Saha R., Saiphoklang N., Saito S., Salem M., Sales G., Salgado P., Samavedam S., Sami Mebazaa M., Samuelsson L., San Juan Roman N., Sanchez P., Sanchez-Ballesteros J., Sandoval Y., Sani E., Santos M., Santos C., Sanui M., Saravanabavan L., Sari S., Sarkany A., Sauneuf B., Savioli M., Sazak H., Scano R., Schneider F., Schortgen F., Schultz M. J., Schwarz G. L., Seckin Yucesoy F., Seely A., Seiler F., Seker Tekdos Y., Seok Chan K., Serano L., Serednicki W., Setten M., Shah A., Shah B., Shang Y., Shanmugasundaram P., Shapovalov K., Shebl E., Shiga T., Shime N., Shin P., Short J., Shuhua C., Siddiqui S., Silesky Jimenez J. I., Silva D., Silva Sales B., Simons K., Sjobo B. A., Slessor D., Smiechowicz J., Smischney N., Smith P., Smith T., Smith M., Snape S., Snyman L., Soetens F., Sook Hong K., Sosa Medellin M. A., Soto G., Souloy X., Sousa E., Sovatzis S., Sozutek D., Spadaro S., Spagnoli M., Spangfors M., Spittle N., Spivey M., Stapleton A., Stefanovic B., Stephenson L., Stevenson E., Strand K., Strano M. T., Straus S., Sun C., Sun R., Sundaram V., SunPark T., Surlemont E., Sutherasan Y., Szabo Z., Tainter C., Takaba A., Tallott M., Tamasato T., Tang Z., Tangsujaritvijit V., Taniguchi L., Taniguchi D., Tarantino F., Teerapuncharoen K., Temprano S., Terragni P., Terzi N., Thakur A., Theerawit P., Thille A. W., Thomas M., Thungtitigul P., Thyrault M., Tilouch N., Timenetsky K., Tirapu J., Todeschini M., Tomas R., Tomaszewski C., Tonetti T., Tonnelier A., Trinder J., Trongtrakul K., Truwit J., Tsuei B., Tulaimat A., Turan S., Turkoglu M., Tyagi S., Ubeda A., Vagginelli F., Valenti M. F., Vallverdu I., Van Axel A., van den Hul I., van der Hoeven H., Van Der Meer N., Vanhoof M., Vargas-Ordonez M., Vaschetto R., Vascotto E., Vatsik M., Vaz A., Vazquez-Sanchez A., Ventura S., Vermeijden J. W., Vidal A., Vieira J., Vilela Costa Pinto B., Villagra A., Villegas Succar C., Vinorum O. G., Vitale G., Vj R., Vochin A., Voiriot G., Volta C. A., von Seth M., Wajdi M., Walsh D., Wang S., Wardi G., Ween-Velken N. C., Wei B. -L., Weller D., Welsh D., Welters I., Wert M., Whiteley S., Wilby E., Williams E., Williams K., Wilson A., Wojtas J., Won Huh J., Wrathall D., Wright C., Wu J. -F., Xi G., Xing Z. -J., Xu H., Yamamoto K., Yan J., Yanez J., Yang X., Yates E., Yazicioglu Mocin O., Ye Z., Yildirim F., Yoshida N., Yoshido H. H. L., Young Lee B., Yu R., Yu G., Yu T., Yuan B., Yuangtrakul N., Yumoto T., Yun X., Zakalik G., Zaki A., Zalba-Etayo B., Zambon M., Zang B., Zani G., Zarka J., Zerbi S. M., Zerman A., Zetterquist H., Zhang J., Zhang H., Zhang W., Zhang G., Zhao H., Zheng J., Zhu B., and Zumaran R.

Abstract

Background: Current management practices and outcomes in weaning from invasive mechanical ventilation are poorly understood. We aimed to describe the epidemiology, management, timings, risk for failure, and outcomes of weaning in patients requiring at least 2 days of invasive mechanical ventilation. Methods: WEAN SAFE was an international, multicentre, prospective, observational cohort study done in 481 intensive care units in 50 countries. Eligible participants were older than 16 years, admitted to a participating intensive care unit, and receiving mechanical ventilation for 2 calendar days or longer. We defined weaning initiation as the first attempt to separate a patient from the ventilator, successful weaning as no reintubation or death within 7 days of extubation, and weaning eligibility criteria based on positive end-expiratory pressure, fractional concentration of oxygen in inspired air, and vasopressors. The primary outcome was the proportion of patients successfully weaned at 90 days. Key secondary outcomes included weaning duration, timing of weaning events, factors associated with weaning delay and weaning failure, and hospital outcomes. This study is registered with ClinicalTrials.gov, NCT03255109. Findings: Between Oct 4, 2017, and June 25, 2018, 10 232 patients were screened for eligibility, of whom 5869 were enrolled. 4523 (77·1%) patients underwent at least one separation attempt and 3817 (65·0%) patients were successfully weaned from ventilation at day 90. 237 (4·0%) patients were transferred before any separation attempt, 153 (2·6%) were transferred after at least one separation attempt and not successfully weaned, and 1662 (28·3%) died while invasively ventilated. The median time from fulfilling weaning eligibility criteria to first separation attempt was 1 day (IQR 0–4), and 1013 (22·4%) patients had a delay in initiating first separation of 5 or more days. Of the 4523 (77·1%) patients with separation attempts, 2927 (64·7%) had a short wean (≤1 d

Published
2023

25. P16INK4a Upregulation Mediated by SIX6 Defines Retinal Ganglion Cell Pathogenesis in Glaucoma

Author

Skowronska-Krawczyk, D, Zhao, L, Zhu, J, Weinreb, RN, Cao, G, Luo, J, Flagg, K, Patel, S, Wen, C, Krupa, M, Luo, H, Ouyang, H, Lin, D, Wang, W, Li, G, Xu, Y, Li, O, Chung, C, Yeh, E, Jafari, M, Ai, M, Zhong, Z, Shi, W, Zheng, L, Krawczyk, M, Chen, D, Shi, C, Zin, C, Mellon, PL, Gao, W, Abagyan, R, Zhang, L, Sun, X, Zhong, S, Zhuo, Y, Rosenfeld, MG, Liu, Y, and Zh, K

Subjects
Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

Glaucoma, a blinding neurodegenerative disease, whose risk factors include elevated intraocular pressure (IOP), age, and genetics, is characterized by accelerated and progressive retinal ganglion cell (RGC) death. Despite decades of research, the mechanism of RGC death in glaucoma is still unknown. Here, we demonstrate that the genetic effect of the SIX6 risk variant (rs33912345, His141Asn) is enhanced by another major POAG risk gene, p16INK4a (cyclin-dependent kinase inhibitor 2A, isoform INK4a). We further show that the upregulation of homozygous SIX6 risk alleles (CC) leads to an increase in p16INK4a expression, with subsequent cellular senescence, as evidenced in a mouse model of elevated IOP and in human POAG eyes. Our data indicate that SIX6 and/or IOP promotes POAG by directly increasing p16INK4a expression, leading to RGC senescence in adult human retinas. Our study provides important insights linking genetic susceptibility to the underlying mechanism of RGC death and provides a unified theory of glaucoma pathogenesis. Zhang et al. report p16INK4a as a downstream integrator of diverse signals, such as inherited genetic risk, age, and intraocular pressure, in the pathogenesis of glaucoma. They demonstrate that upregulation of SIX6 upon stress directly increases p16INK4a, leading to retinal ganglion cell senescence and death.

Published
2015

27. A Case Study of Digital Preservation of Motion Capture for Bā Jiā Jiāng Performance, Taiwan Religious Performing Arts

Author

Syu, Yun-Sheng, Chen, Li-o, Tu, Yu-Fang, Hutchison, David, Editorial Board Member, Kanade, Takeo, Editorial Board Member, Kittler, Josef, Editorial Board Member, Kleinberg, Jon M., Editorial Board Member, Mattern, Friedemann, Editorial Board Member, Mitchell, John C., Editorial Board Member, Naor, Moni, Editorial Board Member, Pandu Rangan, C., Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Terzopoulos, Demetri, Editorial Board Member, Tygar, Doug, Editorial Board Member, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Ioannides, Marinos, editor, Fink, Eleanor, editor, Brumana, Raffaella, editor, Patias, Petros, editor, Doulamis, Anastasios, editor, Martins, João, editor, and Wallace, Manolis, editor

Published
2018
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28. Design and construction of the DEAP-3600 dark matter detector

Author

Amaudruz, P.-A., Baldwin, M., Batygov, M., Beltran, B., Bina, C.E., Bishop, D., Bonatt, J., Boorman, G., Boulay, M.G., Broerman, B., Bromwich, T., Bueno, J.F., Burghardt, P.M., Butcher, A., Cai, B., Chan, S., Chen, M., Chouinard, R., Churchwell, S., Cleveland, B.T., Cranshaw, D., Dering, K., DiGioseffo, J., Dittmeier, S., Duncan, F.A., Dunford, M., Erlandson, A., Fatemighomi, N., Florian, S., Flower, A., Ford, R.J., Gagnon, R., Giampa, P., Golovko, V.V., Gorel, P., Gornea, R., Grace, E., Graham, K., Grant, D.R., Gulyev, E., Hall, A., Hallin, A.L., Hamstra, M., Harvey, P.J., Hearns, C., Jillings, C.J., Kamaev, O., Kemp, A., Kuźniak, M., Langrock, S., La Zia, F., Lehnert, B., Li, O., Lidgard, J.J., Liimatainen, P., Lim, C., Lindner, T., Linn, Y., Liu, S., Majewski, P., Mathew, R., McDonald, A.B., McElroy, T., McFarlane, K., McGinn, T., McLaughlin, J.B., Mead, S., Mehdiyev, R., Mielnichuk, C., Monroe, J., Muir, A., Nadeau, P., Nantais, C., Ng, C., Noble, A.J., O’Dwyer, E., Ohlmann, C., Olchanski, K., Olsen, K.S., Ouellet, C., Pasuthip, P., Peeters, S.J.M., Pollmann, T.R., Rand, E.T., Rau, W., Rethmeier, C., Retière, F., Seeburn, N., Shaw, B., Singhrao, K., Skensved, P., Smith, B., Smith, N.J.T., Sonley, T., Soukup, J., Stainforth, R., Stone, C., Strickland, V., Sur, B., Tang, J., Taylor, J., Veloce, L., Vázquez-Jáuregui, E., Walding, J., Ward, M., Westerdale, S., White, R., Woolsey, E., and Zielinski, J.

Published
2019
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29. Radon backgrounds in the DEAP-1 liquid-argon-based Dark Matter detector

Author

Amaudruz, P. -A., Batygov, M., Beltran, B., Boudjemline, K., Caldwell, M. G. Boulay B. Cai T., Chen, M., Chouinard, R., Cleveland, B. T., Contreras, D., Dering, K., Duncan, F., Ford, R., Giuliani, R. Gagnon F., Golovko, M. Gold V. V., Gorel, P., Graham, K., Grant, D. R., Hakobyan, R., Hallin, A. L., Harvey, P., Hearns, C., Jillings, C. J., Kuźniak, M., Lawson, I., Li, O., Lidgard, J., Liimatainen, P., Lippincott, W. H., Mathew, R., McDonald, A. B., McElroy, T., McFarlane, K., McKinsey, D., Muir, A., Nantais, C., Nicolics, K., Nikkel, J., Noble, T., O'Dwyer, E., Olsen, K. S., Ouellet, C., Pasuthip, P., Pollmann, T., Rau, W., Retiere, F., Ronquest, M., Skensved, P., Sonley, T., Tang, J., Vázquez-Jáuregui, E., Veloce, L., and Ward, M.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Nuclear Experiment, Physics - Instrumentation and Detectors
Abstract

The DEAP-1 \SI{7}{kg} single phase liquid argon scintillation detector was operated underground at SNOLAB in order to test the techniques and measure the backgrounds inherent to single phase detection, in support of the \mbox{DEAP-3600} Dark Matter detector. Backgrounds in DEAP are controlled through material selection, construction techniques, pulse shape discrimination and event reconstruction. This report details the analysis of background events observed in three iterations of the DEAP-1 detector, and the measures taken to reduce them. The $^{222}$Rn decay rate in the liquid argon was measured to be between 16 and \SI{26}{\micro\becquerel\per\kilogram}. We found that the background spectrum near the region of interest for Dark Matter detection in the DEAP-1 detector can be described considering events from three sources: radon daughters decaying on the surface of the active volume, the expected rate of electromagnetic events misidentified as nuclear recoils due to inefficiencies in the pulse shape discrimination, and leakage of events from outside the fiducial volume due to imperfect position reconstruction. These backgrounds statistically account for all observed events, and they will be strongly reduced in the DEAP-3600 detector due to its higher light yield and simpler geometry.

Published
2012
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31. Measurement of the scintillation time spectra and pulse-shape discrimination of low-energy beta and nuclear recoils in liquid argon with DEAP-1

Author

Amaudruz, P. -A., Batygov, M., Beltran, B., Bonatt, J., Boudjemline, K., Boulay, M. G., Broerman, B., Bueno, J. F., Butcher, A., Cai, B., Caldwell, T., Chen, M., Chouinard, R., Cleveland, B. T., Cranshaw, D., Dering, K., Duncan, F., Fatemighomi, N., Ford, R., Gagnon, R., Giampa, P., Giuliani, F., Gold, M., Golovko, V. V., Gorel, P., Grace, E., Graham, K., Grant, D. R., Hakobyan, R., Hallin, A. L., Hamstra, M., Harvey, P., Hearns, C., Hofgartner, J., Jillings, C. J., Kuźniak, M., Lawson, I., La Zia, F., Li, O., Lidgard, J. J., Liimatainen, P., Lippincott, W. H., Mathew, R., McDonald, A. B., McElroy, T., McFarlane, K., Mehdiyev, R., McKinsey, D. N., Monroe, J., Muir, A., Nantais, C., Nicolics, K., Nikkel, J., Noble, A. J., O'Dwyer, E., Olsen, K., Ouellet, C., Pasuthip, P., Peeters, S. J. M., Pollmann, T., Rau, W., Retière, F., Ronquest, M., Seeburn, N., Skensved, P., Smith, B., Sonley, T., Tang, J., Vázquez-Jáuregui, E., Veloce, L., Walding, J., and Ward, M.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The DEAP-1 low-background liquid argon detector was used to measure scintillation pulse shapes of electron and nuclear recoil events and to demonstrate the feasibility of pulse-shape discrimination (PSD) down to an electron-equivalent energy of 20 keV. In the surface dataset using a triple-coincidence tag we found the fraction of beta events that are misidentified as nuclear recoils to be $<1.4\times 10^{-7}$ (90% C.L.) for energies between 43-86 keVee and for a nuclear recoil acceptance of at least 90%, with 4% systematic uncertainty on the absolute energy scale. The discrimination measurement on surface was limited by nuclear recoils induced by cosmic-ray generated neutrons. This was improved by moving the detector to the SNOLAB underground laboratory, where the reduced background rate allowed the same measurement with only a double-coincidence tag. The combined data set contains $1.23\times10^8$ events. One of those, in the underground data set, is in the nuclear-recoil region of interest. Taking into account the expected background of 0.48 events coming from random pileup, the resulting upper limit on the electronic recoil contamination is $<2.7\times10^{-8}$ (90% C.L.) between 44-89 keVee and for a nuclear recoil acceptance of at least 90%, with 6% systematic uncertainty on the absolute energy scale. We developed a general mathematical framework to describe PSD parameter distributions and used it to build an analytical model of the distributions observed in DEAP-1. Using this model, we project a misidentification fraction of approx. $10^{-10}$ for an electron-equivalent energy threshold of 15 keV for a detector with 8 PE/keVee light yield. This reduction enables a search for spin-independent scattering of WIMPs from 1000 kg of liquid argon with a WIMP-nucleon cross-section sensitivity of $10^{-46}$ cm$^2$, assuming negligible contribution from nuclear recoil backgrounds., Comment: Accepted for publication in Astroparticle Physics

Published
2009
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33. Mosaic variant of trisomy on chromosome 8 (Warkany syndrome): report on a rare clinical case in a newborn boy after IVF fertilization

Author

Kagantsov, I. M., primary, Belonog, O. L., additional, Sukhotskaya, A. A., additional, Nikulina, T. S., additional, Sherbakov, A. A., additional, Petrova, N. A., additional, Li, O. A., additional, Petrov, D. V., additional, Volkova, Yu. V., additional, Amidkhonova, S. A., additional, and Pervunina, T. M., additional

Published
2023
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34. Preparation and Properties of Magnetic Composites γ-Fe2O3/SiO2/Aptamer(FAS9) for Magnetic Resonance Hyperthermia.

Author

Stolyar, S. V., Li, O. A., Nikolaeva, E. D., Vorotynov, A. M., Velikanov, D. A., Knyazev, Yu. V., Bayukov, O. A., Iskhakov, R. S., Kryukova, O. V., Pyankov, V. F., Volochaev, M. N., and Mokhov, A. A.

Subjects
MAGNETIC resonance, MAGNETIC properties, FERROMAGNETIC resonance, FEVER, MAGNETIC particles
Abstract

Powders of maghemite γ-Fe2O3 with an average diameter of 8 nm, γ-Fe2O3/SiO2 composites with an agglomerate diameter of about 50 nm and a size of interspersed γ-Fe2O3 particles of 6 nm, and γ‑Fe2O3/SiO2/aptamer(FAS9) composites were synthesized by chemical deposition. Mössbauer spectra were measured, the static and dynamic magnetic properties of the powders were studied, and the coercive force was determined, which decreases from 14 Oe for γ-Fe2O3 powders to 3 Oe for the γ-Fe2O3/SiO2 composite. It is shown that the particle blocking temperature is close to room temperature. The increment of temperature of the powders was measured in the ferromagnetic resonance mode; the temperature of the Fe2O3/SiO2 composite (ΔT ≈ 16°C) turned out to be higher than that of the pure γ-Fe2O3 powder (ΔT ≈ 10°C). It has been experimentally shown that temperature increment ΔT is proportional to the square of the microwave field amplitude. It has been shown that the composition γ-Fe2O3/SiO2/aptamer FAS9 is able to effectively bind to tumor cells, and FMR hyperthermia leads to a decrease in the viability of tumor cells. [ABSTRACT FROM AUTHOR]

Published
2023
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35. Measurement of the scintillation time spectra and pulse-shape discrimination of low-energy β and nuclear recoils in liquid argon with DEAP-1

Author

Amaudruz, P.-A., Batygov, M., Beltran, B., Bonatt, J., Boudjemline, K., Boulay, M.G., Broerman, B., Bueno, J.F., Butcher, A., Cai, B., Caldwell, T., Chen, M., Chouinard, R., Cleveland, B.T., Cranshaw, D., Dering, K., Duncan, F., Fatemighomi, N., Ford, R., Gagnon, R., Giampa, P., Giuliani, F., Gold, M., Golovko, V.V., Gorel, P., Grace, E., Graham, K., Grant, D.R., Hakobyan, R., Hallin, A.L., Hamstra, M., Harvey, P., Hearns, C., Hofgartner, J., Jillings, C.J., Kuźniak, M., Lawson, I., La Zia, F., Li, O., Lidgard, J.J., Liimatainen, P., Lippincott, W.H., Mathew, R., McDonald, A.B., McElroy, T., McFarlane, K., McKinsey, D.N., Mehdiyev, R., Monroe, J., Muir, A., Nantais, C., Nicolics, K., Nikkel, J., Noble, A.J., O’Dwyer, E., Olsen, K., Ouellet, C., Pasuthip, P., Peeters, S.J.M., Pollmann, T., Rau, W., Retière, F., Ronquest, M., Seeburn, N., Skensved, P., Smith, B., Sonley, T., Tang, J., Vázquez-Jáuregui, E., Veloce, L., Walding, J., and Ward, M.

Published
2016
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39. DEAP-3600 Dark Matter Search

Author

Amaudruz, P.-A., Batygov, M., Beltran, B., Bonatt, J., Boulay, M.G., Broerman, B., Bueno, J.F., Butcher, A., Cai, B., Chen, M., Chouinard, R., Cleveland, B.T., Dering, K., DiGioseffo, J., Duncan, F., Flower, T., Ford, R., Giampa, P., Gorel, P., Graham, K., Grant, D.R., Guliyev, E., Hallin, A.L., Hamstra, M., Harvey, P., Jillings, C.J., Lawson, I., Li, O., Liimatainen, P., Majewski, P., McDonald, A.B., McElroy, T., McFarlane, K., Monroe, J., Muir, A., Nantais, C., Ng, C., Noble, A.J., Ouellet, C., Palladino, K., Pasuthip, P., Peeters, S.J.M., Pollmann, T., Rau, W., Retière, F., Seeburn, N., Singhrao, K., Skensved, P., Smith, B., Sonley, T., Tang, J., Vázquez-Jáuregui, E., Veloce, L., Walding, J., Ward, M., and Kuźniak, M.

Published
2016
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40. THE DRAMATURGICAL METHOD AND THE CONCEPT OF 'I': AN ANALYSIS OF THE PRESENTATION OF SELF IN EVERYDAY LIFE

Author

Kogabayev, D., Li, O., Dzhamankulova, A., and Tileubayeva, M.

Subjects
Dramaturgical Method, Concept of 'I', Presentation of Self, Everyday Life, Social Interaction, Impression Management, Front Stage, Backstage, Role Playing, Self-presentation, Symbolic Interactionism, Goffman
Abstract

This article explores the concept of self, focusing on the role of language in shaping and communicating our sense of self to others. The author presents the dramaturgical analysis, a theoretical framework developed by sociologist Erving Goffman, which examines social interactions as a form of performance. The article also explores the importance of communication in contemporary society, discussing how social media platforms, advertising, and public relations shape our public image. The author argues that understanding the dynamics of communication organization can provide insight into how people and organizations form their public image and how this image affects their interaction with others. The article concludes that communication plays a crucial role in how people and organizations present themselves to the world and highlights the strategic nature of social interactions.

Published
2023
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42. Improving photoelectron counting and particle identification in scintillation detectors with Bayesian techniques

Author

Akashi-Ronquest, M., Amaudruz, P.-A., Batygov, M., Beltran, B., Bodmer, M., Boulay, M.G., Broerman, B., Buck, B., Butcher, A., Cai, B., Caldwell, T., Chen, M., Chen, Y., Cleveland, B., Coakley, K., Dering, K., Duncan, F.A., Formaggio, J.A., Gagnon, R., Gastler, D., Giuliani, F., Gold, M., Golovko, V.V., Gorel, P., Graham, K., Grace, E., Guerrero, N., Guiseppe, V., Hallin, A.L., Harvey, P., Hearns, C., Henning, R., Hime, A., Hofgartner, J., Jaditz, S., Jillings, C.J., Kachulis, C., Kearns, E., Kelsey, J., Klein, J.R., Kuźniak, M., LaTorre, A., Lawson, I., Li, O., Lidgard, J.J., Liimatainen, P., Linden, S., McFarlane, K., McKinsey, D.N., MacMullin, S., Mastbaum, A., Mathew, R., McDonald, A.B., Mei, D.-M., Monroe, J., Muir, A., Nantais, C., Nicolics, K., Nikkel, J.A., Noble, T., O’Dwyer, E., Olsen, K., Orebi Gann, G.D., Ouellet, C., Palladino, K., Pasuthip, P., Perumpilly, G., Pollmann, T., Rau, P., Retière, F., Rielage, K., Schnee, R., Seibert, S., Skensved, P., Sonley, T., Vázquez-Jáuregui, E., Veloce, L., Walding, J., Wang, B., Wang, J., Ward, M., and Zhang, C.

Published
2015
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43. Radon backgrounds in the DEAP-1 liquid-argon-based Dark Matter detector

Author

Amaudruz, P.-A., Batygov, M., Beltran, B., Boudjemline, K., Boulay, M.G., Cai, B., Caldwell, T., Chen, M., Chouinard, R., Cleveland, B.T., Contreras, D., Dering, K., Duncan, F., Ford, R., Gagnon, R., Giuliani, F., Gold, M., Golovko, V.V., Gorel, P., Graham, K., Grant, D.R., Hakobyan, R., Hallin, A.L., Harvey, P., Hearns, C., Jillings, C.J., Kuźniak, M., Lawson, I., Li, O., Lidgard, J., Liimatainen, P., Lippincott, W.H., Mathew, R., McDonald, A.B., McElroy, T., McFarlane, K., McKinsey, D., Muir, A., Nantais, C., Nicolics, K., Nikkel, J., Noble, T., O’Dwyer, E., Olsen, K.S., Ouellet, C., Pasuthip, P., Pollmann, T., Rau, W., Retiere, F., Ronquest, M., Skensved, P., Sonley, T., Tang, J., Vázquez-Jáuregui, E., Veloce, L., and Ward, M.

Published
2015
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44. Trophoblastic neoplasia on the background of developing pregnancy: a rare gynecological tumor with a chance of favorable outcome for mother and fetus

Author

Ulrikh, E. A., primary, Dikareva, E. L., additional, Dzharbaeva, A. D., additional, Zhamborova, O. A., additional, Pervuninа, T. M., additional, Komlichenko, E. V., additional, Protsenko, S.  A., additional, Teletaeva, G.  M., additional, Li, O.  A., additional, Artemyeva, A. S., additional, Mashenko, I.  A., additional, Kutusheva, G.  F., additional, Semiglazova, T.  Yu., additional, and Urmancheeva, А. F., additional

Published
2022
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48. BIOGAZ ORQALI AHOLINING TURMUSH TARZINI YAXSHILASH

Author

Madiyev Azizbek Mamasoat Oʻgʻli, Oʻrozova Oʻgʻiloy Fayzullayevna

Abstract

Biogazning afzalliklaridan biri, xohlagan joyda issiqlik va elektr energiyasi ishlab chiqarish mumkinligidir. Chiqindilarni biokonversiya jarayoni energetik muammoni hal qilishdan tashqari yana ikkita masalani hal qiladi. Birinchidan, achigan go’ng odatdagi go’ngga qaraganda qishloq xo’jalik ekinlarining hosildorligini 10 + 20% oshiradi. Ikkinchidan, chiqindilar achigan vaqtda go’ng tarkibida ko’p miqdorda bo’lgan begona o’tlarning urug’lari, har xil mikroblarning birikmalari, gelmintin urug’lar va yoqimsiz hidlar yo’qotiladi.

Published
2022
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49. O'ZBEKISTON RESPUBLIKASI TARIXIY GEOGRAFIYASI (1991 – 2000 - YILLAR)

Author

Elmoʻminov Abduvahob Xudoyberdi oʻgʻli, Oʻrozdavlatov Samandar Alisherovich, Xushboqov Elyor Abdukarim oʻgʻli, Amirqulova Feruza Muzaffar qizi

Abstract

O‘zbekiston geografik o‘rniga ko‘ra O‘rta dengiz bo‘yidagi Ispaniya, Italiya, Gretsiya kabi mamlakatlar bilan taxminan bir geografik kenglikda joylashgan. Lekin O‘zbekiston Yevrosiyo materigining ichki qismida okean va dengizlardan uzoqda joylashganligi tufayli subtropik okrugdan farq qiladi.

Published
2022
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50. BUYUK IPAK YO'LI - MULOQOT YO'LI

Author

Elmoʻminov Abduvahob Xudoyberdi Oʻgʻli, Oʻrozdavlatov Samandar Alisherovich

Abstract

1987 yil YUNESKO madaniy taraqqiyot bo’yicha BMTning umumjahon dekadasi doirasida “Ipak yo’li — muloqot yo’li” xalqaro dasturini qabul qildi. Bu dastur O’rta Osiyo xalqlari boy madaniy tarixlarini keng qamrovda tadqiq etishni nazarda tutadi. Biroq uning asosiy maqsadi — Sharq bilan G’arb o’rtasida yanada mustahkamroq madaniy va iqtisodiy aloqalar o’rnatish, ushbu buyuk qit’alarda yashovchi ko’p sonli xalqlar o’rtasidagi o’zaro munosabatlarni yaxshilashdan iborat. Ko’plab (30 dan ziyod) xalqaro ilmiy konferentsiya (jumladan, Samarqand, 1990 yil oktabr; Buxoro, 1996 yil Fevral) va seminarlar o’tkazildi. Buyuk ipak yo’li bo’ylab birgalikda xalqaro ekspeditsiyalar uyushtirildi, kinofilmlar yaratildi, kitoblar, broshyuralar va maqolalar chop etildi, ba’zi arxeologik va me’moriy yodgorliklar ta’mirlandi. Ba’zi bir Sharq mamlakatlarida (Hindiston, Xitoy, O’zbekiston, Shri Lanka, Yaponiya) Buyuk ipak yo’lini o’rganish bo’yicha maxsus ilmiy institutlar barpo etilgan.

Published
2022
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