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11. [Research progress on mechanism of biotrauma caused by ventilation-induced lung injury].

Author

Lian S, Zhou L, Jiang W, and Zhang X

Subjects
Humans, Respiration, Artificial adverse effects, Lung, Respiratory Physiological Phenomena, Lung Injury etiology, Lung Injury therapy, Ventilator-Induced Lung Injury prevention & control, Respiratory Distress Syndrome therapy
Abstract

Mechanical ventilation is an advanced life support treatment for patients with acute respiratory failure. While stabilizing respiratory function, it also acts as an injury factor to exacerbate or lead to lung injury, that is, ventilation-induced lung injury (VILI). There may be a more subtle form of damage to VILI known as "biotrauma". However, the mechanism of biotrauma in VILI is still unclear. This article intends to review the mechanism of biotrauma of VILI from the aspects of inflammatory response, oxidative stress and complement activation, in order to provide a new strategy for clinical prevention and treatment of biotrauma caused by VILI.

Published
2023
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